Attenuating effect of Acorus calamus extract in chronic constriction injury induced neuropathic pain in rats: An evidence of anti-oxidative, anti-inflammatory, neuroprotective and calcium inhibitory effects

BMC Complementary and Alternative Medicine

Volumn 11, Issue , 2011, Pages

  Muthuraman, Arunachalam ^a   Singh, Nirmal ^a  

^a PUNJABI UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACORUS CALAMUS EXTRACT; CALCIUM; MYELOPEROXIDASE; PREGABALIN; SUPEROXIDE; 4 AMINOBUTYRIC ACID; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; DRUG DERIVATIVE; NEUROPROTECTIVE AGENT; PEROXIDASE; PLANT EXTRACT;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM ANTAGONISM; CHRONIC CONSTRICTION INJURY; CONTROLLED STUDY; FEMALE; MALE; NERVE COMPRESSION; NEUROPATHIC PAIN; NEUROPROTECTION; NONHUMAN; RAT; SCIATIC NERVE; ACORUS; ANIMAL; ANIMAL BEHAVIOR; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; INJURY; METABOLISM; MOTOR ACTIVITY; MOTOR PERFORMANCE; NEURALGIA; PATHOLOGY; PHYTOTHERAPY; RHIZOME; SCIATIC NEUROPATHY; STENOSIS, OCCLUSION AND OBSTRUCTION; WISTAR RAT;

ACORUS; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BEHAVIOR, ANIMAL; CALCIUM; CONSTRICTION, PATHOLOGIC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GAMMA-AMINOBUTYRIC ACID; MALE; MOTOR ACTIVITY; MOTOR SKILLS; NEURALGIA; NEUROPROTECTIVE AGENTS; PEROXIDASE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR; RHIZOME; SCIATIC NERVE; SCIATIC NEUROPATHY; SUPEROXIDES;

EID: 79953113956     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-11-24     Document Type: Article

References (79)

1. Carlton SM, Du J, Tan HY, Nesic O, Hargett GL, Bopp AC, Yamani A, Lin Q, Willis WD, Hulsebosch CE. Peripheral and central sensitization in remote spinal cord regions contribute to central neuropathic pain after spinal cord injury. Pain 2009, 147:265-276. 10.1016/j.pain.2009.09.030, 2787843, 19853381.
2. Muthuraman A, Ramesh M, Sood S. Development of animal model for vasculatic neuropathy: Induction by ischemic-reperfusion in the rat femoral artery. J Neurosci Methods 2010, 186:215-221. 10.1016/j.jneumeth.2009.12.004, 20026113.
3. Wall PD, Waxman SG, Basbaum AI. Ongoing activity in peripheral nerve: injury discharge. Exp Neurol 1974, 45:576-589. 10.1016/0014-4886(74)90163-0, 4435078.
4. Woolf CJ, Mannion RJ. Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet 1999, 353:1959-1964. 10.1016/S0140-6736(99)01307-0, 10371588.
5. Alston RP, Pechon P. Dysaesthesia associated with sternotomy for heart surgery. Br J Anaesth 2005, 95:153-158. 10.1093/bja/aei152, 15894562.
6. Garg R, Dehran M. Leprosy: a precipitating factor for complex regional pain syndrome. Minerva Anestesiol 2010, 76:758-760.
7. Koltzenburg M, Scadding J. Neuropathic pain. Curr Opin Neurol 2001, 14:641-647. 10.1097/00019052-200110000-00014, 11562577.
8. Shaladi AM, Saltari MR, Crestani F, Piva B. Post-surgical neuropathic pain. Recenti Prog Med 2009, 100:371-379.
9. Weisz GM, Houang M, Bogduk N. Complex regional pain syndrome associated with cervical disc protrusion and foraminotomy. Pain Med 2010,
10. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988, 33:87-107. 10.1016/0304-3959(88)90209-6, 2837713.
11. Kramer HH, He L, Lu B, Birklein F, Sommer C. Increased pain and neurogenic inflammation in mice deficient of neutral endopeptidase. Neurobiol Dis 2009, 35:177-183. 10.1016/j.nbd.2008.11.002, 19084065.
