Effects of soy protein and isoflavones on glycemic control and insulin sensitivity: A 6-mo double-blind, randomized, placebo-controlled trial in postmenopausal Chinese women with prediabetes or untreated early diabetes

American Journal of Clinical Nutrition

Volumn 91, Issue 5, 2010, Pages 1394-1401

  Liu, Zhao Min ^a,b   Chen, Yu Ming ^a,b   Ho, Suzanne C ^a   Ho, Yee Ping ^a   Woo, Jean ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOSYLATED PROTEIN; ISOFLAVONE; MILK PROTEIN; PHYTOESTROGEN; SOYBEAN PROTEIN;

ADULT; AGED; ANTHROPOMETRY; ARTICLE; CLINICAL ASSESSMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FEMALE; GASTROINTESTINAL SYMPTOM; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HONG KONG; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN SENSITIVITY; MASTALGIA; NUTRITIONAL ASSESSMENT; OUTCOME ASSESSMENT; PHYSICAL ACTIVITY; POSTMENOPAUSE; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SAMPLE SIZE; TREATMENT DURATION; VAGINA BLEEDING;

AGED; BLOOD GLUCOSE; CHINA; DIABETES MELLITUS; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; GLUCOSE INTOLERANCE; HUMANS; HYPERGLYCEMIA; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; ISOFLAVONES; MIDDLE AGED; PLACEBOS; POSTMENOPAUSE; PREDIABETIC STATE; SOYBEAN PROTEINS;

ANIMALIA;

EID: 77951954720     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.3945/ajcn.2009.28813     Document Type: Article

References (33)

