메뉴 건너뛰기




Volumn 311, Issue 1, 2011, Pages 66-76

Pituitary tumor transforming gene induces epithelial to mesenchymal transition by regulation of Twist, Snail, Slug, and E-cadherin

Author keywords

EMT; Ovarian cancer; PTTG; TGF

Indexed keywords

COMPLEMENTARY DNA; SMALL INTERFERING RNA;

EID: 80052161558     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.06.033     Document Type: Article
Times cited : (56)

References (54)
  • 2
    • 0030910680 scopus 로고    scopus 로고
    • Isolation and characterization of a pituitary tumor-transforming gene (PTTG)
    • Pei L., Melmed S. Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol. Endocrinol. 1997, 11:433-441.
    • (1997) Mol. Endocrinol. , vol.11 , pp. 433-441
    • Pei, L.1    Melmed, S.2
  • 4
    • 0032968414 scopus 로고    scopus 로고
    • Cloning and expression of human cDNA encoding human homologue of pituitary tumor transforming gene
    • Lee I.A., Seong C., Choe I.S. Cloning and expression of human cDNA encoding human homologue of pituitary tumor transforming gene. Biochem. Mol. Biol. Int. 1999, 47:891-897.
    • (1999) Biochem. Mol. Biol. Int. , vol.47 , pp. 891-897
    • Lee, I.A.1    Seong, C.2    Choe, I.S.3
  • 5
    • 0033057332 scopus 로고    scopus 로고
    • Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis
    • Kakar S.S., Jennes L. Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis. Cytogenet. Cell Genet. 1999, 84:211-216.
    • (1999) Cytogenet. Cell Genet. , vol.84 , pp. 211-216
    • Kakar, S.S.1    Jennes, L.2
  • 6
    • 69549124825 scopus 로고    scopus 로고
    • PTTG: an important target gene for ovarian cancer therapy
    • Panguluri S.K., Yeakel C., Kakar S.S. PTTG: an important target gene for ovarian cancer therapy. J. Ovarian. Res. 2008, 1:6.
    • (2008) J. Ovarian. Res. , vol.1 , pp. 6
    • Panguluri, S.K.1    Yeakel, C.2    Kakar, S.S.3
  • 7
    • 0032739848 scopus 로고    scopus 로고
    • Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG)
    • Kakar S.S. Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG). Gene 1999, 240:317-324.
    • (1999) Gene , vol.240 , pp. 317-324
    • Kakar, S.S.1
  • 8
    • 13644256285 scopus 로고    scopus 로고
    • Ectopic expression of PTTG1/securin promotes tumorigenesis in human embryonic kidney cells
    • Hamid T., Malik M.T., Kakar S.S. Ectopic expression of PTTG1/securin promotes tumorigenesis in human embryonic kidney cells. Mol. Cancer 2005, 4:3.
    • (2005) Mol. Cancer , vol.4 , pp. 3
    • Hamid, T.1    Malik, M.T.2    Kakar, S.S.3
  • 9
    • 0033575347 scopus 로고    scopus 로고
    • Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis
    • Zou H., McGarry T.J., Bernal T., Kirschner M.W. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science 1999, 285:418-422.
    • (1999) Science , vol.285 , pp. 418-422
    • Zou, H.1    McGarry, T.J.2    Bernal, T.3    Kirschner, M.W.4
  • 10
    • 0034748340 scopus 로고    scopus 로고
    • Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division
    • Wang Z., Yu R., Melmed S. Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division. Mol. Endocrinol. 2001, 15:1870-1879.
    • (2001) Mol. Endocrinol. , vol.15 , pp. 1870-1879
    • Wang, Z.1    Yu, R.2    Melmed, S.3
  • 13
    • 2442674220 scopus 로고    scopus 로고
    • Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer
    • Yamashita S., Miyagi C., Fukada T., Kagara N., Che Y.S., Hirano T. Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer. Nature 2004, 429:298-302..
    • (2004) Nature , vol.429
    • Yamashita, S.1    Miyagi, C.2    Fukada, T.3    Kagara, N.4    Che, Y.S.5    Hirano, T.6
  • 14
    • 35848946387 scopus 로고    scopus 로고
    • Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: an exception to the norm
    • Ahmed, Thompson E.W., Quinn M.A. Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: an exception to the norm. J. Cell Physiol. 2007, 213:581-588.
    • (2007) J. Cell Physiol. , vol.213 , pp. 581-588
    • Ahmed1    Thompson, E.W.2    Quinn, M.A.3
  • 16
    • 68549106083 scopus 로고    scopus 로고
