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Volumn 8, Issue 5, 2006, Pages 313-317

The proteasome: A novel target for anticancer therapy

Author keywords

Bortezomib; Myeloma; NF kappaB; Proteasome

Indexed keywords

ANTINEOPLASTIC AGENT; BORTEZOMIB; CYCLOOXYGENASE 2; DEXAMETHASONE; FLICE INHIBITORY PROTEIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; LACTACYSTIN BETA LACTONE; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN BCL 2; TUMOR NECROSIS FACTOR; UBIQUITIN; VASCULOTROPIN; BORONIC ACID DERIVATIVE; PROTEINASE INHIBITOR; PYRAZINE DERIVATIVE; TUMOR PROTEIN;

EID: 33747517230     PISSN: 1699048X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12094-006-0176-8     Document Type: Article
Times cited : (73)

References (65)
  • 1
    • 0034981649 scopus 로고    scopus 로고
    • 26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer
    • Shah SA, Potter MW, McDade TP, et al. 26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer. J Cell Biochem. 2001;82:110-22.
    • (2001) J Cell Biochem , vol.82 , pp. 110-122
    • Shah, S.A.1    Potter, M.W.2    McDade, T.P.3
  • 2
    • 0033968043 scopus 로고    scopus 로고
    • The proteasome controls the expression of a proliferation-associated nuclear antigen Ki-67
    • Wu Y, Luo H, Kanaan N, et al. The proteasome controls the expression of a proliferation-associated nuclear antigen Ki-67, J Cell Biochem, 2000;76:596-604.
    • (2000) J Cell Biochem , vol.76 , pp. 596-604
    • Wu, Y.1    Luo, H.2    Kanaan, N.3
  • 3
    • 0033623487 scopus 로고    scopus 로고
    • Proteasome inhibitors induced caspase-dependent apoptosis and accumulation of p21 WAF1/Cipl in human immature leukemic cells
    • Naujokat C, Sezer O, Zinke H, et al. Proteasome inhibitors induced caspase-dependent apoptosis and accumulation of p21 WAF1/Cipl in human immature leukemic cells. Eur J Haematol. 2000;65:221-56.
    • (2000) Eur J Haematol , vol.65 , pp. 221-256
    • Naujokat, C.1    Sezer, O.2    Zinke, H.3
  • 4
    • 0029952441 scopus 로고    scopus 로고
    • In vivo ubiquitination and proteasome-mediated degradation of p53(1)
    • Maki CG, Huibregtse JM, Howley PM. In vivo ubiquitination and proteasome-mediated degradation of p53(1). Cancer Res, 1996;56:2649-54.
    • (1996) Cancer Res , vol.56 , pp. 2649-2654
    • Maki, C.G.1    Huibregtse, J.M.2    Howley, P.M.3
  • 5
    • 0033920566 scopus 로고    scopus 로고
    • Protease inhibitor-induced apoptosis: Accumulation of wt p53, p21WAF1/ CIP1, and induction of apoptosis are independent markers of proteasome inhibition
    • An WG, Hwang SG, Trepel JB, et al. Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition. Leukemia. 2000;14:1276-83.
    • (2000) Leukemia , vol.14 , pp. 1276-1283
    • An, W.G.1    Hwang, S.G.2    Trepel, J.B.3
  • 6
    • 0032535483 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway: On protein death and cell life
    • Ciechanover A. The ubiquitin-proteasome pathway: On protein death and cell life, Embo J. 1998;17:7151-60.
    • (1998) Embo J , vol.17 , pp. 7151-7160
    • Ciechanover, A.1
  • 7
    • 0034915764 scopus 로고    scopus 로고
    • Mechanisms underlying ubiquitination
    • Pickart CM. Mechanisms underlying ubiquitination. Annu Rev Biochem 2001;70:503-53.
    • (2001) Annu Rev Biochem , vol.70 , pp. 503-553
    • Pickart, C.M.1
  • 8
    • 0034652143 scopus 로고    scopus 로고
    • Subcellular localization of proteasomes and their regulatory complexes in mammalian cells
    • Brooks P, Fuertes G, Murray RZ, et al. Subcellular localization of proteasomes and their regulatory complexes in mammalian cells. Biochem J. 2000;346 Pt 1: 155-61.
