The gut microbiota of insects - diversity in structure and function

FEMS Microbiology Reviews

Volumn 37, Issue 5, 2013, Pages 699-735

  Engel, Philipp ^a   Moran, Nancy A ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

Bacterial diversity; Digestive system; Gut communities; Immune system; Mutualism; Symbiosis

Indexed keywords

INSECTICIDE; RNA 16S;

ANIMAL STRUCTURES; ANT; BACTERIAL STRAIN; BEE; BENEFICIAL INSECT; DEFECATION; DIGESTION; DIGESTIVE FUNCTION; DIGESTIVE SYSTEM; ENDOSYMBIONT; GENE EXPRESSION; HABITAT; IMMUNOCOMPETENCE; IMMUNOMODULATION; INNATE IMMUNITY; INSECT; INSECT DEVELOPMENT; INSECT SOCIETY; INTESTINE FLORA; ISOPTERA; MALPIGHIAN TUBULE; METAGENOMICS; MICROBIAL ACTIVITY; MICROBIAL COLONIZATION; MICROBIAL COMMUNITY; MIDGUT; MORPHOLOGY; NONHUMAN; NUTRIENT AVAILABILITY; NUTRITION; PATHOGENESIS; PHYSIOLOGY; PROTECTION; REVIEW; SOCIAL INTERACTION; SYMBIOSIS; VERTICAL TRANSMISSION;

BACTERIAL DIVERSITY; DIGESTIVE SYSTEM; GUT COMMUNITIES; IMMUNE SYSTEM; MUTUALISM; SYMBIOSIS;

ANIMALS; ECOSYSTEM; GASTROINTESTINAL TRACT; INSECTS; MICROBIOTA; SYMBIOSIS;

APOIDEA; BACTERIA (MICROORGANISMS); FORMICIDAE; HEXAPODA; ISOPTERA; MAMMALIA;

EID: 84881248839     PISSN: 01686445     EISSN: 15746976     Source Type: Journal    
DOI: 10.1111/1574-6976.12025     Document Type: Review

References (356)

1. Abe T, Bignell DE & Higashi M (2000) Termites: Evolution, Sociality, Symbioses, Ecology. Springer-Verlag, New York.
2. Aguilar CN, Rodríguez R, Gutiérrez-Sánchez G, Augur C, Favela-Torres E, Prado-Barragan LA, Ramírez-Coronel A & Contreras-Esquivel JC (2007a) Microbial tannases: advances and perspectives. Appl Microbiol Biotechnol 76: 47-59.
3. Aguilar R, Das S, Dong Y & Dimopoulos G (2007b) Continuous exposure to Plasmodium results in decreased susceptibility and transcriptomic divergence of the Anopheles gambiae immune system. BMC Genomics 8: 451.
4. Aharon Y, Pasternak Z, Ben Yosef M, Behar A, Lauzon C, Yuval B & Jurkevitch E (2013) Phylogenetic, metabolic, and taxonomic diversities shape Mediterranean fruit fly microbiotas during ontogeny. Appl Environ Microbiol 79: 303-313.
5. Aksoy S, Weiss B & Attardo G (2008) Paratransgenesis applied for control of tsetse transmitted sleeping sickness. Adv Exp Med Biol 627: 35-48.
6. Alborn HT, Turlings TCJ, Jones TH, Stenhagen G, Loughrin JH & Tumlinson JH (1997) An elicitor of plant volatiles from beet armyworm oral secretion. Science 276: 945-949.
7. Amcheslavsky A, Jiang J & Ip YT (2009) Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell 4: 49-61.
8. Anand AAP, Vennison SJ, Sankar SG, Prabhu DIG, Vasan PT, Raghuraman T, Geoffrey CJ & Vendan SE (2010) Isolation and characterization of bacteria from the gut of Bombyx mori that degrade cellulose, xylan, pectin and starch and their impact on digestion. J Insect Sci 10: 107.
9. Anderson KE, Russell JA, Moreau CS, Kautz S, Sullam KE, Hu Y, Basinger U, Mott BM, Buck N & Wheeler DE (2012) Highly similar microbial communities are shared among related and trophically similar ant species. Mol Ecol 21: 2282-2296.
10. Andert J, Geissinger O & Brune A (2008) Peptidic soil components are a major dietary resource for the humivorous larvae of Pachnoda spp. (Coleoptera: Scarabaeidae). J Insect Physiol 54: 105-113.
11. Appel HM & Martin MM (1990) Gut redox conditions in herbivorous lepidopteran larvae. J Chem Ecol 16: 3277-3290.
12. Ariizumi T & Toriyama K (2011) Genetic regulation of sporopollenin synthesis and pollen exine development. Annu Rev Plant Biol 62: 437-460.
13. Ash C (2011) Control and cooperation. Sci Signal 4: ec300.
14. Ashida H, Ogawa M, Kim M, Mimuro H & Sasakawa C (2012) Bacteria and host interactions in the gut epithelial barrier. Nat Chem Biol 8: 36-45.
15. Attardo GM, Lohs C, Heddi A, Alam UH, Yildirim S & Aksoy S (2008) Analysis of milk gland structure and function in Glossina morsitans: milk protein production, symbiont populations and fecundity. J Insect Physiol 54: 1236-1242.
16. Ayres JS & Schneider DS (2009) The role of anorexia in resistance and tolerance to infections in Drosophila. PLoS Biol 7: e1000150.
17. Ayres JS & Schneider DS (2012) Tolerance of infections. Annu Rev Immunol 30: 271-294.
18. Azambuja P, Garcia ES & Ratcliffe NA (2005) Gut microbiota and parasite transmission by insect vectors. Trends Parasitol 21: 568-572.
19. Bäckhed F, Ley RE, Sonnenburg JL, Peterson DA & Gordon JI (2005) Host-bacterial mutualism in the human intestine. Science 307: 1915-1920.
20. Barbehenn RV & Martin MM (1997) Permeability of the peritrophic envelopes of herbivorous insects to dextran sulfate: a test of the polyanion exclusion hypothesis. J Insect Physiol 43: 243-249.
21. Bartlett JG (1979) Antibiotic-associated pseudomembranous colitis. Rev Infect Dis 1: 530-539.
22. Basset Y, Cizek L, Cuénoud P et al. (2012) Arthropod diversity in a tropical forest. Science 338: 1481-1484.
23. Baumann P (2005) Biology bacteriocyte-associated endosymbionts of plant sap-sucking insects. Annu Rev Microbiol 59: 155-189.
24. Beard CB, Cordon-Rosales C & Durvasula RV (2002) Bacterial symbionts of the Triatominae and their potential use in control of Chagas disease transmission. Annu Rev Entomol 47: 123-141.
25. Becker N (2000) Bacterial control of vector-mosquitoes and black flies. Entomopathogenic Bacteria: From Laboratory to Field Application (Charles JF, Delécluse A & Nielsen-le Roux C, eds), pp. 383-398. Springer-Verlag, New York.
26. Beier MS, Pumpuni CB, Beier JC & Davis JR (1994) Effects of para-aminobenzoic acid, insulin, and gentamicin on Plasmodium falciparum development in anopheline mosquitoes (Diptera: Culicidae). J Med Entomol 31: 561-565.
27. Ben Ami E, Yuval B & Jurkevitch E (2010) Manipulation of the microbiota of mass-reared Mediterranean fruit flies Ceratitis capitata (Diptera: Tephritidae) improves sterile male sexual performance. ISME J 4: 28-37.
28. Benemann JR (1973) Nitrogen fixation in termites. Science 181: 164-165.
29. Berenbaum M (1980) Adaptive significance of midgut pH in larval Lepidoptera. Am Nat 115: 138-146.
30. Bextine B, Lauzon C, Potter S, Lampe D & Miller TA (2004) Delivery of a genetically marked Alcaligenes sp. to the glassy-winged sharpshooter for use in a paratransgenic control strategy. Curr Microbiol 48: 327-331.
31. Bextine B, Lampe D, Lauzon C, Jackson B & Miller TA (2005) Establishment of a genetically marked insect-derived symbiont in multiple host plants. Curr Microbiol 50: 1-7.
32. Bignell DE (2010) Morphology, physiology, biochemistry and functional design of the termite gut: an evolutionary wonderland. Biology of Termites: A Modern Synthesis (Bignell DE, Roisin Y & Lo N, eds), pp. 375-412. Springer, Dordrecht.
33. Bignell DE, Eggleton P, Nunes L & Thomas KL (1997) Termites as mediators of carbon fluxes in tropical forests: budgets for carbon dioxide and methane emissions. Forests and Insects (Watt AD, Stork NE & Hunter MD, eds), pp. 109-134. Chapman & Hall, London.
34. Bischoff V, Vignal C, Duvic B, Boneca IG, Hoffmann JA & Royet J (2006) Down-regulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2. PLoS Pathog 2: e14.
35. Bisi DC & Lampe DJ (2011) Secretion of anti-Plasmodium effector proteins from a natural Pantoea agglomerans isolate by using PelB and HlyA secretion signals. Appl Environ Microbiol 77: 4669-4675.
36. Blumberg R & Powrie F (2012) Microbiota, disease, and back to health: a metastable journey. Sci Transl Med 4: 137rv7.
