메뉴 건너뛰기




Volumn 109, Issue 4, 2013, Pages 994-1003

LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEMETHYLASE; HISTONE H3; HISTONE H3 LYSINE 4; LYSINE SPECIFIC DEMETHYLASE 1; NERVE CELL ADHESION MOLECULE; SMALL INTERFERING RNA; TRANYLCYPROMINE; UNCLASSIFIED DRUG; UVOMORULIN;

EID: 84883154469     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2013.364     Document Type: Article
Times cited : (146)

References (69)
  • 2
    • 77954053278 scopus 로고    scopus 로고
    • LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription
    • Amente S, Bertoni A, Morano A, Lania L, Avvedimento EV, Majello B (2010) LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription. Oncogene 29(25): 3691-3702.
    • (2010) Oncogene , vol.29 , Issue.25 , pp. 3691-3702
    • Amente, S.1    Bertoni, A.2    Morano, A.3    Lania, L.4    Avvedimento, E.V.5    Majello, B.6
  • 3
    • 0003964361 scopus 로고    scopus 로고
    • American Cancer Society American Cancer Society: Atlanta, GA
    • American Cancer Society (2012) Cancer Facts and Figures 2012. American Cancer Society: Atlanta, GA.
    • (2012) Cancer Facts and Figures 2012
  • 4
    • 0035076508 scopus 로고    scopus 로고
    • The cadherin superfamily
    • Angst BD, Marcozzi C, Magee AI (2001) The cadherin superfamily. J Cell Sci 114(Pt 4): 625-626.
    • (2001) J Cell Sci , vol.114 , Issue.PART 4 , pp. 625-626
    • Angst, B.D.1    Marcozzi, C.2    Magee, A.I.3
  • 5
    • 79551718687 scopus 로고    scopus 로고
    • Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex
    • Baron R, Binda C, Tortorici M, McCammon JA, Mattevi A (2011) Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex. Structure 19(2): 212-220.
    • (2011) Structure , vol.19 , Issue.2 , pp. 212-220
    • Baron, R.1    Binda, C.2    Tortorici, M.3    McCammon, J.A.4    Mattevi, A.5
  • 6
    • 84864497997 scopus 로고    scopus 로고
    • LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition
    • Baron R, Vellore NA (2012a) LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition. Proc Natl Acad Sci USA 109(31): 12509-12514.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.31 , pp. 12509-12514
    • Baron, R.1    Vellore, N.A.2
  • 7
    • 84859895302 scopus 로고    scopus 로고
    • LSD1/CoREST reversible opening-closing dynamics: Discovery of a nanoscale clamp for chromatin and protein binding
    • Baron R, Vellore NA (2012b) LSD1/CoREST reversible opening-closing dynamics: Discovery of a nanoscale clamp for chromatin and protein binding. Biochemistry 51(5): 3151-3153.
    • (2012) Biochemistry , vol.51 , Issue.5 , pp. 3151-3153
    • Baron, R.1    Vellore, N.A.2
  • 8
    • 84863987775 scopus 로고    scopus 로고
    • Lysinespecific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma
    • Bennani-Baiti IM, Machado I, Llombart-Bosch A, Kovar H (2012) Lysinespecific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. Hum Pathol 43(8): 1300-1307.
    • (2012) Hum Pathol , vol.43 , Issue.8 , pp. 1300-1307
    • Bennani-Baiti, I.M.1    MacHado, I.2    Llombart-Bosch, A.3    Kovar, H.4
  • 9
    • 0034668172 scopus 로고    scopus 로고
    • Induction and regulation of epithelial-mesenchymal transitions
    • Boyer B, Valles AM, Edme N (2000) Induction and regulation of epithelial-mesenchymal transitions. Biochem Pharmacol 60(8): 1091-1099.
    • (2000) Biochem Pharmacol , vol.60 , Issue.8 , pp. 1091-1099
    • Boyer, B.1    Valles, A.M.2    Edme, N.3
  • 12
    • 0038581169 scopus 로고    scopus 로고
    • Changing neighbours, changing behaviour: Cell adhesion molecule-mediated signalling during tumour progression
    • Christofori G (2003) Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression. EMBO J 22(10): 2318-2323.
    • (2003) EMBO J , vol.22 , Issue.10 , pp. 2318-2323
    • Christofori, G.1
  • 14
    • 77949421463 scopus 로고    scopus 로고
    • Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors
    • Culhane JC, Wang D, Yen PM, Cole PA (2010) Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. J Am Chem Soc 132(9): 3164-3176.