    • (2000) Biochem J , vol.346 , Issue.PART 1 , pp. 155-161
    • Brooks, P.1    Fuertes, G.2    Murray, R.Z.3
  • 9
    • 0032483546 scopus 로고    scopus 로고
    • A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3
    • Glickman MH, Rubin DM, Coux O, et al. A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Cell. 1998;94:615-23.
    • (1998) Cell , vol.94 , pp. 615-623
    • Glickman, M.H.1    Rubin, D.M.2    Coux, O.3
  • 10
    • 0034602845 scopus 로고    scopus 로고
    • Recognition of the polyubiquitin proteolytic signal
    • Thrower JS, Hoffman L, Rechsteiner M, et al. Recognition of the polyubiquitin proteolytic signal. Embo J. 2000;19:94-102.
    • (2000) Embo J , vol.19 , pp. 94-102
    • Thrower, J.S.1    Hoffman, L.2    Rechsteiner, M.3
  • 11
    • 0032514684 scopus 로고    scopus 로고
    • Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1
    • Nussbaum AK, Dick TP, Keilholz W, et al. Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1. Proc Natl Acad Sci U S A. 1998;95:12504-9.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 12504-12509
    • Nussbaum, A.K.1    Dick, T.P.2    Keilholz, W.3
  • 12
    • 0033529596 scopus 로고    scopus 로고
    • The proteasome, a novel protease regulated by multiple mechanisms
    • DeMartino GN, Slaughter CA. The proteasome, a novel protease regulated by multiple mechanisms. J Biol Chem. 1999;274: 22123-6.
    • (1999) J Biol Chem , vol.274 , pp. 22123-22126
    • DeMartino, G.N.1    Slaughter, C.A.2
  • 13
    • 0033615348 scopus 로고    scopus 로고
    • The proteasome: A macromolecular assembly designed for controlled proteolysis
    • Zwickl P, Voges D, Baumeister W. The proteasome: A macromolecular assembly designed for controlled proteolysis. Philos Trans R Soc Lond B Biol Sci. 1999;354: 1501-11.
    • (1999) Philos Trans R Soc Lond B Biol Sci , vol.354 , pp. 1501-1511
    • Zwickl, P.1    Voges, D.2    Baumeister, W.3
  • 14
    • 0036855056 scopus 로고    scopus 로고
    • Proteasome inhibitors as new anticancer drugs
    • Adams J. Proteasome inhibitors as new anticancer drugs. Curr Opin Oncol. 2002;14: 628-34.
    • (2002) Curr Opin Oncol , vol.14 , pp. 628-634
    • Adams, J.1
  • 16
    • 0024285837 scopus 로고
    • Identity of the 19S prosome particle with the large multifunctional protease complex of mammalian cells (the proteasome)
    • Arrigo AP, Tanaka K, Goldberg AL, et al. Identity of the 19S prosome particle with the large multifunctional protease complex of mammalian cells (the proteasome). Nature. 1988;531:192-4.
    • (1988) Nature , vol.531 , pp. 192-194
    • Arrigo, A.P.1    Tanaka, K.2    Goldberg, A.L.3
  • 17
    • 0036172154 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-541, a potential therapeutic agent for adult T-cell leukemia
    • Tan C, Waldmann TA. Proteasome inhibitor PS-541, a potential therapeutic agent for adult T-cell leukemia. Cancer Res. 2002;62:1085-6.
    • (2002) Cancer Res , vol.62 , pp. 1085-1086
    • Tan, C.1    Waldmann, T.A.2
  • 18
    • 0033152760 scopus 로고    scopus 로고
    • Proteasome inhibitors: A novel class of potent and effective antitumor agents
    • Adams J, Palombella VJ, Sausville EA, et al. Proteasome inhibitors: A novel class of potent and effective antitumor agents. Cancer Res. 1999;59:2615-22.