37. Boissière A, Tchioffo MT, Bachar D et al. (2012) Midgut microbiota of the malaria mosquito vector Anopheles gambiae and interactions with Plasmodium falciparum infection. PLoS Pathog 8: e1002742.
38. Bosco-Drayon V, Poidevin M, Boneca IG, Narbonne-Reveau K, Royet J & Charroux B (2012) Peptidoglycan sensing by the receptor PGRP-LE in the Drosophila gut induces immune responses to infectious bacteria and tolerance to microbiota. Cell Host Microbe 12: 153-165.
39. Boudko DY, Moroz LL, Linser PJ, Trimarchi JR, Smith PJ & Harvey WR (2001) In situ analysis of pH gradients in mosquito larvae using non-invasive, self-referencing, pH-sensitive microelectrodes. J Exp Biol 204: 691-699.
40. Boyer L, Magoc L, Dejardin S (2011) Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway. Immunity 35: 536-549.
41. Brandt SM, Dionne MS, Khush RS, Pham LN, Vigdal TJ & Schneider DS (2004) Secreted bacterial effectors and host-produced Eiger/TNF drive death in a Salmonella-infected fruit fly. PLoS Biol 2: e418.
42. Bravo A, Likitvivatanavong S, Gill SS & Soberón M (2011) Bacillus thuringiensis: a story of a successful bioinsecticide. Insect Biochem Mol Biol 41: 423-431.
43. Breznak JA & Switzer JM (1986) Acetate synthesis from H(2) plus CO(2) by termite gut microbes. Appl Environ Microbiol 52: 623-630.
44. Breznak JA, Brill WJ, Mertins JW & Coppel HC (1973) Nitrogen fixation in termites. Nature 244: 577-580.
45. Broderick NA & Lemaitre B (2012) Gut-associated microbes of Drosophila melanogaster. Gut Microbes 3: 307-321.
46. Broderick NA, Raffa KF, Goodman RM & Handelsman J (2004) Census of the bacterial community of the gypsy moth larval midgut by using culturing and culture-independent methods. Appl Environ Microbiol 70: 293-300.
47. Broderick NA, Raffa KF & Handelsman J (2006) Midgut bacteria required for Bacillus thuringiensis insecticidal activity. P Natl Acad Sci USA 103: 15196-15199.
48. Broderick NA, Robinson CJ, McMahon MD, Holt J, Handelsman J & Raffa KF (2009) Contributions of gut bacteria to Bacillus thuringiensis-induced mortality vary across a range of Lepidoptera. BMC Biol 7: 11.
49. Brummel T, Ching A, Seroude L, Simon AF & Benzer S (2004) Drosophila lifespan enhancement by exogenous bacteria. P Natl Acad Sci USA 101: 12974-12979.
50. Brune A (2006) Symbiotic associations between termites and prokaryotes. Prokaryotes (Dworkin M & Falkow S, eds), pp. 439-474. Springer, New York.
51. Brune A (2010) Methanogens in the digestive tract of termites. (Endo)symbiotic Methanogenic Archaea (Microbiology Monographs) (Hackstein JHP, ed.), pp. 81-100. Springer, Berlin.
52. Brune A & Friedrich M (2000) Microecology of the termite gut: structure and function on a microscale. Curr Opin Microbiol 3: 263-269.
53. Brune A & Ohkuma M (2010) Role of the termite gut microbiota in symbiotic digestion. Biology of Termites: A Modern Synthesis (Bignell DE, Roisin Y & Lo N, eds), pp. 439-475. Springer, Dordrecht.
54. Brune A, Emerson D & Breznak JA (1995) The termite gut microflora as an oxygen sink: microelectrode determination of oxygen and pH gradients in guts of lower and higher termites. Appl Environ Microbiol 61: 2681-2687.
55. Buchner P (ed.) (1965) Endosymbiosis of Animals with Plant Microorganisms. John Wiley, New York.
56. Buchon N, Broderick NA, Chakrabarti S & Lemaitre B (2009a) Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev 23: 2333-2344.
57. Buchon N, Broderick NA, Poidevin M, Pradervand S & Lemaitre B (2009b) Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. Cell Host Microbe 5: 200-211.
58. Burnum KE, Callister SJ, Nicora CD, Purvine SO, Hugenholtz P, Warnecke F, Scheffrahn RH, Smith RD & Lipton MS (2010) Proteome insights into the symbiotic relationship between a captive colony of Nasutitermes corniger and its hindgut microbiome. ISME J 5: 161-164.
59. Bution ML & Caetano FH (2008) Ileum of the Cephalotes ants: a specialized structure to harbor symbionts microorganisms. Micron 39: 897-909.
60. Caetano FH, Bution ML & Zara FJ (2009) First report of endocytobionts in the digestive tract of ponerine ants. Micron 40: 194-197.
61. Caragata EP & Walker T (2012) Using bacteria to treat diseases. Expert Opin Biol Ther 12: 701-712.
62. Casadevall A & Pirofski L-A (2003) The damage-response framework of microbial pathogenesis. Nat Rev Microbiol 1: 17-24.
63. Casali A & Batlle E (2009) Intestinal stem cells in mammals and Drosophila. Cell Stem Cell 4: 124-127.
64. Cazemier AE, Hackstein JHP, Op den Camp HJM, Rosenberg J & van der Drift C (1997) Bacteria in the intestinal tract of different species of arthropods. Microb Ecol 33: 189-197.
65. Chambers MC & Schneider DS (2012) Pioneering immunology: insect style. Curr Opin Immunol 24: 10-14.
66. Chambers MC, Lightfield KL & Schneider DS (2012) How the fly balances its ability to combat different pathogens. PLoS Pathog 8: e1002970.
67. Chandler JA, Lang JM, Bhatnagar S, Eisen JA & Kopp A (2011) Bacterial communities of diverse Drosophila species: ecological context of a host-microbe model system. PLoS Genet 7: e1002272.
68. Chapman RF, Simpson SJ & Douglas AE (2013) The Insects: Structure and Function, 5th edn. Cambridge University Press, Cambridge.
69. Charroux B & Royet J (2010) Drosophila immune response: from systemic antimicrobial peptide production in fat body cells to local defense in the intestinal tract. Fly 4: 40-47.
70. Cheung WWK & Purcell AH (1993) Ultrastructure of the digestive system of the Le fhopper Euscelidius variegatus Kirshbaum (Homoptera: Cicadellidae), with and without congenital bacterial infections. Int J Insect Morphol Embryol 22: 49-61.
71. Chisholm ST, Coaker G, Day B & Staskawicz BJ (2006) Host-microbe interactions: shaping the evolution of the plant immune response. Cell 124: 803-814.
72. Chouaia B, Rossi P, Montagna M et al. (2010) Molecular evidence for multiple infections as revealed by typing of Asaia bacterial symbionts of four mosquito species. Appl Environ Microbiol 76: 7444-7450.
73. Chouaia B, Rossi P, Epis S et al. (2012) Delayed larval development in Anopheles mosquitoes deprived of Asaia bacterial symbionts. BMC Microbiol 12(suppl 1): S2.
74. Christou P, Capell T, Kohli A, Gatehouse JA & Gatehouse AMR (2006) Recent developments and future prospects in insect pest control in transgenic crops. Trends Plant Sci 11: 302-308.
75. Cirimotich CM, Dong Y, Clayton AM, Sandiford SL, Souza-Neto JA, Mulenga M & Dimopoulos G (2011a) Natural microbe-mediated refractoriness to Plasmodium infection in Anopheles gambiae. Science 332: 855-858.
76. Cirimotich CM, Ramirez JL & Dimopoulos G (2011b) Native microbiota shape insect vector competence for human pathogens. Cell Host Microbe 10: 307-310.
77. Cleveland LR (1923) Symbiosis between termites and their intestinal protozoa. P Natl Acad Sci USA 9: 424-428.
78. Cleveland LR (1924) The physiological and symbiotic relationships between the intestinal protozoa of termites and their host, with special reference to Reticulitermes flavipes Kollar. Biol Bull 46: 203-227.
79. Cleveland LR & Grimstone AV (1964) The fine structure of the flagellate Mixotricha paradoxa and its associated micro-organisms. Proc R Soc Lond B Biol Sci 159: 668-686.
80. Colman DR, Toolson EC & Takacs-Vesbach CD (2012) Do diet and taxonomy influence insect gut bacterial communities? Mol Ecol 21: 5124-5137.
81. Cook SC & Davidson DW (2006) Nutritional and functional biology of exudate-feeding ants. Entomol Exp Appl 118: 1-10.
82. Corby-Harris V, Pontaroli AC, Shimkets LJ, Bennetzen JL, Habel KE & Promislow DEL (2007) Geographical distribution and diversity of bacteria associated with natural populations of Drosophila melanogaster. Appl Environ Microbiol 73: 3470-3479.
83. Cornman RS, Tarpy DR, Chen Y, Jeffreys L, Lopez D, Pettis JS, vanEngelsdorp D & Evans JD (2012) Pathogen webs in collapsing honey bee colonies. PLoS ONE 7: e43562.
84. Cotter SC, Simpson SJ, Raubenheimer D & Wilson K (2010) Macronutrient balance mediates trade-offs between immune function and life history traits. Funct Ecol 25: 186-198.
