메뉴 건너뛰기




Volumn 4, Issue 1, 2010, Pages 40-47

Drosophila immune response: From systemic antimicrobial peptide production in fat body cells to local defense in the intestinal tract

Author keywords

Antimicrobial peptides; Commensal bacteria; Drosophila; Duox; Gut homeostasis; IMD; Innate immunity; ISC; JAK STAT; JNK; NF B; P38; PGRP; ROS; Toll

Indexed keywords

INVERTEBRATA;

EID: 77952651022     PISSN: 19336934     EISSN: 19336942     Source Type: Journal    
DOI: 10.4161/fly.4.1.10810     Document Type: Article
Times cited : (103)

References (74)
  • 1
    • 34047268684 scopus 로고    scopus 로고
    • The host defense of Drosophila melanogaster
    • Lemaitre B, Hoffmann J. The host defense of Drosophila melanogaster. Annu Rev Immunol 2007; 25:59-62.
    • (2007) Annu Rev Immunol , vol.25 , pp. 59-62
    • Lemaitre, B.1    Hoffmann, J.2
  • 2
    • 35549006674 scopus 로고    scopus 로고
    • The Drosophila systemic immune response: Sensing and signalling during bacterial and fungal infections
    • Ferrandon D, Imler JL, Hetru C, Hoffmann JA. The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections. Nat Rev Immunol 2007; 7:862-74.
    • (2007) Nat Rev Immunol , vol.7 , pp. 862-874
    • Ferrandon, D.1    Imler, J.L.2    Hetru, C.3    Hoffmann, J.A.4
  • 3
    • 67649210789 scopus 로고    scopus 로고
    • Bacterial detection by Drosophila peptidoglycan recognition proteins
    • Charroux B, Rival T, Narbonne-Reveau K, Royet J. Bacterial detection by Drosophila peptidoglycan recognition proteins. Microbes Infect 2009; 11:631-6.
    • (2009) Microbes Infect , vol.11 , pp. 631-636
    • Charroux, B.1    Rival, T.2    Narbonne-Reveau, K.3    Royet, J.4
  • 4
    • 33947374647 scopus 로고    scopus 로고
    • Peptidoglycan recognition proteins: Pleiotropic sensors and effectors of antimicrobial defences
    • Royet J, Dziarski R. Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defences. Nat Rev Microbiol 2007; 5:264-77.
    • (2007) Nat Rev Microbiol , vol.5 , pp. 264-277
    • Royet, J.1    Dziarski, R.2
  • 5
    • 60649091298 scopus 로고    scopus 로고
    • Drosophila intestinal response to bacterial infection: Activation of host defense and stem cell proliferation
    • Buchon N, Broderick NA, Poidevin M, Pradervand S, Lemaitre B. Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. Cell Host Microbe 2009; 5:200-11.
    • (2009) Cell Host Microbe , vol.5 , pp. 200-211
    • Buchon, N.1    Broderick, N.A.2    Poidevin, M.3    Pradervand, S.4    Lemaitre, B.5
  • 6
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996; 86:973-83.
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 7
    • 0028865526 scopus 로고
    • A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense
    • Lemaitre B, Kromer-Metzger E, Michaut L, Nicolas E, Meister M, Georgel P et al. A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense. Proc Natl Acad Sci USA 1995; 92:9465-9.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9465-9469
    • Lemaitre, B.1    Kromer-Metzger, E.2    Michaut, L.3    Nicolas, E.4    Meister, M.5    Georgel, P.6
  • 8
    • 0033578917 scopus 로고    scopus 로고
    • Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
    • Levashina EA, Langley E, Green C, Gubb D, Ashburner M, Hoffmann JA et al. Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. Science 1999; 285:1917-9.