    • (1999) Cancer Res , vol.59 , pp. 2615-2622
    • Adams, J.1    Palombella, V.J.2    Sausville, E.A.3
  • 19
    • 23044443539 scopus 로고    scopus 로고
    • Preclinical and clinical development of the proteasome inhibitor bortezomib in cancer treatment
    • Montagut C, Rovira A, Mellado B, et al. Preclinical and clinical development of the proteasome inhibitor bortezomib in cancer treatment. Drugs Today (Barc). 2005; 41:299-315.
    • (2005) Drugs Today (Barc) , vol.41 , pp. 299-315
    • Montagut, C.1    Rovira, A.2    Mellado, B.3
  • 20
    • 0036879427 scopus 로고    scopus 로고
    • Bortezomib, a proteasome inhibitor for cancer therapy: From concept to clinic
    • Albanell J, Adams J. Bortezomib, a proteasome inhibitor for cancer therapy: From concept to clinic. Drugs of the Future. 2002;27:1-14.
    • (2002) Drugs of the Future , vol.27 , pp. 1-14
    • Albanell, J.1    Adams, J.2
  • 21
    • 0031906567 scopus 로고    scopus 로고
    • The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosis
    • Delic J, Masdehors P, Omura S, et al. The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosis. Br J Cancer. 1998;77:1103-7.
    • (1998) Br J Cancer , vol.77 , pp. 1103-1107
    • Delic, J.1    Masdehors, P.2    Omura, S.3
  • 22
    • 0033621851 scopus 로고    scopus 로고
    • p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells
    • Kudo Y, Takata T, Ogawa I, et al. p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells. Clin Cancer Res. 2000;6:916-23.
    • (2000) Clin Cancer Res , vol.6 , pp. 916-923
    • Kudo, Y.1    Takata, T.2    Ogawa, I.3
  • 23
    • 0033059459 scopus 로고    scopus 로고
    • Increased sensitivity of CLL-derived lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin
    • Masdehors P, Omura S, Merle-Beral H, et al. Increased sensitivity of CLL-derived lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin. Br J Haematol. 1999;105:752-7.
    • (1999) Br J Haematol , vol.105 , pp. 752-757
    • Masdehors, P.1    Omura, S.2    Merle-Beral, H.3
  • 24
    • 0035000515 scopus 로고    scopus 로고
    • The apoptogenic response of human myeloid leukaemia cell lines and of normal and malignant haematopoietic progenitor cells to the proteasome inhibitor PSI
    • Soligo D, Servida F, Delia D, et al. The apoptogenic response of human myeloid leukaemia cell lines and of normal and malignant haematopoietic progenitor cells to the proteasome inhibitor PSI. Br J Haematol. 2001;115:126-35.
    • (2001) Br J Haematol , vol.115 , pp. 126-135
    • Soligo, D.1    Servida, F.2    Delia, D.3
  • 25
    • 0032189685 scopus 로고    scopus 로고
    • Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor
    • Orlowski RZ, Eswara JR, Lafond-Walker A, et al. Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor. Cancer Res. 1998;58:4542-8.
    • (1998) Cancer Res , vol.58 , pp. 4542-4548
    • Orlowski, R.Z.1    Eswara, J.R.2    Lafond-Walker, A.3
  • 26
    • 0035300479 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-541 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
    • Hideshima T, Richardson P, Chauhan D, et al. The proteasome inhibitor PS-541 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 2001;61:5071-6.
    • (2001) Cancer Res , vol.61 , pp. 5071-5076
    • Hideshima, T.1    Richardson, P.2    Chauhan, D.3
  • 27
    • 0343932632 scopus 로고    scopus 로고
    • Deregulation of the ubiquitin system and p55 proteolysis modify the apoptotic response in B-CLL lymphocytes
    • Masdehors P, Merle-Beral H, Maloum K, et al. Deregulation of the ubiquitin system and p55 proteolysis modify the apoptotic response in B-CLL lymphocytes. Blood. 2000;96:269-74.
