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Volumn 8, Issue 5, 2007, Pages 416-422

Drug evaluation: Pumosetrag for the treatment of irritable bowel syndrome and gastroesophageal reflux disease

(1)  Evangelista, Stefano a  

a NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 1 (6 CHLORO 2 PYRIDYL)PIPERIDINE; 4,7 DIHYDRO 7 OXO N (3 QUINUCLIDINYL)THIENO[3,2 B]PYRIDINE 6 CARBOXAMIDE; ALOSETRON; CILANSETRON; CISAPRIDE; CP 2289; DDP 733; HISTAMINE H2 RECEPTOR ANTAGONIST; NALTREXONE; ONDANSETRON; PLACEBO; PROTON PUMP INHIBITOR; PUMOSETRAG; SEROTONIN 3 AGONIST; SEROTONIN 3 ANTAGONIST; TEGASEROD; UNCLASSIFIED DRUG; YM 31636;

EID: 34247842800     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (29)

References (44)
  • 1
    • 0025640876 scopus 로고    scopus 로고
    • 33768 5-HT receptor subtypes outside the central nervous system: Roles in the physiology of the gut. Gershon MD, Wade PR, Kirchgessner AL, Tamir H NEUROPSYCHOPHARMACOLOGY 1990 3 5-6 385-395
    • 33768 5-HT receptor subtypes outside the central nervous system: Roles in the physiology of the gut. Gershon MD, Wade PR, Kirchgessner AL, Tamir H NEUROPSYCHOPHARMACOLOGY 1990 3 5-6 385-395
  • 2
    • 0024999306 scopus 로고    scopus 로고
    • 55510 Colonic transit in man is slowed by ondansetron (GR-38032F, a selective 5-hydroxytryptamine receptor (type 3) antagonist. Gore S, Gilmore IT, Haigh CG, Brownless SM, Stockdale H, Morris AI ALIMENT PHARMACOL THER 1990 4 2 139-144
    • 55510 Colonic transit in man is slowed by ondansetron (GR-38032F), a selective 5-hydroxytryptamine receptor (type 3) antagonist. Gore S, Gilmore IT, Haigh CG, Brownless SM, Stockdale H, Morris AI ALIMENT PHARMACOL THER 1990 4 2 139-144
  • 3
    • 0026926655 scopus 로고    scopus 로고
    • 115844 Trends in the search for bioactive microbial metabolites. Omura S J IND MICROBIOL 1992 10 3-4 135-156
    • 115844 Trends in the search for bioactive microbial metabolites. Omura S J IND MICROBIOL 1992 10 3-4 135-156
  • 4
    • 34247892135 scopus 로고    scopus 로고
    • 175489 Effects of MKC-733, a new prokinetic compound, on gastrointestinal motility in rats and dogs. Yamazaki S, Yano T, Ogawa S, Tobe A JPN J PHARMACOL 1995 67 Suppl 1 P2-96
    • 175489 Effects of MKC-733, a new prokinetic compound, on gastrointestinal motility in rats and dogs. Yamazaki S, Yano T, Ogawa S, Tobe A JPN J PHARMACOL 1995 67 Suppl 1 P2-96
  • 5
    • 34247884226 scopus 로고    scopus 로고
    • 224018 Species difference in the intrinsic activity of MKC-733 for 5-HT3 receptor. Yamazaki S, Yano T, Tobe A JPN J PHARMACOL 1996 71 Suppl 1 62P
    • 3 receptor. Yamazaki S, Yano T, Tobe A JPN J PHARMACOL 1996 71 Suppl 1 62P
  • 6
    • 0027325088 scopus 로고    scopus 로고
    • 226432 SR-57227A: A potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo. Bachy A, Heaulme M, Giudice A, Michaud JC, Lefevre IA, Souilhac J, Manara L, Emerit MB, Gozlan H, Hamon M, Keane PE et al EUR J PHARMACOL 1993 237 2-3 299-309
