Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes inmice

Toxicology and Applied Pharmacology

Volumn 232, Issue 2, 2008, Pages 337-350

  Kleiner, Heather E ^a   Xia, Xiaojun ^b   Sonoda, Junichiro ^b   Zhang, Jun ^c   Pontius, Elizabeth ^a   Abey, Jane ^a   Evans, Ronald M ^b   Moore, David D ^c   DiGiovanni, John ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Constitutive androstane receptor; Coumarins; Furanocoumarins; P450s; Pregnane X receptor

Indexed keywords

5,7 DIMETHOXYCOUMARIN; ANDROSTANE DERIVATIVE; ANGELICIN; AURAPTENE; BERGAMOTTIN; CONSTITUTIVE ANDROSTANE RECEPTOR; COUMARIN; CYTOCHROME P450; CYTOCHROME P450 2B11; CYTOCHROME P450 2C9; CYTOCHROME P450 3A11; DRUG METABOLIZING ENZYME; FUROCOUMARIN DERIVATIVE; GLUTATHIONE TRANSFERASE; ISOPIMPINELLIN; MESSENGER RNA; PENTOSALEN; PREGNANE X RECEPTOR; STEROID RECEPTOR COACTIVATOR 1; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; C57BL 6 MOUSE; CONTROLLED STUDY; CYP2B10 GENE; CYP3A11 GENE; DOSE RESPONSE; DRUG STRUCTURE; ENZYME ACTIVITY; FEMALE; GENE; GENE EXPRESSION; GENETIC TRANSFECTION; GSTA GENE; LIGAND BINDING; LIVER; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION;

ANIMALS; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED SENCAR; MICE, KNOCKOUT;

MUS;

EID: 52149101381     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.07.004     Document Type: Article

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