Repetitive treatment with diluted bee venom reduces neuropathic pain via potentiation of locus coeruleus noradrenergic neuronal activity and modulation of spinal NR1 phosphorylation in rats

Journal of Pain

Volumn 13, Issue 2, 2012, Pages 155-166

  Kang, Suk Yun ^a   Roh, Dae Hyun ^a   Yoon, Seo Yeon ^b   Moon, Ji Young ^a   Kim, Hyun Woo ^c   Lee, Hye Jung ^d   Beitz, Alvin J ^e   Lee, Jang Hern ^a  

^a Seoul National University   (South Korea)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c Chungnam National University   (South Korea)

^d Kyung Hee University   (South Korea)

^e UNIVERSITY OF MINNESOTA   (United States)

Author keywords

allodynia; Bee venom; locus coeruleus; neuropathic pain; NMDA receptor

Indexed keywords

BEE VENOM; IDAZOXAN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; PROTEIN FOS;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPERALGESIA; LOCUS CERULEUS; MALE; NERVE CONDUCTION; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; NORADRENERGIC NERVE; PHOSPHORYLATION; PROTEIN EXPRESSION; RAT;

ADRENERGIC ALPHA-2 RECEPTOR ANTAGONISTS; ADRENERGIC NEURONS; ANALGESICS, NON-NARCOTIC; ANALYSIS OF VARIANCE; ANIMALS; BEE VENOMS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; GENE EXPRESSION REGULATION; IDAZOXAN; LOCUS COERULEUS; MALE; MICROSCOPY, IMMUNOELECTRON; MOTOR ACTIVITY; ONCOGENE PROTEINS V-FOS; PAIN MEASUREMENT; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RECEPTORS, N-METHYL-D-ASPARTATE; ROTAROD PERFORMANCE TEST; SCIATICA; TIME FACTORS; TYROSINE 3-MONOOXYGENASE;

EID: 84856499859     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2011.10.012     Document Type: Article

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