Guinea pig 5-HT transporter: Cloning, expression, distribution, and function in intestinal sensory reception

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 275, Issue 3 38-3, 1998, Pages

  Chen, Jing Xian ^a   Pan, Hui ^a   Rothman, Taube P ^a   Wade, Paul R ^a   Gershon, Michael D ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

Enteric nervous system; Enterochromaffin cells; Fluoxetine; Peristaltic reflex; Serotonin; Serotonin selective reuptake inhibitors

Indexed keywords

CLOMIPRAMINE; COMPLEMENTARY DNA; DESIPRAMINE; FLUOXETINE; IMIPRAMINE; MESSENGER RNA; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; ZIMELDINE;

ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DNA SEQUENCE; GUINEA PIG; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINE CRYPT; INTESTINE VILLUS; MOLECULAR CLONING; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORY NERVE; SEROTONINERGIC NERVE; SMALL INTESTINE MUCOSA;

EID: 0031681197     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1998.275.3.g433     Document Type: Article

References (49)

1. Barker, E. L., and R. D. Blakely. Identification of a single amino acid, phenylalanine 586, that is responsible for high affinity interactions of tricyclic antidepressants with the human serotonin transporter. Mol. Pharmacol. 50: 957-965, 1996.
2. Barker, E. L., H. L. Kimmel, and R. D. Blakely. Chimeric human and rat serotonin transporters reveal domains involved in recognition of transporter ligands. Mol. Pharmacol. 46: 799-807, 1994.
3. Blackshaw, L. A., and D. Grundy. Effects of 5-hydroxytryptamine on discharge of vagal mucosal afferent fibres from the upper gastrointestinal tract of the ferret. J. Auton. Nerv. Syst. 45: 41-50, 1993.
4. Blakely, R. D., H. E. Berson, R. T. Fremeau, M. G. Caron, M. M. Peek, H. K. Prince, and C. C. Bradley. Cloning and expression of a functional serotonin transporter from rat brain. Nature 354: 66-70, 1991.
5. Blakely, R. D., K. R. Moore, and Y. Qian. Tails of serotonin and norepinephrine transporters: deletions and chimeras retain function. In: Molecular Biology and Function of Carrier Proteins, edited by L. Reuss, J. M. Russell, Jr., and M. L. Jennings. New York: Rockefeller Univ. Press, 1993, p. 284-300.
6. Blashko, H., and W. G. Levine. Metabolism of indolealkylamines. In: Handbook of Experimental Pharmacology: 5-Hydroxytryptamine and Related Indolealkylamines, edited by V. Erspamer. New York: Springer-Verlag, 1966, p. 212-244.
7. Bülbring, E., and A. Crema. Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex. Br. J. Pharmacol. 13: 444-457, 1958.
8. Bülbring, E., and A. Crema. The release of 5-hydroxytryptamine in relation to pressure exerted on the intestinal mucosa. J. Physiol. (Lond.) 146: 18-28, 1959.
9. Bülbring, E., and A. Crema. The action of 5-hydroxytryptamine, 5-hydroxytryptophan and reserpine on intestinal peristalsis in anaesthetized guinea-pigs. J. Physiol. (Lond.) 146: 29-53, 1959.
10. Bülbring, E., and R. C. Y. Lin. The effect of intraluminal application of 5-hydroxytryptamine and 5-hydroxytryptophan on peristalsis, the local production of 5-hydroxytryptamine and its release in relation to intraluminal pressure and propulsive activity. J. Physiol. (Lond.) 140: 381-407, 1958.
11. Bülbring, E., R. C. Y. Lin, and G. Schofield. An investigation of the peristaltic reflex in relation to anatomical observations. Q. J. Exp. Physiol. 43: 26-37, 1958.
12. Chang, A. S., S. M. Chang, D. M. Starnes, S. Schroeter, A. L. Bauman, and R. D. Blakely. Cloning and expression of the mouse serotonin transporter. Mol. Brain Res. 43: 185-192, 1996.
