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Volumn 14, Issue 8, 2013, Pages 899-918

Recent developments in the discovery of novel antipsychotic agents modualating dopamine and serotonin receptors

Author keywords

Arylpiperazines; Atypical antipsychotics; Butyrophenones; Dopamine and serotonin receptors; Schizophrenia; Tricycles

Indexed keywords

APOMORPHINE; ASENAPINE; BENZIMIDAZOLE DERIVATIVE; BENZOFURAN DERIVATIVE; BLONANSERIN; BUTYROPHENONE DERIVATIVE; CARIPRAZINE; CLOZAPINE; COUMARIN; DOPAMINE RECEPTOR; HALOPERIDOL; ILOPERIDONE; KETANSERIN; LOXAPINE; LURASIDONE; MOLINDONE; NEUROLEPTIC AGENT; OLANZAPINE; PALIPERIDONE; PIPERIDINE DERIVATIVE; RISPERIDONE; SEROTONIN RECEPTOR; ZIPRASIDONE;

EID: 84881354961     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/13894501113149990007     Document Type: Review
Times cited : (2)

References (94)
  • 1
    • 33751533662 scopus 로고    scopus 로고
    • Schizophrenia and Other Psychotic Disorders
    • Jibson MD, Glick ID, Tandon R. Schizophrenia and Other Psychotic Disorders. Focus 2004; 2: 17-30.
    • (2004) Focus , vol.2 , pp. 17-30
    • Jibson, M.D.1    Glick, I.D.2    Tandon, R.3
  • 3
    • 33748474553 scopus 로고    scopus 로고
    • Pathophysiologically based treatment interventions in schizophrenia
    • Lewis DA, Gonzalez-Burgos G. Pathophysiologically based treatment interventions in schizophrenia. Nat Med 2006; 12: 1016-22.
    • (2006) Nat Med , vol.12 , pp. 1016-1022
    • Lewis, D.A.1    Gonzalez-Burgos, G.2
  • 4
    • 34249074497 scopus 로고    scopus 로고
    • The history of clozapine and its emergence in the US market: A review and analysis
    • Crilly J. The history of clozapine and its emergence in the US market: a review and analysis. Hist Psychiatry 2007; 18: 39-60.
    • (2007) Hist Psychiatry , vol.18 , pp. 39-60
    • Crilly, J.1
  • 5
    • 77952994419 scopus 로고    scopus 로고
    • Efficacy of atypical v. typical antipsychotics in the treatment of early psychosis: Meta-analysis
    • Crossley NA, Constante M, McGuire P, Power P. Efficacy of atypical v. typical antipsychotics in the treatment of early psychosis: meta-analysis. Br J Psychiatry 2010; 196: 434-39.
    • (2010) Br J Psychiatry , vol.196 , pp. 434-439
    • Crossley, N.A.1    Constante, M.2    McGuire, P.3    Power, P.4
  • 6
    • 0031575398 scopus 로고    scopus 로고
    • Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem
    • Eyles DW, Avent KM, Stedman TJ, Pond SM. Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem. Life Sci 1997; 60: 529-34.
    • (1997) Life Sci , vol.60 , pp. 529-534
    • Eyles, D.W.1    Avent, K.M.2    Stedman, T.J.3    Pond, S.M.4
  • 7
    • 7044231857 scopus 로고    scopus 로고
    • Haloperidol: Towards further understanding of the structural contributions of its pharmacophoric elements at D2-like receptors
    • Sikazwe DM, Li S, Mardenborough L, et al. Haloperidol: towards further understanding of the structural contributions of its pharmacophoric elements at D2-like receptors. Bioorg Med Chem Lett 2004; 14: 5739-42.
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 5739-5742
    • Sikazwe, D.M.1    Li, S.2    Mardenborough, L.3
  • 8
    • 33947148162 scopus 로고    scopus 로고
    • Pharmacological profiles in rats of novel antipsychotics with combined dopamine D2/serotonin 5-HT1A activity: Comparison with typical and atypical conventional antipsychotics
    • Bardin L, Auclair A, Kleven MS, et al. Pharmacological profiles in rats of novel antipsychotics with combined dopamine D2/serotonin 5-HT1A activity: comparison with typical and atypical conventional antipsychotics. Behav Pharmacol 2007; 18: 103-18.
    • (2007) Behav Pharmacol , vol.18 , pp. 103-118
    • Bardin, L.1    Auclair, A.2    Kleven, M.S.3
  • 9
    • 33847354629 scopus 로고    scopus 로고
    • Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities
    • Cuisiat S, Bourdiol N, Lacharme V, et al. Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities. J Med Chem 2007; 50: 865-76.
    • (2007) J Med Chem , vol.50 , pp. 865-876
    • Cuisiat, S.1    Bourdiol, N.2    Lacharme, V.3
  • 10
    • 33644684681 scopus 로고    scopus 로고
    • Receptor occupancy-based analysis of the contributions of various receptors to antipsychoticsinduced weight gain and diabetes mellitus
    • Matsui-Sakata A, Ohtani H, Sawada Y. Receptor occupancy-based analysis of the contributions of various receptors to antipsychoticsinduced weight gain and diabetes mellitus. Drug Metab Pharmacokinet 2005; 20: 368-78.
    • (2005) Drug Metab Pharmacokinet , vol.20 , pp. 368-378
    • Matsui-Sakata, A.1    Ohtani, H.2    Sawada, Y.3
  • 11
    • 0028875303 scopus 로고
    • Ziprasidone (CP-88,059): A new antipsychotic with combined dopamine and serotonin receptor antagonist activity
    • Seeger TF, Seymour PA, Schmidt AW, et al. Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity. J Pharmacol Exp Ther 1995; 275: 101-13.
