Establishment and characterization of a new hypoxia-resistant cancer cell line, OCUM-12/Hypo, derived from a scirrhous gastric carcinoma

British Journal of Cancer

Volumn 102, Issue 5, 2010, Pages 898-907

  Kato, Y ^a   Yashiro, M ^a   Noda, S ^a   Tendo, M ^a   Kashiwagi, S ^a   Doi, Y ^a   Nishii, T ^a   Matsuoka, J ^a   Fuyuhiro, Y ^a   Shinto, O ^a   Sawada, T ^a   Ohira, M ^a   Hirakawa, K ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell line; Epithelial to mesenchymal transition; Hypoxia resistant; Scirrhous gastric carcinoma

Indexed keywords

CELL ADHESION MOLECULE; GELATINASE A; INTERSTITIAL COLLAGENASE; MESSENGER RNA; OXYGEN; PROTEIN; PROTEIN ZO1; PROTEIN ZO2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SNAIL1; TRANSCRIPTION FACTOR SNAIL2; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR ZEB 1; TRANSCRIPTION FACTOR ZEB 2; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

ADENOCARCINOMA; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASCITES; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL HYPOXIA; CELL INVASION; CELL MIGRATION; CHROMOSOME ANALYSIS; CONTROLLED STUDY; EPITHELIUM CELL; FIBROSIS; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPH NODE METASTASIS; MALE; MESENCHYME CELL; MOLECULAR CLONING; MOUSE; NONHUMAN; OCUM 12 CELL; OCUM 12 HYPO CELL; PERITONEUM METASTASIS; PRIORITY JOURNAL; STOMACH CARCINOMA;

ADENOCARCINOMA, SCIRRHOUS; ANIMALS; ANOXIA; APOPTOSIS; BLOTTING, WESTERN; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CHROMOSOME MAPPING; FLOW CYTOMETRY; HUMANS; IMMUNOENZYME TECHNIQUES; KARYOTYPING; LOSS OF HETEROZYGOSITY; MALE; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; PERITONEAL NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STOMACH NEOPLASMS;

EID: 77649338215     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605543     Document Type: Article

References (41)