    • 3 receptors in vitro and in vivo. Bachy A, Heaulme M, Giudice A, Michaud JC, Lefevre IA, Souilhac J, Manara L, Emerit MB, Gozlan H, Hamon M, Keane PE et al EUR J PHARMACOL 1993 237 2-3 299-309
  • 7
    • 0032970989 scopus 로고    scopus 로고
    • 352217 A review of central 5-HT receptors and their function. Barnes NM, Sharp T NEUROPHARMACOLOGY 1999 38 8 1083-1152
    • 352217 A review of central 5-HT receptors and their function. Barnes NM, Sharp T NEUROPHARMACOLOGY 1999 38 8 1083-1152
  • 8
    • 34247850681 scopus 로고    scopus 로고
    • 361979 Mitsubishi-Tokyo licenses out gastroprokinetic MKC-733 to Janssen. PHARMA JPN 2000 April 03
    • 361979 Mitsubishi-Tokyo licenses out gastroprokinetic MKC-733 to Janssen. PHARMA JPN 2000 April 03
  • 9
    • 34247892137 scopus 로고    scopus 로고
    • 391671 Glaxo Wellcome to withdraw Lotronex from the US market: Decision follows in-depth discussions with FDA. Glaxo Wellcome plc PRESS RELEASE 2000 November 28
    • 391671 Glaxo Wellcome to withdraw Lotronex from the US market: Decision follows in-depth discussions with FDA. Glaxo Wellcome plc PRESS RELEASE 2000 November 28
  • 10
    • 0030739923 scopus 로고    scopus 로고
    • 401006 CP-2289, a new 5-HT3 receptor ligand: Agonistic activities on gastroenteric motility. Sato Y, Imai M, Amano K, Iwamatsu K, Konno F, Kurata Y, Sakakibara S, Hachisu M, Izumi M, Matsuki N, Saito H BIOL PHARM BULL 1997 20 7 752-755
    • 3 receptor ligand: Agonistic activities on gastroenteric motility. Sato Y, Imai M, Amano K, Iwamatsu K, Konno F, Kurata Y, Sakakibara S, Hachisu M, Izumi M, Matsuki N, Saito H BIOL PHARM BULL 1997 20 7 752-755
  • 11
    • 0035046922 scopus 로고    scopus 로고
    • 404548 5-Hydroxytryptamine and the gastrointestinal migrating motor complex. Plaza MA CURR OPIN INVESTIG DRUGS 2001 2 4 539-544
    • 404548 5-Hydroxytryptamine and the gastrointestinal migrating motor complex. Plaza MA CURR OPIN INVESTIG DRUGS 2001 2 4 539-544
  • 12
    • 34247846002 scopus 로고    scopus 로고
    • 408976 MKC-733, a selective 5-HT3 receptor agonist, stimulates small bowel transit and relaxes the gastric fundus in man. Coleman NS, Marciani L, Blackshaw PE, Gowland PA, Perkins AC, Spiller R GASTROENTEROLOGY 2001 120 5 Suppl 1 Abs 376
    • 3 receptor agonist, stimulates small bowel transit and relaxes the gastric fundus in man. Coleman NS, Marciani L, Blackshaw PE, Gowland PA, Perkins AC, Spiller R GASTROENTEROLOGY 2001 120 5 Suppl 1 Abs 376
  • 13
    • 34247871189 scopus 로고    scopus 로고
    • 409479 MKC-733, a selective 5-HT3 receptor agonist, stimulates fasting human antral motility. Coleman NS, Wright J, Parker M, Spiller RC GASTROENTEROLOGY 2001 120 5 Suppl 1 Abs 2343
    • 3 receptor agonist, stimulates fasting human antral motility. Coleman NS, Wright J, Parker M, Spiller RC GASTROENTEROLOGY 2001 120 5 Suppl 1 Abs 2343
  • 14
    • 34247898776 scopus 로고    scopus 로고
    • 410119 Digestive Disease Week 2001 Part III, Overnight Report, Atlanta, GA, USA. Hilton J IDDB MEETING REPORT 2001 May 20-23