    • E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    • Schmalhofer O., Brabletz S., Brabletz T. E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer. Cancer Metast. Rev. 2009, 28:151-166.
    • (2009) Cancer Metast. Rev. , vol.28 , pp. 151-166
    • Schmalhofer, O.1    Brabletz, S.2    Brabletz, T.3
  • 17
    • 22144464519 scopus 로고    scopus 로고
    • Twist induces an epithelial-mesenchymal transition to facilitate tumor metastasis
    • Karreth F., Tuveson D.A. Twist induces an epithelial-mesenchymal transition to facilitate tumor metastasis. Cancer Biol. Ther. 2004, 3:1058-1059.
    • (2004) Cancer Biol. Ther. , vol.3 , pp. 1058-1059
    • Karreth, F.1    Tuveson, D.A.2
  • 21
    • 33645733588 scopus 로고    scopus 로고
    • N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1
    • Alexander N.R., Tran N.L., Rekapally H., Summers C.E., Glackin C., Heimark R.L. N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1. Cancer Res. 2006, 66:3365-3369.
    • (2006) Cancer Res. , vol.66 , pp. 3365-3369
    • Alexander, N.R.1    Tran, N.L.2    Rekapally, H.3    Summers, C.E.4    Glackin, C.5    Heimark, R.L.6
  • 22
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2002, 2:442-454.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 23
    • 34548329486 scopus 로고    scopus 로고
    • Differentiation plasticity regulated by TGF-beta family proteins in development and disease
    • Derynck R., Akhurst R.J. Differentiation plasticity regulated by TGF-beta family proteins in development and disease. Nat. Cell Biol. 2007, 9:1000-1004.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 1000-1004
    • Derynck, R.1    Akhurst, R.J.2
  • 24
    • 9244227134 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer initiation and progression
    • Bhowmick N.A., Neilson E.G., Moses H.L. Stromal fibroblasts in cancer initiation and progression. Nature 2004, 432:332-337.
    • (2004) Nature , vol.432 , pp. 332-337
    • Bhowmick, N.A.1    Neilson, E.G.2    Moses, H.L.3
  • 26
    • 77951906896 scopus 로고    scopus 로고
    • Regulatory expression of genes related to metastasis by TGF-beta and activin A in B16 murine melanoma cells
    • M. Murakami, M. Suzuki, Y. Nishino, and M. Funaba, Regulatory expression of genes related to metastasis by TGF-beta and activin A in B16 murine melanoma cells, Mol. Biol. Rep. 37, 1279-1286.
    • Mol. Biol. Rep. , vol.37 , pp. 1279-1286
    • Murakami, M.1    Suzuki, M.2    Nishino, Y.3    Funaba, M.4
  • 27
    • 0029664520 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transformation of a newly established cell line from ovarian adenosarcoma by transforming growth factor-beta1
    • Kitagawa K., Murata A., Matsuura N., Tohya K., Takaichi S., Monden M., Inoue M. Epithelial-mesenchymal transformation of a newly established cell line from ovarian adenosarcoma by transforming growth factor-beta1. Int. J. Cancer 1996, 66:91-97.
    • (1996) Int. J. Cancer , vol.66 , pp. 91-97
    • Kitagawa, K.1    Murata, A.2    Matsuura, N.3    Tohya, K.4    Takaichi, S.5    Monden, M.6    Inoue, M.7
  • 28
    • 0033377867 scopus 로고    scopus 로고
    • TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
    • Piek E., Moustakas A., Kurisaki A., Heldin C.H., ten Dijke P. TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J. Cell Sci. 1999, 112(Pt 24):4557-4568.
    • (1999) J. Cell Sci. , vol.112 , Issue.PART 24 , pp. 4557-4568
    • Piek, E.1    Moustakas, A.2    Kurisaki, A.3    Heldin, C.H.4    ten Dijke, P.5
  • 30
    • 33750983855 scopus 로고    scopus 로고
    • Suppression of lung cancer with siRNA targeting PTTG
    • Kakar S.S., Malik M.T. Suppression of lung cancer with siRNA targeting PTTG. Int. J. Oncol. 2006, 29:387-395.
    • (2006) Int. J. Oncol. , vol.29 , pp. 387-395
    • Kakar, S.S.1    Malik, M.T.2
  • 31
    • 72549108963 scopus 로고    scopus 로고
    • Effect of PTTG on endogenous gene expression in HEK 293 cells
    • Panguluri S.K., Kakar S.S. Effect of PTTG on endogenous gene expression in HEK 293 cells. BMC Genom. 2009, 10:577.
    • (2009) BMC Genom. , vol.10 , pp. 577