    • (1999) Science , vol.285 , pp. 1917-1919
    • Levashina, E.A.1    Langley, E.2    Green, C.3    Gubb, D.4    Ashburner, M.5    Hoffmann, J.A.6
  • 9
    • 0035856990 scopus 로고    scopus 로고
    • Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
    • Michel T, Reichhart JM, Hoffmann JA, Royet J. Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein. Nature 2001; 414:756-9.
    • (2001) Nature , vol.414 , pp. 756-759
    • Michel, T.1    Reichhart, J.M.2    Hoffmann, J.A.3    Royet, J.4
  • 10
    • 39449112512 scopus 로고    scopus 로고
    • Toll-like receptors-taking an evolutionary approach
    • Leulier F, Lemaitre B. Toll-like receptors-taking an evolutionary approach. Nat Rev Genet 2008; 9:165-78.
    • (2008) Nat Rev Genet , vol.9 , pp. 165-178
    • Leulier, F.1    Lemaitre, B.2
  • 11
  • 12
    • 0038664357 scopus 로고    scopus 로고
    • The Drosophila immune system detects bacteria through specific peptidoglycan recognition
    • Leulier F, Parquet C, Pili-Floury S, Ryu JH, Caroff M, Lee WJ et al. The Drosophila immune system detects bacteria through specific peptidoglycan recognition. Nat Immunol 2003; 4:478-84.
    • (2003) Nat Immunol , vol.4 , pp. 478-484
    • Leulier, F.1    Parquet, C.2    Pili-Floury, S.3    Ryu, J.H.4    Caroff, M.5    Lee, W.J.6
  • 13
    • 10644267665 scopus 로고    scopus 로고
    • Peptidoglycan recognition protein (PGRP)-LE and PGRP-LC act synergistically in Drosophila immunity
    • Takehana A, Yano T, Mita S, Kotani A, Oshima Y, Kurata S. Peptidoglycan recognition protein (PGRP)-LE and PGRP-LC act synergistically in Drosophila immunity. EMBO J 2004; 23:4690-700.
    • (2004) EMBO J , vol.23 , pp. 4690-4700
    • Takehana, A.1    Yano, T.2    Mita, S.3    Kotani, A.4    Oshima, Y.5    Kurata, S.6
  • 14
    • 0345731463 scopus 로고    scopus 로고
    • Dual activation of the Drosophila toll pathway by two pattern recognition receptors
    • Gobert V, Gottar M, Matskevich A A, Rutschmann S, Royet J, Belvin M et al. Dual activation of the Drosophila toll pathway by two pattern recognition receptors. Science 2003; 302:2126-30.
    • (2003) Science , vol.302 , pp. 2126-2130
    • Gobert, V.1    Gottar, M.2    Matskevich, A.A.3    Rutschmann, S.4    Royet, J.5    Belvin, M.6
  • 15
    • 0034610370 scopus 로고    scopus 로고
    • A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster
    • Werner T, Liu G, Kang D, Ekengren S, Steiner H, Hultmark D. A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster. Proc Natl Acad Sci USA 2000; 97:13772-7.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 13772-13777
    • Werner, T.1    Liu, G.2    Kang, D.3    Ekengren, S.4    Steiner, H.5    Hultmark, D.6
  • 16
    • 0035860732 scopus 로고    scopus 로고
    • Peptidoglycan recognition proteins: A novel family of four human innate immunity pattern recognition molecules
    • Liu C, Xu Z, Gupta D, Dziarski R. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. J Biol Chem 2001; 276:34686-94.
    • (2001) J Biol Chem , vol.276 , pp. 34686-34694
    • Liu, C.1    Xu, Z.2    Gupta, D.3    Dziarski, R.4
  • 17
    • 0037066464 scopus 로고    scopus 로고
    • Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila
    • Choe KM, Werner T, Stoven S, Hultmark D, Anderson KV. Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila. Science 2002; 296:359-62.
