Long vasodilator reflexes projecting through the myenteric plexus in guinea-pig ileum

Journal of Physiology

Volumn 553, Issue 3, 2003, Pages 911-924

  Reed, David E ^a   Vanner, Stephen J ^a,b  

^a QUEEN S UNIVERSITY   (Canada)

^b HOTEL DIEU HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; HEXAMETHONIUM; NIFEDIPINE; SEROTONIN 3 ANTAGONIST; SEROTONIN 4 ANTAGONIST; WORTMANNIN; 4 DIPHENYLACETOXY N (2 CHLOROETHYL)PIPERDINE HYDROCHLORIDE; CALCIUM CHANNEL; MUSCARINIC RECEPTOR BLOCKING AGENT; NICARDIPINE; ONDANSETRON; SDZ 205 577; TETRODOTOXIN; TROPISETRON; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL TISSUE; ARTICLE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; EVOKED RESPONSE; FEMALE; GUINEA PIG; ILEUM; IN VITRO STUDY; INTESTINE BLOOD FLOW; INTESTINE CONTRACTION; INTESTINE INNERVATION; INTESTINE MOTILITY; MALE; MECHANICAL STIMULATION; MOTONEURON; MYENTERIC PLEXUS; NONHUMAN; PERISTALSIS; PRIORITY JOURNAL; VASODILATATION; ADULT; ARTERIOLE; BALLOON DILATATION; CHOLINERGIC NERVE CELL; ENTEROCHROMAFFIN CELL; ILEAL MUSCLE; ILEUM MUCOSA; INTESTINE DISTENSION; LONG VASODILATOR REFLEX; MUSCLE CONTRACTION; MUSCLE STRETCHING; MUSCLE TONE; REFLEX; RESISTANCE BLOOD VESSEL; VIDEO MICROSCOPY;

ANDROSTADIENES; ANIMALS; ARTERIOLES; BALLOON DILATATION; DENERVATION; FEMALE; GUINEA PIGS; ILEUM; INTESTINAL MUCOSA; MALE; MICROVILLI; MYENTERIC PLEXUS; NEURONS; PARASYMPATHOLYTICS; PIPERIDINES; REFLEX; TETRODOTOXIN; VASODILATION;

EID: 0347658981     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.053140     Document Type: Article

References (48)

