A review on natural products for controlling type 2 diabetes with an emphasis on their mechanisms of actions

Current Diabetes Reviews

Volumn 9, Issue 5, 2013, Pages 402-411

  Salimifar, Mohsen ^a   Fatehi Hassanabad, Zahra ^b   Fatehi, Mohammad ^c  

^a NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Parkland Medical Associates   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Alternative and complementary medicine; Anti hyperglycemic; Anti inflammation; Natural product; Type 2 diabetes

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 5BETA,19 EPOXY 25 METHOXY CUCURBITA 6,23 DIENE 3BETA,19 DIOL; ADENYLATE KINASE; ADIPONECTIN; AEGLE MARMELOS EXTRACT; ALPHA GLUCOSIDASE INHIBITOR; AMYLASE INHIBITOR; ANTIDIABETIC AGENT; BIGUANIDE DERIVATIVE; CAPSAICIN; CATECHIN; CURCUMIN; EPICATECHIN; EPIGALLOCATECHIN GALLATE; GARLIC EXTRACT; GENISTEIN; GINGER EXTRACT; GINGEROL; GINSENOSIDE RE; GLUCOSE; GRAPE SEED EXTRACT; LEPTIN; MOMORDICA CHARANTIA EXTRACT; NATURAL PRODUCT; ONION EXTRACT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; QUERCETIN; RESVERATROL; SULFONYLUREA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ABDOMINAL DISTENSION; ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; BLOOD GLUCOSE MONITORING; CARDIOTOXICITY; DIARRHEA; DRUG EFFICACY; DRY SKIN; DYSLIPIDEMIA; ENERGY METABOLISM; FLATULENCE; GARLIC; GLUCOSE METABOLISM; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN RELEASE; INSULIN RESISTANCE; LACTIC ACIDOSIS; LIPID PEROXIDATION; LIVER TOXICITY; MOMORDICA CHARANTIA; NEPHROTOXICITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; ONION; PRIORITY JOURNAL; REVIEW; RUSSIAN FEDERATION; STREPTOZOCIN DIABETES; TRADITIONAL MEDICINE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL PRODUCTS; COMPLEMENTARY THERAPIES; DIABETES MELLITUS, TYPE 2; HUMANS; HYPOGLYCEMIC AGENTS; INCRETINS; SIGNAL TRANSDUCTION;

EID: 84882782567     PISSN: 15733998     EISSN: 18756417     Source Type: Journal    
DOI: 10.2174/15733998113099990076     Document Type: Review

References (105)

1. Konstantinos L et al. (2012). Aretaeus of Cappadocia and the first description of diabetes. Hormones 11 (1): 109-113.
2. Papaspyros NS. The history of Diabetes Mellitus. G.T. Verlag, Stuttgart, 1964, p.7-11
3. Bettini M, Vignali DA. T cell-driven initiation and propagation of autoimmune diabetes. Curr Opin Immunol 2011; 23: 754-60
4. Department of Health and Human Services. Centres for Disease Control and Prevention, 2011. National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011. Available at http://www.cdc.gov/diabetes/pubs/pdf/ndfs_2011.
5. Leiherer A, Mündlein A, Drexel H. Phytochemicals and their impact on adipose tissue inflammation and diabetes. Vascul Pharmacol. 2012; S1537-1891 PMID: 22982056
6. Marshall JA, Bessesen, DH. Dietary fat and the development of type 2 diabetes. Diabetes Care 2002; 25: 620-22.
7. Oh DY, Talukdar S, Bae EJ, et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulinsensitizing effects. Cell 2010; 142:687-98
8. Deng YT, Chang TW, Lee MS, Lin JK. Suppression of free fatty acid-induced insulin resistance by phytopolyphenols in C2C12 mouse skeletal muscle cells. J Agric Food Chem. 2012; 60(4): 1059-66.
9. Bouzakri K, Koistinen HA, Zierath JR. Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes. Curr Diabetes Rev 2005; 1(2): 167-74.
10. Cruz NG, Sousa LP, Sousa MO, Pietrani NT, Fernandes AP, Gomes KB. The linkage between inflammation and Type 2 diabetes mellitus. Diabetes Res Clin Pract 2012; PMID: 23245808
11. Lee SA, Kallianpur A, Xiang YB, et al. Intra-individual variation of plasma adipokine levels and utility of single measurement of these biomarkers in population-based studies. Cancer Epidemiol Biomarkers Prev 2007; 16(11): 2464-70.