85. Coutinho-Abreu IV, Zhu KY & Ramalho-Ortigao M (2010) Transgenesis and paratransgenesis to control insect-borne diseases: current status and future challenges. Parasitol Int 59: 1-8.
86. Cox CR & Gilmore MS (2007) Native microbial colonization of Drosophila melanogaster and its use as a model of Enterococcus faecalis pathogenesis. Infect Immun 75: 1565-1576.
87. Cox-Foster DL, Conlan S, Holmes EC et al. (2007) A metagenomic survey of microbes in honey bee colony collapse disorder. Science 318: 283-287.
88. Cronin SJ, Nehme NT, Limmer S et al. (2009) Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science 325: 340-343.
89. Crotti E, Damiani C, Pajoro M et al. (2009) Asaia, a versatile acetic acid bacterial symbiont, capable of cross-colonizing insects of phylogenetically distant genera and orders. Environ Microbiol 11: 3252-3264.
90. Crotti E, Rizzi A, Chouaia B et al. (2010) Acetic acid bacteria, newly emerging symbionts of insects. Appl Environ Microbiol 76: 6963-6970.
91. Cruden DL & Markovetz AJ (1987) Microbial ecology of the cockroach gut. Annu Rev Microbiol 41: 617-643.
92. Daffre S, Kylsten P, Samakovlis C & Hultmark D (1994) The lysozyme locus in Drosophila melanogaster: an expanded gene family adapted for expression in the digestive tract. Mol Gen Genet 242: 152-162.
93. Dale C & Moran NA (2006) Molecular interactions between bacterial symbionts and their hosts. Cell 126: 453-465.
94. Dale C, Plague GR, Wang B, Ochman H & Moran NA (2002) Type III secretion systems and the evolution of mutualistic endosymbiosis. P Natl Acad Sci USA 99: 12397-12402.
95. Damiani C, Ricci I, Crotti E, Rossi P, Rizzi A, Scuppa P, Esposito F, Bandi C, Daffonchio D & Favia G (2008) Paternal transmission of symbiotic bacteria in malaria vectors. Curr Biol 18: R1087-R1088.
96. De Gregorio E, Spellman PT, Tzou P, Rubin GM & Lemaitre B (2002) The Toll and Imd pathways are the major regulators of the immune response in Drosophila. EMBO J 21: 2568-2579.
97. ® in Sodalis glossinidius, a bacterial symbiont of the tsetse fly. Microb Cell Fact 11: 23.
98. Degnan PH, Yu Y, Sisneros N, Wing RA & Moran NA (2009) Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors. P Natl Acad Sci USA 106: 9063-9068.
99. Desai MS & Brune A (2012) Bacteroidales ectosymbionts of gut flagellates shape the nitrogen-fixing community in dry-wood termites. ISME J 6: 1302-1313.
100. Dillon RJ & Dillon VM (2004) The gut bacteria of insects: nonpathogenic interactions. Annu Rev Entomol 49: 71-92.
101. Dillon RJ, Vennard CT & Charnley AK (2002) A note: gut bacteria produce components of a locust cohesion pheromone. J Appl Microbiol 92: 759-763.
102. Dillon RJ, Vennard CT, Buckling A & Charnley AK (2005) Diversity of locust gut bacteria protects against pathogen invasion. Ecol Lett 8: 1291-1298.
103. Dillon RJ, Webster G, Weightman AJ, Dillon VM, Blanford S & Charnley AK (2008) Composition of Acridid gut bacterial communities as revealed by 16S rRNA gene analysis. J Invertebr Pathol 97: 265-272.
104. Dillon RJ, Webster G, Weightman AJ & Keith Charnley A (2010) Diversity of gut microbiota increases with aging and starvation in the desert locust. Antonie Van Leeuwenhoek 97: 69-77.
105. Dinparast Djadid N, Jazayeri H, Raz A, Favia G, Ricci I & Zakeri S (2011) Identification of the midgut microbiota of An. stephensi and An. maculipennis for their application as a paratransgenic tool against malaria. PLoS ONE 6: e28484.
106. Dobson HEM & Peng YS (1997) Digestion of pollen components by larvae of the flower-specialist bee Chelostoma florisomne (Hymenoptera: Megachilidae). J Insect Physiol 43: 89-100.
107. Dong Y, Aguilar R, Xi Z, Warr E, Mongin E & Dimopoulos G (2006) Anopheles gambiae immune responses to human and rodent Plasmodium parasite species. PLoS Pathog 2: e52.
108. Dong Y, Manfredini F & Dimopoulos G (2009) Implication of the mosquito midgut microbiota in the defense against malaria parasites. PLoS Pathog 5: e1000423.
109. Douglas AE (1988) On the source of sterols in the green peach aphid, Myzus persicae, reared on holidic diets. J Insect Physiol 34: 403-408.
110. Dowd PF & Shen SK (1990) The contribution of symbiotic yeast to toxin resistance of the cigarette beetle (Lasioderma serricorne). Entomol Exp Appl 56: 241-248.
111. Dubreuil RR, Grushko T & Baumann O (2001) Differential effects of a labial mutation on the development, structure, and function of stomach acid-secreting cells in Drosophila melanogaster larvae and adults. Cell Tissue Res 306: 167-178.
112. Dunbar TL, Yan Z, Balla KM, Smelkinson MG & Troemel ER (2012) C. elegans detects pathogen-induced translational inhibition to activate immune signaling. Cell Host Microbe 11: 375-386.
113. Durvasula RV, Gumbs A, Panackal A, Kruglov O, Aksoy S, Merrifield RB, Richards FF & Beard CB (1997) Prevention of insect-borne disease: an approach using transgenic symbiotic bacteria. P Natl Acad Sci USA 94: 3274-3278.
114. Durvasula RV, Gumbs A, Panackal A, Kruglov O, Taneja J, Kang AS, Cordon-Rosales C, Richards FF, Whitham RG & Beard CB (1999) Expression of a functional antibody fragment in the gut of Rhodnius prolixus via transgenic bacterial symbiont Rhodococcus rhodnii. Med Vet Entomol 13: 115-119.
115. Ebert A & Brune A (1997) Hydrogen concentration profiles at the oxic-anoxic interface: a microsensor study of the hindgut of the wood-feeding lower termite Reticulitermes flavipes (Kollar). Appl Environ Microbiol 63: 4039-4046.
116. Edwards M & Jacobs-Lorena M (2000) Permeability and disruption of the peritrophic matrix and caecal membrane from Aedes aegypti and Anopheles gambiae mosquito larvae. J Insect Physiol 46: 1313-1320.
117. Egert M, Wagner B, Lemke T, Brune A & Friedrich MW (2003) Microbial community structure in midgut and hindgut of the humus-feeding larva of Pachnoda ephippiata (Coleoptera: Scarabaeidae). Appl Environ Microbiol 69: 6659-6668.
118. Eichler S & Schaub GA (2002) Development of symbionts in triatomine bugs and the effects of infections with trypanosomatids. Exp Parasitol 100: 17-27.
119. Endt K, Stecher B, Chaffron S et al. (2010) The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea. PLoS Pathog 6: e1001097.
120. Engel P, Martinson VG & Moran NA (2012) Functional diversity within the simple gut microbiota of the honey bee. P Natl Acad Sci USA 109: 11002-11007.
121. Engel P, Kwong WK & Moran NA (2013) Frischella perrara gen. nov., sp. nov., a gammaproteobacterium isolated from the gut of the honey bee, Apis mellifera. Int J Syst Evol Microbiol, doi: 10.1099/ijs.0.049569-0, Epub ahead of print.
122. Engelbrektson A, Kunin V, Wrighton KC, Zvenigorodsky N, Chen F, Ochman H & Hugenholtz P (2010) Experimental factors affecting PCR-based estimates of microbial species richness and evenness. ISME J 4: 642-647.
123. Evans JD & Lopez DL (2004) Bacterial probiotics induce an immune response in the honey bee (Hymenoptera: Apidae). J Econ Entomol 97: 752-756.
124. Favia G, Ricci I, Damiani C et al. (2007) Bacteria of the genus Asaia stably associate with Anopheles stephensi, an Asian malarial mosquito vector. P Natl Acad Sci USA 104: 9047-9051.
125. Feldhaar H, Straka J, Krischke M, Berthold K, Stoll S, Mueller MJ & Gross R (2007) Nutritional upgrading for omnivorous carpenter ants by the endosymbiont Blochmannia. BMC Biol 5: 48.
126. Felton GW & Tumlinson JH (2008) Plant-insect dialogs: complex interactions at the plant-insect interface. Curr Opin Plant Biol 11: 457-463.
127. Ferreira C, Capella AN, Sitnik R & Terra WR (1994) Properties of the digestive enzymes and the permeability of the peritrophic membrane of Spodoptera frugiperda (Lepidoptera) larvae. Comp Biochem Physiol A Physiol 107: 631-640.
128. Ffrench-Constant RH & Waterfield NR (2006) Ground control for insect pests. Nat Biotechnol 24: 660-661.
129. Ffrench-Constant RH, Dowling A & Waterfield NR (2007) Insecticidal toxins from Photorhabdus bacteria and their potential use in agriculture. Toxicon 49: 436-451.
130. Fierer N, Strickland MS, Liptzin D, Bradford MA & Cleveland CC (2009) Global patterns in belowground communities. Ecol Lett 12: 1238-1249.
