Postsynaptic Machinery for Receptor Trafficking

Protein Trafficking in Neurons

Volumn , Issue , 2007, Pages 143-174

  Condon, Kathryn H ^a   Ehlers, Michael D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882827482     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012369437-9/50013-X     Document Type: Chapter

References (196)

1. Amparan D., Avram D., Thomas C.G., Lindahl M.G., Yang J., Bajaj G., Ishmael J.E. Direct interaction of myosin regulatory light chain with the NMDA receptor. J. Neurochem. 2005, 92:349-361.
2. Aridor M., Guzik A.K., Bielli A., Fish K.N. Endoplasmic reticulum export site formation and function in dendrites. J. Neurosci. 2004, 24:3770-3776.
3. Augustine G.J., Burns M.E., DeBello W.M., Hilfiker S., Morgan J.R., Schweizer F.E., et al. Proteins involved in synaptic vesicle trafficking. J. Physiol. 1999, 520:33-41. (Pt 1).
4. Baas P.W., Deitch J.S., Black M.M., Banker G.A. Polarity orientation of microtubules in hippocampal neurons: Uniformity in the axon and nonuniformity in the dendrite. Proc. Natl. Acad. Sci. U S A 1988, 85:8335-8339.
5. Babst M., Katzmann D.J., Snyder W.B., Wendland B., Emr S.D. Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body. Dev. Cell 2002, 3:283-289.
6. Babst M., Katzmann D.J., Estepa-Sabal E.J., Meerloo T., Emr S.D. Escrt-III: An endosome-associated heterooligomeric protein complex required for mvb sorting. Dev. Cell 2002, 3:271-282.
7. Barlowe C., Orci L., Yeung T., Hosobuchi M., Hamamoto S., Salama N., et al. COPII: A membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum. Cell. 1994, 77:895-907.
8. Beattie E.C., Carroll R.C., Yu X., Morishita W., Yasuda H., von Zastrow M., Malenka R.C. Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD. Nat. Neurosci. 2000, 3:1291-1300.
9. Bi X., Corpina R.A., Goldberg J. Structure of the Sec23/24-Sar1 pre-budding complex of the COPII vesicle coat. Nature 2002, 419:271-277.
10. Bingol B., Schuman E.M. A proteasome-sensitive connection between PSD-95 and GluR1 endocytosis. Neuropharmacology 2004, 47:755-763.
11. Blanpied T.A., Scott D.B., Ehlers M.D. Dynamics and regulation of clathrin coats at specialized endocytic zones of dendrites and spines. Neuron 2002, 36:435-449.
12. Blanpied T.A., Scott D.B., Ehlers M.D. Age-related regulation of dendritic endocytosis associated with altered clathrin dynamics. Neurobiol. Aging 2003, 24:1095-1104.
13. Borgdorff A.J., Choquet D. Regulation of AMPA receptor lateral movements. Nature 2002, 417:649-653.
14. Bredt D.S., Nicoll R.A. AMPA receptor trafficking at excitatory synapses. Neuron 2003, 40:361-379.
15. Bridgman P.C. Myosin Va movements in normal and dilute-lethal axons provide support for a dual filament motor complex. J. Cell Biol. 1999, 146:1045-1060.
16. Bridgman P.C. Myosin-dependent transport in neurons. J. Neurobiol. 2004, 58:164-174.
17. Broadwell R.D., Cataldo A.M. The neuronal endoplasmic reticulum: Its cytochemistry and contribution to the endomembrane system. I. Cell bodies and dendrites. J. Histochem. Cytochem. 1983, 31:1077-1088.
18. Brodin L., Löw P., Shupliakov O. Sequential steps in clathrin-mediated synaptic vesicle endocytosis. Curr. Opin. Neurobiol. 2000, 10:312-320.
19. Brown S.S. Cooperation between microtubule- and actin-based motor proteins. Annu. Rev. Cell Dev. Biol. 1999, 15:63-80.
20. Brown T.C., Tran I.C., Backos D.S., Esteban J.A. NMDA receptor-dependent activation of the small GTPase Rab5 drives the removal of synaptic AMPA receptors during hippocampal LTD. Neuron 2005, 45:81-94.
21. Büttner C., Sadtler S., Leyendecker A., Laube B., Griffon N., Betz H., Schmalzing G. Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors. J. Biol. Chem. 2001, 276:42978-42985.
22. Burack M., Silverman M., Banker G. The role of selective transport in neuronal protein sorting. Neuron 2000, 26:465-472.
23. Burbea M., Dreier L., Dittman J.S., Grunwald M.E., Kaplan J.M. Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans. Neuron 2002, 35:107-120.