12. Kurvers H, Daemen M, Slaaf D, Stassen F, van den Wildenberg F, Kitslaar P, de Mey J. Partial peripheral neuropathy and denervation induced adrenoceptor supersensitivity. Functional studies in an experimental model. Acta Orthop Belg 1998, 64:64-70.
13. Nagler RM. CRPS: Central aspects related to locus of pain, pathophysiology, and mood. Neurology 2010, 75:109-110. 10.1212/WNL.0b013e3181e7cae3, 20625163.
14. Chae J. Poststroke complex regional pain syndrome. Top Stroke Rehabil 2010, 17:151-162. 10.1310/tsr1703-151, 20797958.
15. Herlyn P, Müller-Hilke B, Wendt M, Hecker M, Mittlmeier T, Gradl G. Frequencies of polymorphisms in cytokines, neurotransmitters and adrenergic receptors in patients with complex regional pain syndrome type I after distal radial fracture. Clin J Pain 2010, 26:175-181. 10.1097/AJP.0b013e3181bff8b9, 20173430.
16. Li WW, Guo TZ, Liang D, Shi X, Wei T, Kingery WS, Clark JD. The NALP1 inflammasome controls cytokine production and nociception in a rat fracture model of complex regional pain syndrome. Pain 2009, 147:277-286. 10.1016/j.pain.2009.09.032, 19853379.
17. Toms AD, Mandalia V, Haigh R, Hopwood B. The management of patients with painful total knee replacement. J Bone Joint Surg Br 2009, 91:143-150. 10.1302/0301-620X.91B2.20995, 19190044.
18. Botez SA, Herrmann DN. Sensory neuropathies, from symptoms to treatment. Curr Opin Neurol 2010, 23:502-508. 10.1097/WCO.0b013e32833c7a19, 20689428.
19. Driessen B, Bauquier SH, Zarucco L. Neuropathic pain management in chronic laminitis. Vet Clin North Am Equine Pract 2010, 26:315-337. 10.1016/j.cveq.2010.04.002, 20699178.
20. Dwight EM. The clinical management of neuropathic pain. Pain Res Manag 2006, 11:30A-36A.
21. Dworkin RH, O'Connor AB, Audette J, Baron R, Gourlay GK, Haanpää ML, Kent JL, Krane EJ, Lebel AA, Levy RM, Mackey SC, Mayer J, Miaskowski C, Raja SN, Rice AS, Schmader KE, Stacey B, Stanos S, Treede RD, Turk DC, Walco GA, Wells CD. Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clin Proc 2010, 85:S3-S14. 10.4065/mcp.2009.0649, 2844007, 20194146.
22. Lee BH, Won R, Baik EJ, Lee SH, Moon CH. An animal model of neuropathic pain employing injury to the sciatic nerve branches. Neuroreport 2000, 11:657-661. 10.1097/00001756-200003200-00002, 10757496.
23. Carol W, Jane K. Evidence based treatment of diabetic peripheral neuropathy. J Nurse Pract 2006, 2:370-378.
24. Hama AT, Plum AW, Sagen J. Antinociceptive effect of ambroxol in rats with neuropathic spinal cord injury pain. Pharmacol Biochem Behav
25. Wiffen PJ, Collins S, McQuay HJ, Carroll D, Jadad A, Moore RA. WITHDRAWN. anticonvulsant drugs for acute and chronic pain. Cochrane Database Syst Rev 2010, 1:CD001133.
26. Kalita J, Vajpayee A, Misra UK. Comparison of prednisolone with piroxicam in complex regional pain syndrome following stroke: a randomized controlled trial. Q J Med 2006, 99:89-95.
27. Kumar K, Taylor RS, Jacques L, Eldabe S, Meglio M, Molet J, Thomson S, O'Callaghan J, Eisenberg E, Milbouw G, Buchser E, Fortini G, Richardson J, North RB. Spinal cord stimulation versus conventional medical management for neuropathic pain: a multicentre randomised controlled trial in patients with failed back surgery syndrome. Pain 2007, 132:179-188. 10.1016/j.pain.2007.07.028, 17845835.