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 101-113
    • Seeger, T.F.1    Seymour, P.A.2    Schmidt, A.W.3
  • 12
    • 84861536099 scopus 로고    scopus 로고
    • Evaluation of the behavioral and pharmacokinetic profile of SYA013, a homopiperazine analog of haloperidol in rats
    • Bricker B, Jackson T, Boateng B, Zhu XY, Ablordeppe, SY. Evaluation of the behavioral and pharmacokinetic profile of SYA013, a homopiperazine analog of haloperidol in rats. Pharmacol Biochem Behav 2012; 102: 294-301.
    • (2012) Pharmacol Biochem Behav , vol.102 , pp. 294-301
    • Bricker, B.1    Jackson, T.2    Boateng, B.3    Zhu, X.Y.4    Ablordeppe, S.Y.5
  • 13
    • 9144246117 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of metabolism-based analogues of haloperidol incapable of forming MPP+-like species
    • Lyles-Eggleston M, Altundas R, Xia J, et al. Design, synthesis, and evaluation of metabolism-based analogues of haloperidol incapable of forming MPP+-like species. J Med Chem 2004; 47: 497-508.
    • (2004) J Med Chem , vol.47 , pp. 497-508
    • Lyles-Eggleston, M.1    Altundas, R.2    Xia, J.3
  • 14
    • 48149085409 scopus 로고    scopus 로고
    • Sila-haloperidol, a silicon analogue of the dopamine (D2) receptor antagonist haloperidol: Synthesis, pharmacological properties, and metabolic fate
    • Tacke R, Popp F, Muller B, et al. Sila-haloperidol, a silicon analogue of the dopamine (D2) receptor antagonist haloperidol: synthesis, pharmacological properties, and metabolic fate. ChemMedChem 2008, 3: 152-64.
    • (2008) ChemMedChem , vol.3 , pp. 152-164
    • Tacke, R.1    Popp, F.2    Muller, B.3
  • 15
    • 0027430025 scopus 로고
    • Detection of a neurotoxic quaternary pyridinium metabolite in the liver of haloperidol-treated rats
    • Ablordeppey SY, Borne RF. Detection of a neurotoxic quaternary pyridinium metabolite in the liver of haloperidol-treated rats. Pharmacol Biochem Behav 1993; 46: 739-44.
    • (1993) Pharmacol Biochem Behav , vol.46 , pp. 739-744
    • Ablordeppey, S.Y.1    Borne, R.F.2
  • 16
    • 0025017124 scopus 로고
    • Identification of a potentially neurotoxic pyridinium metabolite of haloperidol in rats
    • Subramanyam B, Rollema H, Woolf T, Castagnoli N. Identification of a potentially neurotoxic pyridinium metabolite of haloperidol in rats. Biochem Biophys Res Commun 1990; 166: 238-44.
    • (1990) Biochem Biophys Res Commun , vol.166 , pp. 238-244
    • Subramanyam, B.1    Rollema, H.2    Woolf, T.3    Castagnoli, N.4
  • 17
    • 0026337985 scopus 로고
    • Identification of potentially neurotoxic pyridinium metabolite in the urine of schizophrenic patients treated with haloperidol
    • Subramanyam B, Pond SM, Eyles DW, et al. Identification of potentially neurotoxic pyridinium metabolite in the urine of schizophrenic patients treated with haloperidol. Biochem Biophys Res Commun 1991; 181: 573-78.
    • (1991) Biochem Biophys Res Commun , vol.181 , pp. 573-578
    • Subramanyam, B.1    Pond, S.M.2    Eyles, D.W.3
  • 18
    • 0025966719 scopus 로고
    • Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metabolite
    • Subramanyam B, Woolf T, Castagnoli N. Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metabolite. Chem Res Toxicol 1991; 4: 123-28.
    • (1991) Chem Res Toxicol , vol.4 , pp. 123-128
    • Subramanyam, B.1    Woolf, T.2    Castagnoli, N.3
  • 19
    • 0037294430 scopus 로고    scopus 로고
    • Novel, highly potent, selective 5-HT2A/D2 receptor antagonists as potential atypical antipsychotics
    • Lee T, Robichaud AJ, Boyle KE, et al. Novel, highly potent, selective 5-HT2A/D2 receptor antagonists as potential atypical antipsychotics. Bioorg Med Chem Lett 2003; 13: 767-70.
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 767-770
    • Lee, T.1    Robichaud, A.J.2    Boyle, K.E.3
  • 20
    • 0024466603 scopus 로고
    • Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values
    • Meltzer HY, Matsubara S, Lee JC. Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values. J Pharmacol Exp Ther 1989; 251: 238-46.
    • (1989) J Pharmacol Exp Ther , vol.251 , pp. 238-246
    • Meltzer, H.Y.1    Matsubara, S.2    Lee, J.C.3
  • 21
    • 0024854809 scopus 로고
    • The ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs
    • Meltzer HY, Matsubara S, Lee JC. The ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs. Psychopharmacol Bull 1989; 25: 390-92.
    • (1989) Psychopharmacol Bull , vol.25 , pp. 390-392
    • Meltzer, H.Y.1    Matsubara, S.2    Lee, J.C.3
  • 22
    • 0027947142 scopus 로고
    • Atypical Antipsychotics based on the D2/5-HT2 Ratio Hypothesis
    • Lowe III JA. Atypical Antipsychotics based on the D2/5-HT2 Ratio Hypothesis. Curr Med Chem 1994; 1: 50-60.
    • (1994) Curr Med Chem , vol.1 , pp. 50-60
    • Lowe III, J.A.1
  • 23
    • 0028040921 scopus 로고
    • Synthesis and atypical antipsychotic profile of some 2-(2-piperidinoethyl)benzocycloalkanones as analogues of butyrophenone
    • Fontenla JA, Osuna J, Rosa E, et al. Synthesis and atypical antipsychotic profile of some 2-(2-piperidinoethyl)benzocycloalkanones as analogues of butyrophenone. J Med Chem 1994; 37: 2564-73.
