The relationship between antiglycation activity and procyanidin and phenolic content in commercial grape seed products

Canadian Journal of Physiology and Pharmacology

Volumn 90, Issue 2, 2012, Pages 167-174

  Sun, Cathy ^a   McIntyre, Kristina ^a   Saleem, Ammar ^a   Haddad, Pierre Selim ^b,c   Arnason, John Thor ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c LAVAL UNIVERSITY   (Canada)

Author keywords

Advanced glycation end products; Antiglycation; Grape seed extract; HPLC DAD ELSD; Procyanidins; Vitis vinifera

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CATECHIN; EPICATECHIN; GALLIC ACID; GRAPE SEED EXTRACT; PHENOL; PROCYANIDIN; PROCYANIDIN B1; PROCYANIDIN B2; PROCYANIDIN B4; UNCLASSIFIED DRUG;

ARTICLE; DIABETES MELLITUS; GLYCATION; GRAPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; NONHUMAN; PRIORITY JOURNAL;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOSYLATION; GLYCOSYLATION END PRODUCTS, ADVANCED; GRAPE SEED EXTRACT; HYPOGLYCEMIC AGENTS; LINEAR MODELS; PHENOLS; PROANTHOCYANIDINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SEEDS; SPECTROPHOTOMETRY, ULTRAVIOLET; VITIS;

EID: 84856822903     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/Y11-121     Document Type: Article

References (25)