131. Flor HH (1942) Inheritance of pathogenicity in Melampsora lini. Phytopathology 32: 653-669.
132. Fontana MF, Banga S, Barry KC, Shen X, Tan Y, Luo Z-Q & Vance RE (2011) Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila. PLoS Pathog 7: e1001289.
133. Fontana MF, Shin S & Vance RE (2012) Activation of host mitogen-activated protein kinases by secreted Legionella pneumophila effectors that inhibit host protein translation. Infect Immun 80: 3570-3575.
134. Forsgren E, Olofsson TC, Vásquez A & Fries I (2009) Novel lactic acid bacteria inhibiting Paenibacillus larvae in honey bee larvae. Apidologie 41: 99-108.
135. Fox-Dobbs K, Doak DF, Brody AK & Palmer TM (2010) Termites create spatial structure and govern ecosystem function by affecting N2 fixation in an East African savanna. Ecology 91: 1296-1307.
136. Fraune S, Augustin R, Anton-Erxleben F, Wittlieb J, Gelhaus C, Klimovich VB, Samoilovich MP & Bosch TCG (2010) In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides. P Natl Acad Sci USA 107: 1867-18072.
137. Fujita A, Hojo M, Aoyagi T, Hayashi Y, Arakawa G, Tokuda G & Watanabe H (2010) Details of the digestive system in the midgut of Coptotermes formosanus Shiraki. J Wood Sci 56: 222-226.
138. Fukatsu T & Hosokawa T (2002) Capsule-transmitted gut symbiotic bacterium of the Japanese common plataspid stinkbug, Megacopta punctatissima. Appl Environ Microbiol 68: 389-396.
139. Fukuda S, Toh H, Hase KS et al. (2011) Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 469: 543-547.
140. Gaio Ade O, Gusmão DS, Santos AV, Berbert-Molina MA, Pimenta PFP & Lemos FJA (2011) Contribution of midgut bacteria to blood digestion and egg production in Aedes aegypti (Diptera: Culicidae) (L.). Parasit Vectors 4: 105.
141. Galán JE (2009) Common themes in the design and function of bacterial effectors. Cell Host Microbe 5: 571-579.
142. Ganesan S, Aggarwal K, Paquette N & Silverman N (2011) NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster. Curr Top Microbiol Immunol 349: 25-60.
143. Gavriel S, Jurkevitch E, Gazit Y & Yuval B (2011) Bacterially enriched diet improves sexual performance of sterile male Mediterranean fruit flies. J Appl Entomol 135: 564-573.
144. Geib SM, Filley TR, Hatcher PG, Hoover K, Carlson JE, Jimenez-Gasco MDM, Nakagawa-Izumi A, Sleighter RL & Tien M (2008) Lignin degradation in wood-feeding insects. P Natl Acad Sci USA 105: 12932-12937.
145. Genersch E (2010) Honey bee pathology: current threats to honey bees and beekeeping. Appl Microbiol Biotechnol 87: 87-97.
146. Genta FA, Dillon RJ, Terra WR & Ferreira C (2006) Potential role for gut microbiota in cell wall digestion and glucoside detoxification in Tenebrio molitor larvae. J Insect Physiol 52: 593-601.
147. Gonzalez-Ceron L, Santillan F, Rodriguez MH, Mendez D & Hernandez-Avila JE (2003) Bacteria in midguts of field-collected Anopheles albimanus block Plasmodium vivax sporogonic development. J Med Entomol 40: 371-374.
148. 2-acetogenic spirochete from termite hindguts. Appl Environ Microbiol 70: 1307-1314.
149. Graber JR, Leadbetter JR & Breznak JA (2004) Description of Treponema azotonutricium sp. nov. and Treponema primitia sp. nov., the first spirochetes isolated from termite guts. Appl Environ Microbiol 70: 1315-1320.
150. Gupta AK, Nayduch D, Verma P, Shah B, Ghate HV, Patole MS & Shouche YS (2011) Phylogenetic characterization of bacteria in the gut of house flies (Musca domestica L.). FEMS Microbiol Ecol 79: 581-593.
151. Ha EM, Oh CT, Bae YS & Lee WJ (2005a) A direct role for dual oxidase in Drosophila gut immunity. Science 310: 847-850.
152. Ha EM, Oh CT, Ryu JH, Bae YS, Kang SW, Jang IH, Brey PT & Lee WJ (2005b) An antioxidant system required for host protection against gut infection in Drosophila. Dev Cell 8: 125-132.
153. Ha EM, Lee KA, Seo YY, Kim SH, Lim JH, Oh BH, Kim J & Lee WJ (2009) Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut. Nat Immunol 10: 949-957.
154. Haag LM, Fischer A, Otto B, Plickert R, Kühl AA, Göbel UB, Bereswill S & Heimesaat MM (2012) Intestinal microbiota shifts towards elevated commensal Escherichia coli loads abrogate colonization resistance against Campylobacter jejuni in mice. PLoS ONE 7: e35988.
155. Hansen AK & Moran NA (2011) Aphid genome expression reveals host-symbiont cooperation in the production of amino acids. P Natl Acad Sci USA 108: 2849-2854.
156. Harada H, Oyaizu H, Kosako Y & Ishikawa H (1997) Erwinia aphidicola, a new species isolated from pea aphid, Acyrthosiphon pisum. J Gen Appl Microbiol 43: 349-354.
157. Harrison JF (2001) Insect acid-base physiology. Annu Rev Entomol 46: 221-250.
158. Haslett JR (1983) A photographic account of pollen digestion by adult hoverflies. Physiol Entomol 8: 167-171.
159. Hedges LM, Brownlie JC, O'Neill SL & Johnson KN (2008) Wolbachia and virus protection in insects. Science 322: 702.
160. Hehemann JH, Correc G, Barbeyron T, Helbert W, Czjzek M & Michel G (2010) Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota. Nature 464: 908-912.
161. Hess M, Sczyrba A, Egan R et al. (2011) Metagenomic discovery of biomass-degrading genes and genomes from cow rumen. Science 331: 463-467.
162. Hoffmann AA, Montgomery BL, Popovici J et al. (2011) Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission. Nature 476: 454-457.
163. Honeybee Genome Sequencing Consortium (2006) Insights into social insects from the genome of the honeybee Apis mellifera. Nature 443: 931-949.
164. Hongoh Y (2010) Diversity and genomes of uncultured microbial symbionts in the termite gut. Biosci Biotechnol Biochem 74: 1145-1151.
165. Hongoh Y (2011) Toward the functional analysis of uncultivable, symbiotic microorganisms in the termite gut. Cell Mol Life Sci 68: 1311-1325.
166. Hongoh Y, Deevong P, Inoue T, Moriya S, Trakulnaleamsai S, Ohkuma M, Vongkaluang C, Noparatnaraporn N & Kudo T (2005) Intra- and interspecific comparisons of bacterial diversity and community structure support coevolution of gut microbiota and termite host. Appl Environ Microbiol 71: 6590-6599.
167. Hongoh Y, Ekpornprasit L, Inoue T, Moriya S, Trakulnaleamsai S, Ohkuma M, Noparatnaraporn N & Kudo T (2006) Intracolony variation of bacterial gut microbiota among castes and ages in the fungus-growing termite Macrotermes gilvus. Mol Ecol 15: 505-516.
168. Hongoh Y, Sato T, Dolan MF, Noda S, Ui S, Kudo T & Ohkuma M (2007) The motility symbiont of the termite gut flagellate Caduceia versatilis is a member of the "Synergistes" group. Appl Environ Microbiol 73: 6270-6276.
169. Hongoh Y, Sharma VK, Prakash T, Noda S, Taylor TD, Kudo T, Sakaki Y, Toyoda A, Hattori M & Ohkuma M (2008a) Complete genome of the uncultured Termite Group 1 bacteria in a single host protist cell. P Natl Acad Sci USA 105: 5555-5560.
170. Hongoh Y, Sharma VK, Prakash T et al. (2008b) Genome of an endosymbiont coupling N2 fixation to cellulolysis within protist cells in termite gut. Science 322: 1108-1109.
171. Hosokawa T, Kikuchi Y, Nikoh N, Shimada M & Fukatsu T (2006) Strict host-symbiont cospeciation and reductive genome evolution in insect gut bacteria. PLoS Biol 4: e337.
172. Hosokawa T, Kikuchi Y & Fukatsu T (2007) How many symbionts are provided by mothers, acquired by offspring, and needed for successful vertical transmission in an obligate insect-bacterium mutualism? Mol Ecol 16: 5316-5325.
173. Hosokawa T, Koga R, Kikuchi Y, Meng XY & Fukatsu T (2010a) Wolbachia as a bacteriocyte-associated nutritional mutualist. P Natl Acad Sci USA 107: 769-774.
174. Hosokawa T, Kikuchi Y, Nikoh N, Meng XY, Hironaka M & Fukatsu T (2010b) Phylogenetic position and peculiar genetic traits of a midgut bacterial symbiont of the stinkbug Parastrachia japonensis. Appl Environ Microbiol 76: 4130-4135.
175. Hosokawa T, Kikuchi Y, Nikoh N & Fukatsu T (2012) Polyphyly of gut symbionts in stinkbugs of the family Cydnidae. Appl Environ Microbiol 78: 4758-4761.