    • (1994) J Med Chem , vol.37 , pp. 2564-2573
    • Fontenla, J.A.1    Osuna, J.2    Rosa, E.3
  • 24
    • 0025783781 scopus 로고
    • Synthesis and antidopaminergic activity of some 3-(aminomethyl)tetralones as analogues of butyrophenone
    • Cortizo L, Santana L, Ravina E, et al. Synthesis and antidopaminergic activity of some 3-(aminomethyl)tetralones as analogues of butyrophenone. J Med Chem 1991; 34: 2242-47.
    • (1991) J Med Chem , vol.34 , pp. 2242-2247
    • Cortizo, L.1    Santana, L.2    Ravina, E.3
  • 25
    • 1642575104 scopus 로고    scopus 로고
    • Chemoenzymatic synthesis and binding affinity of novel (R)-and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics
    • Caro Y, Torrado M, Masaguer CF, et al. Chemoenzymatic synthesis and binding affinity of novel (R)-and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics. Bioorg Med Chem Lett 2004; 14: 585-9.
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 585-589
    • Caro, Y.1    Torrado, M.2    Masaguer, C.F.3
  • 26
    • 0027211949 scopus 로고
    • Bridged gammacarbolines and derivatives possessing selective and combined affinity for 5-HT2 and D2 receptors
    • Mewshaw RE, Silverman LS, Mathew RM, et al. Bridged gammacarbolines and derivatives possessing selective and combined affinity for 5-HT2 and D2 receptors. J Med Chem 1993; 36: 1488-95.
    • (1993) J Med Chem , vol.36 , pp. 1488-1495
    • Mewshaw, R.E.1    Silverman, L.S.2    Mathew, R.M.3
  • 27
    • 19944413312 scopus 로고    scopus 로고
    • Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics
    • Alvarado M, Coelho A, Masaguer CF, et al. Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics. Bioorg Med Chem Lett 2005; 15: 3063-66.
    • (2005) Bioorg Med Chem Lett , vol.15 , pp. 3063-3066
    • Alvarado, M.1    Coelho, A.2    Masaguer, C.F.3
  • 28
    • 1642575104 scopus 로고    scopus 로고
    • Chemoenzymatic synthesis and binding affinity of novel (R)-and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics
    • Caro Y, Torrado MA, Masaguer CF, et al. Chemoenzymatic synthesis and binding affinity of novel (R)-and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics. Bioorg. Med. Chem. Lett. 2004; 14: 585-9.
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 585-589
    • Caro, Y.1    Torrado, M.A.2    Masaguer, C.F.3
  • 29
    • 0028947553 scopus 로고
    • Butyrophenone analogues: Synthesis of 2-methyl-3-ethyl-5-aminoethyl-4,5,6,7-tetrahydroindol-4-ones, and their affinities for d1, d2 and 5-ht2a receptors
    • Ravina E, Masaguer CF, Cid J, et al. Butyrophenone analogues: Synthesis of 2-methyl-3-ethyl-5-aminoethyl-4,5,6,7-tetrahydroindol-4-ones, and their affinities for d1, d2 and 5-ht2a receptors. Bioorg Med Chem Lett 1995; 5: 579-84.
    • (1995) Bioorg Med Chem Lett , vol.5 , pp. 579-584
    • Ravina, E.1    Masaguer, C.F.2    Cid, J.3
  • 30
    • 0033032752 scopus 로고    scopus 로고
    • Conformationally Restricted Butyrophenones with Mixed Dopaminergic (D2) and Serotoninergic (5-HT2A) Affinities. Synthesis of 5-Aminoethyl and 6-Aminomethyl-4-oxotetrahydroindoles as Potential Atypical Antipsychotics
    • Masaguer CF, Casariego I, Ravina E. Conformationally Restricted Butyrophenones with Mixed Dopaminergic (D2) and Serotoninergic (5-HT2A) Affinities. Synthesis of 5-Aminoethyl and 6-Aminomethyl-4-oxotetrahydroindoles as Potential Atypical Antipsychotics. Chem Pharm Bull 1999; 47: 621-32.
    • (1999) Chem Pharm Bull , vol.47 , pp. 621-632
    • Masaguer, C.F.1    Casariego, I.2    Ravina, E.3
  • 31
    • 0030907274 scopus 로고    scopus 로고
    • New cyclic butyrophenone derivatives in the indole series as potential atypical antipsychotics. A simple and practical synthesis of 6-aminomethyl tetrahydroindol-4-ones and their affinites for D2 and 5-HT2A receptors
    • Masaguer CF, Raviña E, Loza I, Fontenla J. New cyclic butyrophenone derivatives in the indole series as potential atypical antipsychotics. A simple and practical synthesis of 6-aminomethyl tetrahydroindol-4-ones and their affinites for D2 and 5-HT2A receptors. Bioorg Med Chem Lett 1997; 7: 913-8.
    • (1997) Bioorg Med Chem Lett , vol.7 , pp. 913-918
    • Masaguer, C.F.1    Raviña, E.2    Loza, I.3    Fontenla, J.4
  • 32
    • 0032535552 scopus 로고    scopus 로고
    • Butyrophenone analogues in the carbazole series: Synthesis and determination of affinities at D2 and 5-HT2A receptors
    • Masaguer CF, Formoso E, Ravina E, et al. Butyrophenone analogues in the carbazole series: synthesis and determination of affinities at D2 and 5-HT2A receptors. Bioorg Med Chem Lett 1998; 8: 3571-6.
    • (1998) Bioorg Med Chem Lett , vol.8 , pp. 3571-3576
    • Masaguer, C.F.1    Formoso, E.2    Ravina, E.3
  • 33
    • 0034012571 scopus 로고    scopus 로고
    • Butyrophenone analogues in the carbazole series as potential atypical antipsychotics: Synthesis and determination of affinities at D(2), 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors
    • Masaguer CF, Ravina E, Fontenla JA, et al. Butyrophenone analogues in the carbazole series as potential atypical antipsychotics: synthesis and determination of affinities at D(2), 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Eur J Med Chem 2000; 35: 83-95.