24. Cao H., Orth J.D., Chen J., Weller S.G., Heuser J.E., McNiven M.A. Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis. Mol. Cell Biol. 2003, 23:2162-2170.
25. Carlisle H.J., Kennedy M.B. Spine architecture and synaptic plasticity. Trends Neurosci. 2005, 28:182-187.
26. Carroll R.C., Lissin D.V., von Zastrow M., Nicoll R.A., Malenka R.C. Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures. Nat. Neurosci. 1999, 2:454-460.
27. Carroll R.C., Beattie E.C., von Zastrow M., Malenka R.C. Role of AMPA receptor endocytosis in synaptic plasticity. Nat. Rev. Neurosci. 2001, 2:315-324.
28. Chen C., Brodsky F.M. Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo. J. Biol. Chem. 2005, 280:6109-6117.
29. Claing A., Laporte S.A., Caron M.G., Lefkowitz R.J. Endocytosis of G protein-coupled receptors: Roles of G protein-coupled receptor kinases and beta-arrestin proteins. Prog. Neurobiol. 2002, 66:61-79.
30. Colledge M., Snyder E.M., Crozier R.A., Soderling J.A., Jin Y., Langeberg L.K., et al. Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Neuron 2003, 40:595-607.
31. Connolly C.N., Kittler J.T., Thomas P., Uren J.M., Brandon N.J., Smart T.G., Moss S.J. Cell surface stability of gamma-aminobutyric acid type A receptors. Dependence on protein kinase C activity and subunit composition. J. Biol. Chem. 1999, 274:36565-36572.
32. Cooney J.R., Hurlburt J.L., Selig D.K., Harris K.M., Fiala J.C. Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane. J. Neurosci. 2002, 22:2215-2224.
33. Dahan M., Lévi S., Luccardini C., Rostaing P., Riveau B., Triller A. Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking. Science 2003, 302:442-445.
34. DeFelipe J., Alonso-Nanclares L., Arellano J.I. Microstructure of the neocortex: Comparative aspects. J. Neurocytol. 2002, 31:299-316.
35. Deller T., Korte M., Chabanis S., Drakew A., Schwegler H., Stefani G.G., et al. Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity. Proc. Natl. Acad. Sci. U S A 2003, 100:10494-10499.
36. Donaldson J.G., Lippincott-Schwartz J. Sorting and signaling at the Golgi complex. Cell 2000, 101:693-696.
37. Durand G.M., Kovalchuk Y., Konnerth A. Long-term potentiation and functional synapse induction in developing hippocampus. Nature 1996, 381:71-75.
38. Dwyer N., Adler C., Crump J., L'Etoile N., Bargmann C. Polarized dendritic transport and the AP-1 mu1 clathrin adaptor UNC-101 localize odorant receptors to olfactory cilia. Neuron 2001, 31:277-287.
39. Ehlers M.D. Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting. Neuron 2000, 28:511-525.
40. Ehlers M.D. Molecular morphogens for dendritic spines. Trends Neurosci. 2002, 25:64-67.
41. Engqvist-Goldstein A., Warren R., Kessels M., Keen J., Heuser J., Drubin D. The actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitro. J. Cell Biol. 2001, 154:1209-1223.
42. Engqvist-Goldstein A.E.Y., Zhang C.X., Carreno S., Barroso C., Heuser J.E., Drubin D.G. RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery. Mol. Biol. Cell 2004, 15:1666-1679.
43. Espindola F.S., Suter D.M., Partata L.B., Cao T., Wolenski J.S., Cheney R.E., et al. The light chain composition of chicken brain myosin-Va: Calmodulin, myosin-II essential light chains, and 8-kDa dynein light chain/PIN. Cell Motil. Cytoskeleton 2000, 47:269-281.
44. Feig S., Lipton P. Pairing the cholinergic agonist carbachol with patterned Schaffer collateral stimulation initiates protein synthesis in hippocampal CA1 pyramidal cell dendrites via a muscarinic, NMDA-dependent mechanism. J. Neurosci. 1993, 13:1010-1021.
45. Finch E.A., Augustine G.J. Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites. Nature 1998, 396:753-756.
46. Fuhrmann J.C., Kins S., Rostaing P., Far O.E., Kirsch J., Sheng M., et al. Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes. J. Neurosci. 2002, 22:5393-5402.
47. Gardiol A., Racca C., Triller A. Dendritic and postsynaptic protein synthetic machinery. J. Neurosci. 1999, 19:168-179.