28. Thomson S, Jacques L. Demographic characteristics of patients with severe neuropathic pain secondary to failed back surgery syndrome. Pain Pract 2009, 9:206-215. 10.1111/j.1533-2500.2009.00276.x, 19281499.
29. Comelli F, Giagnoni G, Bettoni I, Colleoni M, Costa B. Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: mechanisms involved. Phytother Res 2008, 8:1017-1024.
30. Kanter M. Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy. Neurochem Res 2008, 1:87-96.
31. Kim YS, Park HJ, Kim TK, Moon DE, Lee HJ. The effects of Ginkgo biloba extract EGb 761 on mechanical and cold allodynia in a rat model of neuropathic pain. Anesth Analg 2009, 108:1958-1963. 10.1213/ane.0b013e31819f1972, 19448231.
32. Muthuraman A, Diwan V, Jaggi AS, Singh N, Singh D. Ameliorative effects of Ocimum sanctum in sciatic nerve transection Induced neuropathy in rats. J Ethnopharmacol 2008, 120:56-62. 10.1016/j.jep.2008.07.049, 18762236.
33. Wirth JH, Hudgins JC, Paice JA. Use of herbal therapies to relieve pain: A review of efficacy and adverse effects. Pain Manag Nurs 2005, 6:145-167. 10.1016/j.pmn.2005.08.003, 16337563.
34. Babbar S, Marier JF, Mouksassi MS, Beliveau M, Vanhove GF, Chanda S, Bley K. Pharmacokinetic analysis of capsaicin after topical administration of a high-concentration capsaicin patch to patients with peripheral neuropathic pain. Ther Drug Monit 2009, 31:502-510. 10.1097/FTD.0b013e3181a8b200, 19494795.
35. Ellis RJ, Toperoff W, Vaida F, van den Brande G, Gonzales J, Gouaux B, Bentley H, Atkinson JH. Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial. Neuropsychopharmacology 2009, 34:672-680. 10.1038/npp.2008.120, 3066045, 18688212.
36. Nurmikko TJ, Serpell MG, Hoggart B, Toomey PJ, Morlion BJ, Haines D. Sativex successfully treats neuropathic pain characterised by allodynia: a randomised, double-blind, placebo-controlled clinical trial. Pain 2007, 133:210-220. 10.1016/j.pain.2007.08.028, 17997224.
37. Duke JA. In CRC handbook of medicinal herbs 1985, Boca Raton: CRC Press.
38. Mittal N, Ginwal HS, Varshney VK. Pharmaceutical and biotechnological potential of Acorus calamus Linn: An indigenous highly valued medicinal plant species. Pharmacog Rev 2009, 3:83-93.
39. Martis G, Rao A, Karanth KS. Neuropharmacological activity of Acorus calamus. Fitoterapia 1991, 4:331-337.
40. Parap RS, Mengi SA. Evaluation of hypolipidemic activity of Acrous calamus Linn in rats. Indian Drugs 2003, 40:25-29.
41. Muthuraman A, Singh N, Jaggi AS. Effect of hydroalcoholic extract of Acorus calamus on tibial and sural nerve transection-induced painful neuropathy in rats. J Nat Med 2011, 65:282-292. 10.1007/s11418-010-0486-6, 21153448.
42. Sommer C, Schafers M. Painful mononeuropathy in C57BL/Wld mice with delayed wallerian degeneration: differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity. Brain Res 1998, 784:154-162. 10.1016/S0006-8993(97)01327-9, 9518588.
43. Eddy NB, Touchberry CF, Lieberman JE. Synthetic analgesics: I. Methadone isomers and derivatives. J Pharmacol Exp Ther 1950, 98:121-137.
44. Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988, 32:77-88. 10.1016/0304-3959(88)90026-7, 3340425.
45. Choi Y, Yoon YW, Na HS, Kim SH, Chung JM. Behavioural signs of ongoing pain and cold allodynia in a rat model of neuropathic pain. Pain 1994, 59:369-376. 10.1016/0304-3959(94)90023-X, 7708411.