    • (2000) Eur J Med Chem , vol.35 , pp. 83-95
    • Masaguer, C.F.1    Ravina, E.2    Fontenla, J.A.3
  • 35
    • 31544472502 scopus 로고    scopus 로고
    • Bioisosterism: Quantitation of structure and property effects
    • Kier LB, Hall LH. Bioisosterism: quantitation of structure and property effects. Chem Biodivers 2004; 1: 138-51.
    • (2004) Chem Biodivers , vol.1 , pp. 138-151
    • Kier, L.B.1    Hall, L.H.2
  • 36
    • 71749083845 scopus 로고    scopus 로고
    • Synthesis and binding affinity of potential atypical antipsychotics with the tetrahydroquinazolinone motif
    • Carro L, Ravina E, Dominguez E, et al. Synthesis and binding affinity of potential atypical antipsychotics with the tetrahydroquinazolinone motif. Bioorg Med Chem Lett 2009; 19: 6059-62.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 6059-6062
    • Carro, L.1    Ravina, E.2    Dominguez, E.3
  • 37
    • 21544439847 scopus 로고    scopus 로고
    • Dopamine D3 receptor antagonists as therapeutic agents
    • Joyce JN, Millan MJ. Dopamine D3 receptor antagonists as therapeutic agents. Drug Discov Today 2005; 10: 917-25.
    • (2005) Drug Discov Today , vol.10 , pp. 917-925
    • Joyce, J.N.1    Millan, M.J.2
  • 38
    • 0030753879 scopus 로고    scopus 로고
    • New CNS agent precursors. A simple and efficient route for synthesis of 6-aminomethyl-4,5,6,7-tetrahydrobenzofuran-4-ones as conformationally constrained butyrophenone analogues
    • Casariego I, Masaguer CF, Raviña E. New CNS agent precursors. A simple and efficient route for synthesis of 6-aminomethyl-4,5,6,7-tetrahydrobenzofuran-4-ones as conformationally constrained butyrophenone analogues. Tetrahedron Lett 1997; 38: 5555-8.
    • (1997) Tetrahedron Lett , vol.38 , pp. 5555-5558
    • Casariego, I.1    Masaguer, C.F.2    Raviña, E.3
  • 39
    • 0034736151 scopus 로고    scopus 로고
    • Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: Synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics
    • Ravina E, Casariego I, Masaguer CF, et al. Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics. J Med Chem 2000; 43: 4678-93.
    • (2000) J Med Chem , vol.43 , pp. 4678-4693
    • Ravina, E.1    Casariego, I.2    Masaguer, C.F.3
  • 40
    • 0037011897 scopus 로고    scopus 로고
    • New Serotonin 5-HT2A, 5-HT2B, and 5-HT2C Receptor Antagonists: Synthesis, Pharmacology, 3D-QSAR, and Molecular Modeling of (Aminoalkyl)benzo and Heterocycloalkanones
    • Brea J, Rodrigo J, Carrieri A, et al. New Serotonin 5-HT2A, 5-HT2B, and 5-HT2C Receptor Antagonists: Synthesis, Pharmacology, 3D-QSAR, and Molecular Modeling of (Aminoalkyl)benzo and Heterocycloalkanones. J Med Chem 2001; 45: 54-71.
    • (2001) J Med Chem , vol.45 , pp. 54-71
    • Brea, J.1    Rodrigo, J.2    Carrieri, A.3
  • 41
    • 0033614954 scopus 로고    scopus 로고
    • Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: Synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo-and-thienocycloalkanones as putative atypical antipsychotics
    • Ravina E, Negreira J, Cid J, et al. Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo-and-thienocycloalkanones as putative atypical antipsychotics. J Med Chem 1999; 42: 2774-97.
    • (1999) J Med Chem , vol.42 , pp. 2774-2797
    • Ravina, E.1    Negreira, J.2    Cid, J.3
  • 42
    • 0141619390 scopus 로고    scopus 로고
    • Pharmacological evaluation of 5-[2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl]-1,3-dihydro-benzimidazol e-2-thione as a potential atypical antipsychotic agent
    • Tomic M, Kundakovic M, Butorovic B, et al. Pharmacological evaluation of 5-[2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl]-1,3-dihydro-benzimidazol e-2-thione as a potential atypical antipsychotic agent. Pharmazie 2003; 58: 677-78.
    • (2003) Pharmazie , vol.58 , pp. 677-678
    • Tomic, M.1    Kundakovic, M.2    Butorovic, B.3
  • 43
    • 3142691095 scopus 로고    scopus 로고
    • Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential
    • Tomic M, Kundakovic M, Butorovic B, et al. Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential. Bioorg Med Chem Lett 2004; 14: 4263-6.
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 4263-4266
    • Tomic, M.1    Kundakovic, M.2    Butorovic, B.3
  • 44
    • 34648847078 scopus 로고    scopus 로고
    • Two new phenylpiperazines with atypical antipsychotic potential
    • Tomic M, Ignjatovic D, Tovilovic G, et al. Two new phenylpiperazines with atypical antipsychotic potential. Bioorg Med Chem Lett 2007; 17: 5749-53.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 5749-5753
    • Tomic, M.1    Ignjatovic, D.2    Tovilovic, G.3
  • 45
    • 48049117780 scopus 로고    scopus 로고
    • Synthesis, binding properties and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, mixed ligands of D2 and 5-HT1A receptors
    • Andric D, Roglic G, Sukalovic V, Soskic V, Kostic-Rajacic S. Synthesis, binding properties and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, mixed ligands of D2 and 5-HT1A receptors. Eur J Med Chem 2008; 43: 1696-705.