12. Poggi M, Engel D, Christ A, et al. CD40L deficiency ameliorates adipose tissue inflammation and metabolic manifestations of obesity in mice. Arterioscler Thromb Vasc Biol 2011; 31: 2251-60.
13. Eriksson JW. Metabolic stress in insulin's target cells leads to ROS accumulation - a hypothetical common pathway causing insulin resistance. FEBS Lett. 2007; 581:3734-42.
14. Hardie DG. Sensing of energy and nutrients by AMP-activated protein kinase. Am J Clin Nutr 2011; 93(4): 891S-6S.
15. Salminen A, Hyttinen JM, Kaarniranta K. AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan. J Mol Med (Berl) 2011; 89: 667-76.
16. Steinberg GR, Kemp BE. AMPK in Health and Disease. Physiol Rev 2009; 89:1025-78.
17. Sozio MS, Lu C, Zeng Y, Liangpunsakul S, Crabb DW. Activated AMPK inhibits PPAR-α and PPAR-γ transcriptional activity in hepatoma cells. Am J Physiol Gastrointest Liver Physiol 2011; 301: G739-47.
18. Varga T, Czimmerer Z, Nagy L. PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. Biochim Biophys Acta 2011; 1812: 1007-22.
19. Lee YH, Giraud J, Davis RJ, White MF. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem 2003; 278: 2896-902.
20. Kim JA, Wei Y, Sowers JR. Role of mitochondrial dysfunction in insulin resistance. Circ Res 2008; 102: 401-14.
21. Lang VY, Fatehi M, Light PE. Pharmacogenomic analysis of ATPsensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A. Pharmacogenet Genomics 2012; 22: 206-14.
22. Senger MR, Gomes Lda C, Ferreira SB, Kaiser CR, Ferreira VF, Silva FP Jr. Kinetics studies on the inhibition mechanism of pancreatic α-amylase by glycoconjugated 1H-1,2,3-triazoles: a new class of inhibitors with hypoglycemiant activity. Chembiochem 2012; 13: 1584-93.
23. Han, SS, Keum, Y-S, et al. Capsaicin suppresses phorbol esterinduced activation of NF-kappaB/Rel and AP-1 transcription factors in mouse epidermis. Cancer Lett 2001; 164: 119-26.
24. Park JY, Kawada T, Han IS, et al. Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism. FEBS Lett 2004; 572: 266-70.
25. Kang JH, Kim CS, Han IS, Kawada T, Yu R. Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages. FEBS Lett 2007; 581: 4389-96.
26. Kawabata F, Inoue N, Masamoto Y, et al. Non-pungent capsaicin analogs (capsinoids) increase metabolic rate and enhance thermogenesis via gastrointestinal TRPV1 in mice. Biosci Biotechnol Biochem 2009; 73: 2690-7.
27. Kang JH, Tsuyoshi G, Le Ngoc H, et al. Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice. J Med Food 2011; 14: 310-5.
28. Sharma AK, Bharti S, Goyal S, et al. Upregulation of PPARγ by Aegle marmelos ameliorates insulin resistance and β-cell dysfunction in high fat diet fed-streptozotocin induced type 2 diabetic rats. Phytother Res 2011; 25: 1457-65.
29. Sheryl A, Lazarus GE, Adamson JF. Hammerstone, and Harold H. Schmitz High-Performance Liquid Chromatography/Mass Spectrometry Analysis of Proanthocyanidins in Foods and Beverages. J. Agric. Food Chem 1999; 47: 3693-3701.
30. Zunino S. Type 2 diabetes and glycemic response to grapes or grape products. J Nutr 2009; 139: 1794S-800S.
31. Thielecke F, Boschmann M. The potential role of green tea catechins in the prevention of the metabolic syndrome - a review. Phytochemistry 2009; 70: 11-24.
32. Singh R, Akhtar N, Haqqi TM. Green tea polyphenol epigallocatechin- 3-gallate: inflammation and arthritis. Life Sci 2010; 86: 907-18.
33. Chen N, Bezzina R, Hinch E, et al. Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet. Nutr Res. 2009; 29: 784-93.
34. Roghani M, Baluchnejadmojarad T. Chronic epigallocatechingallate improves aortic reactivity of diabetic rats: underlying mechanisms. Vascul Pharmacol 2009; 51: 84-89.
35. Roghani M, Baluchnejadmojarad T. Hypoglycemic and hypolipidemic effect and antioxidant activity of chronic epigallocatechingallate in streptozotocindiabetic rats. Pathophysiology 2010: 17: 55-59.