    • 410119 Digestive Disease Week 2001 (Part III) - Overnight Report, Atlanta, GA, USA. Hilton J IDDB MEETING REPORT 2001 May 20-23
  • 15
    • 34247875862 scopus 로고    scopus 로고
    • 413329 Digestive Disease Week 2001 Part VIII, Esophageal, Gastric and Intestinal Motility, and Functional Disorders, Atlanta, GA, USA. Quigley EMM IDDB MEETING REPORT 2001 May 20-23
    • 413329 Digestive Disease Week 2001 (Part VIII), Esophageal, Gastric and Intestinal Motility, and Functional Disorders, Atlanta, GA, USA. Quigley EMM IDDB MEETING REPORT 2001 May 20-23
  • 16
    • 34247854750 scopus 로고    scopus 로고
    • 453617 Drug Development Pipeline: Johnson & Johnson. Johnson & Johnson COMPANY COMMUNICATION 2002 March 25
    • 453617 Drug Development Pipeline: Johnson & Johnson. Johnson & Johnson COMPANY COMMUNICATION 2002 March 25
  • 17
    • 34247880127 scopus 로고    scopus 로고
    • 454009 Lotronex tablets to be re-introduced for women with severe diarrhea-predominant IBS. GlaxoSmithKline plc PRESS RELEASE 2002 June 07
    • 454009 Lotronex tablets to be re-introduced for women with severe diarrhea-predominant IBS. GlaxoSmithKline plc PRESS RELEASE 2002 June 07
  • 18
    • 34247846001 scopus 로고    scopus 로고
    • 467593 MKC-733, a 5-HT3 receptor agonist, stimulates small bowel transit and relaxes the gastric fundus in man. Coleman N, Marciani L, Blackshaw PE, Gowland PA, Perkins A, Spiller RC GUT 2001 48 1 Abs 44
    • 3 receptor agonist, stimulates small bowel transit and relaxes the gastric fundus in man. Coleman N, Marciani L, Blackshaw PE, Gowland PA, Perkins A, Spiller RC GUT 2001 48 1 Abs 44
  • 19
    • 34247892136 scopus 로고    scopus 로고
    • 467594 5-HT3 receptors stimulate fasting human antral motility. Coleman N, Wright J, Parker M, Spiller R GUT 2001 48 1 Abs 43-47
    • 3 receptors stimulate fasting human antral motility. Coleman N, Wright J, Parker M, Spiller R GUT 2001 48 1 Abs 43-47
  • 20
    • 34247844258 scopus 로고    scopus 로고
    • 467601 The effects of MKC-733, a new potent 5-HT3 receptor agonist, on ion transport of guinea pig distal colon. Yano T, Kuwahara A, Yamazaki S JPN J PHARMACOL 1996 71 1 109P
    • 467601 The effects of MKC-733, a new potent 5-HT3 receptor agonist, on ion transport of guinea pig distal colon. Yano T, Kuwahara A, Yamazaki S JPN J PHARMACOL 1996 71 1 109P
  • 21
    • 0036119338 scopus 로고    scopus 로고
    • 512856 Molecular, pharmacological and functional diversity of 5-HT receptors. Hoyer D, Hannon JP, Martin GR PHARMACOL BIOCHEM BEHAV 2002 71 4 533-554
    • 512856 Molecular, pharmacological and functional diversity of 5-HT receptors. Hoyer D, Hannon JP, Martin GR PHARMACOL BIOCHEM BEHAV 2002 71 4 533-554
  • 22
    • 34247884225 scopus 로고    scopus 로고
    • 568780 Dynogen acquires exclusive rights to a clinical-stage prokinetic drug candidate for gastrointestinal disorders. Dynogen Pharmaceuticals Inc PRESS RELEASE 2004 November 04