    • (2000) Blood , vol.96 , pp. 269-274
    • Masdehors, P.1    Merle-Beral, H.2    Maloum, K.3
  • 28
    • 0034488466 scopus 로고    scopus 로고
    • Response and determinants of sensitivity to paclitaxel in human non-small cell lung cancer tumors heterotransplanted in nude mice
    • Pérez-Soler R, Kemp B, Wu QP, et al. Response and determinants of sensitivity to paclitaxel in human non-small cell lung cancer tumors heterotransplanted in nude mice. Clin Cancer Res. 2000;6:4952-8.
    • (2000) Clin Cancer Res , vol.6 , pp. 4952-4958
    • Pérez-Soler, R.1    Kemp, B.2    Wu, Q.P.3
  • 29
    • 0026315682 scopus 로고
    • Changes in expressions of proteasome and ubiquitin genes in human renal cancer cells
    • Kanayama H, Tanaka K, Aki M, et al. Changes in expressions of proteasome and ubiquitin genes in human renal cancer cells. Cancer Res. 1991;51:6677-85.
    • (1991) Cancer Res , vol.51 , pp. 6677-6685
    • Kanayama, H.1    Tanaka, K.2    Aki, M.3
  • 30
    • 0025346087 scopus 로고
    • cDNA cloning and sequencing of component C9 of proteasomes from rat hepatoma cells
    • Kumatori A, Tanaka K, Tamura T, et al. cDNA cloning and sequencing of component C9 of proteasomes from rat hepatoma cells. FEBS Lett. 1990;264:279-82.
    • (1990) FEBS Lett , vol.264 , pp. 279-282
    • Kumatori, A.1    Tanaka, K.2    Tamura, T.3
  • 32
    • 0033965742 scopus 로고    scopus 로고
    • Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells
    • Drexler HC, Risau W, Konerding MA. Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells. Faseb J. 2000;14:65-77.
    • (2000) Faseb J , vol.14 , pp. 65-77
    • Drexler, H.C.1    Risau, W.2    Konerding, M.A.3
  • 33
    • 0035207110 scopus 로고    scopus 로고
    • The role of nuclear factor-kappaB in the biology and treatment of multiple myeloma
    • Berenson JR, Ma HM, Vescio R. The role of nuclear factor-kappaB in the biology and treatment of multiple myeloma. Semin Oncol. 2001;28:626-33.
    • (2001) Semin Oncol , vol.28 , pp. 626-633
    • Berenson, J.R.1    Ma, H.M.2    Vescio, R.3
  • 34
    • 0035886024 scopus 로고    scopus 로고
    • Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells
    • Guzmán ML, Neering SJ, Upchurch D, et al Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood. 2001;98: 2501-7.
    • (2001) Blood , vol.98 , pp. 2501-2507
    • Guzmán, M.L.1    Neering, S.J.2    Upchurch, D.3
  • 35
    • 3042716638 scopus 로고    scopus 로고
    • NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis
    • Biswas DK, Shi Q, Baily S, et al. NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis. Proc Natl Acad Sci U S A. 2004;101:10157-42.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10157-10242
    • Biswas, D.K.1    Shi, Q.2    Baily, S.3
  • 36
    • 27944434722 scopus 로고    scopus 로고
    • Activation of nuclear factor-kappaB in human prostate carcinogensis and association to biochemical relapse
    • Domingo-Doménech J, Mellado B, Ferrer B, et al. Activation of nuclear factor-kappaB in human prostate carcinogensis and association to biochemical relapse. Br J Cancer. 2005;95:1285-94.
    • (2005) Br J Cancer , vol.95 , pp. 1285-1294
    • Domingo-Doménech, J.1    Mellado, B.2    Ferrer, B.3
  • 37
    • 0034902354 scopus 로고    scopus 로고
    • Novel proteasome inhibitor PS-541 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma
    • Sunwoo JB, Chen Z, Dong G, et al. Novel proteasome inhibitor PS-541 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin Cancer Res. 2001;7:1419-28.
    • (2001) Clin Cancer Res , vol.7 , pp. 1419-1428
    • Sunwoo, J.B.1    Chen, Z.2    Dong, G.3
  • 38
    • 0035328584 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-kappaB inhibition
    • Cusack JC, Jr., Liu R, Houston M, et al. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-kappaB inhibition. Cancer Res. 2001;61:3535-40.