    • (2002) Science , vol.296 , pp. 359-362
    • Choe, K.M.1    Werner, T.2    Stoven, S.3    Hultmark, D.4    Anderson, K.V.5
  • 18
    • 0037061482 scopus 로고    scopus 로고
    • Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli
    • Ramet M, Manfruelli P, Pearson A, Mathey-Prevot B, Ezekowitz RA. Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. Nature 2002; 416:644-8.
    • (2002) Nature , vol.416 , pp. 644-648
    • Ramet, M.1    Manfruelli, P.2    Pearson, A.3    Mathey-Prevot, B.4    Ezekowitz, R.A.5
  • 19
    • 0037061450 scopus 로고    scopus 로고
    • The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein
    • Gottar M, Gobert V, Michel T, Belvin M, Duyk G, Hoffmann JA et al. The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Nature 2002; 416:640-4.
    • (2002) Nature , vol.416 , pp. 640-644
    • Gottar, M.1    Gobert, V.2    Michel, T.3    Belvin, M.4    Duyk, G.5    Hoffmann, J.A.6
  • 20
    • 10344251507 scopus 로고    scopus 로고
    • Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway
    • Stenbak CR, Ryu JH, Leulier F, Pili-Floury S, Parquet C, Herve M et al. Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway. J Immunol 2004; 173:7339-48.
    • (2004) J Immunol , vol.173 , pp. 7339-7348
    • Stenbak, C.R.1    Ryu, J.H.2    Leulier, F.3    Pili-Floury, S.4    Parquet, C.5    Herve, M.6
  • 21
    • 0032544089 scopus 로고    scopus 로고
    • A peptidoglycan recognition protein in innate immunity conserved from insects to humans
    • Kang D, Liu G, Lundstrom A, Gelius E, Steiner H. A peptidoglycan recognition protein in innate immunity conserved from insects to humans. Proc Natl Acad Sci USA 1998; 95:10078-82.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10078-10082
    • Kang, D.1    Liu, G.2    Lundstrom, A.3    Gelius, E.4    Steiner, H.5
  • 22
    • 0037108754 scopus 로고    scopus 로고
    • Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae
    • Takehana A, Katsuyama T, Yano T, Oshima Y, Takada H, Aigaki T et al. Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Proc Natl Acad Sci USA 2002; 99:13705-10.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13705-13710
    • Takehana, A.1    Katsuyama, T.2    Yano, T.3    Oshima, Y.4    Takada, H.5    Aigaki, T.6
  • 23
  • 24
    • 40849111159 scopus 로고    scopus 로고
    • Crystal structure of Drosophila PGRP-SD suggests binding to DAP-type but not lysine-type peptidoglycan
    • Leone P, Bischoff V, Kellenberger C, Hetru C, Royet J, Roussel A. Crystal structure of Drosophila PGRP-SD suggests binding to DAP-type but not lysine-type peptidoglycan. Mol Immunol 2008; 45:2521-30.
    • (2008) Mol Immunol , vol.45 , pp. 2521-2530
    • Leone, P.1    Bischoff, V.2    Kellenberger, C.3    Hetru, C.4    Royet, J.5    Roussel, A.6
  • 25
    • 9244251126 scopus 로고    scopus 로고
    • Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria
    • Bischoff V, Vignal C, Boneca IG, Michel T, Hoffmann JA, Royet J. Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria. Nat Immunol 2004; 5:1175-80.