    • 568780 Dynogen acquires exclusive rights to a clinical-stage prokinetic drug candidate for gastrointestinal disorders. Dynogen Pharmaceuticals Inc PRESS RELEASE 2004 November 04
  • 23
    • 0037375433 scopus 로고    scopus 로고
    • 593302 New thiazole derivatives as potent and selective 5-hydroxytryptamine 3 (5-HT3) receptor agonists for the treatment of constipation. Naoki I, Kiyoshi I, Hiroyuki K, Shin-ya N, Ken-ichi K, Mitsuaki O, Shuichi S, Hiroyuki I, Shinobu A, Tetsuo K, Shin-ichi T et al BIOORG MED CHEM 2003 11 7 1493-1502
    • 3) receptor agonists for the treatment of constipation. Naoki I, Kiyoshi I, Hiroyuki K, Shin-ya N, Ken-ichi K, Mitsuaki O, Shuichi S, Hiroyuki I, Shinobu A, Tetsuo K, Shin-ichi T et al BIOORG MED CHEM 2003 11 7 1493-1502
  • 24
    • 34247863606 scopus 로고    scopus 로고
    • 610657 MHRA requests further trials of Solvay's IBS therapy. Solvay Pharmaceuticals Inc PRESS RELEASE 2005 July 01
    • 610657 MHRA requests further trials of Solvay's IBS therapy. Solvay Pharmaceuticals Inc PRESS RELEASE 2005 July 01
  • 25
    • 34247874387 scopus 로고    scopus 로고
    • 625582 Dynogen starts phase II study of DDP-733 for IBS. Dynogen Pharmaceuticals Inc PRESS RELEASE 2005 September 28
    • 625582 Dynogen starts phase II study of DDP-733 for IBS. Dynogen Pharmaceuticals Inc PRESS RELEASE 2005 September 28
  • 26
    • 34247882519 scopus 로고    scopus 로고
    • 637949 Cilansetron; Solvay Pharmaceuticals suspends registration activities in the US, while discussions in Europe continue. Solvay Pharmaceuticals Inc PRESS RELEASE 2005 November 29
    • 637949 Cilansetron; Solvay Pharmaceuticals suspends registration activities in the US, while discussions in Europe continue. Solvay Pharmaceuticals Inc PRESS RELEASE 2005 November 29
  • 27
    • 34247853149 scopus 로고    scopus 로고
    • 668696 The effect of a novel 5-HT3 receptor partial agonist (DDP-733) on feline esophageal peristalsis and lower esophageal sphincter pressure. Venkova K, Johnson AC, Fraser MO, Thor KB, Greenwood-Van Meerveld B GASTROENTEROLOGY 2006 130 4 Suppl 2 Abs W1798
    • 3 receptor partial agonist (DDP-733) on feline esophageal peristalsis and lower esophageal sphincter pressure. Venkova K, Johnson AC, Fraser MO, Thor KB, Greenwood-Van Meerveld B GASTROENTEROLOGY 2006 130 4 Suppl 2 Abs W1798
  • 28
    • 33644976832 scopus 로고    scopus 로고
    • 682989 Effect of MKC-733, a 5-HT3 receptor partial agonist, on bowel motility and symptoms in subjects with constipation: An exploratory study. Fujita T, Yokota S, Sawada M, Majima M, Ohtani Y, Kumagai Y J CLIN PHARM THER 2005 30 6 611-622 • Evidence from a phase II exploratory study of pumosetrag's potential to treat constipation is described
    • 3 receptor partial agonist, on bowel motility and symptoms in subjects with constipation: An exploratory study. Fujita T, Yokota S, Sawada M, Majima M, Ohtani Y, Kumagai Y J CLIN PHARM THER 2005 30 6 611-622 • Evidence from a phase II exploratory study of pumosetrag's potential to treat constipation is described.