176. Hultmark D (1996) Insect lysozymes. Lysozymes: Model Enzymes Biochemistry and Biology (Experientia-Supplementum) (Jolles P, ed.), pp. 87-102. Birkhäuser, Basel.
177. Hungate RE (1943) Quantitative analyses on the cellulose fermentation by termite protozoa. Ann Entomol Soc Am 36: 730-739.
178. Inoue T, Murashima K, Azuma JI, Sugimoto A & Slaytor M (1997) Cellulose and xylan utilisation in the lower termite Reticulitermes speratus. J Insect Sci 43: 235-242.
179. International Aphid Genomics Consortium (2010) Genome sequence of the pea aphid Acyrthosiphon pisum. PLoS Biol 8: e1000313.
180. Inward DJG, Vogler AP & Eggleton P (2007) A comprehensive phylogenetic analysis of termites (Isoptera) illuminates key aspects of their evolutionary biology. Mol Phylogenet Evol 44: 953-967.
181. Ivanov II, Atarashi K, Manel N et al. (2009) Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139: 485-498.
182. Jaenike J, Unckless R, Cockburn SN, Boelio LM & Perlman SJ (2010) Adaptation via symbiosis: recent spread of a Drosophila defensive symbiont. Science 329: 212-215.
183. Jiang H, Patel PH, Kohlmaier A, Grenley MO, McEwen DG & Edgar BA (2009) Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 137: 1343-1355.
184. Johnson KS & Barbehenn RV (2000) Oxygen levels in the gut lumens of herbivorous insects. J Insect Physiol 46: 897-903.
185. Johnston PR & Crickmore N (2009) Gut bacteria are not required for the insecticidal activity of Bacillus thuringiensis toward the tobacco hornworm, Manduca sexta. Appl Environ Microbiol 75: 5094-5099.
186. Jones JDG & Dangl JL (2006) The plant immune system. Nature 444: 323-329.
187. Kaiwa N, Hosokawa T, Kikuchi Y, Nikoh N, Meng X-Y, Kimura N, Ito M & Fukatsu T (2010) Primary gut symbiont and secondary, Sodalis-allied symbiont of the Scutellerid stinkbug Cantao ocellatus. Appl Environ Microbiol 76: 3486-3494.
188. Kaneko T & Silverman N (2005) Bacterial recognition and signalling by the Drosophila IMD pathway. Cell Microbiol 7: 461-469.
189. Kashima T, Nakamura T & Tojo S (2006) Uric acid recycling in the hindgut of the shield bug Parastrachia japonicus (Hemiptera: Parastrachiidae) during diapause. J Insect Physiol 52: 816-825.
190. Kaufman MG & Klug MJ (1991) The contribution of hindgut bacteria to dietary carbohydrate utilization by crickets (Orthoptera: Gryllidae). Comp Biochem Physiol A Physiol 98: 117-123.
191. Kaufman MG, Klug MJ & Merritt RW (1989) Growth and food utilization parameters of germ-free house crickets, Acheta domesticus. J Insect Physiol 35: 957-967.
192. Keeney KM & Finlay BB (2011) Enteric pathogen exploitation of the microbiota-generated nutrient environment of the gut. Curr Opin Microbiol 14: 92-98.
193. Kikuchi Y & Yumoto I (2013) Efficient colonization of the environmentally transmitted Burkholderia symbiont in the bean bug Riptortus pedestris. Appl Environ Microbiol, doi: 10.1128/AEM.03299-12, Epub ahead of print.
194. Kikuchi Y, Meng XY & Fukatsu T (2005) Gut symbiotic bacteria of the genus Burkholderia in the broad-headed bugs Riptortus clavatus and Leptocorisa chinensis (Heteroptera: Alydidae). Appl Environ Microbiol 71: 4035-4043.
195. Kikuchi Y, Hosokawa T & Fukatsu T (2007) Insect-microbe mutualism without vertical transmission: a stinkbug acquires a beneficial gut symbiont from the environment every generation. Appl Environ Microbiol 73: 4308-4316.
196. Kikuchi Y, Hosokawa T, Nikoh N, Meng XY, Kamagata Y & Fukatsu T (2009) Host-symbiont co-speciation and reductive genome evolution in gut symbiotic bacteria of acanthosomatid stinkbugs. BMC Biol 7: 2.
197. Kikuchi Y, Hosokawa T & Fukatsu T (2010) An ancient but promiscuous host-symbiont association between Burkholderia gut symbionts and their heteropteran hosts. ISME J 5: 446-460.
198. Kikuchi Y, Hosokawa T & Fukatsu T (2011) Specific developmental window for establishment of an insect-microbe gut symbiosis. Appl Environ Microbiol 77: 4075-4081.
199. Kikuchi Y, Hayatsu M, Hosokawa T, Nagayama A, Tago K & Fukatsu T (2012) Symbiont-mediated insecticide resistance. P Natl Acad Sci USA 109: 8618-8622.
200. Kleino A, Myllymäki H, Kallio J, Vanha-aho L-M, Oksanen K, Ulvila J, Hultmark D, Valanne S & Rämet M (2008) Pirk is a negative regulator of the Drosophila Imd pathway. J Immunol 180: 5413-5422.
201. Klungness LM & Peng YS (1984) A histochemical study of pollen digestion in the alimentary canal of honeybees (Apis mellifera L.). J Insect Physiol 30: 511-521.
202. Koch H & Schmid-Hempel P (2011a) Bacterial communities in central European bumblebees: low diversity and high specificity. Microb Ecol 62: 121-133.
203. Koch H & Schmid-Hempel P (2011b) Socially transmitted gut microbiota protect bumble bees against an intestinal parasite. P Natl Acad Sci USA 108: 19288-19292.
204. Koch H & Schmid-Hempel P (2012) Gut microbiota instead of host genotype drive the specificity in the interaction of a natural host-parasite system. Ecol Lett 15: 1095-1103.
205. Koch H, Abrol DP, Li J & Schmid-Hempel P (2013) Diversity and evolutionary patterns of bacterial gut associates of corbiculate bees. Mol Ecol 22: 2028-2044.
206. Köhler T (2011) Physicochemical gradients and deep sequencing of the bacterial microbiota indicate functional compartmentation in the gut of the higher termite Nasutitermes corniger. Diversity and evolutionary patterns in the bacterial gut microbiota of termites and cockroaches. PhD Thesis, Philipps-Universität Marburg, Marburg, Germany, pp. 11-42.
207. Köhler T, Stingl U, Meuser K & Brune A (2008) Novel lineages of Planctomycetes densely colonize the alkaline gut of soil-feeding termites (Cubitermes spp.). Environ Microbiol 10: 1260-1270.
208. Köhler T, Dietrich C, Scheffrahn RH & Brune A (2012) High-resolution analysis of gut environment and bacterial microbiota reveals functional compartmentation of the gut in wood-feeding higher termites (Nasutitermes spp.). Appl Environ Microbiol 78: 4691-4701.
209. Kölsch G & Pedersen BV (2010) Can the tight co-speciation between reed beetles (Col., Chrysomelidae, Donaciinae) and their bacterial endosymbionts, which provide cocoon material, clarify the deeper phylogeny of the hosts? Mol Phylogenet Evol 54: 810-821.
210. Kölsch G, Matz-Grund C & Pedersen BV (2009) Ultrastructural and molecular characterization of endosymbionts of the reed beetle genus Macroplea (Chrysomelidae, Donaciinae), and proposal of "Candidatus Macropleicola appendiculatae" and "Candidatus Macropleicola muticae". Can J Microbiol 55: 1250-1260.
211. Kuechler SM, Renz P, Dettner K & Kehl S (2012) Diversity of symbiotic organs and bacterial endosymbionts of lygaeoid bugs of the families Blissidae and Lygaeidae (Hemiptera: Heteroptera: Lygaeoidea). Appl Environ Microbiol 78: 2648-2659.
212. Kumar S, Molina-Cruz A, Gupta L, Rodrigues J & Barillas-Mury C (2010) A peroxidase/dual oxidase system modulates midgut epithelial immunity in Anopheles gambiae. Science 327: 1644-1648.
213. Kuraishi T, Binggeli O, Opota O, Buchon N & Lemaitre B (2011) Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster. P Natl Acad Sci USA 108: 15966-15971.
214. Kwong W & Moran NA (2012) Cultivation and characterization of the gut symbionts of honey bees and bumble bees: Snodgrassella alvi gen. nov., sp. nov., a member of the Neisseriaceae family of the Betaproteobacteria; and Gilliamella apicola gen. nov., sp. nov., a member of Orbaceae fam. nov., Orbales ord. nov., a sister taxon to the Enterobacteriales order of the Gammaproteobacteria. Intl J Syst Evol Microbiol [Epub ahead of print].
215. Lance DR, McInnis DO, Rendon P & Jackson CG (2000) Courtship among sterile and wild Ceratitis capitata (Diptera: Tephritidae) in field cages in Hawaii and Guatemala. Ann Entomol Soc Am 93: 1179-1185.
216. Laughton AM, Garcia JR, Altincicek B, Strand MR & Gerardo NM (2011) Characterisation of immune responses in the pea aphid, Acyrthosiphon pisum. J Insect Physiol 57: 830-839.
