Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice

Laboratory Investigation

Volumn 92, Issue 5, 2012, Pages 769-782

  Matsumoto, Kenjiro ^a   Lo, Mee Wah ^a,b   Hosoya, Takuji ^a,b   Tashima, Kimihito ^a   Takayama, Hiromitsu ^b   Murayama, Toshihiko ^b   Horie, Syunji ^a  

^a JOSAI INTERNATIONAL UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

Enteric nervous system; Inflammatory bowel disease; Serotonin; TRPV1; Visceral hypersensitivity

Indexed keywords

ALOSETRON; ANTIBODY; DEXTRAN SULFATE; FLUORESCEIN; ISOPROPAMIDE IODIDE; N (4 TERT BUTYLPHENYL) 4 (3 CHLORO 2 PYRIDINYL) 1 PIPERAZINECARBOXAMIDE; SEROTONIN; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; SEROTONIN 4 RECEPTOR; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 1; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST;

ABDOMINAL WALL MUSCULATURE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATTENUATION; CELL COUNT; CELL STRUCTURE; COLITIS; COLORECTAL DISEASE; COLORECTAL DISTENSION; CONJUGATION; CONTROLLED STUDY; ELECTROMYOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; HYPERALGESIA; HYPERSENSITIVITY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFLAMMATION; INTESTINE MUCOSA; MALE; MOLECULAR DYNAMICS; MOTOR PERFORMANCE; MOUSE; NERVE FIBER; NOCICEPTION; NONHUMAN; NUCLEIC ACID AMPLIFICATION; PAIN ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR DOWN REGULATION; RISK FACTOR; SIGNAL TRANSDUCTION; STAINING; VISCERAL HYPERALGESIA; VISCERAL PAIN; VISCEROMOTOR RESPONSE;

ANIMALS; CARBOLINES; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; ELECTROMYOGRAPHY; HYPERALGESIA; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; NOCICEPTION; PYRAZINES; PYRIDINES; RECEPTORS, SEROTONIN, 5-HT3; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN; SEROTONIN ANTAGONISTS; TIME FACTORS; TRPV CATION CHANNELS; TRYPTOPHAN HYDROXYLASE; VISCERAL AFFERENTS;

EID: 84860295415     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2012.14     Document Type: Article

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