1. Ahmed, N. 2005. Advanced glycation endproducts-role in pathology of diabetic complications. Diabetes Res. Clin. Pract. 67(1): 3-21. doi:10.1016/j.diabres.2004.09.004. PMID:15620429.
2. Babu, P.V.A., Sabitha, K.E., and Shyamaladevi, C.S. 2006. Therapeutic effect of green tea extract on advanced glycation and crosslinking of collagen in the Aorta of STZ diabetic rats. Clin. Exp. Pharmacol. Physiol. 33(4): 351-357.doi:10.1111/j.1440-1681.2006.04374.x. PMID:16620300.
3. Farrar, J.L., Hartle, D.K., Hargrove, J.L., and Greenspan, P. 2008. A novel nutraceutical property of select sorghum (Sorghum bicolor) brans: inhibition of protein glycation. Phytother. Res. 22(8): 1052-1056. doi:10.1002/ptr.2431. PMID:18570276.
4. Farsi, D.A., Harris, C.S., Reid, L., Bennett, S.A.L., Haddad, P.S., Martineau, L.C., and Arnason, J.T. 2008. Inhibition of nonenzymatic glycation by silk extracts from a Mexican land race and modern inbred lines of maize (Zea mays). Phytother. Res. 22(1): 108-112. doi:10.1002/ptr.2275. PMID:17724765.
5. Fuleki, T., and Ricardo-da-Silva, J.M. 1997. Catechin and procyanidin composition of seeds from grape cultivars grown in Ontario. J. Agric. Food Chem. 45(4): 1156-1160. doi:10.1021/jf960493k.
6. Fuleki, T., and Ricardo-da-Silva, J.M. 2003. Effects of cultivar and processing method on the contents of catechins and procyanidins in grape juice. J. Agric. Food Chem. 51(3): 640-646. doi:10.1021/jf020689m. PMID:12537435.
7. Harris, C.S., Burt, A.J., Saleem, A., Le, P.M., Martineau, L.C., Haddad, P.S., et al. 2007. A single HPLC-PAD-APCI/MS method for the quantitative comparison of phenolic compounds found in leaf, stem, root and fruit extracts of Vaccinium angustifolium. Phytochem. Anal. 18(2): 161-169. doi:10.1002/pca.970. PMID:17439018.
8. Harris, C.S., Beaulieu, L.-P., Fraser, M.-H., McIntyre, K.L., Owen, P.L., Martineau, L.C., et al. 2011. Inhibition of advanced glycation end product formation by medicinal plant extracts correlates with phenolic metabolites and antioxidant activity. Planta Med. 77(2): 196-204. doi:10.1055/s-0030-1250161. PMID:20717877.
9. Hwang, I.K., Kim, D.W., Park, J.H., Lim, S.S., Yoo, K.Y., Kwon, D.Y., et al. 2009. Effects of grape seed extract and its ethylacetate/ ethanol fraction on blood glucose levels in a model of type 2 diabetes. Phytother. Res. 23(8): 1182-1185. doi:10.1002/ptr.2779. PMID:19172663.
10. International Diabetes Federation. 2007. Diabetes prevalence. Available from www.idf.org/diabetes-prevalence [Accessed 25 August 2009].
11. Jain, S.K., Rains, J., and Jones, K. 2006. Effect of cucurmin on protein glycosylation, lipid peroxidation, and oxygen radical generation in human red blood cells exposed to high glucose levels. Free Radic. Biol. Med. 41(1): 92-96. doi:10.1016/j.freeradbiomed.2006.03.008. PMID:16781457.
12. Jang, D.S., Lee, G.Y., Lee, Y.M., Kim, Y.S., Sun, H., Kim, D.H., and Kim, J.S. 2009. Flavan-3-ols having a g-lactam from the roots of Actinidia arguta inhibit the formation of advanced glycation end products in vitro. Chem. Pharm. Bull. (Tokyo), 57(4): 397-400.doi:10.1248/cpb.57.397. PMID:19336935.
13. Kar, P., Laight, D., Shaw, K.M., and Cummings, M.H. 2006. Flavonoid-rich grapeseed extracts: a new approach in high cardiovascular risk patients? Int. J. Clin. Pract. 60(11): 1484-1492. doi:10.1111/j.1742-1241.2006.01038.x. PMID:17073843.
14. Leifert, W.R., and Abeywardena, M.Y. 2008a. Cardioprotective actions of grape polyphenols. Nutr. Res. 28(11): 729-737. doi:10.1016/j.nutres.2008.08.007. PMID:19083481.
15. Leifert, W.R., and Abeywardena, M.Y. 2008b. Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity. Nutr. Res. 28(12): 842-850. doi:10.1016/j.nutres.2008.09.001. PMID:19083497.
16. McIntyre, K.L., Harris, C.S., Saleem, A., Beaulieu, L.P., Ta, C.A., Haddad, P.S., and Arnason, J.T. 2009. Seasonal phytochemical variation of anti-glycation principles in lowbush blueberry (Vaccinium angustifolium). Planta Med. 75(3): 286-292. doi:10.1055/s-0028-1088394. PMID:19085814.
17. Peyroux, J., and Sternberg, M. 2006. Advanced glycation endproducts (AGEs): pharmacological inhibition in diabetes. Pathol. Biol. (Paris), 54(7): 405-419. doi:10.1016/j.patbio.2006.07.006.PMID:16978799.
18. Pietta, P.-G. 2000. Flavonoids as antioxidants. J. Nat. Prod. 63(7): 1035-1042. doi:10.1021/np9904509. PMID:10924197.
19. Renaud, S., and De Lorgeril, M. 1992. Wine, alcohol, platelets, and the French Paradox for coronary heart disease. Lancet, 339(8808): 1523-1526. doi:10.1016/0140-6736(92)91277-F. PMID:1351198.
20. Singleton, V.L., and Rossi, J.A., Jr. 1965. Colorimetry of total phenolics with phosphomolybdic-phosphotungistic acid reagents. Am. J. Enol. Vitic. 16(3): 144-158.
21. Smit, A.J., and Lutgers, H.L. 2004. The clinical relevance of advanced glycation endproducts (AGE) and recent developments in pharmaceutics to reduce AGE accumulation. Curr. Med. Chem. 11(20): 2767-2784. PMID:15544475.
22. Ulrich, P., and Cerami, A. 2001. Protein glycation, diabetes, and aging. Recent Prog. Horm. Res. 56(1): 1-22. doi:10.1210/rp.56.1.PMID:11237208.
23. Wu, J.W., Hsieh, C.L., Wang, H.Y., and Chen, H.Y. 2009. Inhibitory effects of guava (Psidium guajava L.) leaf extracts and its active compounds on the glycation process of protein. Food Chem. 113 (1): 78-84. doi:10.1016/j.foodchem.2008.07.025.
24. Yilmaz, Y., and Toledo, R.T. 2004. Major flavonoids in grape seeds and skins: antioxidant capacity of catechin, epicatechin, and gallic acid. J. Agric. Food Chem. 52(2): 255-260. doi:10.1021/jf030117h. PMID:14733505.
25. Zhang, F.L., Gao, H.Q., Wu, J.M., Ma, Y.B., You, B.A., Li, B.Y., and Xuan, J.H. 2006. Selective inhibition by grape seed proanthocyanidin extracts of cell adhesion molecule expression induced by advanced glycation end products in endothelial cells. J. Cardiovasc. Pharmacol. 48(2): 47-53. doi:10.1097/01.fjc.0000242058.72471.0c. PMID:16954821