217. Le Roes-Hill M, Rohland J & Burton S (2011) Actinobacteria isolated from termite guts as a source of novel oxidative enzymes. Antonie Van Leeuwenhoek 100: 589-605.
218. 2 by spirochetes from termite guts. Science 283: 686-689.
219. Lee KA, Kim SH, Kim EK, Ha EM, You H, Kim B, Kim MJ, Kwon Y, Ryu JH & Lee WJ (2013) Bacterial-derived uracil as a modulator of mucosal immunity and gut-microbe homeostasis in Drosophila. Cell 153: 797-811.
220. Lehane MJ (1997) Peritrophic matrix structure and function. Annu Rev Entomol 42: 525-550.
221. Lemaitre B & Hoffmann J (2007) The host defense of Drosophila melanogaster. Annu Rev Immunol 25: 697-743.
222. Lemaitre B, Kromer-Metzger E, Michaut L, Nicolas E, Meister M, Georgel P, Reichhart JM & Hoffmann JA (1995) A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense. P Natl Acad Sci USA 92: 9465-9469.
223. Lemaitre B, Nicolas E, Michaut L, Reichhart JM & Hoffmann JA (1996) The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86: 973-983.
224. Lemke T, Stingl U, Egert M, Friedrich MW & Brune A (2003) Physicochemical conditions and microbial activities in the highly alkaline gut of the humus-feeding larva of Pachnoda ephippiata (Coleoptera: Scarabaeidae). Appl Environ Microbiol 69: 6650-6658.
225. Leroy PD, Sabri A, Heuskin S, Thonart P, Lognay G, Verheggen FJ, Francis F, Brostaux Y, Felton GW & Haubruge E (2011) Microorganisms from aphid honeydew attract and enhance the efficacy of natural enemies. Nat Commun 2: 348.
226. Leulier F & Royet J (2009) Maintaining immune homeostasis in the fly gut. Nat Immunol 10: 936-938.
227. Leulier F, Parquet C, Pili-Floury S, Ryu J-H, Caroff M, Lee W-J, Mengin-Lecreulx D & Lemaitre B (2003) The Drosophila immune system detects bacteria through specific peptidoglycan recognition. Nat Immunol 4: 478-484.
228. Lhocine N, Ribeiro PS, Buchon N, Wepf A, Wilson R, Tenev T, Lemaitre B, Gstaiger M, Meier P & Leulier F (2008) PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling. Cell Host Microbe 4: 147-158.
229. Li J, Qin H, Wu J, Sadd BM, Wang X, Evans JD, Peng W & Chen Y (2012) The Prevalence of parasites and pathogens in Asian honeybees Apis cerana in China. PLoS ONE 7: e47955.
230. Liehl P, Blight M, Vodovar N, Boccard F & Lemaitre B (2006) Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model. PLoS Pathog 2: e56.
231. Lo N, Engel MS, Cameron S et al. (2007) Save Isoptera: a comment on Inward et al. Biol Lett 3: 562-563; discussion 564-5.
232. Login FH & Heddi A (2012) Insect immune system maintains long-term resident bacteria through a local response. J Insect Physiol 59: 232-239.
233. Lupp C, Robertson ML, Wickham ME, Sekirov I, Champion OL, Gaynor EC & Finlay BB (2007) Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe 2: 119-129.
234. Maddrell SHP & Gardiner BOC (1980) The permeability of the cuticular lining of the insect alimentary canal. J Exp Biol 85: 227-237.
235. Martinson VG, Danforth BN, Minckley RL, Rueppell O, Tingek S & Moran NA (2011) A simple and distinctive microbiota associated with honey bees and bumble bees. Mol Ecol 20: 619-628.
236. Martinson VG, Moy J & Moran NA (2012) Establishment of characteristic gut bacteria during development of the honeybee worker. Appl Environ Microbiol 78: 2830-2840.
237. Marzorati M, Alma A, Sacchi L et al. (2006) A Novel Bacteroidetes symbiont is localized in Scaphoideus titanus, the insect vector of Flavescence Dorée in Vitis vinifera. Appl Environ Microbiol 72: 1467-1475.
238. Maslowski KM, Vieira AT, Ng A et al. (2009) Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461: 1282-1286.
239. Mason KL, Stepien TA, Blum JE, Holt JF, Labbe NH, Rush JS, Raffa KF & Handelsman J (2011) From commensal to pathogen: translocation of Enterococcus faecalis from the midgut to the hemocoel of Manduca sexta. MBio 2: e00065-11.
240. Masson-Boivin C, Giraud E, Perret X & Batut J (2009) Establishing nitrogen-fixing symbiosis with legumes: how many rhizobium recipes? Trends Microbiol 17: 458-466.
241. Mazmanian SK, Liu CH, Tzianabos AO & Kasper DL (2005) An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122: 107-118.
242. McCutcheon JP & Moran NA (2010) Functional convergence in reduced genomes of bacterial symbionts spanning 200 My of evolution. Genome Biol Evol 2: 708-718.
243. McCutcheon JP & Moran NA (2012) Extreme genome reduction in symbiotic bacteria. Nat Rev Microbiol 10: 13-26.
244. McEwan DL, Kirienko NV & Ausubel FM (2012) Host translational inhibition by Pseudomonas aeruginosa Exotoxin A triggers an immune response in Caenorhabditis elegans. Cell Host Microbe 11: 364-374.
245. McFall-Ngai MJ (2007) Adaptive immunity: care for the community. Nature 445: 153.
246. McMeniman CJ, Lane RV, Cass BN, Fong AWC, Sidhu M, Wang Y-F & O'Neill SL (2009) Stable introduction of a life-shortening Wolbachia infection into the mosquito Aedes aegypti. Science 323: 141-144.
247. Mead LJ, Khachatourians GG & Jones GA (1988) Microbial ecology of the gut in laboratory stocks of the migratory grasshopper, Melanoplus sanguinipes (Fab.) (Orthoptera: Acrididae). Appl Environ Microbiol 54: 1174-1181.
248. Meister S, Agianian B, Turlure F, Relógio A, Morlais I, Kafatos FC & Christophides GK (2009) Anopheles gambiae PGRPLC-mediated defense against bacteria modulates infections with malaria parasites. PLoS Pathog 5: e1000542.
249. Miller TA (2010) Paratransgenesis as a potential tool for pest control: review of applied arthropod symbiosis. J Appl Entomol 135: 474-478.
250. Miller MM, Popova LB, Meleshkevitch EA, Tran PV & Boudko DY (2008) The invertebrate B(0) system transporter, D. melanogaster NAT1, has unique d-amino acid affinity and mediates gut and brain functions. Insect Biochem Mol Biol 38: 923-931.
251. Moll RM, Romoser WS, Modrakowski MC, Moncayo AC & Lerdthusnee K (2001) Meconial peritrophic membranes and the fate of midgut bacteria during mosquito (Diptera: Culicidae) metamorphosis. J Med Entomol 38: 29-32.
252. Moran NA, Hansen AK, Powell JE & Sabree ZL (2012) Distinctive gut microbiota of honey bees assessed using deep sampling from individual worker bees. PLoS ONE 7: e36393.
253. Müller U, Vogel P, Alber G & Schaub G (2008) The innate immune system of mammals and insects. Contrib Microbiol 15: 21-44.
254. Nakajima H, Hongoh Y, Usami R, Kudo T & Ohkuma M (2005) Spatial distribution of bacterial phylotypes in the gut of the termite Reticulitermes speratus and the bacterial community colonizing the gut epithelium. FEMS Microbiol Ecol 54: 247-255.
255. Nakashima K, Watanabe H, Saitoh H, Tokuda G & Azuma JI (2002) Dual cellulose-digesting system of the wood-feeding termite, Coptotermes formosanus Shiraki. Insect Biochem Mol Biol 32: 777-784.
256. Nardi JB & Bee CM (2012) Regenerative cells and the architecture of beetle midgut epithelia. J Morphol 273: 1010-1020.
257. Nehme NT, Liegeois S, Kele B, Giammarinaro P, Pradel E, Hoffmann JA, Ewbank JJ & Ferrandon D (2007) A model of bacterial intestinal infections in Drosophila melanogaster. PLoS Pathog 3: e173.
258. Neyen C, Poidevin M, Roussel A & Lemaitre B (2012) Tissue- and ligand-specific sensing of Gram-negative infection in Drosophila by PGRP-LC isoforms and PGRP-LE. J Immunol 189: 1886-1897.
259. Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W & Pettersson S (2012) Host-gut microbiota metabolic interactions. Science 336: 1262-1267.
260. Nikoh N, Hosokawa T, Oshima K, Hattori M & Fukatsu T (2011) Reductive evolution of bacterial genome in insect gut environment. Genome Biol Evol 3: 702-714.
261. Nyholm SV & Graf J (2012) Knowing your friends: invertebrate innate immunity fosters beneficial bacterial symbioses. Nat Rev Microbiol 10: 815-827.
262. Nyholm SV & McFall-Ngai MJ (2004) The winnowing: establishing the squid-vibrio symbiosis. Nat Rev Microbiol 2: 632-642.
263. Odelson DA & Breznak JA (1983) Volatile fatty acid production by the hindgut microbiota of xylophagous termites. Appl Environ Microbiol 45: 1602-1613.