13. Chou, P. Y., and G. D. Fasman. Prediction of the secondary structure of proteins from their amino acid sequence. Adv. Enzymol. Relat. Areas Mol. Biol. 47: 45-148, 1978.
14. Cooke, H. J., M. Sidhu, and Y.-Z. Wang. 5-HT activates neural reflexes regulating secretion in the guinea-pig colon. Neurogastroenterol. Motil. 9: 181-186, 1997.
15. Costa, M., J. B. Furness, A. C. Cuello, A. A. J. Verhofstad, H. W. J. Steinbusch, and R. P. Elde. Neurons with 5-hydroxytryptamine-like immunoreactivity in the enteric nervous system: their visualization and reactions to drug treatment. Neuroscience 7: 351-363, 1982.
16. Erde, S. M., D. Sherman, and M. D. Gershon. Morphology and serotonergic innervation of physiologically identified cells of the guinea pig's myenteric plexus. J. Neurosci. 5: 617-633, 1985.
17. Erspamer, V. Occurrence of indolealkylamines in nature. In: Handbook of Experimental Pharmacology: 5-Hydroxytryptamine and Related Indolealkylamines, edited by V. Erspamer. New York: Springer-Verlag, 1966, p. 132-181.
18. Fujimaya, M., K. Okumiya, and A. Kuwahara. Immunoelectron microscopic study of the luminal release of serotonin from rat enterochromaffin cells induced by high intraluminal pressure. Histochem. Cell Biol. 108: 105-113, 1997.
19. Fuller, R. W., and D. T. Wong. Serotonin uptake and serotonin uptake inhibition. Ann. NY Acad. Sci. 600: 68-80, 1990.
20. Furness, J. B., and M. Costa. Neurons with 5-hydroxytryptamine-like immunoreactivity in the enteric nervous system: their projections in the guinea pig small intestine. Neuroscience 7: 341-350, 1982.
21. Furness, J. B., and M. Costa. The Enteric Nervous System. New York: Churchill Livingstone, 1987.
22. Galli, A., L. J. DeFelice, B. J. Duke, K. R. Moore, and R. D. Blakely. Sodium-dependent norepinephrine-induced currents in norepinephrine transporter transfected HEK-293 cells blocked by cocaine and antidepressants. J. Exp. Biol. 198: 2197-2212, 1995.
23. Gershon, M. D. Biochemistry and physiology of serotonergic transmission. In: Handbook of Physiology: The Nervous System, edited by J. M. Brookhart and V. B. Mountcastle. Bethesda, MD: Am. Physiol. Soc., 1977, p. 573-623.
24. Gershon, M. D., and R. F. Altman. An analysis of the uptake of 5-hydroxytryptamine by the myenteric plexus of the small intestine of the guinea pig. J. Pharmacol. Exp. Ther. 179: 29-41, 1971.
25. Gershon, M. D., A. L. Kirchgessner, and P. R. Wade. Functional anatomy of the enteric nervous system. In: Physiology of the Gastrointestinal Tract (3rd ed.), edited by L. R. Johnson, D. H. Alpers, E. D. Jacobson, and J. H. Walsh. New York: Raven, 1994, p. 381-422.
26. Gershon, M. D., R. Robinson, and L. L. Ross. Serotonin accumulation in the guinea pig's myenteric plexus: ion dependence, structure activity relationship and the effect of drugs. J. Pharmacol. Exp. Ther. 198: 548-561, 1976.
27. Gershon, M. D., and L. L. Ross. Radioisotopic studies of the binding, exchange, and distribution of 5-hydroxytryptamine synthesized from its radioactive precursor. J. Physiol. (Lond.) 186: 451-476, 1966.
28. Gershon, M. D., and D. L. Sherman. Identification of and interactions between noradrenergic and serotonergic neurites in the myenteric plexus. J. Comp. Neurol. 204: 407-421, 1982.
29. Gershon, M. D., and D. L. Sherman. Noradrenergic innervation of serotonergic neurons in the myenteric plexus. J. Comp. Neurol. 259: 193-210, 1987.
30. Gershon, M. D., D. L. Sherman, and J. E. Pintar. Type-specific localization of monoamine oxidase in the enteric nervous system: relatonship to 5-hydroxytryptamine, neuropeptides, and sympathetic nerves. J. Comp. Neurol. 301: 191-213, 1990.