    • (2010) J Am Chem Soc , vol.132 , Issue.9 , pp. 3164-3176
    • Culhane, J.C.1    Wang, D.2    Yen, P.M.3    Cole, P.A.4
  • 15
    • 78649485519 scopus 로고    scopus 로고
    • Involvement of a Jumonji-C domain-containing histone demethylase in DRM2-mediated maintenance of DNA methylation
    • Deleris A, Greenberg MV, Ausin I, Law RW, Moissiard G, Schubert D, Jacobsen SE (2010) Involvement of a Jumonji-C domain-containing histone demethylase in DRM2-mediated maintenance of DNA methylation. EMBO Rep 11(12): 950-955.
    • (2010) EMBO Rep , vol.11 , Issue.12 , pp. 950-955
    • Deleris, A.1    Greenberg, M.V.2    Ausin, I.3    Law, R.W.4    Moissiard, G.5    Schubert, D.6    Jacobsen, S.E.7
  • 16
    • 84879500615 scopus 로고    scopus 로고
    • Positive expression of LSD1 and negative expression of E-cadherin correlates with metastasis and poor prognosis of colon cancer
    • Ding J, Liao G, Zhang Z, Wen J, Zeng L, Liu S, Zhang Y (2013) Positive expression of LSD1 and negative expression of E-cadherin correlates with metastasis and poor prognosis of colon cancer. Dig Dis Sci 58(6): 1581-1589.
    • (2013) Dig Dis Sci , vol.58 , Issue.6 , pp. 1581-1589
    • Ding, J.1    Liao, G.2    Zhang, Z.3    Wen, J.4    Zeng, L.5    Liu, S.6    Zhang, Y.7
  • 19
    • 16344368814 scopus 로고    scopus 로고
    • Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process
    • Forneris F, Binda C, Vanoni MA, Mattevi A, Battaglioli E (2005) Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. FEBS Lett 579(10): 2203-2207.
    • (2005) FEBS Lett , vol.579 , Issue.10 , pp. 2203-2207
    • Forneris, F.1    Binda, C.2    Vanoni, M.A.3    Mattevi, A.4    Battaglioli, E.5
  • 20
    • 81855169565 scopus 로고    scopus 로고
    • Cancer invasion and the microenvironment: Plasticity and reciprocity
    • Friedl P, Alexander S (2011) Cancer invasion and the microenvironment: plasticity and reciprocity. Cell 147(5): 992-1009.
    • (2011) Cell , vol.147 , Issue.5 , pp. 992-1009
    • Friedl, P.1    Alexander, S.2
  • 21
    • 56649097577 scopus 로고    scopus 로고
    • NF-Y substitutes H2A-H2B on active cell-cycle promoters: Recruitment of CoREST-KDM1 and fine-tuning of H3 methylations
    • Gatta R, Mantovani R (2008) NF-Y substitutes H2A-H2B on active cell-cycle promoters: recruitment of CoREST-KDM1 and fine-tuning of H3 methylations. Nucleic Acids Res 36(20): 6592-6607.
    • (2008) Nucleic Acids Res , vol.36 , Issue.20 , pp. 6592-6607
    • Gatta, R.1    Mantovani, R.2
  • 23
    • 79955610423 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate regulates the expression of adherens junction protein E-cadherin and enhances intestinal epithelial cell barrier function
    • Greenspon J, Li R, Xiao L, Rao JN, Sun R, Strauch ED, Shea-Donohue T, Wang JY, Turner DJ (2011) Sphingosine-1-phosphate regulates the expression of adherens junction protein E-cadherin and enhances intestinal epithelial cell barrier function. Dig Dis Sci 56(5): 1342-1353.
    • (2011) Dig Dis Sci , vol.56 , Issue.5 , pp. 1342-1353
    • Greenspon, J.1    Li, R.2    Xiao, L.3    Rao, J.N.4    Sun, R.5    Strauch, E.D.6    Shea-Donohue, T.7    Wang, J.Y.8    Turner, D.J.9
  • 26
    • 79960459027 scopus 로고    scopus 로고
    • The LSD1-type zinc finger motifs of Pisum sativa LSD1 are a novel nuclear localization signal and interact with importin alpha
    • He S, Huang K, Zhang X, Yu X, Huang P, An C (2011) The LSD1-type zinc finger motifs of Pisum sativa LSD1 are a novel nuclear localization signal and interact with importin alpha. PLoS One 6(7): e22131.