48. Golgi C. On the structure of nerve cells. 1898. J. Microsc. 1989, 155:3-7. (Pt 1).
49. Gray E.G. Electron microscopy of synaptic contacts on dendrite spines of the cerebral cortex. Nature 1959, 183:1592-1593.
50. Gray N.W., Fourgeaud L., Huang B., Chen J., Cao H., Oswald B.J., et al. Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer. Curr. Biol. 2003, 13:510-515.
51. Gray N.W., Kruchten A.E., Chen J., McNiven M.A. A dynamin-3 spliced variant modulates the actin/cortactin-dependent morphogenesis of dendritic spines. J. Cell Sci. 2005, 118:1279-1290.
52. Greger I.H., Khatri L., Ziff E.B. RNA editing at arg607 controls AMPA receptor exit from the endoplasmic reticulum. Neuron 2002, 34:759-772.
53. Groc L., Heine M., Cognet L., Brickley K., Stephenson F.A., Lounis B., Choquet D. Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors. Nat. Neurosci. 2004, 7:695-696.
54. Guillaud L., Setou M., Hirokawa N. KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons. J. Neurosci. 2003, 23:131-140.
55. Haglund K., Fiore P.P.D., Dikic I. Distinct monoubiquitin signals in receptor endocytosis. Trends Biochem. Sci. 2003, 28:598-603.
56. Haglund K., Sigismund S., Polo S., Szymkiewicz I., Fiore P.P.D., Dikic I. Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat. Cell Biol. 2003, 5:461-466.
57. Hanus C., Vannier C., Triller A. Intracellular association of glycine receptor with gephyrin increases its plasma membrane accumulation rate. J. Neurosci. 2004, 24:1119-1128.
58. Hayashi Y., Shi S.H., Esteban J.A., Piccini A., Poncer J.C., Malinow R. Driving AMPA receptors into synapses by LTP and CaMKII: Requirement for GluR1 and PDZ domain interaction. Science 2000, 287:2262-2267.
59. Hegde A.N. Ubiquitin-proteasome-mediated local protein degradation and synaptic plasticity. Prog. Neurobiol. 2004, 73:311-357.
60. Hering H., Sheng M. Activity-dependent redistribution and essential role of cortactin in dendritic spine morphogenesis. J. Neurosci. 2003, 23:11759-11769.
61. Hicke L., Dunn R. Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins. Annu. Rev. Cell Dev. Biol. 2003, 19:141-172.
62. Hicke L., Riezman H. Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. Cell 1996, 84:277-287.
63. Hoop M.J.D., Huber L.A., Stenmark H., Williamson E., Zerial M., Parton R.G., Dotti C.G. The involvement of the small GTP-binding protein Rab5a in neuronal endocytosis. Neuron 1994, 13:11-22.
64. Horton A.C., Ehlers M.D. Dual modes of endoplasmic reticulum-to-Golgi transport in dendrites revealed by live-cell imaging. J. Neurosci. 2003, 23:6188-6199.
65. Horton A.C., Ehlers M.D. Secretory trafficking in neuronal dendrites. Nat. Cell Biol. 2004, 6:585-591.
66. Huang J.D., Brady S.T., Richards B.W., Stenolen D., Resau J.H., Copeland N.G., Jenkins N.A. Direct interaction of microtubule- and actin-based transport motors. Nature 1999, 397:267-270.
67. Isaac J.T., Nicoll R.A., Malenka R.C. Evidence for silent synapses: Implications for the expression of LTP. Neuron 1995, 15:427-434.
68. Jaskolski F., Coussen F., Nagarajan N., Normand E., Rosenmund C., Mulle C. Subunit composition and alternative splicing regulate membrane delivery of kainate receptors. J. Neurosci. 2004, 24:2506-2515.
69. Ju W., Morishita W., Tsui J., Gaietta G., Deerinck T.J., Adams S.R., et al. Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors. Nat. Neurosci. 2004, 7:244-253.
70. Kabbani N., Jeromin A., Levenson R. Dynamin-2 associates with the dopamine receptor signalplex and regulates internalization of activated D2 receptors. Cell Signal 2004, 16:497-503.
71. Kacharmina J.E., Job C., Crino P., Eberwine J. Stimulation of glutamate receptor protein synthesis and membrane insertion within isolated neuronal dendrites. Proc. Natl. Acad. Sci. U S A 2000, 97:11545-11550.
72. Kanaani J., Diacovo M.J., El-Husseini A.E., Bredt D.S., Baekkeskov S. Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters. J. Cell Sci. 2004, 117:2001-2013.
73. Kato A., Rouach N., Nicoll R.A., Bredt D.S. Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination. Proc. Natl. Acad. Sci. U S A 2005, 102:5600-5605.