    • (2008) Eur J Med Chem , vol.43 , pp. 1696-1705
    • Andric, D.1    Roglic, G.2    Sukalovic, V.3    Soskic, V.4    Kostic-Rajacic, S.5
  • 46
    • 77957584720 scopus 로고    scopus 로고
    • 6-Alkoxyisoindolin-1-one based dopamine D2 partial agonists as potential antipsychotics
    • Favor DA, Powers JJ, White AD, et al. 6-Alkoxyisoindolin-1-one based dopamine D2 partial agonists as potential antipsychotics. Bioorg Med Chem Lett 2010; 20: 5666-9.
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 5666-5669
    • Favor, D.A.1    Powers, J.J.2    White, A.D.3
  • 47
    • 6444231506 scopus 로고    scopus 로고
    • Selective serotonin re-uptake inhibitor augmentation in the treatment of negative symptoms of schizophrenia
    • Silver H. Selective serotonin re-uptake inhibitor augmentation in the treatment of negative symptoms of schizophrenia. Expert Opin Pharmacother 2004; 5: 2053-58.
    • (2004) Expert Opin Pharmacother , vol.5 , pp. 2053-2058
    • Silver, H.1
  • 48
    • 69949086742 scopus 로고    scopus 로고
    • Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia
    • Rotella DP, McFarlane GR, Greenfield A, et al. Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia. Bioorg Med Chem Lett 2009; 19: 5552-5.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 5552-5555
    • Rotella, D.P.1    McFarlane, G.R.2    Greenfield, A.3
  • 49
  • 50
    • 17944395201 scopus 로고    scopus 로고
    • New arylpiperazine derivatives with high affinity for alpha1A, D2 and 5-HT2A receptors
    • Gonzalez-Gomez JC, Santana L, Uriarte E, et al. New arylpiperazine derivatives with high affinity for alpha1A, D2 and 5-HT2A receptors. Bioorg Med Chem Lett 2003; 13: 175-8.
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 175-178
    • Gonzalez-Gomez, J.C.1    Santana, L.2    Uriarte, E.3
  • 51
    • 0033777513 scopus 로고    scopus 로고
    • Enhancement of antipsychotic-like effects by combined treatment with the alpha1-adrenoceptor antagonist prazosin and the dopamine D2 receptor antagonist raclopride in rats
    • Wadenberg ML, Hertel P, Fernholm R, et al. Enhancement of antipsychotic-like effects by combined treatment with the alpha1-adrenoceptor antagonist prazosin and the dopamine D2 receptor antagonist raclopride in rats. J Neural Transm 2000; 107: 1229-38.
    • (2000) J Neural Transm , vol.107 , pp. 1229-1238
    • Wadenberg, M.L.1    Hertel, P.2    Fernholm, R.3
  • 52
    • 59449085290 scopus 로고    scopus 로고
    • Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: Design, synthesis, and effects on behavior
    • Butini S, Gemma S, Campiani G, et al. Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior. J Med Chem 2009; 52: 151-69.
    • (2009) J Med Chem , vol.52 , pp. 151-169
    • Butini, S.1    Gemma, S.2    Campiani, G.3
  • 53
    • 0028847688 scopus 로고
    • A novel series of arylpiperazines with high affinity and selectivity for the dopamine D3 receptor
    • John Murray P, Harrison LA, Johnson MR, et al. A novel series of arylpiperazines with high affinity and selectivity for the dopamine D3 receptor. Bioorg Med Chem Lett 1995; 5: 219-22.
    • (1995) Bioorg Med Chem Lett , vol.5 , pp. 219-222
    • John Murray, P.1    Harrison, L.A.2    Johnson, M.R.3
  • 54
    • 0035801722 scopus 로고    scopus 로고
    • New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D(2)-receptor and serotonin 5-HT(1A)-receptor affinities
    • Feenstra RW, De Moes J, Hofma JJ, et al. New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D(2)-receptor and serotonin 5-HT(1A)-receptor affinities. Bioorg Med Chem Lett 2001; 11: 2345-9.
    • (2001) Bioorg Med Chem Lett , vol.11 , pp. 2345-2349
    • Feenstra, R.W.1    de Moes, J.2    Hofma, J.J.3
  • 55
    • 53449092050 scopus 로고    scopus 로고
    • Serotonergic approaches in the development of novel antipsychotics
    • Jones CA, McCreary AC. Serotonergic approaches in the development of novel antipsychotics. Neuropharmacology 2008; 55: 1056-65.
    • (2008) Neuropharmacology , vol.55 , pp. 1056-1065
    • Jones, C.A.1    McCreary, A.C.2
  • 56
    • 77249147333 scopus 로고    scopus 로고
    • Searching for multitarget antipsychotics: Discovery of orally active heterocyclic Nphenylpiperazine ligands of D2-like and 5-HT1A receptors
    • Neves G, Menegatti R, Antonio CB, et al. Searching for multitarget antipsychotics: Discovery of orally active heterocyclic Nphenylpiperazine ligands of D2-like and 5-HT1A receptors. Bioorg Med Chem 2010; 18: 1925-35.
    • (2010) Bioorg Med Chem , vol.18 , pp. 1925-1935
    • Neves, G.1    Menegatti, R.2    Antonio, C.B.3
  • 57
    • 22344431960 scopus 로고    scopus 로고
    • Novel antipsychotics activate recombinant human and native rat serotonin 5-HT1A receptors: Affinity, efficacy and potential implications for treatment of schizophrenia
    • Newman-Tancredi A, Assié MB, Leduc N, et al. Novel antipsychotics activate recombinant human and native rat serotonin 5-HT1A receptors: affinity, efficacy and potential implications for treatment of schizophrenia. Int J of Neuropsychoph 2005; 8: 341-56.
    • (2005) Int J of Neuropsychoph , vol.8 , pp. 341-356
    • Newman-Tancredi, A.1    Assié, M.B.2    Leduc, N.3
  • 58
    • 84861576055 scopus 로고    scopus 로고
    • Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-ylacetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT(1A) receptors
    • Sukalovic V, Ignjatovic D, Tovilovic G, et al. Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-ylacetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT(1A) receptors. Bioorg Med Chem Lett 2012; 22: 3967-72.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 3967-3972
    • Sukalovic, V.1    Ignjatovic, D.2    Tovilovic, G.3
  • 59
    • 0037057578 scopus 로고    scopus 로고
    • Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors
    • Asproni B, Pau A, Bitti M, et al. Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors. J Med Chem 2002; 45: 4655-68.
