Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST

Biochemistry

Volumn 50, Issue 4, 2011, Pages 546-557

  Hwang, Sunhee ^a   Schmitt, Allison A ^a   Luteran, Andrea E ^a   Toone, Eric J ^a   McCafferty, Dewey G ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING DETERMINANT; BINDING INTERACTION; COILED COIL; DEMETHYLASE; DEMETHYLATION; DISSOCIATION CONSTANT; ENTHALPY CHANGE; FLAVIN-DEPENDENT; HEAT CAPACITY CHANGE; HELICAL BUNDLE; HELICAL COILED-COIL; HETERODIMERIC COMPLEXES; HISTONE DEACETYLASES; HISTONE DEMETHYLASE LSD1; IN-VIVO; ISOTHERMAL TITRATION CALORIMETRY; LINKER REGION; LYSINE RESIDUES; MOLECULAR BASIS; MULTI-PROTEIN COMPLEX; NEAR ROOM TEMPERATURE; PROTEIN-PROTEIN INTERACTIONS; SCAFFOLDING PROTEINS; STRUCTURAL BASIS; TEMPERATURE DEPENDENCE; THERMODYNAMIC CHARACTERIZATION; THERMODYNAMIC PARAMETER;

AMINO ACIDS; BINDING ENERGY; DISSOCIATION; ENZYME ACTIVITY; HYDROGEN PEROXIDE; STOICHIOMETRY; THERMODYNAMICS; TOWERS;

PROTEINS;

COREST PROTEIN; HISTONE DEMETHYLASE; HISTONE DEMETHYLASE LSD1; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DEMETHYLATION; DISSOCIATION CONSTANT; ENTHALPY; ENTROPY; ISOTHERMAL TITRATION CALORIMETRY; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTON TRANSPORT; ROOM TEMPERATURE; STOICHIOMETRY; TEMPERATURE DEPENDENCE; THERMODYNAMICS;

CALORIMETRY; ENTROPY; HISTONE DEMETHYLASES; HUMANS; HYDROGEN-ION CONCENTRATION; NERVE TISSUE PROTEINS; NUCLEOSOMES; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; SUBSTRATE SPECIFICITY; SURFACE PLASMON RESONANCE; THERMODYNAMICS;

EID: 79952087232     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101776t     Document Type: Article

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