Stabilization of mitochondrial function by tetramethylpyrazine protects against kainate-induced oxidative lesions in the rat hippocampus

Free Radical Biology and Medicine

Volumn 48, Issue 4, 2010, Pages 597-608

  Li, Shu Yan ^a   Jia, Yu Hong ^a   Sun, Wen Ge ^a   Tang, Yuan ^a   An, Guo Shun ^a   Ni, Ju Hua ^a   Jia, Hong Ti ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Free radicals; Kainate; Mitochondrial dysfunction; Neuroprotection; Reactive oxygen species; Tetramethylpyrazine

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; KAINIC ACID; LIPID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); TETRAMETHYLPYRAZINE; UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN DAMAGE; CONTROLLED STUDY; DRUG MECHANISM; EPILEPTIC STATE; EXCITOTOXICITY; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; CALCIUM; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; KAINIC ACID; LIPID PEROXIDATION; MALE; MEDICINE, CHINESE TRADITIONAL; MITOCHONDRIA; NEURONS; OXIDATIVE STRESS; PLANT EXTRACTS; PYRAZINES; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

LIGUSTICUM; RATTUS;

EID: 74149085909     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.12.004     Document Type: Article

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