Effect of CYP2A13 active site mutation N297A on metabolism of coumarin and tobacco-specific nitrosamines

Drug Metabolism and Disposition

Volumn 37, Issue 3, 2009, Pages 665-671

  Schlicht, Kari E ^a   Berg, Jeannette Zinggeler ^a   Murphy, Sharon E ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; COUMARIN; CYTOCHROME P450 2A13; CYTOCHROME P450 ISOENZYME; NITROSONORNICOTINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; EPOXIDATION; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; TOBACCO; XENOBIOTIC METABOLISM;

ARYL HYDROCARBON HYDROXYLASES; CATALYTIC DOMAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NITROSAMINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; TANDEM MASS SPECTROMETRY; TOBACCO;

NICOTIANA TABACUM;

EID: 61449158840     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.025072     Document Type: Article

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