1. Albini A, Iwamoto Y, Kleinman HK, Martin GR, Aaronson SA, Kozlowski JM, McEwan RN (1987) A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res 47: 3239-3245
2. Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP (1989) Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 57: 327-334
3. Biron-Shental T, Schaiff WT, Rimon E, Shim TL, Nelson DM, Sadovsky Y (2008) Hypoxia enhances the expression of follistatin-like 3 in term human trophoblasts. Placenta 29: 51-57
4. Borensztajn K, Stiekema J, Nijmeijer S, Reitsma PH, Peppelenbosch MP, Spek CA (2008) Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation. Am J Pathol 172: 309-320
5. Brown JM (1979) Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation. Br J Radiol 52: 650-656
6. Driessen A, Landuyt W, Pastorekova S, Moons J, Goethals L, Haustermans K, Nafteux P, Penninckx F, Geboes K, Lerut T, Ectors N (2006) Expression of carbonic anhydrase IX (CA IX), a hypoxia-related protein, rather than vascular-endothelial growth factor (VEGF), a pro-angiogenic factor, correlates with an extremely poor prognosis in esophageal and gastric adenocarcinomas. Ann Surg 243: 334-340
7. Fujiwara I, Yashiro M, Kubo N, Maeda K, Hirakawa K (2008) Ulcerative colitis-associated colorectal cancer is frequently associated with the microsatellite instability pathway. Dis Colon Rectum 51: 1387-1394
8. Furuta E, Pai SK, Zhan R, Bandyopadhyay S, Watabe M, Mo YY, Hirota S, Hosobe S, Tsukada T, Miura K, Kamada S, Saito K, Iiizumi M, Liu W, Ericsson J, Watabe K (2008) Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1. Cancer Res 68: 1003-1011
9. Harris JW, Shrieve DC (1979) Effects of adriamycin and X-rays on euoxic and hypoxic EMT-6 cells in vitro. Int J Radiat Oncol Biol Phys 5: 1245-1248
10. Hayette S, Gadoux M, Martel S, Bertrand S, Tigaud I, Magaud JP, Rimokh R (1998) FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders. Oncogene 16: 2949-2954
11. Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P (1996) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56: 4509-4515
12. Hockel M, Vaupel P (2001) Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 93: 266-276
13. Ichida K, Amaya Y, Noda K, Minoshima S, Hosoya T, Sakai O, Shimizu N, Nishino T (1993) Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): structural analysis of the protein and chromosomal location of the gene. Gene 133: 279-284
14. Imai T, Horiuchi A, Wang C, Oka K, Ohira S, Nikaido T, Konishi I (2003) Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am J Pathol 163: 1437-1447
15. Japanese Gastric Cancer Association (1998) Japanese classification of gastric carcinoma-2nd English edition. Gastric Cancer 1: 10-24
16. Jung AC, Ribeiro C, Michaut L, Certa U, Affolter M (2006) Polychaetoid/ ZO-1 is required for cell specification and rearrangement during Drosophila tracheal morphogenesis. Curr Biol 16: 1224-1231
17. Kieser A, Weich HA, Brandner G, Marme D, Kolch W (1994) Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene 9: 963-969
18. Kim JY, Kim YJ, Lee S, Park JH (2009a) The critical role of ERK in death resistance and invasiveness of hypoxia-selected glioblastoma cells. BMC Cancer 9: 27
19. Kim MA, Lee HS, Lee HE, Kim JH, Yang HK, Kim WH (2009b) Prognostic importance of epithelial-mesenchymal transition-related protein expression in gastric carcinoma. Histopathology 54: 442-451
20. Linder N, Haglund C, Lundin M, Nordling S, Ristimaki A, Kokkola A, Mrena J, Wiksten JP, Lundin J (2006) Decreased xanthine oxidoreductase is a predictor of poor prognosis in early-stage gastric cancer. J Clin Pathol 59: 965-971
21. Ludwig C (1984) Drug resistance of hypoxic tumour cells in vitro. Cancer Treat Rev 11(Suppl A): 173-178
22. Mayer A, Hockel M, Wree A, Leo C, Horn LC, Vaupel P (2008) Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia. Cancer Res 68: 4719-4726
23. Moen I, Oyan AM, Kalland KH, Tronstad KJ, Akslen LA, Chekenya M, Sakariassen PO, Reed RK, Stuhr LE (2009) Hyperoxic treatment induces mesenchymal-to-epithelial transition in a rat adenocarcinoma model. PLoS One 4: e6381
24. Motoyama T, Hojo H, Watanabe H (1986) Comparison of seven cell lines derived from human gastric carcinomas. Acta Pathol Jpn 36: 65-83
25. Nomura H, Nishimori H, Yasoshima T, Hata F, Sogahata K, Tanaka H, Nakajima F, Ikeda S, Kamiguchi K, Isomura H, Sato N, Denno R, Hirata K (2001) A novel experimental mouse model of peritoneal dissemination of human gastric cancer cells: analysis of the mechanism of peritoneal dissemination using cDNA macroarrays. Jpn J Cancer Res 92: 748-754
26. Revenu C, Gilmour D (2009) EMT 2.0: shaping epithelia through collective migration. Curr Opin Genet Dev 19: 338-342
27. Royds JA, Dower SK, Qwarnstrom EE, Lewis CE (1998) Response of tumour cells to hypoxia: role of p53 and NFkB. Mol Pathol 51: 55-61
28. Sato H, Takino T, Miyamori H (2005) Roles of membrane-type matrix metalloproteinase-1 in tumor invasion and metastasis. Cancer Sci 96: 212-217
29. Seabright M (1971) A rapid banding technique for human chromosomes. Lancet 2: 971-972
30. Semenza GL (2002) HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med 8: S62-S67
31. Song MS, Park YK, Lee JH, Park K (2001) Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade. Cancer Res 61: 8322-8330
32. Subarsky P, Hill RP (2003) The hypoxic tumour microenvironment and metastatic progression. Clin Exp Metastasis 20: 237-250
33. Tahara E (1990) Growth factors and oncogenes in human gastrointestinal carcinomas. J Cancer Res Clin Oncol 116: 121-131
34. Takada A, Ohmori K, Yoneda T, Tsuyuoka K, Hasegawa A, Kiso M, Kannagi R (1993) Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium. Cancer Res 53: 354-361
35. Takahashi Y, Cleary KR, Mai M, Kitadai Y, Bucana CD, Ellis LM (1996) Significance of vessel count and vascular endothelial growth factor and its receptor (KDR) in intestinal-type gastric cancer. Clin Cancer Res 2: 1679-1684
36. Takemura S, Yashiro M, Sunami T, Tendo M, Hirakawa K (2004) Novel models for human scirrhous gastric carcinoma in vivo. Cancer Sci 95: 893-900
37. Vaupel P (2004) The role of hypoxia-induced factors in tumor progression. Oncologist 9(Suppl 5): 10-17
38. Vaupel P, Fortmeyer HP, Runkel S, Kallinowski F (1987) Blood flow, oxygen consumption, and tissue oxygenation of human breast cancer xenografts in nude rats. Cancer Res 47: 3496-3503
39. Vaupel P, Mayer A, Briest S, Hockel M (2003) Oxygenation gain factor: a novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers. Cancer Res 63: 7634-7637
40. Yashiro M, Chung YS, Nishimura S, Inoue T, Sowa M (1995) Establishment of two new scirrhous gastric cancer cell lines: analysis of factors associated with disseminated metastasis. Br J Cancer 72: 1200-1210
41. Yashiro M, Chung YS, Nishimura S, Inoue T, Sowa M (1996) Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice. Clin Exp Metastasis 14: 43-54