74. Katzmann D.J., Babst M., Emr S.D. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell 2001, 106:145-155.
75. Katzmann D.J., Odorizzi G., Emr S.D. Receptor downregulation and multivesicular-body sorting. Nat. Rev. Mol. Cell Biol. 2002, 3:893-905.
76. Kelleher R.J., Govindarajan A., Tonegawa S. Translational regulatory mechanisms in persistent forms of synaptic plasticity. Neuron 2004, 44:59-73.
77. Keller P., Simons K. Post-Golgi biosynthetic trafficking. J. Cell Sci. 1997, 110:3001-3009. (Pt 24).
78. Kessels M., Engqvist-Goldstein A., Drubin D., Qualmann B. Mammalian Abp1, a signal-responsive F-actin-binding protein, links the actin cytoskeleton to endocytosis via the GTPase dynamin. J. Cell Biol. 2001, 153:351-366.
79. Kirsch J., Betz H. Glycine-receptor activation is required for receptor clustering in spinal neurons. Nature 1998, 392:717-720.
80. Kittler J.T., Delmas P., Jovanovic J.N., Brown D.A., Smart T.G., Moss S.J. Constitutive endocytosis of GABA-A receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J. Neurosci. 2000, 20:7972-7977.
81. Kittler J.T., Thomas P., Tretter V., Bogdanov Y.D., Haucke V., Smart T.G., Moss S.J. Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking. Proc. Natl. Acad. Sci. U S A 2004, 101:12736-12741.
82. Kneussel M., Betz H. Receptors, gephyrin and gephyrin-associated proteins: Novel insights into the assembly of inhibitory postsynaptic membrane specializations. J. Physiol. 2000, 525:1-9. (Pt 1).
83. Kneussel M., Haverkamp S., Fuhrmann J.C., Wang H., Wässle H., Olsen R.W., Betz H. The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse. Proc. Natl. Acad. Sci. U S A 2000, 97:8594-8599.
84. Lanzetti L., Palamidessi A., Areces L., Scita G., Fiore P.P.D. Rab5 is a signaling GTPase involved in actin remodelling by receptor tyrosine kinases. Nature 2004, 429:309-314.
85. Lavezzari G., McCallum J., Dewey C.M., Roche K.W. Subunit-specific regulation of NMDA receptor endocytosis. J. Neurosci. 2004, 24:6383-6391.
86. Lavezzari G., McCallum J., Lee R., Roche K.W. Differential binding of the AP-2 adaptor complex and PSD-95 to the C-terminus of the NMDA receptor subunit NR2B regulates surface expression. Neuropharmacology 2003, 45:729-737.
87. Lee M.C.S., Miller E.A., Goldberg J., Orci L., Schekman R. Bi-directional protein transport between the ER and Golgi. Annu. Rev. Cell Dev. Biol. 2004, 20:87-123.
88. Lee S.H., Liu L., Wang Y.T., Sheng M. Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD. Neuron 2002, 36:661-674.
89. Lee S.H., Simonetta A., Sheng M. Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons. Neuron 2004, 43:221-236.
90. Legendre-Guillemin V., Metzler M., Lemaire J., Philie J., Gan L., Hayden M.R., McPherson P.S. Huntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain. J. Biol. Chem. 2005, 280:6101-6108.
91. Liao D., Hessler N.A., Malinow R. Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice. Nature 1995, 375:400-404.
92. Lin J.W., Ju W., Foster K., Lee S.H., Ahmadian G., Wyszynski M., et al. Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. Nat. Neurosci. 2000, 3:1282-1290.
93. Lippincott-Schwartz J., Roberts T.H., Hirschberg K. Secretory protein trafficking and organelle dyanmics in living cells. Annu. Rev. Cell Dev. Biol. 2000, 16:557-589.
94. Lissin D.V., Carroll R.C., Nicoll R.A., Malenka R.C., von Zastrow M. Rapid, activation-induced redistribution of ionotropic glutamate receptors in cultured hippocampal neurons. J. Neurosci. 1999, 19:1263-1272.
95. Lüscher C., Xia H., Beattie E.C., Carroll R.C., von Zastrow M., Malenka R.C., Nicoll R.A. Role of AMPA receptor cycling in synaptic transmission and plasticity. Neuron 1999, 24:649-658.
96. Malenka R.C., Bear M.F. LTP and LTD: An embarrassment of riches. Neuron 2004, 44:5-21.
97. Malinow R., Malenka R.C. AMPA receptor trafficking and synaptic plasticity. Annu. Rev. Neurosci. 2002, 25:103-126.
98. Man H.Y., Lin J.W., Ju W.H., Ahmadian G., Liu L., Becker L.E., et al. Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization. Neuron 2000, 25:649-662.