46. Randall LO, Selitto J. A method for measurement of analgesic activity of inflamed tissue. Arch Int Pharmacodyn Ther 1957, 111:409-419.
47. Erichsen HK, Blackburn-Munro G. Pharmacological characterization of the spared nerve injury model of neuropathic pain. Pain 2002, 98:151-161. 10.1016/S0304-3959(02)00039-8, 12098627.
48. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994, 53:55-63. 10.1016/0165-0270(94)90144-9, 7990513.
49. Jones BJ, Roberts DJ. The quantitative measurement of motor incoordination in naive mice using an accelerating rotarod. J Pharm Pharmacol 1968, 20:302-304.
50. Goddard M, Zheng Y, Darlington CL, Smith PF. Locomotor and exploratory behavior in the rat following bilateral vestibular deafferentation. Behav Neurosci 2008, 122:448-459. 10.1037/0735-7044.122.2.448, 18410183.
51. Wang HD, Pagano PJ, Du Y, Cayatte AJ, Quinn MT, Brecher P, Cohen RA. Superoxide anion from the adventitia of the rat thoracic aorta inactivates nitric oxide. Circ Res 1998, 82:810-818.
52. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with folin phenol reagent. J Biol Chem 1951, 193:265-275.
53. Grisham MB, Specian RD, Zimmerman TE. Effects of nitric oxide synthase inhibition on the pathophysiology observed in a model of chronic granulomatous colitis. J Pharmacol Exp Ther 1994, 271:1114-1121.
54. Severinghaus JW, Ferrebee JW. Calcium determination by flame photometry; methods for serum, urine, and other fluids. J Biol Chem 1950, 187:621-630.
55. Muthuraman A, Jaggi AS, Singh N, Singh D. Ameliorative effects of amiloride and pralidoxime in chronic constriction injury and vincristine-induced painful neuropathy in rats. Eur J Pharmacol 2008, 587:104-111. 10.1016/j.ejphar.2008.03.042, 18486127.
56. Sudoh Y, Desai SP, Haderer AE, Sudoh S, Gerner P, Anthony DC, De Girolami U, Wang GK. Neurologic and histopathologic evaluation after high volume intrathecal amitriptyline. Reg Anesth Pain Med 2004, 29:434-440.
57. Cui JG, Holmin S, Mathiesen T, Meyerson BA, Linderoth B. Possible role of inflammatory mediators in tactile hypersensitivity in rat models of mononeuropathy. Pain 2000, 88:239-248. 10.1016/S0304-3959(00)00331-6, 11068111.
58. Marchand F, Perretti M, McMahon SB. Role of immune system in chronic pain. Nat Rev Neurosci 2005, 6:521-532. 10.1038/nrn1700, 15995723.
59. Jain V, Jaggi AS, Singh N. Ameliorative potential of rosiglitazone in tibial and sural nerve transection-induced painful neuropathy in rats. Pharmacol Res 2009, 59:385-392. 10.1016/j.phrs.2009.02.001, 19429470.
60. Siau C, Bennett GJ. Dysregulation of neuronal calcium homeostasis in chemotherapy-evoked painful peripheral neuropathy. Anesth Analg 2006, 102:1485-1490. 10.1213/01.ane.0000204318.35194.ed, 1805480, 16632831.
61. Young W. Role of calcium in central nervous system injuries. J Neurotrauma 1992, 9:9-25.
62. Glass JD, Culver DG, Levey AI, Nash NR. Very early activation of m-calpain in peripheral nerve during Wallerian degeneration. J Neurol Sci 2002, 196:9-20. 10.1016/S0022-510X(02)00013-8, 11959150.
63. Honda K, Casadesus G, Petersen RB, Perry G, Smith MA. Oxidative stress and redox-active iron in Alzheimer's disease. Ann N Y Acad Sci 2004, 1012:179-182. 10.1196/annals.1306.015, 15105265.
64. Muthuraman A, Sood S. Pharmacological evaluation of tacrolimus (FK-506) on ischemia reperfusion induced vasculatic neuropathic pain in rats. J Brachial Plex Peripher Nerve Inj 2010, 5:13-23. 10.1186/1749-7221-5-13, 2890670, 20529260.