36. Hollenberg NK, Fisher ND, McCullough ML. Flavanols, the Kuna, cocoa consumption, and nitric oxide. J Am Soc Hypertens. 2009; 3: 105-12.
37. Grove KA, Lambert JD. Laboratory, epidemiological, and human intervention studies show that tea (Camellia sinensis) may be useful in the prevention of obesity. J Nutr 2010; 140: 446-53.
38. Cheng HL, Kuo CY, Liao YW, Lin CC. EMCD, a hypoglycemic triterpene isolated from Momordica charantia wild variant, attenuates TNF--induced inflammation in FL83B cells in an AMPactivated protein kinase-independent manner. Eur J Pharmacol. 2012; 689(1-3):241-8.
39. Foltz-Gray D. Alternative treatments for arthritis. Atlanta: Arthritis Foundation 2005; p 231-33.
40. Belcaro G, Cesarone MR, Dugall M, et al. Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev 2010; 15: 337-44.
41. Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci 2008; 65: 1631-52.
42. Seo KI, Choi MS, Jung UJ, et al. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Mol Nutr Food Res 2008; 52: 995-1004.
43. Aggarwal BB. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr 2010; 30: 173-99.
44. Buhrmann C, Mobasheri A, Matis U, Shakibaei M. Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density coculture microenvironment. Arthritis Res Ther 2010; 12: R127.
45. Jain SK, Rains J, Croad J, Larson B, Jones K. Curcumin Supplementation Lowers TNF-α, IL-6, IL-8, and MCP-1 Secretion in High Glucose-Treated Cultured Monocytes and Blood Levels of TNF-a, IL-6, MCP-1, Glucose, and Glycosylated Hemoglobin in Diabetic Rats Antioxid Redox Signal 2009; 11: 241-249.
46. Fatehi-Hassanabad Z, Gholamnezhad Z, Jafazadeh M, Fatehi M. The anti-inflamatory effects of aqueous extract of ginger root in diabetic mice. DARU 2005; 13: 70-3.
47. Natural Standard Professional Monograph: Ginger (Zingiber officinale) (www.naturalstandard.com).
48. Li y, Tran VH, Duke CC, Roufogalis BD. Preventive and Protective Properties of Zingiber officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review. Evid Based Complement Alternat Med 2012; 2012: 516870.
49. Al-Amin ZM, Thomson M, Al-Qattan KK, Peltonen-Shalaby R, Ali M. Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. Br J Nutr 2006; 96: 660-666.
50. Ali BH, Blunden G, Tanira MO, Nemmar, A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food and Chemical Toxicology 2008; 46: 409-420.
51. Fischer-Posovszky P, Kukulus V, Tews D, et al. Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. Am J Clin Nutr 2010; 92: 5-15.
52. Timmers S, Auwerx J, Schrauwen P. The journey of resveratrol from yeast to human. Aging (Albany NY) 2012; 4: 146-158.
53. Zheng J, Chen LL, Zhang HH, Hu X, Kong W, Hu D. Resveratrol improves insulin resistance of catch-up growth by increasing mitochondrial complexes and antioxidant function in skeletal muscle. Metabolism 2012; 61: 954-65.
54. Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006; 127: 1109-22.
55. Timmers S, Konings E, Bilet L, et al. Calorie restrictionlike effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 2011; 14: 612622.
56. Jeong SM, Kang MJ, Choi HN, Kim JH, Kim JI. Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice. Nutr Res Pract 2012; 6: 201-7.
57. Alade GO, Adebajo AC, Omobuwajo OR, Proksch P, Verspohl EJ. Quercetin, a minor constituent of the antihyperglycaemic fraction of Bauhinia monandra leaf. J Diabetes 2012; 4: 439-41.
58. Rivera L, Moron R, Sanchez M, Zarzuelo A, Galisteo M. Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity (Silver Spring) 2008; 16: 2081-2087.
59. Babu PV, Si H, Liu D. Epigallocatechin gallate reduces vascular inflammation in db/db mice possibly through an NF-κB-mediated mechanism. Mol Nutr Food Res 2012; 56: 1424-32.
60. Jurikova T, Rop O, Mlcek J, et al. Phenolic profile of edible honeysuckle berries (genus lonicera) and their biological effects. Molecules. 201; 17: 61-79.
61. Shimada T, Tokuhara D, Tsubata M, et al. Flavangenol (pine bark extract) and its major component procyanidin B1 enhance fatty acid oxidation in fat-loaded models. Eur J Pharmacol. 2012; 677: 147-53.