99. Marsh B.J., Volkmann N., McIntosh J.R., Howell K.E. Direct continuities between cisternae at different levels of the Golgi complex in glucose-stimulated mouse islet beta cells. Proc. Natl. Acad. Sci. U S A 2004, 101:5565-5570.
100. Martin S., Henley J.M. Activity-dependent endocytic sorting of kainate receptors to recycling or degradation pathways. EMBO J. 2004, 23:4749-4759.
101. Matsuzaki M., Ellis-Davies G.C., Nemoto T., Miyashita Y., Iino M., Kasai H. Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons. Nat. Neurosci. 2001, 4:1086-1092.
102. Maxfield F.R., McGraw T.E. Endocytic recycling. Nat. Rev. Mol. Cell Biol. 2004, 5:121-132.
103. Meier J., Vannier C., Sergé A., Triller A., Choquet D. Fast and reversible trapping of surface glycine receptors by gephyrin. Nat. Neurosci. 2001, 4:253-260.
104. Merrifield C.J., Perrais D., Zenisek D. Coupling between clathrin-coated-pit invagination, cortactin recruitment, and membrane scission observed in live cells. Cell 2005, 121:593-606.
105. Meusser B., Hirsch C., Jarosch E., Sommer T. ERAD: The long road to destruction. Nat. Cell Biol. 2005, 7:766-772.
106. Miller T.M., Heuser J.E. Endocytosis of synaptic vesicle membrane at the frog neuromuscular junction. J. Cell Biol. 1984, 98:685-698.
107. Miyashiro K., Dichter M., Eberwine J. On the nature and differential distribution of mRNAs in hippocampal neurites: implications for neuronal functioning. Proc. Natl. Acad. Sci. U S A 1994, 91:10800-10804.
108. Miyata M., Finch E.A., Khiroug L., Hashimoto K., Hayasaka S., Oda S.I., et al. Local calcium release in dendritic spines required for long-term synaptic depression. Neuron 2000, 28:233-244.
109. Mogelsvang S., Marsh B.J., Ladinsky M.S., Howell K.E. Predicting function from structure: 3D structure studies of the mammalian Golgi complex. Traffic 2004, 5:338-345.
110. Momiyama A., Silver R.A., Hausser M., Notomi T., Wu Y., Shigemoto R., Cull-Candy S.G. The density of AMPA receptors activated by a transmitter quantum at the climbing fibre-Purkinje cell synapse in immature rats. J. Physiol. 2003, 549:75-92.
111. Mori S., Heldin C.H., Claesson-Welsh L. Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor. J. Biol. Chem. 1992, 267:6429-6434.
112. Mosesson Y., Shtiegman K., Katz M., Zwang Y., Vereb G., Szollosi J., Yarden Y. Endocytosis of receptor tyrosine kinases is driven by monoubiquitylation, not polyubiquitylation. J. Biol. Chem. 2003, 278:21323-21326.
113. Mu Y., Otsuka T., Horton A.C., Scott D.B., Ehlers M.D. Activity-dependent mRNA splicing controls ER export and synaptic delivery of NMDA receptors. Neuron 2003, 40:581-594.
114. Naisbitt S., Valtschanoff J., Allison D.W., Sala C., Kim E., Craig A.M., et al. Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein. J. Neurosci. 2000, 20:4524-4534.
115. Nimchinsky E.A., Sabatini B.L., Svoboda K. Structure and function of dendritic spines. Annu. Rev. Physiol. 2002, 64:313-353.
116. Nimchinsky E.A., Yasuda R., Oertner T.G., Svoboda K. The number of glutamate receptors opened by synaptic stimulation in single hippocampal spines. J. Neurosci. 2004, 24:2054-2064.
117. O'Brien R.J., Kamboj S., Ehlers M.D., Rosen K.R., Fischbach G.D., Huganir R.L. Activity-dependent modulation of synaptic AMPA receptor accumulation. Neuron 1998, 21:1067-1078.
118. Okamoto P., Gamby C., Wells D., Fallon J., Vallee R. Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the post-synaptic density and actin cytoskeleton. J. Biol. Chem. 2001, 276:48458-48465.
119. Okano A., Usuda N., Furihata K., Nakayama K., Tian Q.B., Okamoto T., Suzuki T. Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is localized in the postsynaptic regions. Brain Res. 2003, 967:210-225.
120. Osterweil E., Wells D.G., Mooseker M.S. A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis. J. Cell Biol. 2005, 168:329-338.