    • (2011) PLoS One , vol.6 , Issue.7
    • He, S.1    Huang, K.2    Zhang, X.3    Yu, X.4    Huang, P.5    An, C.6
  • 28
    • 78651289082 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases
    • Huang PH, Chen CH, Chou CC, Sargeant AM, Kulp SK, Teng CM, Byrd JC, Chen CS (2011) Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases. Mol Pharmacol 79(1): 197-206.
    • (2011) Mol Pharmacol , vol.79 , Issue.1 , pp. 197-206
    • Huang, P.H.1    Chen, C.H.2    Chou, C.C.3    Sargeant, A.M.4    Kulp, S.K.5    Teng, C.M.6    Byrd, J.C.7    Chen, C.S.8
  • 31
    • 79952087232 scopus 로고    scopus 로고
    • Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST
    • Hwang S, Schmitt AA, Luteran AE, Toone EJ, McCafferty DG (2011) Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST. Biochemistry 50(4): 546-557.
    • (2011) Biochemistry , vol.50 , Issue.4 , pp. 546-557
    • Hwang, S.1    Schmitt, A.A.2    Luteran, A.E.3    Toone, E.J.4    McCafferty, D.G.5
  • 32
    • 84871419643 scopus 로고    scopus 로고
    • Loss of Lysine-Specific Demethylase 1 (LSD1) suppresses growth and alters gene expression of human colon cancer cells in a p53 and DNA methyltransferase 1 (DNMT1) independent manner
    • Jin L, Hanigan CL, Wu Y, WangW, Park BH,Woster PM, Casero RA Jr. (2013) Loss of Lysine-Specific Demethylase 1 (LSD1) suppresses growth and alters gene expression of human colon cancer cells in a p53 and DNA methyltransferase 1 (DNMT1) independent manner. Biochem J 449(2): 459-468.
    • (2013) Biochem J , vol.449 , Issue.2 , pp. 459-468
    • Jin, L.1    Hanigan, C.L.2    Wu, Y.3    Wang, W.4    Park, B.H.5    Woster, P.M.6    Casero Jr., R.A.7
  • 34
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: Twist in development and metastasis
    • Kang Y, Massagué J (2004) Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118(3): 277-279.
    • (2004) Cell , vol.118 , Issue.3 , pp. 277-279
    • Kang, Y.1    Massagué, J.2
  • 37
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function 2007)
    • Kouzarides T. Chromatin modifications and their function (2007) Cell 128(4): 693-705.
    • Cell , vol.128 , Issue.4 , pp. 693-705
    • Kouzarides, T.1
  • 38
    • 44649163849 scopus 로고    scopus 로고
    • Mechanisms involved in the regulation of histone lysine demethylases
    • Lan F, Nottke AC, Shi Y (2008) Mechanisms involved in the regulation of histone lysine demethylases. Curr Opin Cell Biol 20(3): 316-325.
    • (2008) Curr Opin Cell Biol , vol.20 , Issue.3 , pp. 316-325
    • Lan, F.1    Nottke, A.C.2    Shi, Y.3
  • 39
    • 84861214055 scopus 로고    scopus 로고
    • A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain
    • Laurent B, Randrianarison-Huetz V, Frisan E, Andrieu-Soler C, Soler E, Fontenay M, Dusanter-Fourt I, Duménil D (2012) A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain. J Cell Sci 125(Pt 4): 993-1002.
    • (2012) J Cell Sci , vol.125 , Issue.PART 4 , pp. 993-1002
    • Laurent, B.1    Randrianarison-Huetz, V.2    Frisan, E.3    Andrieu-Soler, C.4    Soler, E.5    Fontenay, M.6    Dusanter-Fourt, I.7    Duménil, D.8
  • 40
    • 25144519737 scopus 로고    scopus 로고
    • An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation
    • Lee MG, Wynder C, Cooch N, Shiekhattar R (2005) An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature 437(7057): 432-435.
    • (2005) Nature , vol.437 , Issue.7057 , pp. 432-435
    • Lee, M.G.1    Wynder, C.2    Cooch, N.3    Shiekhattar, R.4
  • 41
    • 33847070442 scopus 로고    scopus 로고
    • The role of chromatin during transcription
    • Li B, Carey M, Workman JL (2007) The role of chromatin during transcription. Cell 128(4): 707-719.
