New CNS agent precursors. A simple and efficient route for synthesis of 6-aminomethyl-4,5,6,7- tetrahydrobenzofuran-4-ones as conformationally constrained butyrophenone analogues

Tetrahedron Letters

Volumn 38, Issue 31, 1997, Pages 5555-5558

  Casariego, Isabel ^a   Masaguer, Christian F ^a   Raviña, Enrique ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

6 AMINOMETHYL 4,5,6,7 TETRAHYDROBENZOFURAN 4 ONE DERIVATIVE; BUTYROPHENONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0030753879     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01242-2     Document Type: Article

References (19)

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17. 4) and concentrated under reduced presure. Silica gel chromatography of the residue (hexane/ethyl acetate 1:4 as eluent) gave the alcohol 2 (0.63 g, 60%) as yellow oil.
18. 2: C, 70.55%; H, 8.65%; N, 6.32. Found: C, 70.81; H, 8.64; N, 6.13.
19. 13C-NMR, FTIR, MS). Yields given correspond to isolated pure compounds.