62. Willcox DC, Willcox BJ, Todoriki H, Suzuki M. The Okinawan diet: health implications of a low-calorie, nutrient-dense, antioxidant-rich dietary pattern low in glycemic load. J Am Coll Nutr 2009; 28 Suppl: 500S-516S.
63. Mozaffarian D, Appel LJ, Van Horn L. Components of a cardioprotective diet: new insights. Circulation 2011; 123: 2870-91.
64. Ludvik B, Waldhäusl W, Prager R, Kautzky-Willer A, Pacini G. Mode of action of ipomoea batatas (Caiapo) in type 2 diabetic patients. Metabolism 2003; 52: 875-80.
65. Akhtar MS, Khan QM, Khaliq T. Effects of Euphorbia prostrata and Fumaria parviflora in normoglycaemic and alloxan-treated hyperglycaemic rabbits. Planta Med 1984; 50: 138-42.
66. Murase T, Misawa K, Haramizu S, Hase T. Catechin-induced activation of the LKB1/AMP-activated protein kinase pathway. Biochem Pharmacol 2009; 78: 78-84.
67. Smirin P, Taler D, Abitbol G, et al. Sarcopoterium spinosum extract as an antidiabetic agent: in vitro and in vivo study. J Ethnopharmacol 2010; 129: 10-7.
68. Yan J, Zhao Y, Suo S, Liu Y, Zhao B. Green tea catechins ameliorate adipose insulin resistance by improving oxidative stress. Free Radic Biol Med 2012; 52: 1648-57.
69. Taub PR, Ramirez-Sanchez I, Ciaraldi TP, et al. Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa. Clin Transl Sci 2012; 5: 43-7.
70. Sun C, McIntyre K, Saleem A, Haddad PS, Arnason JT. The relationship between antiglycation activity and procyanidin and phenolic content in commercial grape seed products. Can J Physiol Pharmacol 2012; 90: 167-74.
71. Kang C, Kim E. Synergistic effect of curcumin and insulin on muscle cell glucose metabolism. Food Chem Toxicol 2010; 48: 2366-73.
72. Tang Y, Chen A. Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter- 4 and increasing glucokinase. Br J Pharmacol 2010; 161: 1137-49.
73. Sahebkar A. Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome? Biofactors 2012; doi: 10.1002/biof.1062.
74. Chen D, Pamu S, Cui Q, Chan TH, Dou QP. Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells. Bioorg Med Chem 2012; 20: 3031-7.
75. Mueller NT, Odegaard AO, Gross MD, et al. Soy intake and risk of type 2 diabetes mellitus in Chinese Singaporeans: Soy intake and risk of type 2 diabetes. Eur J Nutr 2012; 51: 1033-40.
76. Arunkumar E, Anuradha CV. Genistein promotes insulin action through adenosine monophosphate-activated protein kinase activation and p70 ribosomal protein S6 kinase 1 inhibition in the skeletal muscle of mice fed a high energy diet. Nutr Res 2012; 32: 617-25.
77. Crisafulli A, Altavilla D, Marini H, et al. Effects of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women. Menopause 2005; 12: 186-92.
78. Liu ZM, Chen YM, Ho SC, Ho YP, Woo J. Effects of soy protein and isoflavones on glycemic control and insulin sensitivity: a 6-mo double-blind, randomized, placebo-controlled trial in postmenopausal Chinese women with prediabetes or untreated early diabetes. Am J Clin Nutr 2010; 91:1394-401.
79. Quan HY, Yuan HD, Jung MS, Ko SK, Park YG, Chung SH. Ginsenoside Re lowers blood glucose and lipid levels via activation of AMP-activated protein kinase in HepG2 cells and high-fat diet fed mice. Int J Mol Med 2012; 29: 73-80.
80. Singh J, Cumming E, Manoharan G, Kalasz H, Adeghate E. Medicinal chemistry of the anti-diabetic effects of momordica charantia: active constituents and modes of actions. Open Med Chem J 2011; 5(Suppl 2): 70-7.
81. Ahn J, Lee H, Kim S, Park J, Ha T. The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochem Biophys Res Commun 2008; 373: 545-549.
82. Nkobole N, Houghton PJ, Hussein A, Lall N. Antidiabetic activity of Terminalia sericea constituents. Nat Prod Commun. 2011; 6(11): 1585-8.
83. Vingtdeux V, Giliberto L, Zhao H, et al. AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem 2010; 285: 9100-13.
