Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region

Journal of Molecular Biology

Volumn 425, Issue 17, 2013, Pages 3192-3204

  Tiyanont, Kittichoat ^a,b   Wales, Thomas E ^c   Siebel, Christian W ^d   Engen, John R ^c   Blacklow, Stephen C ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c NORTHEASTERN UNIVERSITY   (United States)

^d GENENTECH INC   (United States)

Author keywords

autoinhibition; hydrogen exchange mass spectrometry; Notch signaling; regulated intramembrane proteolysis; signal transduction

Indexed keywords

ANTIBODY; EDETIC ACID; EPITOPE; HYDROGEN; MONOCLONAL ANTIBODY; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR;

ARTICLE; CONTROLLED STUDY; DYNAMICS; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

METAZOA;

EID: 84881660609     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.05.025     Document Type: Article

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