121. Pak D.T., Yang S., Rudolph-Correia S., Kim E., Sheng M. Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron 2001, 31:289-303.
122. Pak D.T.S., Sheng M. Targeted protein degradation and synapse remodeling by an inducible protein kinase. Science 2003, 302:1368-1373.
123. Park M., Penick E.C., Edwards J.G., Kauer J.A., Ehlers M.D. Recycling endosomes supply AMPA receptors for LTP. Science 2004, 305:1972-1975.
124. Passafaro M., Piëch V., Sheng M. Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons. Nat. Neurosci. 2001, 4:917-926.
125. Patrick G.N., Bingol B., Weld H.A., Schuman E.M. Ubiquitin-mediated proteasome activity is required for agonist-induced endocytosis of GluRs. Curr. Biol. 2003, 13:2073-2081.
126. Pearse B., Smith C., Owen D. Clathrin coat construction in endocytosis. Curr. Opin. Struct. Biol. 2000, 10:220-228.
127. Pérez-Otaño I., Ehlers M.D. Homeostatic plasticity and NMDA receptor trafficking. Trends Neurosci. 2005, 28:229-238.
128. Petralia R.S., Wang Y., Wenthold R.J. Internalization at glutamatergic synapses during development. Eur. J. Neurosci. 2003, 18:3207-3217.
129. Pierce J., van Leyen K., McCarthy J. Translocation machinery for synthesis of integral membrane and secretory proteins in dendritic spines. Nat. Neurosci. 2000, 3:311-313.
130. Pierce J., Mayer T., McCarthy J. Evidence for a satellite secretory pathway in neuronal dendritic spines. Curr. Biol. 2001, 11:351-355.
131. Polo S., Sigismund S., Faretta M., Guidi M., Capua M.R., Bossi G., et al. A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Nature 2002, 416:451-455.
132. Prekeris R., Klumperman J., Chen Y.A., Scheller R.H. Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. J. Cell. Biol. 1998, 143:957-971.
133. Prybylowski K., Chang K., Sans N., Kan L., Vicini S., Wenthold R.J. The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2. Neuron 2005, 47:845-857.
134. Puertollano R., Bonifacino J.S. Interactions of GGA3 with the ubiquitin sorting machinery. Nat. Cell Biol. 2004, 6:244-251.
135. Racca C., Gardiol A., Triller A. Dendritic and postsynaptic localizations of glycine receptor alpha subunit mRNAs. J. Neurosci. 1997, 17:1691-1700.
136. Racca C., Stephenson F.A., Streit P., Roberts J.D., Somogyi P. NMDA receptor content of synapses in stratum radiatum of the hippocampal CA1 area. J. Neurosci. 2000, 20:2512-2522.
137. Rácz B., Blanpied T.A., Ehlers M.D., Weinberg R.J. Lateral organization of endocytic machinery in dendritic spines. Nat. Neurosci. 2004, 7:917-918.
138. Rácz B., Weinberg R.J. The subcellular organization of cortactin in hippocampus. J. Neurosci. 2004, 24:10310-10317.
139. Ren Z., Riley N.J., Garcia E.P., Sanders J.M., Swanson G.T., Marshall J. Multiple trafficking signals regulate kainate receptor KA2 subunit surface expression. J. Neurosci. 2003, 23:6608-6616.
140. Ren Z., Riley N.J., Needleman L.A., Sanders J.M., Swanson G.T., Marshall J. Cell surface expression of GluR5 kainate receptors is regulated by an endoplasmic reticulum retention signal. J. Biol. Chem. 2003, 278:52700-52709.
141. Roche K.W., Standley S., McCallum J., Ly C.D., Ehlers M.D., Wenthold R.J. Molecular determinants of NMDA receptor internalization. Nat. Neurosci. 2001, 4:794-802.
142. Rosenberg M., Meier J., Triller A., Vannier C. Dynamics of glycine receptor insertion in the neuronal plasma membrane. J. Neurosci. 2001, 21:5036-5044.
143. Sala C., Piëch V., Wilson N.R., Passafaro M., Liu G., Sheng M. Regulation of dendritic spine morphology and synaptic function by Shank and Homer. Neuron 2001, 31:115-130.
144. Sampo B., Kaech S., Kunz S., Banker G. Two distinct mechanisms target membrane proteins to the axonal surface. Neuron 2003, 37:611-624.
145. Sanes J., Lichtman J. Can molecules explain long-term potentiation?. Nat. Neurosci. 1999, 2:597-604.
146. Sans N., Prybylowski K., Petralia R.S., Chang K., Wang Y., Racca C., et al. NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Nat. Cell Biol. 2003, 5:520-530.