31. Grundy, D., L. A. Blackshaw, and K. Hillsley. Role of 5-hydroxytryptamine in gastrointestinal chemosensitivity. Dig. Dis. Sci. 39, Suppl. 12: 44S-47S, 1994.
32. Hoffman, B., E. Mezey, and M. Brownstein. Cloning of a serotonin transporter affected by antidepressants. Science 254: 579-580, 1991.
33. Hornsby, C. D., J. M. Barnes, N. M. Barnes, S. Champaneria, B. Costall, and R. J. Naylor. Pharmacological comparison of the rat and guinea-pig cortical high affinity 5-hydroxytrptamine uptake system. Biochem. Pharmacol. 43: 1865-1868, 1992.
34. Karaosmanoglu, T., B. Aygun, P. R. Wade, and M. D. Gershon. Regional differences in the number of neurons in the myenteric plexus of the guinea pig small intestine and colon: an evaluation of markers used to count neurons. Anat. Rec. 244: 470-480, 1996.
35. Kirchgessner, A. L., M.-T. Liu, and M. D. Gershon. In situ identification and visualization of neurons that mediate enteric and enteropancreatic reflexes. J. Comp. Neurol. 371: 270-286, 1996.
36. Kirchgessner, A. L., H. Tamir, and M. D. Gershon. Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity-induced expression of Fos immunoreactivity. J. Neurosci. 12: 235-249, 1992.
37. Kyte, J., and R. F. Doolittle. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157: 105-132, 1982.
38. Nilsson, O., H. Ahlman, M. Geffard, A. Dahlstrom, and L. E. Ericson. Bipolarity of duodenal enterochromaffin cells in the rat. Cell Tissue Res. 248: 49-54, 1987.
39. Pan, H., P. R. Wade, and M. D. Gershon. Activation of and transmission from intrinsic sensory neurons of the submucosal plexus (Abstract). Gastroenterology 112: A803, 1997.
40. Qian, Y., H. E. Melikian, D. B. Rye, A. I. Levey, and R. D. Blakely. Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies. J. Neurosci. 15: 1261-1274, 1995.
41. Ramamoothy, S., A. L. Bauman, K. R. Moore, H. Han, T. Yang-Fen, A. S. Chang, V. Ganapathy, and R. D. Blakely. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning expression, and chromosomal localization. Proc. Natl. Acad. Sci. USA 90: 2542-2546, 1993.
42. Robinson, R., and M. D. Gershon. Synthesis and uptake of 5-hydroxytryptamine by the myenteric plexus of the small intestine of the guinea pig. J. Pharmacol. Exp. Ther. 178: 311-324, 1971.
43. Ross, S. B., and A. L. Renyi. Accumulation of tritiated 5-hydroxytryptamine in brain slices. Life Sci. 6: 1407-1415, 1967.
44. Sidhu, M., and H. J. Cooke. Role for 5-HT and ACh in submucosal reflexes mediating colonic secretion. Am. J. Physiol. 269 (Gastrointest. Liver Physiol. 32): G346-G351, 1995.
45. Takaki, M., T. Branchek, H. Tamir, and M. D. Gershon. Specific antagonism of enteric neural serotonin receptors by dipeptides of 5-hydroxytryptophan: evidence that serotonin is a mediatory of slow synaptic excitation in the myenteric plexus. J. Neurosci. 5: 1769-1780, 1985.
46. Tutton, P. J. M. The influence of serotonin on crypt cell proliferation in the jejunum of rat. Virchows Arch. 16: 79-87, 1974.
47. Tutton, P. J. M., and D. H. Barkla. Neural control of colonic cell proliferation. Cancer 45: 1172-1177, 1980.
48. Wade, P. R., J. Chen, B. Jaffe, I. S. Kassem, R. D. Blakely, and M. D. Gershon. Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. J. Neurosci. 16: 2352-2364, 1996.
49. Wade, P. R., H. Tamir, A. L. Kirchgessner, and M. D. Gershon. Analysis of the role of 5-HT in the enteric nervous system using anti-idiotypic antibodies to 5-HT receptors. Am. J. Physiol. 266 (Gastrointest. Liver Physiol. 29): G403-G416, 1994.