    • (2002) J Med Chem , vol.45 , pp. 4655-4668
    • Asproni, B.1    Pau, A.2    Bitti, M.3
  • 60
    • 33144464648 scopus 로고    scopus 로고
    • Synthesis and SAR of highly potent and selective dopamine D3-receptor antagonists: Variations on the 1H-pyrimidin-2-one theme
    • Geneste H, Amberg W, Backfisch G, et al. Synthesis and SAR of highly potent and selective dopamine D3-receptor antagonists: variations on the 1H-pyrimidin-2-one theme. Bioorg Med Chem Lett 2006; 16: 1934-7.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 1934-1937
    • Geneste, H.1    Amberg, W.2    Backfisch, G.3
  • 61
    • 29544431769 scopus 로고    scopus 로고
    • Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: 1H-pyrimidin-2-one derivatives
    • Geneste H, Backfisch G, Braje W, et al. Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: 1H-pyrimidin-2-one derivatives. Bioorg Med Chem Lett 2006; 16: 490-94.
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 490-494
    • Geneste, H.1    Backfisch, G.2    Braje, W.3
  • 62
    • 77949701274 scopus 로고    scopus 로고
    • Cariprazine (RGH-188), a dopamine D3 receptor-preferring, D3/D2 dopamine receptor antagonist-partial agonist antipsychotic candidate: In vitro and neurochemical profile
    • Kiss B, Horvath A, Nemethy Z, et al. Cariprazine (RGH-188), a dopamine D3 receptor-preferring, D3/D2 dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile. J Pharmacol Exp Ther 2010; 333(1): 328-40.
    • (2010) J Pharmacol Exp Ther , vol.333 , Issue.1 , pp. 328-340
    • Kiss, B.1    Horvath, A.2    Nemethy, Z.3
  • 63
    • 84877037499 scopus 로고    scopus 로고
    • Profile of blonanserin for the treatment of schizophrenia
    • Tenjin T, Miyamoto S, Ninomiya Y, et al. Profile of blonanserin for the treatment of schizophrenia. Neuropsychiatr Dis Treat 2013; 9: 587-94.
    • (2013) Neuropsychiatr Dis Treat , vol.9 , pp. 587-594
    • Tenjin, T.1    Miyamoto, S.2    Ninomiya, Y.3
  • 64
    • 77953753014 scopus 로고    scopus 로고
    • Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity
    • Ishibashi T, Horisawa T, Tokuda K, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther 2010; 334(1): 171-81.
    • (2010) J Pharmacol Exp Ther , vol.334 , Issue.1 , pp. 171-181
    • Ishibashi, T.1    Horisawa, T.2    Tokuda, K.3
  • 65
    • 65149105853 scopus 로고    scopus 로고
    • Synthesis and evaluation of 1-(quinoliloxypropyl)-4-aryl piperazines for atypical antipsychotic effect
    • Bali A, Malhotra S, Dhir H, Kumar A, Sharma A. Synthesis and evaluation of 1-(quinoliloxypropyl)-4-aryl piperazines for atypical antipsychotic effect. Bioorg Med Chem Lett 2009; 19: 3041-4.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 3041-3044
    • Bali, A.1    Malhotra, S.2    Dhir, H.3    Kumar, A.4    Sharma, A.5
  • 66
    • 77950861250 scopus 로고    scopus 로고
    • Synthesis, evaluation and computational studies on a series of acetophenone based 1-(aryloxypropyl)-4-(chloroaryl) piperazines as potential atypical antipsychotics
    • Bali A, Sharma K, Bhalla A, et al. Synthesis, evaluation and computational studies on a series of acetophenone based 1-(aryloxypropyl)-4-(chloroaryl) piperazines as potential atypical antipsychotics. Eur J Med Chem 2010; 45: 2656-62.
    • (2010) Eur J Med Chem , vol.45 , pp. 2656-2662
    • Bali, A.1    Sharma, K.2    Bhalla, A.3
  • 67
    • 0032830939 scopus 로고    scopus 로고
    • Synthesis and preliminary pharmacological investigations of 1-(1,2-dihydro-2-acenaphthylenyl)piperazine derivatives as potential atypical antipsychotic agents in mice
    • Srinivas P, Subramanian AR, Brust P, et al. Synthesis and preliminary pharmacological investigations of 1-(1,2-dihydro-2-acenaphthylenyl)piperazine derivatives as potential atypical antipsychotic agents in mice. Farmaco 1999; 54: 567-72.
    • (1999) Farmaco , vol.54 , pp. 567-572
    • Srinivas, P.1    Subramanian, A.R.2    Brust, P.3
  • 68
    • 13344283414 scopus 로고    scopus 로고
    • 3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents
    • Howard HR, Lowe JA, Seeger TF, et al. 3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents. J Med Chem 1996; 39: 143-8.
    • (1996) J Med Chem , vol.39 , pp. 143-148
    • Howard, H.R.1    Lowe, J.A.2    Seeger, T.F.3
  • 69
    • 0025784898 scopus 로고
    • 1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents
    • Lowe JA, Seeger TF, Nagel AA, et al. 1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents. J Med Chem 1991; 34: 1860-6.
