Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 5, 2010, Pages 1925-1935

  Neves, Gilda ^a,b   Menegatti, Ricardo ^b,c   Antonio, Camila B ^a   Grazziottin, Luiza R ^a   Vieira, Renan O ^b   Rates, Stela M K ^a   Noël, François ^b   Barreiro, Eliezer J ^b   Fraga, Carlos A M ^b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c UFGO Universidade Federal University de Goiás   (Brazil)

Author keywords

1 Aryl 1,2,3 triazole; 1 Arylpyrazole; Atypical antipsychotic drugs; Imidazo 1,2 a pyridine; N Phenylpiperazine derivatives; Schizophrenia

Indexed keywords

1 (4 CHLOROPHENYL) 4 [(1 PHENYL 1H 1,2,3 TRIAZOL 4 YL)METHYL]PIPERAZINE; 1 (4 CHLOROPHENYL) 4 [(1 PHENYL 1H PYRAZOL 4 YL)METHYL]PIPERAZINE; 1 (4 CHLOROPHENYL) 4 [[1 (4 CHLOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]PIPERAZINE; 1 (4 CHLOROPHENYL) 4 [[1 (4 CHLOROPHENYL) 1H PYRAZOL 4 YL]METHYL]PIPERAZINE; 1 (4 FLUOROPHENYL) 4 [(1 PHENYL 1H 1,2,3 TRIAZOL 4 YL)METHYL]PIPERAZINE; 1 (4 FLUOROPHENYL) 4 [(1 PHENYL 1H PYRAZOL 4 YL)METHYL]PIPERAZINE; 1 (4 FLUOROPHENYL) 4 [[1 (4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]PIPERAZINE; 1 (4 FLUOROPHENYL) 4 [[1 (4 FLUOROPHENYL) 1H PYRAZOL 4-YL]METHYL]PIPERAZINE; 1 (4 HYDROXYPHENYL) 4 [[1 (4 CHLOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]PIPERAZINE; 1 (4 METHOXYPHENYL) 4 [[1 (4 CHLOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]PIPERAZINE; 1 [[1 (4 CHLOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 4 PHENYLPIPERAZINE; 1 [[1 (4 CHLOROPHENYL) 1H PYRAZOL 4 YL]METHYL] 4 (4 METHOXYPHENYL)PIPERAZINE; 1 [[1 (4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 4 PHENYLPIPERAZINE; 1 [[1 (4 FLUOROPHENYL) 1H PYRAZOL 4 YL]METHYL] 4 PHENYLPIPERAZINE; 1 [[1 (4 NITROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 4 PHENYLPIPERAZINE; 1 [[1(4 CHLOROPHENYL) 1H PYRAZOL 4 YL]METHYL] 4 PHENYLPIPERAZINE; 1 PHENYL 4 [(1 PHENYL 1H 1,2,3 TRIAZOL 4 YL)METHYL]PIPERAZINE; 1 PHENYL 4 [(1 PHENYL 1H PYRAZOL 4 YL)METHYL]PIPERAZINE; 2 METHYL 3 (4 PHENYLPIPERAZINYLMETHYL)IMIDAZO[1,2 A] PYRIDINE; 2 METHYL 3 [4 (4 CHLOROPHENYL)PIPERAZINYLMETHYL]IMIDAZO[1,2 A]PYRIDINE; 4 [4 (4 PHENYLPIPERAZINILMETIL) 1H 1,2,3 TRIAZOL 4 YL]ACETAMIDE; 4 [4 (4 PHENYLPIPERAZINILMETIL) 1H 1,2,3 TRIAZOL 4 YL]ANILINE; CLOZAPINE; DOPAMINE 2 RECEPTOR; HALOPERIDOL; LASSBIO 579; LASSBIO 664; NEUROLEPTIC AGENT; PIPERAZINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALEPSY; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; MALE; NONHUMAN; RAT; ROTAROD TEST; SCHIZOPHRENIA; SUBSTITUTION REACTION;

ADMINISTRATION, ORAL; ANIMALS; ANTIPSYCHOTIC AGENTS; CELL LINE; HUMANS; LIGANDS; MALE; MICE; PIPERAZINES; PYRAZOLES; RATS; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, DOPAMINE D2; SCHIZOPHRENIA;

EID: 77249147333     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.040     Document Type: Article

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