Metformin Protects Rat Hepatocytes against Bile Acid-Induced Apoptosis

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Woudenberg Vrenken, Titia E ^a   Conde de la Rosa, Laura ^a,b   Buist Homan, Manon ^a   Faber, Klaas Nico ^a   Moshage, Han ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b CSIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; DACTINOMYCIN; GLYCOCHENODEOXYCHOLIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; LIVER CELL; LIVER PROTECTION; MALE; NONHUMAN; RAT;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; BILE ACIDS AND SALTS; CASPASE 3; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOCHENODEOXYCHOLIC ACID; HEPATOCYTES; HYPOGLYCEMIC AGENTS; MALE; METFORMIN; NECROSIS; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84881536255     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071773     Document Type: Article

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