Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2

Current Alzheimer Research

Volumn 10, Issue 1, 2013, Pages 4-10

  Pintchovski, Sean A ^a   Schenk, Dale B ^a   Basi, Guriqbal S ^a  

^a ELAN PHARMACEUTICALS   (United States)

Author keywords

AICD; A ; NICD; Processivity; PS1; PS2; secretase

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; NOTCH RECEPTOR; PRESENILIN 1; PRESENILIN 2; APP PROTEIN, HUMAN; ENZYME INHIBITOR; PEPTIDE FRAGMENT; PROTEASOME; SECRETASE; VIRUS FUSION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NOTCH INTRACELLULAR DOMAIN; PHASE 1 CLINICAL TRIAL; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; ANIMAL; ANIMAL EMBRYO; BINDING SITE; CELL CULTURE; DRUG EFFECT; FIBROBLAST; GENETIC TRANSFECTION; GENETICS; METABOLISM; MUTATION; TRANSGENIC MOUSE;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BINDING SITES; CELLS, CULTURED; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; FIBROBLASTS; HUMANS; MICE; MICE, TRANSGENIC; MUTATION; PEPTIDE FRAGMENTS; PRESENILIN-1; PRESENILIN-2; PROTEASOME ENDOPEPTIDASE COMPLEX; RECEPTORS, NOTCH; TRANSFECTION; VIRAL FUSION PROTEINS;

EID: 84882323303     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/156720513804871480     Document Type: Article

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