    • Panguluri, S.K.1    Kakar, S.S.2
  • 32
    • 34548596630 scopus 로고    scopus 로고
    • Small interfering RNA against PTTG: a novel therapy for ovarian cancer
    • El-Naggar S.M., Malik M.T., Kakar S.S. Small interfering RNA against PTTG: a novel therapy for ovarian cancer. Int. J. Oncol. 2007, 31:137-143.
    • (2007) Int. J. Oncol. , vol.31 , pp. 137-143
    • El-Naggar, S.M.1    Malik, M.T.2    Kakar, S.S.3
  • 33
    • 17844400784 scopus 로고    scopus 로고
    • Early multipotential pituitary focal hyperplasia in the alpha-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice
    • Abbud R.A., Takumi I., Barker E.M., Ren S.G., Chen D.Y., Wawrowsky K., Melmed S. Early multipotential pituitary focal hyperplasia in the alpha-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice. Mol. Endocrinol. 2005, 19:1383-1391.
    • (2005) Mol. Endocrinol. , vol.19 , pp. 1383-1391
    • Abbud, R.A.1    Takumi, I.2    Barker, E.M.3    Ren, S.G.4    Chen, D.Y.5    Wawrowsky, K.6    Melmed, S.7
  • 34
    • 34547461651 scopus 로고    scopus 로고
    • Development of cystic glandular hyperplasia of the endometrium in Mullerian inhibitory substance type II receptor-pituitary tumor transforming gene transgenic mice
    • El-Naggar S.M., Malik M.T., Martin A., Moore J.P., Proctor M., Hamid T., Kakar S.S. Development of cystic glandular hyperplasia of the endometrium in Mullerian inhibitory substance type II receptor-pituitary tumor transforming gene transgenic mice. J. Endocrinol. 2007, 194:179-191.
    • (2007) J. Endocrinol. , vol.194 , pp. 179-191
    • El-Naggar, S.M.1    Malik, M.T.2    Martin, A.3    Moore, J.P.4    Proctor, M.5    Hamid, T.6    Kakar, S.S.7
  • 35
    • 65349132693 scopus 로고    scopus 로고
    • EMT, the cytoskeleton, and cancer cell invasion
    • Yilmaz M., Christofori G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metast. Rev. 2009, 28:15-33.
    • (2009) Cancer Metast. Rev. , vol.28 , pp. 15-33
    • Yilmaz, M.1    Christofori, G.2
  • 36
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery J.P., Sleeman J.P. Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 2006, 7:131-142.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 37
    • 0032533696 scopus 로고    scopus 로고
    • Dynamic behavior of the cadherin-based cell-cell adhesion system during Drosophila gastrulation
    • Oda H., Tsukita S., Takeichi M. Dynamic behavior of the cadherin-based cell-cell adhesion system during Drosophila gastrulation. Dev. Biol. 1998, 203:435-450.
    • (1998) Dev. Biol. , vol.203 , pp. 435-450
    • Oda, H.1    Tsukita, S.2    Takeichi, M.3
  • 38
    • 0036840363 scopus 로고    scopus 로고
    • Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer
    • Rosivatz E., Becker I., Specht K., Fricke E., Luber B., Busch R., Hofler H., Becker K.F. Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am. J. Pathol. 2002, 161:1881-1891.
    • (2002) Am. J. Pathol. , vol.161 , pp. 1881-1891
    • Rosivatz, E.1    Becker, I.2    Specht, K.3    Fricke, E.4    Luber, B.5    Busch, R.6    Hofler, H.7    Becker, K.F.8
  • 42
    • 15544362735 scopus 로고    scopus 로고
    • Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level
    • Kurrey N.K., Amit K., Bapat S.A. Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level. Gynecol. Oncol. 2005, 97:155-165.
    • (2005) Gynecol. Oncol. , vol.97 , pp. 155-165
    • Kurrey, N.K.1    Amit, K.2    Bapat, S.A.3
  • 44
    • 0037033693 scopus 로고    scopus 로고
    • Inverse correlation between E-cadherin and Snail expression in hepatocellular carcinoma cell lines in vitro and in vivo
    • Jiao W., Miyazaki K., Kitajima Y. Inverse correlation between E-cadherin and Snail expression in hepatocellular carcinoma cell lines in vitro and in vivo. Br. J. Cancer 2002, 86:98-101.
    • (2002) Br. J. Cancer , vol.86 , pp. 98-101
    • Jiao, W.1    Miyazaki, K.2    Kitajima, Y.3
  • 45
    • 0035215136 scopus 로고    scopus 로고
    • Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro
    • Yokoyama K., Kamata N., Hayashi E., Hoteiya T., Ueda N., Fujimoto R., Nagayama M. Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro. Oral. Oncol. 2001, 37:65-71.
    • (2001) Oral. Oncol. , vol.37 , pp. 65-71
    • Yokoyama, K.1    Kamata, N.2    Hayashi, E.3    Hoteiya, T.4    Ueda, N.5    Fujimoto, R.6    Nagayama, M.7
  • 46
    • 0035816677 scopus 로고    scopus 로고
    • Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail
    • Poser I., Dominguez D., de Herreros A.G., Varnai A., Buettner R., Bosserhoff A.K. Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail. J. Biol. Chem. 2001, 276:24661-24666.
    • (2001) J. Biol. Chem. , vol.276 , pp. 24661-24666
    • Poser, I.1    Dominguez, D.2    de Herreros, A.G.3    Varnai, A.4    Buettner, R.5    Bosserhoff, A.K.6
  • 47
    • 0037452986 scopus 로고    scopus 로고
    • Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes
    • Wang Z., Moro E., Kovacs K., Yu R., Melmed S. Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes. Proc. Natl. Acad. Sci. USA 2003, 100:3428-3432.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 3428-3432
    • Wang, Z.1    Moro, E.2    Kovacs, K.3    Yu, R.4    Melmed, S.5
  • 48
    • 24344490148 scopus 로고    scopus 로고
    • Pituitary hypoplasia in Pttg-/- mice is protective for Rb pituitary tumorigenesis
    • Chesnokova V., Kovacs K., Castro A.V., Zonis S., Melmed S. Pituitary hypoplasia in Pttg-/- mice is protective for Rb pituitary tumorigenesis. Mol. Endocrinol. 2005, 19:2371-2379.
    • (2005) Mol. Endocrinol. , vol.19 , pp. 2371-2379
    • Chesnokova, V.1    Kovacs, K.2    Castro, A.V.3    Zonis, S.4    Melmed, S.5
  • 49
    • 0035281783 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma
    • Hasegawa Y., Takanashi S., Kanehira Y., Tsushima T., Imai T., Okumura K. Transforming growth factor-beta1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma. Cancer 2001, 91:964-971.
    • (2001) Cancer , vol.91 , pp. 964-971
    • Hasegawa, Y.1    Takanashi, S.2    Kanehira, Y.3    Tsushima, T.4    Imai, T.5    Okumura, K.6
  • 50
    • 0033570029 scopus 로고    scopus 로고
    • The expression of transforming growth factor-beta1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma
    • Saito H., Tsujitani S., Oka S., Kondo A., Ikeguchi M., Maeta M., Kaibara N. The expression of transforming growth factor-beta1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma. Cancer 1999, 86:1455-1462.
    • (1999) Cancer , vol.86 , pp. 1455-1462
    • Saito, H.1    Tsujitani, S.2    Oka, S.3    Kondo, A.4    Ikeguchi, M.5    Maeta, M.6    Kaibara, N.7
  • 52
    • 47949103896 scopus 로고    scopus 로고
    • Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition
    • Do T.V., Kubba L.A., Du H., Sturgis C.D., Woodruff T.K. Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition. Mol. Cancer Res. 2008, 6:695-705.
    • (2008) Mol. Cancer Res. , vol.6 , pp. 695-705
    • Do, T.V.1    Kubba, L.A.2    Du, H.3    Sturgis, C.D.4    Woodruff, T.K.5
  • 53
    • 18744362996 scopus 로고    scopus 로고
    • Transforming growth factor-beta and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition (EMT) through a MEK-dependent mechanism in primary cultured pig thyrocytes
    • Grande M., Franzen A., Karlsson J.O., Ericson L.E., Heldin N.E., Nilsson M. Transforming growth factor-beta and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition (EMT) through a MEK-dependent mechanism in primary cultured pig thyrocytes. J. Cell Sci. 2002, 115:4227-4236.
    • (2002) J. Cell Sci. , vol.115 , pp. 4227-4236
    • Grande, M.1    Franzen, A.2    Karlsson, J.O.3    Ericson, L.E.4    Heldin, N.E.5    Nilsson, M.6
  • 54
    • 0037816160 scopus 로고    scopus 로고
    • Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
    • Siegel P.M., Shu W., Cardiff R.D., Muller W.J., Massague J. Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc. Natl. Acad. Sci. USA 2003, 100:8430-8435.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8430-8435
    • Siegel, P.M.1    Shu, W.2    Cardiff, R.D.3    Muller, W.J.4    Massague, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.