    • (2007) Cell , vol.128 , Issue.4 , pp. 707-719
    • Li, B.1    Carey, M.2    Workman, J.L.3
  • 42
    • 77956338683 scopus 로고    scopus 로고
    • Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition
    • Lin T, Ponn A, Hu X, Law BK, Lu J (2010) Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition. Oncogene 29(35): 4896-4904.
    • (2010) Oncogene , vol.29 , Issue.35 , pp. 4896-4904
    • Lin, T.1    Ponn, A.2    Hu, X.3    Law, B.K.4    Lu, J.5
  • 43
    • 77953107054 scopus 로고    scopus 로고
    • The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1
    • Lin Y, Wu Y, Li J, Dong C, Ye X, Chi YI, Evers BM, Zhou BP (2010) The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J 29(11): 1803-1816.
    • (2010) EMBO J , vol.29 , Issue.11 , pp. 1803-1816
    • Lin, Y.1    Wu, Y.2    Li, J.3    Dong, C.4    Ye, X.5    Chi, Y.I.6    Evers, B.M.7    Zhou, B.P.8
  • 44
    • 84859480637 scopus 로고    scopus 로고
    • Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer
    • Lv T, Yuan D, Miao X, Lv Y, Zhan P, Shen X, Song Y (2012) Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer. PLoS One 7(4): e35065.
    • (2012) PLoS One , vol.7 , Issue.4
    • Lv, T.1    Yuan, D.2    Miao, X.3    Lv, Y.4    Zhan, P.5    Shen, X.6    Song, Y.7
  • 45
    • 33645751058 scopus 로고    scopus 로고
    • Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state
    • McGarvey KM, Fahrner JA, Greene E, Martens J, Jenuwein T, Baylin SB (2006) Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res 66(7): 3541-3549.
    • (2006) Cancer Res , vol.66 , Issue.7 , pp. 3541-3549
    • McGarvey, K.M.1    Fahrner, J.A.2    Greene, E.3    Martens, J.4    Jenuwein, T.5    Baylin, S.B.6
  • 46
    • 18944408348 scopus 로고    scopus 로고
    • Mapping global histone methylation patterns in the coding regions of human genes
    • Miao F, Natarajan R (2005) Mapping global histone methylation patterns in the coding regions of human genes. Mol Cell Biol 25(11): 4650-4661.
    • (2005) Mol Cell Biol , vol.25 , Issue.11 , pp. 4650-4661
    • Miao, F.1    Natarajan, R.2
  • 47
    • 20444375490 scopus 로고    scopus 로고
    • Dynamic lysine methylation on histone H3 defines the regulatory phase of gene transcription
    • Morillon A, Karabetsou N, Nair A, Mellor J (2005) Dynamic lysine methylation on histone H3 defines the regulatory phase of gene transcription. Mol Cell 18(6): 723-734.
    • (2005) Mol Cell , vol.18 , Issue.6 , pp. 723-734
    • Morillon, A.1    Karabetsou, N.2    Nair, A.3    Mellor, J.4
  • 48
    • 73449092854 scopus 로고    scopus 로고
    • SUMO engages multiple corepressors to regulate chromatin structure and transcription
    • Ouyang J, Gill G (2009) SUMO engages multiple corepressors to regulate chromatin structure and transcription. Epigenetics 4(7): 440-444.
    • (2009) Epigenetics , vol.4 , Issue.7 , pp. 440-444
    • Ouyang, J.1    Gill, G.2
  • 49
    • 84864127389 scopus 로고    scopus 로고
    • Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERa-dependent and-independent manners
    • Pollock JA, Larrea MD, Jasper JS, McDonnell DP, McCafferty DG (2012) Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERa-dependent and-independent manners. ACS Chem Biol 7(7): 1221-1231.
    • (2012) ACS Chem Biol , vol.7 , Issue.7 , pp. 1221-1231
    • Pollock, J.A.1    Larrea, M.D.2    Jasper, J.S.3    McDonnell, D.P.4    McCafferty, D.G.5
  • 53
    • 34447519212 scopus 로고    scopus 로고
    • The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and-independent manners
    • Scoumanne A, Chen X (2007) The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and-independent manners. J Biol Chem 282(21): 15471-15475.
    • (2007) J Biol Chem , vol.282 , Issue.21 , pp. 15471-15475
    • Scoumanne, A.1    Chen, X.2
  • 54
    • 80052161558 scopus 로고    scopus 로고
    • Pituitary tumor transforming gene induces epithelial to mesenchymal transition by regulation of Twist, Snail, Slug, and E-cadherin
    • Shah PP, Kakar SS (2011) Pituitary tumor transforming gene induces epithelial to mesenchymal transition by regulation of Twist, Snail, Slug, and E-cadherin. Cancer Lett 311(1): 66-76.