    • (2004) Nat Immunol , vol.5 , pp. 1175-1180
    • Bischoff, V.1    Vignal, C.2    Boneca, I.G.3    Michel, T.4    Hoffmann, J.A.5    Royet, J.6
  • 26
    • 34249851525 scopus 로고    scopus 로고
    • Clustering of peptidoglycan recognition protein-SA is required for sensing lysine-type peptidoglycan in insects
    • Park JW, Kim CH, Kim JH, Je BR, Roh KB, Kim SJ et al. Clustering of peptidoglycan recognition protein-SA is required for sensing lysine-type peptidoglycan in insects. Proc Natl Acad Sci USA 2007; 104:6602-7.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6602-6607
    • Park, J.W.1    Kim, C.H.2    Kim, J.H.3    Je, B.R.4    Roh, K.B.5    Kim, S.J.6
  • 27
    • 68149091551 scopus 로고    scopus 로고
    • A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway
    • Buchon N, Poidevin M, Kwon HM, Guillou A, Sottas V, Lee BL et al. A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway. Proc Natl Acad Sci USA 2009; 106:12442-7.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12442-12447
    • Buchon, N.1    Poidevin, M.2    Kwon, H.M.3    Guillou, A.4    Sottas, V.5    Lee, B.L.6
  • 28
    • 29744438644 scopus 로고    scopus 로고
    • A Spatzle-processing enzyme required for toll signaling activation in Drosophila innate immunity
    • Jang IH, Chosa N, Kim SH, Nam HJ, Lemaitre B, Ochiai M et al. A Spatzle-processing enzyme required for toll signaling activation in Drosophila innate immunity. Dev Cell 2006; 10:45-55.
    • (2006) Dev Cell , vol.10 , pp. 45-55
    • Jang, I.H.1    Chosa, N.2    Kim, S.H.3    Nam, H.J.4    Lemaitre, B.5    Ochiai, M.6
  • 29
    • 12844279852 scopus 로고    scopus 로고
    • Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor
    • Choe KM, Lee H, Anderson KV. Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor. Proc Natl Acad Sci USA 2005; 102:1122-6.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1122-1126
    • Choe, K.M.1    Lee, H.2    Anderson, K.V.3
  • 31
    • 33745225236 scopus 로고    scopus 로고
    • PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan
    • Kaneko T, Yano T, Aggarwal K, Lim JH, Ueda K, Oshima Y et al. PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan. Nat Immunol 2006; 7:715-23.
    • (2006) Nat Immunol , vol.7 , pp. 715-723
    • Kaneko, T.1    Yano, T.2    Aggarwal, K.3    Lim, J.H.4    Ueda, K.5    Oshima, Y.6
  • 32
    • 47849094901 scopus 로고    scopus 로고
    • Autophagic control of listeria through intracellular innate immune recognition in drosophila
    • Yano T, Mita S, Ohmori H, Oshima Y, Fujimoto Y, Ueda R et al. Autophagic control of listeria through intracellular innate immune recognition in drosophila. Nat Immunol 2008; 9:908-16.
    • (2008) Nat Immunol , vol.9 , pp. 908-916
    • Yano, T.1    Mita, S.2    Ohmori, H.3    Oshima, Y.4    Fujimoto, Y.5    Ueda, R.6
  • 33
    • 33645236166 scopus 로고    scopus 로고
    • Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor
    • Chang CI, Chelliah Y, Borek D, Mengin-Lecreulx D, Deisenhofer J. Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor. Science 2006; 311:1761-4.
    • (2006) Science , vol.311 , pp. 1761-1764
    • Chang, C.I.1    Chelliah, Y.2    Borek, D.3    Mengin-Lecreulx, D.4    Deisenhofer, J.5
  • 35
    • 0042195829 scopus 로고    scopus 로고
    • Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster
    • Kim MS, Byun M, Oh BH. Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster. Nat Immunol 2003; 4:787-93.
    • (2003) Nat Immunol , vol.4 , pp. 787-793
    • Kim, M.S.1    Byun, M.2    Oh, B.H.3
  • 36
    • 33645994799 scopus 로고    scopus 로고
    • The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection
    • Zaidman-Remy A, Herve M, Poidevin M, Pili-Floury S, Kim MS, Blanot D et al. The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection. Immunity 2006; 24:463-73.
