Gastrodia elata BL mediates the suppression of nnos and microglia activation to protect against neuronal damage in kainic acid-treated rats

American Journal of Chinese Medicine

Volumn 33, Issue 4, 2005, Pages 599-611

  Hsieh, Ching Liang ^a,b   Chen, Chi Long ^c   Tang, Nou Ying ^b   Chuang, Chin Min ^a   Hsieh, Ching Tou ^d   Chiang, Su Yin ^b   Lin, Jaung Geng ^b   Hsu, Sheng Feng ^b  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d JEN AI HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Gastrodia elata; Kainic acid; Microglia; Nitric oxide synthase (NOS)

Indexed keywords

ARGININE METHYL ESTER; GASTRODIA ELATA EXTRACT; INDUCIBLE NITRIC OXIDE SYNTHASE; KAINIC ACID; NITRIC OXIDE SYNTHASE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL COUNT; CHINESE MEDICINE; GASTRODIA; GASTRODIA ELATA; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MEDICINAL PLANT; MICROGLIA; NERVE CELL; NERVE INJURY; NERVE STIMULATION; NEUROPROTECTION; NONHUMAN; RAT; RAT STRAIN;

ANIMALS; APOPTOSIS; BRAIN DISEASES; DRUGS, CHINESE HERBAL; EXCITATORY AMINO ACID AGONISTS; GASTRODIA; HIPPOCAMPUS; KAINIC ACID; MALE; MICROGLIA; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY;

EID: 23944451375     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X0500320X     Document Type: Article

References (34)