1. Bertrand PP, Kunze WA, Bornstein JC, Furness JB & Smith ML (1997). Analysis of the responses of myenteric neurons in the small intestine to chemical stimulation of the mucosa. Am J Physiol 273, G422-435.
2. Bertrand PP, Kunze WA, Furness JB & Bornstein JC (2000). The terminals of myenteric intrinsic primary afferent neurons of the guinea-pig ileum are excited by 5-hydroxytryptamine acting at 5--hydroxytryptamine-3 receptors. Neuroscience 101, 459-469.
3. Biber B (1973). Vasodilator mechanisms in the small intestine. Acta Physiol Scand Suppl 401, 1-31.
4. Biber B, Fara J & Lundgren O (1973). Intestinal vasodilatation in response to transmural electrical field stimulation. Acta Physiol Scand 87, 277-282.
5. Biber B, Fara J & Lundgren O (1974). A pharmacological study of intestinal vasodilator mechanisms in the cat. Acta Physiol Scand 90, 673-683.
6. Biber B, Lundgren O & Svanvik J (1971). Studies on the intestinal vasodilatation observed after mechanical stimulation of the mucosa of the gut. Acta Physiol Scand 82, 177-190.
7. Bornstein JC, Furness JB & Costa M (1987). Sources of excitatory synaptic inputs to neurochemically identified submucous neurons of guinea-pig small intestine. J Auton Nerv Syst 18, 83-91.
8. Bornstein JC, Furness JB, Smith TK & Trussell DC (1991). Synaptic responses evoked by mechanical stimulation of the mucosa in morphologically characterized myenteric neurons of the guinea-pig ileum. J Neurosci 11, 505-518.
9. Cannon WB (1912). Peristalsis, segmentation and the myenteric reflex. Am J Physiol 30, 114-128.
10. Cooke HJ, Sidhu M & Wang YZ (1997). Activation of 5-HT1P receptors on submucosal afferents subsequently triggers VIP neurons and chloride secretion in the guinea-pig colon. J Auton Nerv Syst 66, 105-110.
11. Cousins HM, Edwards FR & Hirst GD (1995). Neuronally released and applied acetylcholine on the longitudinal muscle of the guinea-pig ileum. Neuroscience 65, 193-207.
12. Foxx-Orenstein AE, Kuemmerle JF & Grider JR (1996). Distinct 5-HT receptors mediate the peristaltic reflex induced by mucosal stimuli in human and guinea pig intestine. Gastroenterology 111, 1281-1290.
13. Furness JB, Johnson PJ, Pompolo S & Bornstein JC (1995). Evidence that enteric motility reflexes can be initiated through entirely intrinsic mechanisms in the guinea-pig small intestine. Neurogastroenterol Motil 7, 89-96.
14. Furness JB, Kunze WA, Bertrand PP, Clerc N & Bornstein JC (1998). Intrinsic primary afferent neurons of the intestine. Prog Neurobiol 54, 1-18.
15. Galligan JJ, Jiang MM, Shen KZ & Surprenant A (1990). Substance P mediates neurogenic vasodilatation in extrinsically denervated guinea-pig submucosal arterioles. J Physiol 420, 267-280.
16. Granger DN, Kvietys PR, Korthuis RJ & Preman AJ (1989). Microcirculation of the Intestinal Mucosa, pp. 1405-1474. American Physiological Society, Bethesda, MD.
17. Grider JR, Foxx-Orenstein AE & Jin JG (1998). 5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine. Gastroenterology 115, 370-380.
18. Hirst GD, Holman ME & McKirdy HC (1975).Two descending nerve pathways activated by distension of guinea-pig small intestine. J Physiol 244, 113-127.
19. Hirst GD & McKirdy HC (1975). Synaptic potentials recorded from neurones of the submucous plexus of guinea-pig small intestine. J Physiol 249, 369-385.
20. Jiang MM, Kirchgessner A, Gershon MD & Surprenant A (1993). Cholera toxin-sensitive neurons in guinea pig submucosal plexus. Am J Physiol 264, G86-94.
21. Kirchgessner AL, Liu MT & Gershon MD (1996). In situ identification and visualization of neurons that mediate enteric and enteropancreatic reflexes. J Comp Neural 371, 270-286.
22. Kirchgessner AL, Tamir H & Gershon MD (1992). Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity-induced expression of Fos immunoreactivity. J Neurosci 12, 235-248.
23. Kunze WA, Bertrand PP, Furness JB & Bornstein JC (1997). Influence of the mucosa on the excitability of myenteric neurons. Neuroscience 76, 619-634.
24. Kunze WA, Bornstein JC &Furness JB (1995). Identification of sensory nerve cells in a peripheral organ (the intestine) of a mammal. Neuroscience 66, 1-4.