1. Alberti KG, Zimmet P, Shaw J. International Diabetes Federation: a consensus on type 2 diabetes prevention. Diabet Med 2007;24:451-463
2. Akiyama T, Ishida J, Nakagawa S, et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. 1987;262:5592-5595
3. Vedavanam K, Srijayanta S, O'Reilly J, Raman A,Wiseman H. Antioxidant action and potential antidiabetic properties of an isoflavonoid-containing soyabean phytochemical extract (SPE). Phytother Res 1999;13:601-608 (Pubitemid 29520939)
4. Sanchez A, Hubbard RW. Plasma amino acids and the insulin/glucagon ratio as an explanation for the dietary protein modulation of atherosclerosis. Med Hypotheses 1991;35:324-329
5. Ascencio C, Torres N, Isoard-Acosta F, Gomez-Perez FJ, Hernandez-Pando R, Tovar AR. Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats. J Nutr 2004;134:522-529 (Pubitemid 38298490)
6. Lavigne C, Marette A, Jacques H. Cod and soy proteins compared with casein improve glucose tolerance and insulin sensitivity in rats. Am J Physiol Endocrinol Metab 2000;278:E491-500. (Pubitemid 30149394)
7. Goodman-Gruen D, Kritz-Silverstein D. Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women. J Nutr 2001;131:1202-1206 (Pubitemid 32275100)
8. Yang G, Shu XO, Jin F, et al. Soyfood consumption and risk of glycosuria: a cross-sectional study within the Shanghai Women's Health Study. Eur J Clin Nutr 2004;58:615-620 (Pubitemid 38500131)
9. Villegas R, Gao YT, Yang G, et al. Legume and soy food intake and the incidence of type 2 diabetes in the Shanghai Women's Health Study. Am J Clin Nutr 2008;87:162-167
10. Jayagopal V, Albertazzi P, Kilpatrick ES, et al. Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care 2002;25:1709-1714 (Pubitemid 41071075)
11. Azadbakht L, Shakerhosseini R, Atabak S, Jamshidian M, Mehrabi Y, Esmaill-Zadeh A. Beneficiary effect of dietary soy protein on lowering plasma levels of lipid and improving kidney function in type II diabetes with nephropathy. Eur J Clin Nutr 2003;57:1292-1294 (Pubitemid 37259396)
12. Li Z, Hong K, Saltsman P, et al. Long-term efficacy of soy-based meal replacements vs an individualized diet plan in obese type II DM patients: relative effects on weight loss, metabolic parameters, and C-reactive protein. Eur J Clin Nutr 2005;59:411-418 (Pubitemid 40403296)
13. Hermansen K, Hansen B, Jacobsen R, et al. Effects of soy supplementation on blood lipids and arterial function in hypercholesterolaemic subjects. Eur J Clin Nutr 2005;59:843-850 (Pubitemid 41025262)
14. Sites CK, Cooper BC, Toth MJ, Gastaldelli A, Arabshahi A, Barnes S. Effect of a daily supplement of soy protein on body composition and insulin secretion in postmenopausal women. Fertil Steril 2007;88: 1609-1617 (Pubitemid 350216852)
15. Azadbakht L, Atabak S, Esmaillzadeh A. Soy protein intake, cardiorenal indices, and C-reactive protein in type 2 diabetes with nephropathy: a longitudinal randomized clinical trial. Diabetes Care 2008;31:648-654
16. Azadbakht L, Kimiagar M, Mehrabi Y, et al. Soy inclusion in the diet improves features of the metabolic syndrome: a randomized crossover study in postmenopausal women. Am J Clin Nutr 2007;85:735-741 (Pubitemid 46393504)
17. Hall WL, Vafeiadou K, Hallund J, et al. Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: interactions with genotype and equol production. Am J Clin Nutr 2006;83:592-600. (Pubitemid 44699204)
18. Hermansen K, Sondergaard M, Hoie L, Carstensen M, Brock B. Beneficial effects of a soy-based dietary supplement on lipid levels and cardiovascular risk markers in type 2 diabetic subjects. Diabetes Care 2001;24:228-233 (Pubitemid 32119116)
19. Gallagher JC, Satpathy R, Rafferty K, Haynatzka V. The effect of soy protein isolate on bone metabolism: menopause. 2004;11:290-298
20. Gardner CD, Newell KA, Cherin R, Haskell WL. The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. Am J Clin Nutr 2001;73:728-735 (Pubitemid 32239227)
21. Ho SC, Chen YM, Ho SS, Woo JL. Soy isoflavone supplementation and fasting serum glucose and lipid profile among postmenopausal Chinese women: a double-blind, randomized, placebo-controlled trial. Menopause 2007;14:905-912
22. Yang Y, ed. China food composition 2004. Beijing, China: Peking University Medical Press, 2004.
23. Ma J, Liu Z, Ling W. Physical activity, diet and cardiovascular disease risks in Chinese women. Public Health Nutr 2003;6:139-146 (Pubitemid 36542430)
24. Chinese Nutrition Society (CNS). Dietary Guidelines For Chinese Residents 2007. Available from: http://www.cnsoc.org/asp-bin/EN/?page=8&class= 42&id=131 (cited 31 January 2008).
25. Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med 1995;333: 276-282
26. Zhang X, Shu XO, Gao YT, et al. Soy food consumption is associated with lower risk of coronary heart disease in Chinese women. J Nutr 2003;133:2874-2878 (Pubitemid 37099774)
27. Nikander E, Tiitinen A, Laitinen K, Tikkanen M, Ylikorkala O. Effects of isolated isoflavonoids on lipids, lipoproteins, insulin sensitivity, and ghrelin in postmenopausal women. J Clin Endocrinol Metab 2004;89: 3567-3572 (Pubitemid 38960693)
28. Atteritano M, Marini H, Minutoli L, et al. Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 2007;92:3068-3075
29. Bartke A, Peluso MR, Moretz N, et al. Effects of soy-derived diets on plasma and liver lipids, glucose tolerance, and longevity in normal, long-lived and short-lived mice. Horm Metab Res 2004;36: 550-558
30. Li Z, Hong K, Saltsman P, et al. Long-term efficacy of soy-based meal replacements vs an individualized diet plan in obese type II DM patients: relative effects on weight loss, metabolic parameters, and C-reactive protein. Eur J Clin Nutr 2005;59:411-418
31. Muthyala RS, Ju YH, Sheng S, et al. Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg Med Chem 2004;12: 1559-1567
32. Pereira MA, Jacobs DR Jr, Van Horn L, Slattery ML, Kartashov AI, Ludwig DS. Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study. JAMA 2002;287:2081-2089
33. Liu S, Choi HK, Ford E, et al. A prospective study of dairy intake and the risk of type 2 diabetes in women. Diabetes Care 2006;29: 1579-1584 (Pubitemid 44127584)