1. Andersson, M.,O. Bergendorff M. Nielsen, O. Sterner, R. Witt, J. Ai, A. Lu and A.M. Wang. Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia, Phytochemistry 38(4): 835-836, 1995.
2. Andersson, P.B., VH. Perry and S. Gordon. The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration. Neuroscience 42(1): 201-214, 1991.
3. Balcioglu, A. and T.J. Maher. Determination of kainic acid-induced release of nitric oxide using a novel hemoglobin trapping technique with microdialysis. J. Neurochem. 61(6): 2311-2313, 1993.
4. Ben-Ari, Y. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 14: 375-403, 1985.
5. Boje, K.M. and P.K. Arora. Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res. 587: 250-256, 1992.
6. Buisson, A.,N. Lakhmeche, C. Verrecchia, M. Plotkine and R.G. Boulu. Nitric oxide: An endogenous anticonvulsant substance. NeuroReport 4: 444-446, 1993.
7. Chao, CC., S. Hu, T.W. Molitor, E.G. Shaskan and P.K. Peterson. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J. Immunol. 149(8): 2736-2741, 1993.
8. Dawson, V.L., T.M. Dawson, E.D. London, D.S. Bredt and S.H. Snyder. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA 88: 6368-6371, 1991.
9. Gally, J.A., P.R. Montague, G.N. Reeke and G.M. Edelman. The NO hypothesis: Possible effects of a short-lived rapidly diffusible signal in the development and function of the nervous system. Proc. Natl. Acad. Sci. USA 87: 3547-3551, 1990.
10. Ha, J.H., D.U. Lee, J.T. Lee, J.S. Kim, C.S. Yong, JA. Kim, J.S. Ha and K. Huh. 4-Hydroxybenzaldehyde from Gastrodia eleata B1. is active in the antioxidation and CABAergic neuromodulation of the rat brain. J. Ethnopharmacol. 73: 329-333, 2000.
11. Holeik, M., C.S. Thompson, Z. Yaraghi, C.A. Lefebvre, A.E. Mackenzie and R.G. Korneluk. The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injury. PNAS 97(15): 2286-2290, 2000.
12. Hsieh, C.L., S.Y. Chiang, K.S. Cheng, Y.H. Lin, N.Y. Tang, C.J. Lee, C.Z. Pon and C.T. Hsieh. Anticonvulsive and free radical scavenging activities of Gastrodia elata B1. in kainic acid-treated rats. Am. J. Chin. Med. 29(2): 331-341, 2001.
13. Kashihara, K., K. Sakai, K. Marui and T. Shohmori. Kainic acid may enhance hippocampal NO generation of awake rats in a seizure stage-related fashion. Neurosci. Res. 32: 189-194, 1998.
14. Kim, H.J., K.D. Moon, S.Y. Oh, S.P. Kim and S.R. Lee. Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus. Neurosci. Lett. 314: 65-68, 2001.
15. Kreutzberg, G.W. Microglia: A sensor for pathological events in the CNS. Trends Neurosci. 19(8): 312-318, 1996.
16. Lipton, S.A., Y.B. Choi, Z.H. Pan, S.Z. Lei, H.S.V Chen, N.J. Sucher, J. Loscalzo, D.J. Singel and J.S. Stamler. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364: 626-632, 1993.
17. Liu, J. and A. Mori. Antioxidant and free radical scavenging activities of Gastrodia elata B1. and Uncaria rhynchophylla (Miq) jacks. Neuropharmacol. 31(12): 1287-1298, 1992.
18. Maggio, R., F. Fumagalli, E. Donati, P. Barbier, G. Racagni, G.U. Corsini and M. Riva. Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats. Brain Res. 679: 184-187, 1995.
19. Manzoni, O. and J. Bockaert. Nitric oxide synthase activity endogenously modulates NMDA receptors. J. Neurochem. 61(1): 368-370, 1993.
20. Montécot, C., J. Borredon, J. Seylaz and E. Pinard. Nitric oxide of neuronal origin is involved in cerebral blood flow increase during seizures induced by kainate. J. Cereb. Blood Flow Metab. 17(1): 94-99, 1997.
21. Morioka, T., A.N. Kalehua and W.J. Streit. The microglial reaction in the rat dorsal hippocampus following transient forebrain ischemia. J. Cereb. Blood Flow Metab. 11 (6): 966-973, 1991.
22. Mülsch, A., R. Busse, P.I. Mordvinteev, A.F. Vanin, E.O. Nielsen, J. Scheel-Krüger and S.P. Olesen. Nitric oxide promotes seizure activity in kainate-treated rats. NeuroReport 5(17): 2325-2328, 1994.
23. Osonoe, K., N. Mori, K. Suzuki and M. Osonoe. Anti-epileptic effects of inhibitors of nitric oxide synthase examined in pentylenetetrazol-induced seizures in rats. Brain Res. 663: 338-340, 1994.
24. Rondouin, G., J. Bockaert and M. Lerner-Natoli. L-Nitroarginine, an inhibitor of NO synthase, dramatically worsens limbic epilepsy in rats. NeuroReport 4(10): 1187-1190, 1993.
25. Samdani, A.F., T.M. Dawson and V.L. Dawson. Nitric oxide synthase in models of focal ischemia. Stroke 28(6): 1283-1288, 1997.
26. Schwor, J.E., T. Fuller, J.L. Price and J.W. Olney. Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: A histological study. Neuroscience 5: 991-1014, 1980.
27. Simonian, N.A., R.L. Getz, J.C. Leveque, C. Konradi and J.T. Coyle. Kainic acid induces apoptosis in neurons. Neuroscience 75(4): 1047-1055, 1996.
28. Solà, C., J.M. Tusell and J. Serratosa. Calmodulin is expressed by reactive microglia in the hippocampus of kainic acid-treated mice. Neuroscience 81(3): 699-705, 1997.
29. Taniwaki, Y., M. Kato, T. Araki and T. Kobayashi. Microglial activation by epileptic activities through the propagation pathway of kainic acid-induced hippocampal seizures in the rat. Neurosci. Lett. 217: 29-32, 1996.
30. Togashi, H., M. Sasaki, E. Frohman, E. Taira, R.R. Ratan, T.M. Dawson and V.L. Dawson. Neuronal (type I) nitric oxide synthase regulates nuclear factor κB activity and immunologic (type II) nitric oxide synthase expression. Proc. Natl. Acad. Sci. USA 94: 2676-2680, 1997.
31. Tzeng, S.F. and J.P. Wu. Responses of microglia and neural progenitors to mechanical brain injury. NeuroReport 10(11): 2287-2292, 1999.
32. Venero, J.L., M. Revuelta, A. Machado and J. Cano. Delayed apoptotic pyramidal cell death in CA4 and CA1 hippocampal subfields after a single intraseptal injection of kainate. Neuroscience 94(4): 1071-1081, 1999.
33. Vezzani, A., M. Conti, A.D. Luigi, T. Ravizza, D. Moneta, F. Marchesi and M.G. De Simoni. Interleukin-1β immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainite application: Functional evidence for enhancement of electrographic seizures. J. Neurosci. 19(12): 5054-5065, 1999.
34. Wang, Q., M.A. Theard, D.A. Pelligrino, V.L. Baughman, W.E. Hoffman, R.F. Albrecht, M. Cwik, O.B. Paulson and N.A. Lassen. Nitric oxide (NO) is an endogenous anti-convulsant but not a mediator of the increase in cerebral blood flow accompanying bicuculline-induced seizures in rats. Brain Res. 658: 192-198, 1994.