Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

Nature Medicine

Volumn 19, Issue 8, 2013, Pages 1054-1060

  Pajvani, Utpal B ^a   Qiang, Li ^a   Kangsamaksin, Thaned ^a,b   Kitajewski, Jan ^a   Ginsberg, Henry N ^a   Accili, Domenico ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; NOTCH1 RECEPTOR; PROTEIN KINASE B; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FATTY LIVER; LIPID LIVER LEVEL; LIPID STORAGE; LIPOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; CELL LINE, TUMOR; DIET, HIGH-FAT; ENZYME ACTIVATION; FATTY LIVER; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; INSULIN; INSULIN RESISTANCE; LIPID METABOLISM; LIPOGENESIS; LIVER; MALE; MICE; MICE, INBRED C57BL; MULTIPROTEIN COMPLEXES; PROTEIN STABILITY; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRIGLYCERIDES;

MAMMALIA;

EID: 84882245596     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3259     Document Type: Article

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