25. Kunze WA, Clerc N, Bertrand PP & Furness JB (1999). Contractile activity in intestinal muscle evokes action potential discharge in guinea-pig myenteric neurons. J Physiol 517, 547-561.
26. Kunze WA, Clerc N, Furness JB & Gola M (2000). The soma and neurites of primary afferent neurons in the guinea-pig intestine respond differentially to deformation. J Physiol 526, 375-385.
27. Moore BA & Vanner S (1998). Organization of intrinsic cholinergic neurons projecting within submucosal plexus of guinea pig ileum. Am J Physiol 275, G490-497.
28. Moore BA & Vanner S (2000). Properties of synaptic inputs from myenteric neurons innervating submucosal S neurons in guinea pig ileum. Am J Physiol Gastrointest Liver Physiol 278, G273-280.
29. Neild TO (1989). Measurement of arteriole diameter changes by analysis of television images. Blood Vessels 26, 48-52.
30. Neild TO, Shen KZ & Surprenant A (1990). Vasodilatation of arterioles by acetylcholine released from single neurones in the guinea-pig submucosal plexus. J Physiol 420, 247-265.
31. Neunlist M, Frieling T, Rupprecht C & Schemann M (1998). Polarized enteric submucosal circuits involved in secretory responses of the guinea-pig proximal colon. J Physiol 506, 539-550.
32. Pan H & Gershon MD (2000). Activation of intrinsic afferent pathways in submucosal ganglia of the guinea pig small intestine. J Neurosci 20, 3295-3309.
33. Sjoqvist A, Fahretikrug J, Jodal M & Lundgren O (1983). Effect of apamin on release of vasoactive intestinal polypeptide (VIP) from the cat intestines. Acta Physiol Scand 119, 69-76.
34. Smith TK, Bornstein JC & Furness JB (1990). Distension-evoked ascending and descending reflexes in the circular muscle of guinea-pig ileum: an intracellular study. J Auton Nerv Syst 29, 203-217.
35. Smith TK, Bornstein JC & Furness JB (1991). Interactions between reflexes evoked by distension and mucosal stimulation: electrophysiological studies of guinea-pig ileum. J Auton Nerv Syst 34, 69-75.
36. Smith TK, Bornstein JC & Furness JB (1992). Convergence of reflex pathways excited by distension and mechanical stimulation of the mucosa onto the same myenteric neurons of the guinea pig small intestine. J Neurosci 12, 1502-1510.
37. Smith TK & Furness JB (1988). Reflex changes in circular muscle activity elicited by stroking the mucosa: an electrophysiological analysis in the isolated guinea-pig ileum. J Auton Nerv Syst 25, 205-218.
38. Song Z, Brookes SJ & Costa M (1996). Projections of specific morphological types of neurons within the myenteric plexus of the small intestine of the guinea-pig. Cell Tissue Res 285, 149-156.
39. Spencer NJ, Hennig GW & Smith TK (2003). Stretch-activated neuronal pathways to longitudinal and circular muscle in guinea pig distal colon. Am J Physiol Gastrointest Liver Physiol 284, G231-241.
40. Spencer NJ, Smith CB & Smith TK (2001). Role of muscle tone in peristalsis in guinea-pig small intestine. J Physiol 530, 295-306.
41. Spencer N, Walsh M & Smith TK (1999). Does the guinea-pig ileum obey the 'law of the intestine'? J Physiol 517, 889-898.
42. Spencer NJ, Walsh M & Smith TK (2000). Purinergic and cholinergic neuro-neuronal transmission underlying reflexes activated by mucosal stimulation in the isolated guinea-pig ileum. J Physiol 522, 321-331.
43. Surprenant A (1984). Slow excitatory synaptic potentials recorded from neurones of guinea-pig submucous plexus. J Physiol 351, 343-361.
44. Vanner S (2000). Myenteric neurons activate submucosal vasodilator neurons in guinea pig ileum. Am J Physiol Gastrointest Liver Physiol 279, G380-387.
45. Vanner S & Bolton M (1996). Neural circuitry of capsaicin-sensitive afferents innervating submucosal arterioles in guinea pig ileum. Am J Physiol 270, G948-955.
46. Vanner S, Jiang MM & Surprenant A (1993). Mucosal stimulation evokes vasodilation in submucosal arterioles by neuronal and nonneuronal mechanisms. Am J Physiol 264, G202-212.
47. Vanner S & Surprenant A (1996). Neural reflexes controlling intestinal microcirculation. Am J Physiol 271, G223-230.
48. Weber E, Neunlist M, Schemann M & Frieling T (2001). Neural components of distension-evoked secretory responses in the guinea-pig distal colon. J Physiol 536, 741-751.