    • (2011) Cancer Lett , vol.311 , Issue.1 , pp. 66-76
    • Shah, P.P.1    Kakar, S.S.2
  • 56
    • 33846025127 scopus 로고    scopus 로고
    • Dynamic regulation of histone lysine methylation by demethylases
    • Shi Y, Whetstine Jr. (2007) Dynamic regulation of histone lysine methylation by demethylases. Mol Cell 25(1): 1-14.
    • (2007) Mol Cell , vol.25 , Issue.1 , pp. 1-14
    • Shi, Y.1    Whetstine, J.R.2
  • 60
    • 82655179979 scopus 로고    scopus 로고
    • Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties
    • Wang J, Lu F, Ren Q, Sun H, Xu Z, Lan R, Liu Y, Ward D, Quan J, Ye T, Zhang H (2011) Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties. Cancer Res 71(23): 7238-7249.
    • (2011) Cancer Res , vol.71 , Issue.23 , pp. 7238-7249
    • Wang, J.1    Lu, F.2    Ren, Q.3    Sun, H.4    Xu, Z.5    Lan, R.6    Liu, Y.7    Ward, D.8    Quan, J.9    Ye, T.10    Zhang, H.11
  • 62
    • 84855445188 scopus 로고    scopus 로고
    • Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B
    • Wen L, Chen Y, Zeng LL, Zhao F, Li R, Liu Y, Zhang C (2012) Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B. Acta Pharmacol Sin 33(1): 109-119.
    • (2012) Acta Pharmacol Sin , vol.33 , Issue.1 , pp. 109-119
    • Wen, L.1    Chen, Y.2    Zeng, L.L.3    Zhao, F.4    Li, R.5    Liu, Y.6    Zhang, C.7
  • 65
    • 65349092794 scopus 로고    scopus 로고
    • Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion
    • Wu Y, Deng J, Rychahou PG, Qiu S, Evers BM, Zhou BP (2009) Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell 15(5): 416-428.
    • (2009) Cancer Cell , vol.15 , Issue.5 , pp. 416-428
    • Wu, Y.1    Deng, J.2    Rychahou, P.G.3    Qiu, S.4    Evers, B.M.5    Zhou, B.P.6
  • 67
    • 81955160824 scopus 로고    scopus 로고
    • Analysis of the expression of BohLOL1, which encodes an LSD1-like zinc finger protein in Bambusa oldhamii
    • Yeh SH, Lin CS, Wu FH, Wang AY (2011) Analysis of the expression of BohLOL1, which encodes an LSD1-like zinc finger protein in Bambusa oldhamii. Planta 234(6): 1179-1189.
    • (2011) Planta , vol.234 , Issue.6 , pp. 1179-1189
    • Yeh, S.H.1    Lin, C.S.2    Wu, F.H.3    Wang, A.Y.4
  • 68
    • 84858157215 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase/Akt signaling by EGF downregulates membranous E-cadherin and b-catenin and enhances invasion in nasopharyngeal carcinoma cells
    • Yip WK, Seow HF (2012) Activation of phosphatidylinositol 3-kinase/Akt signaling by EGF downregulates membranous E-cadherin and b-catenin and enhances invasion in nasopharyngeal carcinoma cells. Cancer Lett 318(2): 162-172.
    • (2012) Cancer Lett , vol.318 , Issue.2 , pp. 162-172
    • Yip, W.K.1    Seow, H.F.2
  • 69
    • 84872776825 scopus 로고    scopus 로고
    • Overexpression of LSD1 in hepatocellular carcinoma: A latent target for the diagnosis and therapy of hepatoma
    • Zhao ZK, Dong P, Gu J, Chen L, Zhuang M, Lu WJ, Wang DR, Liu YB (2013) Overexpression of LSD1 in hepatocellular carcinoma: a latent target for the diagnosis and therapy of hepatoma. Tumour Biol 34(1): 173-180.
    • (2013) Tumour Biol , vol.34 , Issue.1 , pp. 173-180
    • Zhao, Z.K.1    Dong, P.2    Gu, J.3    Chen, L.4    Zhuang, M.5    Lu, W.J.6    Wang, D.R.7    Liu, Y.B.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.