New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure

Journal of Medicinal Chemistry

Volumn 41, Issue 20, 1998, Pages 3763-3772

  Campiani, Giuseppe ^a   Nacci, Vito ^a   Bechelli, Susanna ^a   Ciani, Silvia M ^a   Garofalo, Antonio ^a   Fiorini, Isabella ^a   Wikström, Håkan ^b   De Boer, Peter ^b   Liao, Yi ^b   Tepper, Pieter G ^b   Cagnotto, Alfredo ^c   Mennini, Tiziana ^c  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 7 CHLORO 9 (4 METHYLPIPERAZIN 1 YL) 9,10 DIHYDROPYRROLO[2,1 B][1,3]BENZOTHIAZEPINE; APOMORPHINE; BENZOTHIAZEPINE DERIVATIVE; CLOROTEPINE; CLOZAPINE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; NEUROLEPTIC AGENT; OLANZAPINE; SEROTONIN 2 RECEPTOR; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALEPSY; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE BRAIN LEVEL; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LOCOMOTION; MALE; NONHUMAN; PSYCHOSIS; RAT; RECEPTOR AFFINITY;

3,4-DIHYDROXYPHENYLACETIC ACID; ANIMALS; ANTIPSYCHOTIC AGENTS; BRAIN; CATALEPSY; DOPAMINE; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MOTOR ACTIVITY; PYRROLES; RATS; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZEPINES;

EID: 14444269458     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9706832     Document Type: Article

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