84. Bhat M, Zinjarde SS, Bhargava SY, Kumar AR, Joshi BN. Antidiabetic Indian plants: a good source of potent amylase inhibitors. Evid Based Complement Alternat Med 2011; 2011: 810207.
85. Jain RC, Vyas CR, Mahatma OP. Hypoglycaemic action of onion and garlic. Lancet 1973; ii: 1491.
86. Grover JK, Yadav S, Vats V. Medicinal plants of India with antidiabetic potential. J Ethnopharmacol 2002; 81: 81-100.
87. Kim SH, Jo SH, Kwon YI, Hwang JK. Effects of Onion (Allium cepa L.) Extract Administration on Intestinal α-Glucosidases Activities and Spikes in Postprandial Blood Glucose Levels in SD Rats Model. Int J Mol Sci 2011; 12: 3757-69.
88. Padiya R, Banerjee SK. Garlic as an Anti-diabetic agent: Recent Progress and Patent Reviews. Recent Pat Food Nutr Agric. 2012; PMID: 23270395
89. Cazzola R, Camerotto C, Cestaro B. Anti-oxidant, anti-glycant, and inhibitory activity against α-amylase and α -glucosidase of selected spices and culinary herbs. Int J Food Sci Nutr 2011; 62: 175-84.
90. Lawson LD. Garlic: a review of its medicinal effects and indicated active compounds. In Lawson LD, Bauer R (eds): "Phytomedicines of Europe: Chemistry and Biological Activity." Washington DC, ACS Symposium Series 91, American Chemical Society 1998; pp 176-209.
91. Jain AK, Vargas R, Gotzkowsky S, McMahon FG. Can garlic reduce levels of serum lipids? A controlled clinical study. Am J Med 1993; 94: 632-5.
92. Dwivedi S, Aggarwal A. Indigenous drugs in ischemic heart disease in patients with diabetes. J Altern Complement Med 2009; 15:1215-21.
93. Kiesewetter H, Jung F, Pindur G, Jung EM, Mrowietz C, Wenzel E. Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors. Int J Clin Pharmacol Ther Toxicol 1991; 29: 151-5.
94. Moorthy R, Prabhu KM, Murthy PS. Anti-hyperglycemic compound (GII) from fenugreek (Trigonella foenum-graecum Linn.) seeds, its purification and effect in diabetes mellitus. Indian J Exp Biol 2010; 48: 1111-8.
95. Dey L, Attele AS, Yuan CS. Alternative therapies for type 2 diabetes. Altern Med Rev 2002; 7: 45-58.
96. Xue WL, Li XS, Zhang J, Liu YH, Wang ZL, Zhang RJ. Effect of Trigonella foenum-graecum (fenugreek) extract on blood glucose, blood lipid and hemorheological properties in streptozotocininduced diabetic rats. Asia Pac J Clin Nutr 2007; 16 Suppl 1: 422-6.
97. Srinivasan K. Fenugreek (trigonella foenum-graecum): A review of health beneficial physiological effects. Food Rev Internat 2006; 22: 203-24.
98. Hannan JM, Ali L, Rokeya B, et al. Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action. Br J Nutr. 2007 Mar;97(3):514-21.
99. Bobek P, Chorváthová V. Effect of pectin on cholesterol distribution in the lipoproteins of streptozotocin-diabetic rats fed cholesterol diet. Physiol Bohemoslov 1984; 33(3): 230-6.
100. Al-Shamaony L, Al-Khazraji SM, Twaij HA. Hypoglycaemic effect of Artemisia herba alba. II. Effect of a valuable extract on some blood parameters in diabetic animals. J Ethnopharmacol 1994; 43: 167-71.
101. Savage DB, Petersen KF, Shulman GI. Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev 2007; 87: 507-20.
102. Solinas G, Karin M. JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. FASEB J 2010; 24: 2596-611.
103. Meydani M, Das S, Band M, Epstein S, Roberts S. The effect of caloric restriction and glycemic load on measures of oxidative stress and antioxidants in humans: Results from the calerie trial of human caloric restriction. J Nutr Health Aging 2011; 15: 456-460.
104. Qatanani M, Lazar MA. Mechanisms of obesity-associated insulin resistance: many choices on the menu. Genes Dev 2007; 21: 1443-55.
105. Jacob A, Wu R, Zhou M, Wang P. Mechanism of the Antiinflammatory Effect of Curcumin: PPAR-gamma Activation. PPAR Res 2007; 89369.