  • 29
    • 34247891455 scopus 로고    scopus 로고
    • 690102 Dynogen starts phase Ib GERD trial of pumosetrag. Dynogen Pharmaceuticals Inc PRESS RELEASE 2006 September 13
    • 690102 Dynogen starts phase Ib GERD trial of pumosetrag. Dynogen Pharmaceuticals Inc PRESS RELEASE 2006 September 13
  • 30
    • 10744222165 scopus 로고    scopus 로고
    • 759957 Effect of a novel 5-HT3 receptor agonist MKC-733 on upper gastrointestinal motility in humans. Coleman NS, Marciani L, Blackshaw E, Wright J, Parker M, Yano T, Yamazaki S, Chan PQ, Wilde K, Gowland PA, Perkins AC et al ALIMENT PHARMACOL THER 2003 18 10 1039-1048 • This paper describes all three phase I clinical studies and provides evidence for the potential activity of pumosetrag as a prokinetic
    • 3 receptor agonist MKC-733 on upper gastrointestinal motility in humans. Coleman NS, Marciani L, Blackshaw E, Wright J, Parker M, Yano T, Yamazaki S, Chan PQ, Wilde K, Gowland PA, Perkins AC et al ALIMENT PHARMACOL THER 2003 18 10 1039-1048 • This paper describes all three phase I clinical studies and provides evidence for the potential activity of pumosetrag as a prokinetic.
  • 31
    • 34247853154 scopus 로고    scopus 로고
    • 765733 Dynogen's pumosetrag effective in phase II IBS-c trial. Dynogen Pharmaceuticals Inc PRESS RELEASE 2007 February 13
    • 765733 Dynogen's pumosetrag effective in phase II IBS-c trial. Dynogen Pharmaceuticals Inc PRESS RELEASE 2007 February 13
  • 32
    • 34247853153 scopus 로고    scopus 로고
    • 765981 NCT00215566: A study to evaluate the safety, tolerability and pharmacodynamics of DDP-733 for IBS-c. National Institutes of Health, Bethesda, MD, USA 2007
    • 765981 NCT00215566: A study to evaluate the safety, tolerability and pharmacodynamics of DDP-733 for IBS-c. National Institutes of Health, Bethesda, MD, USA 2007 http://www.clinicaltrials.gov/ct/show/NCT00215566? order=1
  • 33
    • 34247850680 scopus 로고    scopus 로고
    • 766697 Effects of MKC-733, a new prokinetic agent, on the gastrointestinal tract. Yano T, Yamazaki S, Tobe A DIGESTION 1998 59 Suppl 3 737
    • 766697 Effects of MKC-733, a new prokinetic agent, on the gastrointestinal tract. Yano T, Yamazaki S, Tobe A DIGESTION 1998 59 Suppl 3 737
  • 34
    • 0030833013 scopus 로고    scopus 로고
    • 767555 In vivo effects of the 5-HT3 antagonist alosetron on basal and cholera toxin-induced secretion in the human jejunum: A segmental perfusion study. Bearcroft CP, Andre EA, Farthing MJ ALIMENT PHARMACOL THER 1997 11 6 1109-1114
    • 3 antagonist alosetron on basal and cholera toxin-induced secretion in the human jejunum: A segmental perfusion study. Bearcroft CP, Andre EA, Farthing MJ ALIMENT PHARMACOL THER 1997 11 6 1109-1114
  • 35
    • 13344269708 scopus 로고    scopus 로고
    • 767557 Regulation of 5-HT release from enterochromaffin cells. Racke K, Reimann A, Schworer H, Kilbinger H BEHAV BRAIN RES 1996 73 1-2 83-87
    • 767557 Regulation of 5-HT release from enterochromaffin cells. Racke K, Reimann A, Schworer H, Kilbinger H BEHAV BRAIN RES 1996 73 1-2 83-87
  • 36