147. Schafer D.A., Weed S.A., Binns D., Karginov A.V., Parsons J.T., Cooper J.A. Dynamin2 and cortactin regulate actin assembly and filament organization. Curr. Biol. 2002, 12:1852-1857.
148. Schröder M., Kaufman R.J. The Mammalian unfolded protein response. Annu. Rev. Biochem. 2005, 74:739-789.
149. Scott D., Blanpied T., Swanson G., Zhang C., Ehlers M. An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing. J. Neurosci. 2001, 21:3063-3072.
150. Scott D.B., Blanpied T.A., Ehlers M.D. Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors. Neuropharmacology 2003, 45:755-767.
151. Scott D.B., Michailidis I., Mu Y., Logothetis D., Ehlers M.D. Endocytosis and degradative sorting of NMDA receptors by conserved membrane-proximal signals. J. Neurosci. 2004, 24:7096-7109.
152. Serge A., Fourgeaud L., Hemar A., Choquet D. Active surface transport of metabotropic glutamate receptors through binding to microtubules and actin flow. J. Cell Sci. 2003, 116:5015-5022.
153. Setou M., Nakagawa T., Seog D.H., Hirokawa N. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science 2000, 288:1796-1802.
154. Shenoy S.K., McDonald P.H., Kohout T.A., Lefkowitz R.J. Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science 2001, 294:1307-1313.
155. Shi S.H., Hayashi Y., Petralia R.S., Zaman S.H., Wenthold R.J., Svoboda K., Malinow R. Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science 1999, 284:1811-1816.
156. Shim J., Umemura T., Nothstein E., Rongo C. The unfolded protein response regulates glutamate receptor export from the endoplasmic reticulum. Mol. Biol. Cell 2004, 15:4818-4828.
157. Slepnev V.I., Camilli P.D. Accessory factors in clathrin-dependent synaptic vesicle endocytosis. Nat. Rev. Neurosci. 2000, 1:161-172.
158. Snyder E.M., Philpot B.D., Huber K.M., Dong X., Fallon J.R., Bear M.F. Internalization of ionotropic glutamate receptors in response to mGluR activation. Nat. Neurosci. 2001, 4:1079-1085.
159. Soubeyran P., Kowanetz K., Szymkiewicz I., Langdon W.Y., Dikic I. Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. Nature 2002, 416:183-187.
160. Spaargaren M., Bos J.L. Rab5 induces Rac-independent lamellipodia formation and cell migration. Mol. Biol. Cell 1999, 10:3239-3250.
161. Spacek J., Harris K.M. Three-dimensional organization of smooth endoplasmic reticulum in hippocampal CA1 dendrites and dendritic spines of the immature and mature rat. J. Neurosci. 1997, 17:190-203.
162. Standley S., Roche K.W., McCallum J., Sans N., Wenthold R.J. PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants. Neuron 2000, 28:887-898.
163. Steward O., Schuman E.M. Protein synthesis at synaptic sites on dendrites. Annu. Rev. Neurosci. 2001, 24:299-325.
164. Sun W., Ginovart N., Ko F., Seeman P., Kapur S. In vivo evidence for dopamine-mediated internalization of D2-receptors after amphetamine: Differential findings with [3H]raclopride versus [3H]spiperone. Mol. Pharmacol. 2003, 63:456-462.
165. Sur C., McKernan R., Triller A. GABAA receptor-like immunoreactivity in the goldfish brainstem with emphasis on the Mauthner cell. Neuroscience 1995, 66:697-706.
166. Sutton M.A., Schuman E.M. Local translational control in dendrites and its role in long-term synaptic plasticity. J. Neurobiol. 2005, 64:116-131.
167. Svitkina T.M., Bulanova E.A., Chaga O.Y., Vignjevic D.M., Kojima S., Vasiliev J.M., Borisy G.G. Mechanism of filopodia initiation by reorganization of a dendritic network. J. Cell Biol. 2003, 160:409-421.
168. Sytnyk V., Leshchyns'ka I., Dityatev A., Schachner M. Trans-Golgi network delivery of synaptic proteins in synaptogenesis. J. Cell Sci. 2004, 117:381-388.
169. Takumi Y., Ramírez-León V., Laake P., Rinvik E., Ottersen O.P. Different modes of expression of AMPA and NMDA receptors in hippocampal synapses. Nat. Neurosci. 1999, 2:618-624.
170. Tanaka J., Matsuzaki M., Tarusawa E., Momiyama A., Molnar E., Kasai H., Shigemoto R. Number and density of AMPA receptors in single synapses in immature cerebellum. J. Neurosci. 2005, 25:799-807.