    • (2006) Immunity , vol.24 , pp. 463-473
    • Zaidman-Remy, A.1    Herve, M.2    Poidevin, M.3    Pili-Floury, S.4    Kim, M.S.5    Blanot, D.6
  • 37
    • 33645770760 scopus 로고    scopus 로고
    • Downregulation of the Drosophila Immune Response by Peptidoglycan-Recognition Proteins SC1 and SC2
    • Bischoff V, Vignal C, Duvic B, Boneca IG, Hoffmann JA, Royet J. Downregulation of the Drosophila Immune Response by Peptidoglycan-Recognition Proteins SC1 and SC2. PLoS Pathog 2006; 2:14.
    • (2006) PLoS Pathog , vol.2 , pp. 14
    • Bischoff, V.1    Vignal, C.2    Duvic, B.3    Boneca, I.G.4    Hoffmann, J.A.5    Royet, J.6
  • 38
    • 0037757622 scopus 로고    scopus 로고
    • A mammalian peptidoglycan recognition protein with N-acetylmuramoyl-L-alanine amidase activity
    • Gelius E, Persson C, Karlsson J, Steiner H. A mammalian peptidoglycan recognition protein with N-acetylmuramoyl-L-alanine amidase activity. Biochem Biophys Res Commun 2003; 306:988-94.
    • (2003) Biochem Biophys Res Commun , vol.306 , pp. 988-994
    • Gelius, E.1    Persson, C.2    Karlsson, J.3    Steiner, H.4
  • 39
    • 0037470091 scopus 로고    scopus 로고
    • A scavenger function for a Drosophila peptidoglycan recognition protein
    • Mellroth P, Karlsson J, Steiner H. A scavenger function for a Drosophila peptidoglycan recognition protein. J Biol Chem 2003; 278:7059-64.
    • (2003) J Biol Chem , vol.278 , pp. 7059-7064
    • Mellroth, P.1    Karlsson, J.2    Steiner, H.3
  • 40
    • 35449002517 scopus 로고    scopus 로고
    • Peptidoglycan recognition protein LF: A negative regulator of Drosophila immunity
    • Persson C, Oldenvi S, Steiner H. Peptidoglycan recognition protein LF: A negative regulator of Drosophila immunity. Insect Biochem Mol Biol 2007; 37:1309-16.
    • (2007) Insect Biochem Mol Biol , vol.37 , pp. 1309-1316
    • Persson, C.1    Oldenvi, S.2    Steiner, H.3
  • 41
    • 43049157518 scopus 로고    scopus 로고
    • The Drosophila peptidoglycan recognition protein PGRP-LF blocks PGRP-LC and IMD/JNK pathway activation
    • Maillet F, Bischoff V, Vignal C, Hoffmann J, Royet J. The Drosophila peptidoglycan recognition protein PGRP-LF blocks PGRP-LC and IMD/JNK pathway activation. Cell Host Microbe 2008; 3:293-303.
    • (2008) Cell Host Microbe , vol.3 , pp. 293-303
    • Maillet, F.1    Bischoff, V.2    Vignal, C.3    Hoffmann, J.4    Royet, J.5
  • 42
    • 38949153861 scopus 로고    scopus 로고
    • Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila
    • Ryu JH, Kim SH, Lee HY, Bai JY, Nam YD, Bae JW et al. Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila. Science 2008; 319:777-82.
    • (2008) Science , vol.319 , pp. 777-782
    • Ryu, J.H.1    Kim, S.H.2    Lee, H.Y.3    Bai, J.Y.4    Nam, Y.D.5    Bae, J.W.6
  • 44
    • 34547440528 scopus 로고    scopus 로고
    • Increased internal and external bacterial load during Drosophila aging without life-span trade-off
    • Ren C, Webster P, Finkel SE, Tower J. Increased internal and external bacterial load during Drosophila aging without life-span trade-off. Cell Metab 2007; 6:144-52.