    • 0036460817 scopus 로고    scopus 로고
    • 767564 Ligand-gated ion channels in the enteric nervous system. Galligan JJ NEUROGASTROENTEROL MOTIL 2002 14 6 611-623
    • 767564 Ligand-gated ion channels in the enteric nervous system. Galligan JJ NEUROGASTROENTEROL MOTIL 2002 14 6 611-623
  • 37
    • 33749430820 scopus 로고    scopus 로고
    • 768013 5-HT3 receptors. Thompson AJ, Lummis SC CURR PHARM DESIGN 2006 12 28 3615-3630
    • 3 receptors. Thompson AJ, Lummis SC CURR PHARM DESIGN 2006 12 28 3615-3630
  • 38
    • 0035984071 scopus 로고    scopus 로고
    • 768023 Expression of 5-HT3 receptors in the rat gastrointestinal tract. Glatzle J, Sternini C, Robin C, Zittel TT, Wong H, Reeve JR Jr, Raybould HE GASTROENTEROLOGY 2002 123 1 217-226
    • 3 receptors in the rat gastrointestinal tract. Glatzle J, Sternini C, Robin C, Zittel TT, Wong H, Reeve JR Jr, Raybould HE GASTROENTEROLOGY 2002 123 1 217-226
  • 39
    • 0036849547 scopus 로고    scopus 로고
    • 768026 Excitation of rat colonic afferent fibres by 5-HT3 receptors. Hicks GA, Coldwell JR, Schindler M, Ward PA, Jenkins D, Lynn PA, Humphrey PP, Blackshaw LA J PHYSIOL LONDON 2002 544 3 861-869
    • 3 receptors. Hicks GA, Coldwell JR, Schindler M, Ward PA, Jenkins D, Lynn PA, Humphrey PP, Blackshaw LA J PHYSIOL LONDON 2002 544 3 861-869
  • 40
    • 33646178930 scopus 로고    scopus 로고
    • 768038 Functional gastroduodenal disorders. Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, Stanghellini V GASTROENTEROLOGY 2006 130 5 1466-1479
    • 768038 Functional gastroduodenal disorders. Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, Stanghellini V GASTROENTEROLOGY 2006 130 5 1466-1479
  • 41
    • 10644290207 scopus 로고    scopus 로고
    • 768041 Serotonin receptors and transporters, roles in normal and abnormal gastrointestinal motility. Gershon MD ALIMENT PHARMACOL THER 2004 20 Suppl 7 3-14
    • 768041 Serotonin receptors and transporters - roles in normal and abnormal gastrointestinal motility. Gershon MD ALIMENT PHARMACOL THER 2004 20 Suppl 7 3-14
  • 42
    • 0034676474 scopus 로고    scopus 로고
    • 768042 Neurochemistry and neuropharmacology of emesis, the role of serotonin. Endo T, Minami M, Hirafuji M, Ogawa T, Akita K, Nemoto M, Saito H, Yoshioka M, Parvez SH TOXICOLOGY 2000 153 1-3 189-201
    • 768042 Neurochemistry and neuropharmacology of emesis - the role of serotonin. Endo T, Minami M, Hirafuji M, Ogawa T, Akita K, Nemoto M, Saito H, Yoshioka M, Parvez SH TOXICOLOGY 2000 153 1-3 189-201
  • 43
    • 30444442327 scopus 로고    scopus 로고
    • 770582 Neuropharmacology of 5-hydroxytryptamine. Green AR BR J PHARMACOL 2006 147 Suppl 1 S145-S152
    • 770582 Neuropharmacology of 5-hydroxytryptamine. Green AR BR J PHARMACOL 2006 147 Suppl 1 S145-S152
  • 44
    • 0242407382 scopus 로고    scopus 로고
    • 771011 Alosetron and irritable bowel syndrome. Mayer EA, Bradesi S EXPERT OPIN PHARMACOTHER 2003 4 11 2089-2098
    • 771011 Alosetron and irritable bowel syndrome. Mayer EA, Bradesi S EXPERT OPIN PHARMACOTHER 2003 4 11 2089-2098


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