    • (2001) Cancer Res , vol.61 , pp. 3535-3540
    • Cusack Jr., J.C.1    Liu, R.2    Houston, M.3
  • 39
    • 0030610472 scopus 로고    scopus 로고
    • Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C
    • Das KC, White CW. Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C. J Biol Chem. 1997;272: 14914-20.
    • (1997) J Biol Chem , vol.272 , pp. 14914-14920
    • Das, K.C.1    White, C.W.2
  • 40
    • 0036546501 scopus 로고    scopus 로고
    • NF-kappaB in cancer: From innocent bystander to major culprit
    • Karin M, Cao Y, Greten FR, et al. NF-kappaB in cancer: From innocent bystander to major culprit. Nat Rev Cancer. 2002;2:501-10.
    • (2002) Nat Rev Cancer , vol.2 , pp. 501-510
    • Karin, M.1    Cao, Y.2    Greten, F.R.3
  • 41
    • 0032905030 scopus 로고    scopus 로고
    • Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB
    • Wang CY, Cusack JC Jr., Liu R, et al. Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nat Med. 1999;5:412-7.
    • (1999) Nat Med , vol.5 , pp. 412-417
    • Wang, C.Y.1    Cusack Jr., J.C.2    Liu, R.3
  • 42
    • 49849102453 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: Therapeutic applications
    • Mitsiades N, Mitsiades CS, Richardson PG, et al. The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: Therapeutic applications. Blood. 2005;101:2577-80.
    • (2005) Blood , vol.101 , pp. 2577-2580
    • Mitsiades, N.1    Mitsiades, C.S.2    Richardson, P.G.3
  • 43
    • 0034875305 scopus 로고    scopus 로고
    • Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome
    • Bold RJ, Virudachalam S, McConkey DJ. Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome. J Surg Res. 2001;100:11-7.
    • (2001) J Surg Res , vol.100 , pp. 11-17
    • Bold, R.J.1    Virudachalam, S.2    McConkey, D.J.3
  • 44
    • 3042562304 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib enhances the activity of docetaxel in orthotopic human pancreatic tumor xenografts
    • Nawrocki ST, Sweeney-Gotsch B, Takamori R, et al. The proteasome inhibitor bortezomib enhances the activity of docetaxel in orthotopic human pancreatic tumor xenografts. Mol Cancer Ther. 2004;5: 59-70.
    • (2004) Mol Cancer Ther , vol.5 , pp. 59-70
    • Nawrocki, S.T.1    Sweeney-Gotsch, B.2    Takamori, R.3
  • 45
    • 0032539702 scopus 로고    scopus 로고
    • Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids
    • Adams J, Behnke M, Chen S, et al. Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids. Bioorg Med Chem Lett. 1998;8:333-8.
    • (1998) Bioorg Med Chem Lett , vol.8 , pp. 333-338
    • Adams, J.1    Behnke, M.2    Chen, S.3
  • 46
    • 0030850669 scopus 로고    scopus 로고
    • Proteasome inhibitors and antigen presentation
    • Bogyo M, Gaczynska M, Ploegh HL. Proteasome inhibitors and antigen presentation. Biopolymers. 1997;43:269-80.
    • (1997) Biopolymers , vol.43 , pp. 269-280
    • Bogyo, M.1    Gaczynska, M.2    Ploegh, H.L.3
  • 47
    • 0035902778 scopus 로고    scopus 로고
    • Crystal structure of the 20 S proteasome: TMC-95A complex: A non-covalent proteasome inhibitor
    • Groll M, Koguchi Y, Huber R, et al. Crystal structure of the 20 S proteasome:ATMC-95A complex: a non-covalent proteasome inhibitor. J Mol Biol. 2001;511: 545-8.
    • (2001) J Mol Biol , vol.511 , pp. 545-548
    • Groll, M.1    Koguchi, Y.2    Huber, R.3
  • 48
    • 0033564512 scopus 로고    scopus 로고
    • Eponemycin exerts its antitumor effect through the inhibition of proteasome function
    • Meng L, Kwok BH, Sin N, et al. Eponemycin exerts its antitumor effect through the inhibition of proteasome function. Cancer Res. 1999;59:2798-801.