    • (1991) J Med Chem , vol.34 , pp. 1860-1866
    • Lowe, J.A.1    Seeger, T.F.2    Nagel, A.A.3
  • 70
    • 55549131866 scopus 로고    scopus 로고
    • Synthesis and preliminary pharmacological evaluation of N-2-(4-(4-(2-substitutedthiazol-4-yl) piperazin-1-yl)-2-oxoethyl)acetamides as novel atypical antipsychotic agents
    • Sekhar KV, Rao VS, Vyas DR, Kumar MM. Synthesis and preliminary pharmacological evaluation of N-2-(4-(4-(2-substitutedthiazol-4-yl) piperazin-1-yl)-2-oxoethyl)acetamides as novel atypical antipsychotic agents. Bioorg Med Chem Lett 2008; 18: 6054-7.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 6054-6057
    • Sekhar, K.V.1    Rao, V.S.2    Vyas, D.R.3    Kumar, M.M.4
  • 71
    • 0024466603 scopus 로고
    • Lee JC. Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values
    • Meltzer HY, Matsubara S, Lee JC. Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values. J Pharmacol Expl Ther 1989; 251: 238-46.
    • (1989) J Pharmacol Expl Ther , vol.251 , pp. 238-246
    • Meltzer, H.Y.1    Matsubara, S.2
  • 72
    • 0033578044 scopus 로고    scopus 로고
    • New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: Chemistry and pharmacological evaluation
    • Liao Y, Venhuis BJ, Rodenhuis N, et al. New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. J Med Chem 1999; 42: 2235-44.
    • (1999) J Med Chem , vol.42 , pp. 2235-2244
    • Liao, Y.1    Venhuis, B.J.2    Rodenhuis, N.3
  • 73
    • 14444269458 scopus 로고    scopus 로고
    • New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure
    • Campiani G, Nacci V, Bechelli S, et al. New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure. J Med Chem 1998; 41: 3763-72.
    • (1998) J Med Chem , vol.41 , pp. 3763-3772
    • Campiani, G.1    Nacci, V.2    Bechelli, S.3
  • 74
    • 0037122780 scopus 로고    scopus 로고
    • Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies
    • Campiani G, Butini S, Gemma S, et al. Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies. J Med Chem 2002; 45: 344-59.
    • (2002) J Med Chem , vol.45 , pp. 344-359
    • Campiani, G.1    Butini, S.2    Gemma, S.3
  • 75
    • 9144232388 scopus 로고    scopus 로고
    • Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents
    • Campiani G, Butini S, Fattorusso C, et al. Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents. J Med Chem 2004; 47: 143-57.
    • (2004) J Med Chem , vol.47 , pp. 143-157
    • Campiani, G.1    Butini, S.2    Fattorusso, C.3
  • 76
    • 20144377689 scopus 로고    scopus 로고
    • Novel atypical antipsychotic agents: Rational design, an efficient palladiumcatalyzed route, and pharmacological studies
    • Campiani G, Butini S, Fattorusso C, et al. Novel atypical antipsychotic agents: rational design, an efficient palladiumcatalyzed route, and pharmacological studies. J Med Chem 2005; 48: 1705-8.
    • (2005) J Med Chem , vol.48 , pp. 1705-1708
    • Campiani, G.1    Butini, S.2    Fattorusso, C.3
  • 77
    • 0029130158 scopus 로고
    • Putative atypical antipsychotics with mixed dopaminergic (D1, D2) and serotonergic (5HT2) activity: The design evolution of ZD3638
    • Klimas MT, Goldstein JM, Trainor DA, et al. Putative atypical antipsychotics with mixed dopaminergic (D1, D2) and serotonergic (5HT2) activity: The design evolution of ZD3638. Bioorg Med Chem Lett 1995; 5: 1795-800.
    • (1995) Bioorg Med Chem Lett , vol.5 , pp. 1795-1800
    • Klimas, M.T.1    Goldstein, J.M.2    Trainor, D.A.3
  • 78
    • 74549125415 scopus 로고    scopus 로고
    • BL-1020, an oral antipsychotic agent that reduces dopamine activity and enhances GABA
    • Fitzgerald PB. BL-1020, an oral antipsychotic agent that reduces dopamine activity and enhances GABA. Curr Opin Investig Drugs. 2010; 11(1): 92-100.
    • (2010) Curr Opin Investig Drugs , vol.11 , Issue.1 , pp. 92-100
    • Fitzgerald, P.B.1
  • 79
    • 58649100010 scopus 로고    scopus 로고
    • Asenapine: A novel psychopharmacologic agent with a unique human receptor signature
    • Shahid M, Walker GB, Zorn SH, Wong E. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009; 23(1): 65-73.
    • (2009) J Psychopharmacol , vol.23 , Issue.1 , pp. 65-73
    • Shahid, M.1    Walker, G.B.2    Zorn, S.H.3    Wong, E.4
  • 80
    • 0032585501 scopus 로고    scopus 로고
    • 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen-4-one (abaperidone, FI-8602)
    • Bolos J, Anglada L, Gubert S, et al. 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen-4-one (abaperidone, FI-8602). J Med Chem 1998; 41: 5402-9.
    • (1998) J Med Chem , vol.41 , pp. 5402-5409
    • Bolos, J.1    Anglada, L.2    Gubert, S.3
  • 81
    • 84860447812 scopus 로고    scopus 로고
    • Synthesis and Evaluation of a Series of 2-Substituted-5-Thiopropylpiperazine (Piperidine)-1, 3, 4-Oxadiazoles Derivatives as Atypical Antipsychotics
    • e35186
    • Chen Y, Xu X, Liu X, et al. Synthesis and Evaluation of a Series of 2-Substituted-5-Thiopropylpiperazine (Piperidine)-1, 3, 4-Oxadiazoles Derivatives as Atypical Antipsychotics. PLoS One 2012; 7: e35186.
    • (2012) PLoS One , vol.7
    • Chen, Y.1    Xu, X.2    Liu, X.3
  • 82
    • 0026562188 scopus 로고
    • In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone
    • Leysen JE, Janssen P, Gommeren W, Wynants J, Pauwels PJ, Janssen P. In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone. Mol pharmacol. 1992; 41(3): 494-508.