264. Oerke EC (2006) Crop losses to pests. J Agric Sci 144: 31-43.
265. O'Hara AM & Shanahan F (2006) The gut flora as a forgotten organ. EMBO Rep 7: 688-693.
266. Ohkuma M & Brune A (2010) Diversity, structure, and evolution of the termite gut microbial community. Biology of Termites: A Modern Synthesis (Bignell DE, Roisin Y & Lo N, eds), pp. 413-438. Springer, Dordrecht.
267. Oliver KM, Degnan PH, Burke GR & Moran NA (2010) Facultative symbionts in aphids and the horizontal transfer of ecologically important traits. Annu Rev Entomol 55: 247-266.
268. Olson KE, Higgs S, Gaines PJ, Powers AM, Davis BS, Kamrud KI, Carlson JO, Blair CD & Beaty BJ (1996) Genetically engineered resistance to dengue-2 virus transmission in mosquitoes. Science 272: 884-886.
269. Osei-Poku J, Mbogo CM, Palmer WJ & Jiggins FM (2012) Deep sequencing reveals extensive variation in the gut microbiota of wild mosquitoes from Kenya. Mol Ecol 21: 5138-5150.
270. Paine TD, Raffa KF & Harrington TC (1997) Interactions among scolytid bark beetles, their associated fungi, and live host conifers. Annu Rev Entomol 42: 179-206.
271. Peng YS, Nasr ME, Marston JM & Fang Y (1985) The digestion of dandelion pollen by adult worker honeybees. Physiol Entomol 10: 75-82.
272. Pester M & Brune A (2006) Expression profiles of fhs (FTHFS) genes support the hypothesis that spirochaetes dominate reductive acetogenesis in the hindgut of lower termites. Environ Microbiol 8: 1261-1270.
273. Pester M & Brune A (2007) Hydrogen is the central free intermediate during lignocellulose degradation by termite gut symbionts. ISME J 1: 551-565.
274. Peters W & Wiese B (1986) Permeability of the peritrophic membranes of some Diptera to labelled dextrans. J Insect Physiol 32: 43-49.
275. Pham LN, Dionne MS, Shirasu-Hiza M & Schneider DS (2007) A specific primed immune response in Drosophila is dependent on phagocytes. PLoS Pathog 3: e26.
276. Ping L, Büchler R, Mithöfer A, Svatos A, Spiteller D, Dettner K, Gmeiner S, Piel J, Schlott B & Boland W (2007) A novel Dps-type protein from insect gut bacteria catalyses hydrolysis and synthesis of N-acyl amino acids. Environ Microbiol 9: 1572-1583.
277. Poliakov A, Russell CW, Ponnala L, Hoops HJ, Sun Q, Douglas AE & van Wijk KJ (2011) Large-scale label-free quantitative proteomics of the pea aphid-Buchnera symbiosis. Mol Cell Proteomics 10: M110.007039.
278. Pope PB, Denman SE, Jones M et al. (2010) Adaptation to herbivory by the Tammar wallaby includes bacterial and glycoside hydrolase profiles different from other herbivores. P Natl Acad Sci USA 107: 14793-14798.
279. Potrikus CJ & Breznak JA (1981) Gut bacteria recycle uric acid nitrogen in termites: a strategy for nutrient conservation. P Natl Acad Sci USA 78: 4601-4605.
280. Prado SS, Rubinoff D & Almeida RPP (2006) Vertical transmission of a pentatomid caeca-associated symbiont. Ann Entomol Soc Am 99: 577-585.
281. Priya NG, Ojha A, Kajla MK, Raj A & Rajagopal R (2012) Host plant induced variation in gut bacteria of Helicoverpa armigera. PLoS ONE 7: e30768.
282. Pumpuni CB, Beier MS, Nataro JP, Guers LD & Davis JR (1993) Plasmodium falciparum: inhibition of sporogonic development in Anopheles stephensi by gram-negative bacteria. Exp Parasitol 77: 195-199.
283. Raddadi N, Gonella E, Camerota C, Pizzinat A, Tedeschi R, Crotti E, Mandrioli M, Bianco PA, Daffonchio D & Alma A (2011) "Candidatus Liberibacter europaeus" sp. nov. that is associated with and transmitted by the psyllid Cacopsylla pyri apparently behaves as an endophyte rather than a pathogen. Environ Microbiol 23: 414-426.
284. Raffa KF, Aukema BH, Bentz BJ, Carroll A, Hicke JA, Turner MG & Romme WH (2008) Cross-scale drivers of natural disturbances prone to anthropogenic amplification: the dynamics of bark beetle eruptions. Bioscience 58: 501-618.
285. Rangberg A, Diep DB, Rudi K & Amdam GV (2012) Paratransgenesis: an approach to improve colony health and molecular insight in honey bees (Apis mellifera)? Integr Comp Biol 52: 89-99.
286. Reis RS & Horn F (2010) Enteropathogenic Escherichia coli, Samonella, Shigella and Yersinia: cellular aspects of host-bacteria interactions in enteric diseases. Gut Pathog 2: 8.
287. Ren C, Webster P, Finkel SE & Tower J (2007) Increased internal and external bacterial load during Drosophila aging without life-span trade-off. Cell Metab 6: 144-152.
288. Ricci I, Valzano M, Ulissi U, Epis S, Cappelli A & Favia G (2012) Symbiotic control of mosquito borne disease. Pathog Glob Health 106: 380-385.
289. Ridley EV, Wong AC-N, Westmiller S & Douglas AE (2012) Impact of the resident microbiota on the nutritional phenotype of Drosophila melanogaster. PLoS ONE 7: e36765.
290. Robinson CJ, Schloss P, Ramos Y, Raffa K & Handelsman J (2010) Robustness of the bacterial community in the cabbage white butterfly larval midgut. Microb Ecol 59: 199-211.
291. Roche RK & Wheeler DE (1999) Morphological specializations of the digestive tract of Zacryptocerus rohweri (Hymenoptera: Formicidae). J Morphol 234: 253-262.
292. Rodrigues J, Brayner FA, Alves LC, Dixit R & Barillas-Mury C (2010) Hemocyte differentiation mediates innate immune memory in Anopheles gambiae mosquitoes. Science 329: 1353-1355.
293. Roh SW, Nam YD, Chang HW, Kim KH, Kim MS, Ryu JH, Kim SH, Lee WJ & Bae JW (2008) Phylogenetic characterization of two novel commensal bacteria involved with innate immune homeostasis in Drosophila melanogaster. Appl Environ Microbiol 74: 6171-6177.
294. Ruby E, Henderson B & McFall-Ngai M (2004) Microbiology. We get by with a little help from our (little) friends. Science 303: 1305-1307.
295. Russell JA, Moreau CS, Goldman-Huertas B, Fujiwara M, Lohman DJ & Pierce NE (2009a) Bacterial gut symbionts are tightly linked with the evolution of herbivory in ants. P Natl Acad Sci USA 106: 21236-21241.
296. Russell JB, Muck RE & Weimer PJ (2009b) Quantitative analysis of cellulose degradation and growth of cellulolytic bacteria in the rumen. FEMS Microbiol Ecol 67: 183-197.
297. Ryu JH, Kim SH, Lee HY, Bai JY, Nam YD, Bae JW, Lee DG, Shin SC, Ha EM & Lee WJ (2008) Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila. Science 319: 777-782.
298. Ryu JH, Ha EM & Lee WJ (2010) Innate immunity and gut-microbe mutualism in Drosophila. Dev Comp Immunol 34: 369-376.
299. Sabree ZL, Kambhampati S & Moran NA (2009) Nitrogen recycling and nutritional provisioning by Blattabacterium, the cockroach endosymbiont. P Natl Acad Sci USA 106: 19521-19526.
300. Sabree ZL, Hansen AK & Moran NA (2012a) Independent studies using deep sequencing resolve the same set of core bacterial species dominating gut communities of honey bees. PLoS ONE 7: e41250.
301. Sabree ZL, Huang CY, Arakawa G, Tokuda G, Lo N, Watanabe H & Moran NA (2012b) Genome shrinkage and loss of nutrient-providing potential in the obligate symbiont of the primitive termite Mastotermes darwiniensis. Appl Environ Microbiol 78: 204-210.
302. Sadd BM & Schmid-Hempel P (2006) Insect immunity shows specificity in protection upon secondary pathogen exposure. Curr Biol 16: 1206-1210.
303. Salem H, Kreutzer E, Sudakaran S & Kaltenpoth M (2012) Actinobacteria as essential symbionts in firebugs and cotton stainers (Hemiptera, Pyrrhocoridae). Environ Microbiol, doi: 10.1111/1462-2920.12001.
304. Salmassi TM & Leadbetter JR (2003) Analysis of genes of tetrahydrofolate-dependent metabolism from cultivated spirochaetes and the gut community of the termite Zootermopsis angusticollis. Microbiology 149: 2529-2537.
305. Sanahuja G, Banakar R, Twyman RM, Capell T & Christou P (2011) Bacillus thuringiensis: a century of research, development and commercial applications. Plant Biotechnol J 9: 283-300.
306. Santo Domingo JW, Kaufman MG, Klug MJ, Holben WE, Harris D & Tiedje JM (1998) Influence of diet on the structure and function of the bacterial hindgut community of crickets. Mol Ecol 7: 761-767.