    • (1999) Cancer Res , vol.59 , pp. 2798-2801
    • Meng, L.1    Kwok, B.H.2    Sin, N.3
  • 49
    • 0029033981 scopus 로고
    • Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
    • Fenteany G, Standaert RF, Lane WS, et al. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science. 1995;268:726-31.
    • (1995) Science , vol.268 , pp. 726-731
    • Fenteany, G.1    Standaert, R.F.2    Lane, W.S.3
  • 50
    • 0034951049 scopus 로고    scopus 로고
    • Lactacystin inhibits cathepsin A activity in melanoma cell lines
    • Kozlowski L, Stoklosa T, Omura S, et al. Lactacystin inhibits cathepsin A activity in melanoma cell lines. Tumour Biol. 2001; 22:211-5.
    • (2001) Tumour Biol , vol.22 , pp. 211-215
    • Kozlowski, L.1    Stoklosa, T.2    Omura, S.3
  • 51
    • 0034864799 scopus 로고    scopus 로고
    • Proteasome inhibitors: From research tools to drug candidates
    • Kisselev AF, Goldberg AL. Proteasome inhibitors: From research tools to drug candidates. Chem Biol. 2001;8:739-58.
    • (2001) Chem Biol , vol.8 , pp. 739-758
    • Kisselev, A.F.1    Goldberg, A.L.2
  • 52
    • 0036023407 scopus 로고    scopus 로고
    • A phase 1 trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies
    • Aghajanian C, Soignet S, Dizon DS, et al. A phase 1 trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies. Clin Cancer Res. 2002;8:2505-11.
    • (2002) Clin Cancer Res , vol.8 , pp. 2505-2511
    • Aghajanian, C.1    Soignet, S.2    Dizon, D.S.3
  • 53
    • 2942692143 scopus 로고    scopus 로고
    • Phase I trial of the proleasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer
    • Papandreou CN, Daliani DD, Nix D, et al. Phase I trial of the proleasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer. J Clin Oncol. 2004;22:2108-21.
    • (2004) J Clin Oncol , vol.22 , pp. 2108-2121
    • Papandreou, C.N.1    Daliani, D.D.2    Nix, D.3
  • 54
    • 0037111832 scopus 로고    scopus 로고
    • Phase 1 trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
    • Orlowski RZ, Stinchcombe TE, Mitchell BS, et al. Phase 1 trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol. 2002;20:4420-7.
    • (2002) J Clin Oncol , vol.20 , pp. 4420-4427
    • Orlowski, R.Z.1    Stinchcombe, T.E.2    Mitchell, B.S.3
  • 55
    • 67049126311 scopus 로고    scopus 로고
    • Phase I study of bortezomib in refractory or relapsed acute leukemias
    • Cortes J, Thomas D, Koller C, et al. Phase I study of bortezomib in refractory or relapsed acute leukemias. Clin Cancer Res. 2004;348:2609-17.
    • (2004) Clin Cancer Res , vol.348 , pp. 2609-2617
    • Cortes, J.1    Thomas, D.2    Koller, C.3
  • 56
    • 20444433230 scopus 로고    scopus 로고
    • Bortezomib or high-dose dexamethasone for relapsed multiple myetoma
    • Richardson PG, Sonneveld P, Schuster MW, et al. Bortezomib or high-dose dexamethasone for relapsed multiple myetoma. N Engl J Med. 2005;352:2487-98.
    • (2005) N Engl J Med , vol.352 , pp. 2487-2498
    • Richardson, P.G.1    Sonneveld, P.2    Schuster, M.W.3
  • 57
    • 21344435052 scopus 로고    scopus 로고
    • PAD combination therapy (PS-341/bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma
    • Oakervee HE, Popat R, Curry N, et al. PAD combination therapy (PS-341/ bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma. Br J Haematol. 2005;129: 755-62.
    • (2005) Br J Haematol , vol.129 , pp. 755-762
    • Oakervee, H.E.1    Popat, R.2    Curry, N.3
  • 58
    • 21344469223 scopus 로고    scopus 로고
    • Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma
    • Jagannath S, Durie BG, Wolf J, et al. Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma. Br J Haematol. 2005;129:776-85.