    • (2007) Cell Metab , vol.6 , pp. 144-152
    • Ren, C.1    Webster, P.2    Finkel, S.E.3    Tower, J.4
  • 45
    • 34147172817 scopus 로고    scopus 로고
    • Native microbial colonization of Drosophila melanogaster and its use as a model of Enterococcus faecalis pathogenesis
    • Cox CR, Gilmore MS. Native microbial colonization of Drosophila melanogaster and its use as a model of Enterococcus faecalis pathogenesis. Infect Immun 2007; 75:1565-76.
    • (2007) Infect Immun , vol.75 , pp. 1565-1576
    • Cox, C.R.1    Gilmore, M.S.2
  • 46
    • 66449098226 scopus 로고    scopus 로고
    • Epithelial ultrastructure and cellular mechanisms of acid and base transport in the Drosophila midgut
    • Shanbhag S, Tripathi S. Epithelial ultrastructure and cellular mechanisms of acid and base transport in the Drosophila midgut. J Exp Biol 2009; 212:1731-44.
    • (2009) J Exp Biol , vol.212 , pp. 1731-1744
    • Shanbhag, S.1    Tripathi, S.2
  • 48
    • 33747586778 scopus 로고    scopus 로고
    • An essential complementary role of NFkappaB pathway to microbicidal oxidants in Drosophila gut immunity
    • Ryu JH, Ha EM, Oh CT, Seol JH, Brey PT, Jin I et al. An essential complementary role of NFkappaB pathway to microbicidal oxidants in Drosophila gut immunity. EMBO J 2006; 25:3693-701.
    • (2006) EMBO J , vol.25 , pp. 3693-3701
    • Ryu, J.H.1    Ha, E.M.2    Oh, C.T.3    Seol, J.H.4    Brey, P.T.5    Jin, I.6
  • 49
    • 61749104447 scopus 로고    scopus 로고
    • Regulation of DUOX by the Galphaq-phospholipase Cβ-Ca2+ pathway in Drosophila gut immunity
    • Ha EM, Lee KA, Park SH, Kim SH, Nam HJ, Lee HY et al. Regulation of DUOX by the Galphaq-phospholipase Cβ-Ca2+ pathway in Drosophila gut immunity. Dev Cell 2009; 16:386-97.
    • (2009) Dev Cell , vol.16 , pp. 386-397
    • Ha, E.M.1    Lee, K.A.2    Park, S.H.3    Kim, S.H.4    Nam, H.J.5    Lee, H.Y.6
  • 50
    • 27644498442 scopus 로고    scopus 로고
    • A direct role for dual oxidase in Drosophila gut immunity
    • Ha EM, Oh CT, Bae YS, Lee WJ. A direct role for dual oxidase in Drosophila gut immunity. Science 2005; 310:847-50.
    • (2005) Science , vol.310 , pp. 847-850
    • Ha, E.M.1    Oh, C.T.2    Bae, Y.S.3    Lee, W.J.4
  • 51
    • 11244343895 scopus 로고    scopus 로고
    • An antioxidant system required for host protection against gut infection in Drosophila
    • Ha EM, Oh CT, Ryu JH, Bae YS, Kang SW, Jang IH et al. An antioxidant system required for host protection against gut infection in Drosophila. Dev Cell 2005; 8:125-32.
    • (2005) Dev Cell , vol.8 , pp. 125-132
    • Ha, E.M.1    Oh, C.T.2    Ryu, J.H.3    Bae, Y.S.4    Kang, S.W.5    Jang, I.H.6
  • 52
    • 72649083654 scopus 로고    scopus 로고
    • The Drosophila ubiquitin-specific protease dUSP36/Scny targets IMD to prevent constitutive immune signaling
    • Thevenon D, Engel E, Avet-Rochex A, Gottar M, Bergeret E, Tricoire H et al. The Drosophila ubiquitin-specific protease dUSP36/Scny targets IMD to prevent constitutive immune signaling. Cell Host Microbe 2009; 6:309-20.
