Synthesis of novel psoralen analogues and their in vitro antitumor activity

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 5047-5053

  Francisco, Carla S ^a   Rodrigues, Lígia R ^a   Cerqueira, Nuno M F S A ^b   Oliveira Campos, Ana M F ^a   Rodrigues, Lígia M ^a   Esteves, Ana P ^a  

^a UNIVERSITY OF MINHO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Antitumor activity; Benzofurocoumarins; Benzopsoralen analogues; Computational studies; Docking

Indexed keywords

2 HYDROXY 9H CARBAZOLE 1 CARBALDEHYDE; 2 HYDROXYCARBAZOLE; 3,11 DIHYDRO 3 OXOPYRANO[3,2 A]CARBAZOLE 2 CARBOXYLIC ACID; 4 METHYL 2H BENZOFURO[2,3 G]CHROMEN 2 ONE; 4 METHYLPYRANO[2,3 B]CARBAZOL 2(10H) ONE; BENZOPSORALEN DERIVATIVE; CYTOCHROME P450 2A6; ETHYL 3,11 DIHYDRO 3 OXOPYRANO[3,2 A]CARBAZOLE 2 CARBOXYLATE; PSORALEN DERIVATIVE; PYRANO[3,2 A]CARBAZOL 3(11H) ONE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; FEMALE; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

ANTITUMOR ACTIVITY; BENZOFUROCOUMARINS; BENZOPSORALEN ANALOGUES; COMPUTATIONAL STUDIES; DOCKING;

ANTINEOPLASTIC AGENTS; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; FICUSIN; HELA CELLS; HUMANS; MOLECULAR DOCKING SIMULATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881372431     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.049     Document Type: Article

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