LSD1/CoREST reversible opening-closing dynamics: Discovery of a nanoscale clamp for chromatin and protein binding

Biochemistry

Volumn 51, Issue 15, 2012, Pages 3151-3153

  Baron, Riccardo ^a   Vellore, Nadeem A ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC SITE; BINDING POCKETS; CONFORMATIONAL DYNAMICS; COREPRESSORS; DRUG DISCOVERY; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR FLEXIBILITY; NANO SCALE; PROTEIN BINDING; RECEPTOR FLEXIBILITY; RELEVANT TARGET;

CHROMOSOMES; DYNAMICS; MOLECULAR DYNAMICS; NANOTECHNOLOGY;

BIOCHEMISTRY;

HISTONE DEMETHYLASE; HISTONE H3; LYSINE HISTONE DEMETHYLASE; LYSINE SPECIFIC DEMETHYLASE 1; PROTEIN COREST; REPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHROMATIN; CRYSTAL STRUCTURE; DEMETHYLATION; DRUG TARGETING; ENZYME ACTIVITY; EPIGENETICS; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROCESSING;

BINDING SITES; CHROMATIN; HISTONE DEACETYLASES; HISTONES; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; REPRESSOR PROTEINS;

EID: 84859895302     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300068r     Document Type: Article

References (20)

1. Berger, S. L. (2007) Nature 447, 407-412
2. Kouzarides, T. (2007) Cell 128, 693-705
3. Ruthenburg, A. J., Li, H., Patel, D. J., and Allis, C. D. (2007) Nat. Rev. Mol. Cell Biol. 8, 983-994
4. Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., and Shi, Y. (2004) Cell 119, 941-953
5. Forneris, F., Binda, C., Battaglioli, E., and Mattevi, A. (2008) Trends Biochem. Sci. 33, 181-189
6. Mosammaparast, N. and Shi, Y. (2010) Annu. Rev. Biochem. 79, 155-179
7. Shi, Y. (2007) Nat. Rev. Genet. 8, 829-833
8. Rotili, D. and Mai, A. (2011) Genes Cancer 2, 663-679
9. Yang, M., Gocke, C. B., Luo, X., Borek, D., Tomchick, D. R., Machius, M., Otwinowski, Z., and Yu, H. (2006) Mol. Cell 23, 377-387
10. Lin, Y., Wu, Y., Li, J., Dong, C., Ye, X., Chi, Y.-I., Evers, B. M., and Zhou, B. P. (2010) EMBO J. 29, 1803-1816
11. Forneris, F., Binda, C., DallAglio, A., and Fraaije, M. (2006) J. Biol. Chem. 281, 35289-35295
12. Forneris, F., Binda, C., Adamo, A., Battaglioli, E., and Mattevi, A. (2007) J. Biol. Chem. 282, 20070-20074
13. Baron, R., Binda, C., Tortorici, M., McCammon, J. A., and Mattevi, A. (2011) Structure 19, 212-220
14. Yang, M., Culhane, J. C., Szewczuk, L. M., Gocke, C. B., Brautigam, C. A., Tomchick, D. R., Machius, M., Cole, P. A., and Yu, H. (2007) Nat. Struct. Mol. Biol. 14, 535-539
15. Hess, B., Kutzner, C., van der Spoel, D., and Lindahl, E. (2008) J. Chem. Theory Comput. 4, 435-447
16. Garcia, A. E. (1992) Phys. Rev. Lett. 68, 2696-2699
17. Amadei, A., Linssen, A. B., and Berendsen, H. J. (1993) Proteins 17, 412-425
18. Grant, B. J., Rodrigues, A. P. C., ElSawy, K. M., McCammon, J. A., and Caves, L. S. D. (2006) Bioinformatics 22, 2695-2696
19. Barrallo-Gimeno, A. and Nieto, M. A. (2009) Trends Genet. 25, 248-252
20. Durrant, J. D., de Oliveira, C. A. F., and McCammon, J. A. (2011) J. Mol. Graphics Modell. 29, 773-776