Ginsenoside Re lowers blood glucose and lipid levels via activation of AMP-activated protein kinase in HepG2 cells and high-fat diet fed mice

International Journal of Molecular Medicine

Volumn 29, Issue 1, 2012, Pages 73-80

  Quan, Hai Yan ^a   Yuan, Hai Dan ^a   Jung, M I Song ^a   Ko, Sung Kwon ^b   Park, Young Guk ^a   Chung, Sung Hyun ^a  

^a Kyung Hee University   (South Korea)

^b Semyung University   (South Korea)

Author keywords

AMP activated protein kinase; C57BL 6J; Diabetes; Ginsenoside Re; HepG2 cells; Hyperlipidemia

Indexed keywords

ACYL COENZYME A DESATURASE 1; FATTY ACID SYNTHASE; GINSENOSIDE RE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; ORPHAN NUCLEAR RECEPTOR; SHP PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG MECHANISM; FATTY LIVER; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPERLIPIDEMIA; IN VIVO STUDY; INSULIN RESISTANCE; LIPID BLOOD LEVEL; LIPID DIET; LIPOGENESIS; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING;

AMP-ACTIVATED PROTEIN KINASES; ANALYSIS OF VARIANCE; ANIMALS; BLOOD GLUCOSE; DIET, HIGH-FAT; DRUGS, CHINESE HERBAL; FATTY LIVER; GENE EXPRESSION REGULATION; GINSENOSIDES; GLUCONEOGENESIS; HEP G2 CELLS; HUMANS; LIPIDS; LIPOGENESIS; LIVER; MICE; MICE, INBRED C57BL; PROTEIN-SERINE-THREONINE KINASES; RANDOM ALLOCATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRIGLYCERIDES;

EID: 84355167381     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.805     Document Type: Article

References (27)

1. Semenkovich CF: Insulin resistance and atherosclerosis. J Clin Invest 116: 1813-1822, 2006.
2. Kahn BB, Alquier T, Carling D and Hardie DG: AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1: 15-25, 2005. (Pubitemid 43960587)
3. Horton JD, Goldstain JL and Brown MS: SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109: 1125-1131, 2002. (Pubitemid 34496588)
4. Goldstain JL and Brown MS: From fatty streak to fatty liver: 33 years of joint publications in the JCI. J Clin Invest 118: 214-226, 2008.
5. Yang J, Craddock L, Hong S and Liu ZM: AMP-activated protein kinase suppresses LXR-dependent sterol regulatory element-binding protein-1c transcription in rat hepatoma McA-RH7777 cells. J Cell Biochem 106: 414-426, 2009.
6. Zang M, Xu S, Maitland-Toolan K, Zuccolio A, Hou X, Jiang B, Wierzbicki M, Verbeuren TJ and Cohen RA: Polyphenols stimulates AMP-activated protein kinase, lower lipids, and inhibits accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes 55: 2180-2191, 2006. (Pubitemid 44743614)
7. Yang CY, Wang J, Zhao Y, Shen L, Jiang X, Xie ZG, Liang N, Zhang L and Chen ZH: Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic components. J Ethnopharmacol 130: 231-236, 2010.
8. Yuan HD, Kim SJ and Chung SH: Beneficial effects of IH-901 on glucose and lipid metabolisms via activating adenosine monophosphate-activated protein kinase and phosphatidylinositol-3 kinase pathways. Metabolism 60: 43-51, 2011.
9. Lee HJ, Lee Y H, Park SK, Kang ES, Kim HJ, Lee YC, Choi CS, Park SE, Ahn CW, Cha BS, Lee KW, Kim KS, Lim SK and Lee HC: Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats. Metabolism 58: 1170-1177, 2009.
10. Luo JZ and Luo L: Ginseng on hyperglycemia: effects and mechanisms. Evid Based Complement Alternat Med 6: 423-427, 2008.
11. Vuksan V, Sung MK, Sievenpiper JL, Stavro PM, Jenkins AL, Di Buono M, Lee KS, Leiter LA, Nam KY, Arnason JT, Choi M and Naeem A: Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety. Nutr Metab Cardiovasc Dis 18: 46-56, 2008. (Pubitemid 350297892)
12. Xiong Y, Shen L, Liu KJ, Tso P, Xiong Y, Wang G, Woods SC and Liu M: Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats. Diabetes 59: 2505-2512, 2010.
13. Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L, Pugh W, Rue PA, Polonsky KS, and Yuan CS: Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 51: 1851-1858, 2002. (Pubitemid 34564298)
14. Kim SJ, Yuan HD and Chung SH: Ginsenoside Rg1 suppresses hepatic glucose production via AMP-activated protein kinase in HepG2 cells. Biol Pharm Bull 33: 325-328, 2010.
15. Hardie DG: The AMP-activated protein kinase pathway - new players upstream and downstream. J Cell Sci 117: 5479-5487, 2004.
16. Birnbaum MJ: Activating AMP-activated protein kinase without AMP. Mol Cell 19: 289-290, 2005.
17. Kim YD, Park KG, Lee YS, Park YY, Kim DK, Nedumaran B, Jang WG, Cho WJ, Ha J, Lee IK, Lee CH and Choi HS: Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP. Diabetes 57: 306-314, 2008.
18. Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA and Zang M: AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 13: 376-388, 2011.
19. + T cells through regulation of autophagy. Int Immunopharmacol 10: 626-631, 2010.
20. Song X, Chen J, Sakwiwatkul K, Li R and Hu S: Enhancement of immune responses to influenza vaccine (H3N2) by ginsenoside Re. Int immunopharmacol 10: 351-356, 2010.
21. Wang YG, Zima AV, Ji X, Pabbidi R, Blatter LA and Lipsius SL: Ginsenoside Re suppresses electromechanical alternans in cat and human cardiomyocytes. Am J Physiol Heart Circ Physiol 295: 851-859, 2008.
22. 2-terminal kinase and nuclear factor-κB. Mol Endocrinol 22: 186-195, 2007.
23. Cho WC, Chung WS, Lee SK, Leung AW, Cheng CH and Yue KK: Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats. Eur J Pharmacol 550: 173-179, 2006. (Pubitemid 44572271)
24. Xie JT, Mehendale SR, Li X, Quigg R, Wang X, Wang CZ, Wu JA, Aung HH, A Rue P, Bell GI and Yuan CS: Anti-diabetic effect of ginsenoside Re in ob/ob mice. Biochim Biophys Acta 1740: 319-325, 2005. (Pubitemid 40804743)
25. Viollet B, Guigas B, Leclerc J, Herbrard S, Lantier L, Mounier R, Andreelli F and Foretz M: AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. Acta Physiol 196: 81-98, 2009.
26. Lee JM, Seo WY, Song KH, Chanda D, Kim YD, Kim DK, Lee MW, Ryu D, Kim YH, Noh JR, Lee CH, Chiang JY, Koo SH and Choi HS: AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner. J Biol Chem 285: 32182-32191, 2010.
27. Shaw RJ, Lamia KA, Vasquez D, et al.: The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310: 1642-1646, 2005. (Pubitemid 41780780)