65. Gao X, Kim HK, Chung JM, Chung K. Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain. Pain 2007, 131:262-271. 10.1016/j.pain.2007.01.011, 2048490, 17317010.
66. Otto M, Bak S, Bach FW, Jensen TS, Sindrup SH. Pain phenomena and possible mechanisms in patients with painful polyneuropathy. Pain 2003, 101:187-192. 10.1016/S0304-3959(02)00313-5, 12507713.
67. Rafatullah S, Tariq M, Mossa JS, Al-Yahya MA, Al-Said MS, Ageel AM. Anti-secretagogue, anti-ulcer and cytoprotective proberties of Acorus calamus in rats. Fitotherpia 1994, 65:19-23.
68. Gilani AU, Shah AJ, Ahmad M, Shaheen F. Antispasmodic effect of Acorus calamus Linn. is mediated through calcium channel blockade. Phytother Res 2006, 20:1080-1084. 10.1002/ptr.2000, 17009206.
69. Mehrotra S, Mishra KP, Maurya R, Srimal RC, Yadav VS, Pandey R, Singh VK. Anticellular and immunosuppressive properties of ethanolic extract of Acorus calamus rhizome. Int Immunopharmacol 2003, 3:53-61. 10.1016/S1567-5769(02)00212-6, 12538034.
70. Manikandan S, Srikumar R, Jeya Parthasarathy N, Sheela Devi R. Protective effect of Acorus calamus Linn on free radical scavengers and lipid peroxidation in discrete regions of brain against noise stress exposed rat. Biol Pharm Bull 2005, 28:2327-2330. 10.1248/bpb.28.2327, 16327175.
71. Tippani R, Porika M, Rao AV, Abbagani S, Yellu NR, Tammidala C. Analgesic activity of root extract of Acorus calamus Linn. Pharmacologyonline 2008, 3:240-243.
72. Yang L, Li S, Huang Y, Liang J, Wang Y. Effects of Acorus gramineus and its component, alpha-asarone, on apoptosis of hippocampal neurons after seizure in immature rats. Neural Reg Res 2008, 3:19-24.
73. Geetha RK, Vasudevan DM. Inhibition of lipid peroxidation by botanical extracts of Ocimum sanctum: In vivo and in vitro studies. Life Sci 2004, 76:21-28. 10.1016/j.lfs.2004.05.036, 15532130.
74. Hazra R, Ray K, Guha D. Inhibitory role of Acorus calamus in ferric chloride-induced epileptogenesis in rat. Hum Exp Toxicol 2007, 26:947-953. 10.1177/0960327107087791, 18375638.
75. Shukla PK, Khanna VK, Ali MM, Maurya R, Khan MY, Srimal RC. Neuroprotective effect of Acorus calamus against middle cerebral artery occlusion-induced ischaemia in rat. Hum Exp Toxicol 2006, 25:187-194. 10.1191/0960327106ht613oa, 16696294.
76. Kumar N, Laferriere A, Yu JS, Leavitt A, Coderre TJ. Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. J Neurochem 2010, 113:552-561. 10.1111/j.1471-4159.2010.06625.x, 20132471.
77. Stump P. Pregabalin--profile of efficacy and tolerability in neuropathic pain. Drugs Today (Barc) 2009, 45:19-27.
78. Bender G, Florian JA, Bramwell S, Field MJ, Tan KK, Marshall S, DeJongh J, Bies RR, Danhof M. Pharmacokinetic-pharmacodynamic analysis of the static allodynia response to pregabalin and sildenafil in a rat model of neuropathic pain. J Pharmacol Exp Ther 2010, 334:599-608. 10.1124/jpet.110.166074, 20444880.
79. Park HJ, Joo HS, Chang HW, Lee JY, Hong SH, Lee Y, Moon DE. Attenuation of neuropathy-induced allodynia following intraplantar injection of pregabalin. Can J Anaesth 2010, 57:664-671. 10.1007/s12630-010-9318-0, 20440664.