    • (1992) Mol Pharmacol , vol.41 , Issue.3 , pp. 494-508
    • Leysen, J.E.1    Janssen, P.2    Gommeren, W.3    Wynants, J.4    Pauwels, P.J.5    Janssen, P.6
  • 84
    • 84875235187 scopus 로고    scopus 로고
    • Paliperidone in the treatment of Schizophrenia: An overview
    • Capasso A, Milano W. Paliperidone in the treatment of Schizophrenia: An overview. Curr Neurobiol 2012; 3(2): 133-50.
    • (2012) Curr Neurobiol , vol.3 , Issue.2 , pp. 133-150
    • Capasso, A.1    Milano, W.2
  • 85
    • 0033004807 scopus 로고    scopus 로고
    • Synthesis and Pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT
    • Homan EJ, Copinga S, Unelius L, et al. Synthesis and Pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT. Bioorg Med Chem 1999; 7: 1263-71.
    • (1999) Bioorg Med Chem , vol.7 , pp. 1263-1271
    • Homan, E.J.1    Copinga, S.2    Unelius, L.3
  • 86
    • 0032589349 scopus 로고    scopus 로고
    • Synthesis and dopamine D2-like receptor binding affinity of substituted 5-phenyl-pyrrole-3-carboxamides
    • Pinna GA, Curzu MM, Sechi M, Chelucci G, Maciocco E. Synthesis and dopamine D2-like receptor binding affinity of substituted 5-phenyl-pyrrole-3-carboxamides. Farmaco 1999; 54: 542-50.
    • (1999) Farmaco , vol.54 , pp. 542-550
    • Pinna, G.A.1    Curzu, M.M.2    Sechi, M.3    Chelucci, G.4    Maciocco, E.5
  • 87
    • 0032700686 scopus 로고    scopus 로고
    • Synthesis and pharmacological evaluation of novel 4-(4-fluorobenzoyl)piperidine derivatives as mixed 5-HT1A/5-HT2A/D2 receptor ligands
    • Diouf O, Carato P, Lesieur I, Rettori MC, Caignard DH. Synthesis and pharmacological evaluation of novel 4-(4-fluorobenzoyl)piperidine derivatives as mixed 5-HT1A/5-HT2A/D2 receptor ligands. Eur J Med Chem 1999; 34: 69-73.
    • (1999) Eur J Med Chem , vol.34 , pp. 69-73
    • Diouf, O.1    Carato, P.2    Lesieur, I.3    Rettori, M.C.4    Caignard, D.H.5
  • 88
    • 0035927196 scopus 로고    scopus 로고
    • Pharmacological evaluation of a diarylmethylene-piperidine derivative: A new potent atypical antipsychotic?
    • Talaga P, Matagne A, Klitgaard H. Pharmacological evaluation of a diarylmethylene-piperidine derivative: a new potent atypical antipsychotic? Bioorg Med Chem Lett 2001; 11: 1313-6.
    • (2001) Bioorg Med Chem Lett , vol.11 , pp. 1313-1316
    • Talaga, P.1    Matagne, A.2    Klitgaard, H.3
  • 89
    • 33846087420 scopus 로고    scopus 로고
    • Studies towards the identification of a new generation of atypical antipsychotic agents
    • Garzya V, Forbes IT, Gribble AD, et al. Studies towards the identification of a new generation of atypical antipsychotic agents. Bioorg Med Chem Lett 2007; 17: 400-5.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 400-405
    • Garzya, V.1    Forbes, I.T.2    Gribble, A.D.3
  • 90
    • 84862498407 scopus 로고    scopus 로고
    • Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia
    • Langlois X, Megens A, Lavreysen H, et al. Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia. J Pharmacol Exp Ther 2012; 342: 91-105.
    • (2012) J Pharmacol Exp Ther , vol.342 , pp. 91-105
    • Langlois, X.1    Megens, A.2    Lavreysen, H.3
  • 91
    • 77954348924 scopus 로고    scopus 로고
    • Synthesis and antipsychotic and anticonvulsant activity of some new substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles
    • Kaur H, Kumar S, Vishwakarma P, et al. Synthesis and antipsychotic and anticonvulsant activity of some new substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles. Eur J Med Chem 2010; 45: 2777-83.
    • (2010) Eur J Med Chem , vol.45 , pp. 2777-2783
    • Kaur, H.1    Kumar, S.2    Vishwakarma, P.3
  • 92
    • 0035938409 scopus 로고    scopus 로고
    • 1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors
    • Sabb AL, Vogel RL, Kelly MG, et al. 1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors. Bioorg Med Chem Lett 2001; 11: 1069-71.
    • (2001) Bioorg Med Chem Lett , vol.11 , pp. 1069-1071
    • Sabb, A.L.1    Vogel, R.L.2    Kelly, M.G.3
  • 93
    • 70449625291 scopus 로고    scopus 로고
    • Synthesis and pharmacological evaluation of novel N-alkyl/aryl substituted thiazolidinone arecoline analogues as muscarinic receptor 1 agonist in Alzheimer's dementia models
    • Sadashiva CT, Chandra JN, Kavitha CV, et al. Synthesis and pharmacological evaluation of novel N-alkyl/aryl substituted thiazolidinone arecoline analogues as muscarinic receptor 1 agonist in Alzheimer's dementia models. Eur J Med Chem 2009; 44: 4848-54.
    • (2009) Eur J Med Chem , vol.44 , pp. 4848-4854
    • Sadashiva, C.T.1    Chandra, J.N.2    Kavitha, C.V.3
  • 94
    • 84861680445 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of some new substituted benzoxazepine and benzothiazepine as antipsychotic as well as anticonvulsant agents
    • Kaur H, Kumar S, Chaudhary A, Kumar A. Synthesis and biological evaluation of some new substituted benzoxazepine and benzothiazepine as antipsychotic as well as anticonvulsant agents. Arab J of Chem 2012; 5: 271-83.
    • (2012) Arab J of Chem , vol.5 , pp. 271-283
    • Kaur, H.1    Kumar, S.2    Chaudhary, A.3    Kumar, A.4


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