307. Schauer C, Thompson CL & Brune A (2012) The bacterial community in the gut of the cockroach Shelfordella lateralis reflects the close evolutionary relatedness of cockroaches and termites. Appl Environ Microbiol 78: 2758-2767.
308. Schloss PD, Delalibera I Jr, Handelsman J & Raffa KF (2006) Bacteria associated with the guts of two wood-boring beetles: Anoplophora glabripennis and Saperda vestita (Cerambycidae). Environ Entomol 35: 625-629.
309. Schmid-Hempel P (2005) Evolutionary ecology of insect immune defenses. Annu Rev Entomol 50: 529-551.
310. Schneider DS & Ayres JS (2008) Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases. Nat Rev Immunol 8: 889-895.
311. Scott HG & Stojanovich CJ (1963) Digestion of juniper pollen by Collembola. Fla Entomol 46: 189-191.
312. Shao L, Devenport M & Jacobs-Lorena M (2001) The peritrophic matrix of hematophagous insects. Arch Insect Biochem Physiol 47: 119-125.
313. Sharon G, Segal D, Ringo JM, Hefetz A, Zilber-Rosenberg I & Rosenberg E (2010) Commensal bacteria play a role in mating preference of Drosophila melanogaster. P Natl Acad Sci USA 107: 20051-20056.
314. Sharon G, Segal D, Zilber-Rosenberg I & Rosenberg E (2011) Symbiotic bacteria are responsible for diet-induced mating preference in Drosophila melanogaster, providing support for the hologenome concept of evolution. Gut Microbes 2: 190-192.
315. Shigenobu S, Watanabe H, Hattori M, Sakaki Y & Ishikawa H (2000) Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS. Nature 407: 81-86.
316. Shin SC, Kim SH, You H, Kim B, Kim AC, Lee KA, Yoon JH, Ryu JH & Lee WJ (2011) Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling. Science 334: 670-674.
317. Silver AC, Kikuchi Y, Fadl AA, Sha J, Chopra AK & Graf J (2007) Interaction between innate immune cells and a bacterial type III secretion system in mutualistic and pathogenic associations. P Natl Acad Sci USA 104: 9481-9486.
318. Slaytor M (1992) Cellulose digestion in termites and cockroaches: what role do symbionts play? Comp Biochem Physiol B 103: 775-784.
319. Spence KD & Kawata MY (1993) Permeability characteristics of the peritrophic membranes of Manduca sexta larvae. J Insect Physiol 39: 785-790.
320. Srygley RB, Lorch PD, Simpson SJ & Sword GA (2009) Immediate protein dietary effects on movement and the generalised immunocompetence of migrating Mormon crickets Anabrus simplex (Orthoptera: Tettigoniidae). Ecol Entomol 34: 663-668.
321. Stappenbeck TS, Hooper LV & Gordon JI (2002) Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. P Natl Acad Sci USA 99: 15451-15455.
322. Stavrinides J, McCloskey JK & Ochman H (2009) Pea aphid as both host and vector for the phytopathogenic bacterium Pseudomonas syringae. Appl Environ Microbiol 75: 2230-2235.
323. Stavrinides J, No A & Ochman H (2010) A single genetic locus in the phytopathogen Pantoea stewartii enables gut colonization and pathogenicity in an insect host. Environ Microbiol 12: 147-155.
324. Stecher B & Hardt WD (2008) The role of microbiota in infectious disease. Trends Microbiol 16: 107-114.
325. Stecher B & Hardt WD (2011) Mechanisms controlling pathogen colonization of the gut. Curr Opin Microbiol 14: 82-91.
326. Stecher B, Robbiani R, Walker AW et al. (2007) Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota. PLoS Biol 5: 2177-2189.
327. Storelli G, Defaye A, Erkosar B, Hols P, Royet J & Leulier F (2011) Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing. Cell Metab 14: 403-414.
328. Stuart LM, Paquette N & Boyer L (2013) Effector-triggered versus pattern-triggered immunity: how animals sense pathogens. Nat Rev Immunol 13: 199-206.
329. Sudakaran S, Salem H, Kost C & Kaltenpoth M (2012) Geographical and ecological stability of the symbiotic mid-gut microbiota in European firebugs, Pyrrhocoris apterus (Hemiptera, Pyrrhocoridae). Mol Ecol 21: 6134-6151.
330. Tahar R, Boudin C, Thiery I & Bourgouin C (2002) Immune response of Anopheles gambiae to the early sporogonic stages of the human malaria parasite Plasmodium falciparum. EMBO J 21: 6673-6680.
331. Tamm SL (1982) Flagellated ectosymbiotic bacteria propel a eucaryotic cell. J Cell Biol 94: 697-709.
332. Tang X, Freitak D, Vogel H, Ping L, Shao Y, Cordero EA, Andersen G, Westermann M, Heckel DG & Boland W (2012) Complexity and variability of gut commensal microbiota in polyphagous lepidopteran larvae. PLoS ONE 7: e36978.
333. Taylor LP & Hepler PK (1997) Pollen germination and tube growth. Annu Rev Plant Biol 48: 461-491.
334. Teixeira L, Ferreira A & Ashburner M (2008) The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster. PLoS Biol 6: e2.
335. Terra WR (1990) Evolution of digestive systems of insects. Annu Rev Entomol 35: 181-200.
336. Thong-On A, Suzuki K, Noda S, Inoue JI, Kajiwara S & Ohkuma M (2012) Isolation and characterization of anaerobic bacteria for symbiotic recycling of uric acid nitrogen in the gut of various termites. Microbes Environ 27: 186-192.
337. Tokuda G & Watanabe H (2007) Hidden cellulases in termites: revision of an old hypothesis. Biol Lett 3: 336-339.
338. Tokuda G, Lo N & Watanabe H (2005) Marked variations in patterns of cellulase activity against crystalline- vs. carboxymethyl-cellulose in the digestive systems of diverse, wood-feeding termites. Physiol Entomol 30: 372-380.
339. Tzou P, Ohresser S, Ferrandon D, Capovilla M, Reichhart JM, Lemaitre B, Hoffmann JA & Imler J-L (2000) Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity 13: 737-748.
340. Visôtto LE, Oliveira MGA, Guedes RNC, Ribon AOB & Good-God PIV (2009) Contribution of gut bacteria to digestion and development of the velvetbean caterpillar, Anticarsia gemmatalis. J Insect Physiol 55: 185-191.
341. Vollaard EJ & Clasener HA (1994) Colonization resistance. Antimicrob Agents Chemother 38: 409-414.
342. Warnecke F, Luginbühl P, Ivanova N et al. (2007) Metagenomic and functional analysis of hindgut microbiota of a wood-feeding higher termite. Nature 450: 560-565.
343. Watanabe H & Tokuda G (2010) Cellulolytic systems in insects. Annu Rev Entomol 55: 609-632.
344. Watanabe H, Noda H, Tokuda G & Lo N (1998) A cellulase gene of termite origin. Nature 394: 330-331.
345. Weiss BL, Wang J, Maltz MA, Wu Y & Aksoy S (2013) Trypanosome infection establishment in the tsetse fly gut is influenced by microbiome-regulated host immune barriers. PLoS Pathog 9: e1003318.
346. Wenzel M, Schönig I, Berchtold M, Kämpfer P & König H (2002) Aerobic and facultatively anaerobic cellulolytic bacteria from the gut of the termite Zootermopsis angusticollis. J Appl Microbiol 92: 32-40.
347. Werren JH, Baldo L & Clark ME (2008) Wolbachia: master manipulators of invertebrate biology. Nat Rev Microbiol 6: 741-751.
348. Wier AM, Nyholm SV, Mandel MJ et al. (2010) Transcriptional patterns in both host and bacterium underlie a daily rhythm of anatomical and metabolic change in a beneficial symbiosis. P Natl Acad Sci USA 107: 2259-2264.
349. Wong CNA, Ng P & Douglas AE (2011) Low-diversity bacterial community in the gut of the fruitfly Drosophila melanogaster. Environ Microbiol 13: 1889-1900.
350. Woodbury N & Gries G (2013) Firebrats, Thermobia domestica, aggregate in response to the microbes Enterobacter cloacae and Mycotypha microspora. Entomol Exp Appl 147: 154-159.
351. Woodbury N, Moore M & Gries G (2013) Horizontal transmission of the microbial symbionts Enterobacter cloacae and Mycotypha microspora to their firebrat host. Entomol Exp Appl 147: 160-166.
352. World Health Organization (2011) World Malaria Report 2011, World Health Organization, Geneva. Available at: http://www.who.int/malaria/world_malaria_report_2011/WMR2011_noprofiles_lowres.pdf.
353. Xu J & Gordon JI (2003) Honor thy symbionts. P Natl Acad Sci USA 100: 10452-10459.
354. Yamin MA (1981) Cellulose metabolism by the flagellate trichonympha from a termite is independent of endosymbiotic bacteria. Science 211: 58-59.
355. Zaidman-Rémy A, Hervé M, Poidevin M, Pili-Floury S, Kim MS, Blanot D, Oh BH, Ueda R, Mengin-Lecreulx D & Lemaitre B (2006) The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection. Immunity 24: 463-473.
356. Zurek L & Keddie BA (1996) Contribution of the colon and colonic bacterial flora to metabolism and development of the American cockroach Periplaneta americana L. J Insect Physiol 42: 743-748.