171. Teng H., Cole J.C., Roberts R.L., Wilkinson R.S. Endocytic active zones: hot spots for endocytosis in vertebrate neuromuscular terminals. J. Neurosci. 1999, 19:4855-4866.
172. Terry-Lorenzo R.T., Roadcap D.W., Otsuka T., Blanpied T.A., Zamorano P.L., Garner C.C., et al. Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation. Mol. Biol. Cell. 2005, 16:2349-2362.
173. Thomas P., Mortensen M., Hosie A.M., Smart T.G. Dynamic mobility of functional GABA(A) receptors at inhibitory synapses. Nat. Neurosci. 2005, 8:889-897.
174. Toni N., Buchs P.A., Nikonenko I., Povilaitite P., Parisi L., Muller D. Remodeling of synaptic membranes after induction of long-term potentiation. J. Neurosci. 2001, 21:6245-6251.
175. Torre E., Steward O. Protein synthesis within dendrites: Glycosylation of newly synthesized proteins in dendrites of hippocampal neurons in culture. J. Neurosci. 1996, 16:5967-5978.
176. Tovar K.R., Westbrook G.L. Mobile NMDA receptors at hippocampal synapses. Neuron 2002, 34:255-264.
177. Triller A., Choquet D. Surface trafficking of receptors between synaptic and extrasynaptic membranes: and yet they do move!. Trends Neurosci. 2005, 28:133-139.
178. Trucco A., Polishchuk R.S., Martella O., Pentima A.D., Fusella A., Giandomenico D.D., et al. Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments. Nat. Cell Biol. 2004, 6:1071-1081.
179. Turrigiano G.G., Nelson S.B. Homeostatic plasticity in the developing nervous system. Nat. Rev. Neurosci. 2004, 5:97-107.
180. van Rijnsoever C., Täuber M., Choulli M.K., Keist R., Rudolph U., Mohler H. Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice. J. Neurosci. 2004, 24:6785-6790.
181. van Vliet C., Thomas E.C., Merino-Trigo A., Teasdale R.D., Gleeson P.A. Intracellular sorting and transport of proteins. Prog. Biophys. Mol. Biol. 2003, 83:1-45.
182. Vandenberghe W., Nicoll R.A., Bredt D.S. Interaction with the unfolded protein response reveals a role for stargazin in biosynthetic AMPA receptor transport. J. Neurosci. 2005, 25:1095-1102.
183. Verkhratsky A. Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons. Physiol. Rev. 2005, 85:201-279.
184. Wang Y.T., Linden D.J. Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis. Neuron 2000, 25:635-647.
185. Washbourne P., Liu X., Jones E.G., McAllister A.K. Cycling of NMDA
186. West A., Neve R., Buckley K. Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor. J. Neurosci. 1997, 17:6038-6047.
187. West A., Neve R., Buckley K. Targeting of the synaptic vesicle protein synaptobrevin in the axon of cultured hippocampal neurons: Evidence for two distinct sorting steps. J. Cell Biol. 1997, 139:917-927.
188. White S.H., von Heijne G. Transmembrane helices before, during, and after insertion. Curr. Opin. Struct. Biol. 2005, 15:378-386.
189. Winckler B., Forscher P., Mellman I. A diffusion barrier maintains distribution of membrane proteins in polarized neurons. Nature 1999, 397:698-701.
190. Wisco D., Anderson E.D., Chang M.C., Norden C., Boiko T., Fölsch H., Winckler B. Uncovering multiple axonal targeting pathways in hippocampal neurons. J. Cell Biol. 2003, 162:1317-1328.
191. Yap C.C., Murate M., Kishigami S., Muto Y., Kishida H., Hashikawa T., Yano R. Adaptor protein complex-4 (AP-4) is expressed in the central nervous system neurons and interacts with glutamate receptor delta2. Mol. Cell Neurosci. 2003, 24:283-295.
192. Yi J.J., Ehlers M.D. Ubiquitin and protein turnover in synapse function. Neuron 2005, 47:629-632.
193. Yoshida Y., Chiba T., Tokunaga F., Kawasaki H., Iwai K., Suzuki T., et al. E3 ubiquitin ligase that recognizes sugar chains. Nature 2002, 418:438-442.
194. Zerangue N., Schwappach B., Jan Y.N., Jan L.Y. A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels. Neuron 1999, 22:537-548.
195. Zhu J.J., Qin Y., Zhao M., Aelst L.V., Malinow R. Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Cell 2002, 110:443-455.
196. Zito K., Knott G., Shepherd G.M.G., Shenolikar S., Svoboda K. Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton. Neuron 2004, 44:321-334.