    • (2005) Br J Haematol , vol.129 , pp. 776-785
    • Jagannath, S.1    Durie, B.G.2    Wolf, J.3
  • 59
    • 20044396543 scopus 로고    scopus 로고
    • Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma
    • Goy A, Younes A, McLaughlin P, et al. Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma. J Clin Oncol. 2005;25:667-75.
    • (2005) J Clin Oncol , vol.25 , pp. 667-675
    • Goy, A.1    Younes, A.2    McLaughlin, P.3
  • 60
    • 33644875054 scopus 로고    scopus 로고
    • Marked clinical activity of the proteasome inhibitor bortezomib in patients with follicular and mantle-cell lymphoma
    • O'Connor OA. Marked clinical activity of the proteasome inhibitor bortezomib in patients with follicular and mantle-cell lymphoma. Clin Lymphoma Myeloma. 2005; 6:191-9.
    • (2005) Clin Lymphoma Myeloma , vol.6 , pp. 191-199
    • O'Connor, O.A.1
  • 61
    • 2442510143 scopus 로고    scopus 로고
    • Phase II trial of PS-541 in patients with renal cell cancer: A University of Chicago phase II consortium study
    • Davis NB, Taber DA, Ansari RH, et al. Phase II trial of PS-541 in patients with renal cell cancer: A University of Chicago phase II consortium study. J Clin Oncol. 2004;22:115-9.
    • (2004) J Clin Oncol , vol.22 , pp. 115-119
    • Davis, N.B.1    Taber, D.A.2    Ansari, R.H.3
  • 62
    • 4644304196 scopus 로고    scopus 로고
    • Phase II trial of bortezomib for patients with advanced renal cell carcinoma
    • Kondagunta GV, Drucker B, Schwartz L, et al. Phase II trial of bortezomib for patients with advanced renal cell carcinoma. J Clin Oncol. 2004;22:3720-5.
    • (2004) J Clin Oncol , vol.22 , pp. 3720-3725
    • Kondagunta, G.V.1    Drucker, B.2    Schwartz, L.3
  • 63
    • 49849087232 scopus 로고    scopus 로고
    • Effects of bortezomib (PS-541) of NF-κB activation in peripheral blood mononuclear cells (PBMCs) of advanced nonsmall lung cancer (NSCLC) patients: A phase II/pharmacodynamic trial
    • abstr. 7145
    • Stevenson JP, Nho CW, Johnson SW, et al. Effects of bortezomib (PS-541) of NF-κB activation in peripheral blood mononuclear cells (PBMCs) of advanced nonsmall lung cancer (NSCLC) patients: A phase II/ pharmacodynamic trial. Proc Am Soc Clin Oncol. 2004; abstr. 7145.
    • (2004) Proc Am Soc Clin Oncol
    • Stevenson, J.P.1    Nho, C.W.2    Johnson, S.W.3
  • 64
    • 0142139039 scopus 로고    scopus 로고
    • Phase I study of bortezomib in combination with docetaxel in anthracycline-pretreated advanced breast cancer
    • abstr. 63
    • Albanell J, Baselga J, Guix M, et al. Phase I study of bortezomib in combination with docetaxel in anthracycline-pretreated advanced breast cancer. Proc Am Soc Clin Oncol. 2003; abstr. 63.
    • (2003) Proc Am Soc Clin Oncol
    • Albanell, J.1    Baselga, J.2    Guix, M.3
  • 65
    • 33645470112 scopus 로고    scopus 로고
    • Differential cellular and molecular effects of bortezomib, a proteasome inhibitor, in human breast cancer cells
    • Codony-Servat J, Tapia MA, Bosch M, et al. Differential cellular and molecular effects of bortezomib, a proteasome inhibitor, in human breast cancer cells. Mol Cancer Ther. 2006;5:665-75.
    • (2006) Mol Cancer Ther , vol.5 , pp. 665-675
    • Codony-Servat, J.1    Tapia, M.A.2    Bosch, M.3


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