    • (2009) Cell Host Microbe , vol.6 , pp. 309-320
    • Thevenon, D.1    Engel, E.2    Avet-Rochex, A.3    Gottar, M.4    Bergeret, E.5    Tricoire, H.6
  • 55
    • 48649085941 scopus 로고    scopus 로고
    • PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling
    • Lhocine N, Ribeiro PS, Buchon N, Wepf A, Wilson R, Tenev T et al. PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling. Cell Host Microbe 2008; 4:147-58.
    • (2008) Cell Host Microbe , vol.4 , pp. 147-158
    • Lhocine, N.1    Ribeiro, P.S.2    Buchon, N.3    Wepf, A.4    Wilson, R.5    Tenev, T.6
  • 56
    • 69049088645 scopus 로고    scopus 로고
    • Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut
    • Ha EM, Lee KA, Seo YY, Kim SH, Lim JH, Oh BH et al. Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut. Nat Immunol 2009; 10:949-57.
    • (2009) Nat Immunol , vol.10 , pp. 949-957
    • Ha, E.M.1    Lee, K.A.2    Seo, Y.Y.3    Kim, S.H.4    Lim, J.H.5    Oh, B.H.6
  • 57
    • 0027070519 scopus 로고
    • The function of the neurogenic genes during epithelial development in the Drosophila embryo
    • Hartenstein AY, Rugendorff A, Tepass U, Hartenstein V. The function of the neurogenic genes during epithelial development in the Drosophila embryo. Development 1992; 116:1203-20.
    • (1992) Development , vol.116 , pp. 1203-1220
    • Hartenstein, A.Y.1    Rugendorff, A.2    Tepass, U.3    Hartenstein, V.4
  • 58
    • 64549110803 scopus 로고    scopus 로고
    • EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors
    • Jiang H, Edgar BA. EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development 2009; 136:483-93.
    • (2009) Development , vol.136 , pp. 483-493
    • Jiang, H.1    Edgar, B.A.2
  • 59
    • 31444452338 scopus 로고    scopus 로고
    • Evidence that stem cells reside in the adult Drosophila midgut epithelium
    • Micchelli CA, Perrimon N. Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature 2006; 439:475-9.
    • (2006) Nature , vol.439 , pp. 475-479
    • Micchelli, C.A.1    Perrimon, N.2
  • 60
    • 31444444485 scopus 로고    scopus 로고
    • The adult Drosophila posterior midgut is maintained by pluripotent stem cells
    • Ohlstein B, Spradling A. The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature 2006; 439:470-4.
    • (2006) Nature , vol.439 , pp. 470-474
    • Ohlstein, B.1    Spradling, A.2
  • 61
    • 0034725575 scopus 로고    scopus 로고
    • Expression and functional characterization of a Drosophila neuropeptide precursor with homology to mammalian preprotachykinin A
    • Siviter RJ, Coast GM, Winther AM, Nachman RJ, Taylor CA, Shirras AD et al. Expression and functional characterization of a Drosophila neuropeptide precursor with homology to mammalian preprotachykinin A. J Biol Chem 2000; 275:23273-80.
    • (2000) J Biol Chem , vol.275 , pp. 23273-23280
    • Siviter, R.J.1    Coast, G.M.2    Winther, A.M.3    Nachman, R.J.4    Taylor, C.A.5    Shirras, A.D.6
  • 62
    • 0029585432 scopus 로고
    • Immunocytochemical localization of Diploptera punctata allatostatin-like peptide in Drosophila melanogaster
    • Yoon JG, Stay B. Immunocytochemical localization of Diploptera punctata allatostatin-like peptide in Drosophila melanogaster. J Comp Neurol 1995; 363:475-88.
    • (1995) J Comp Neurol , vol.363 , pp. 475-488
    • Yoon, J.G.1    Stay, B.2
  • 63
    • 33646182727 scopus 로고    scopus 로고
    • Organizing cell renewal in the intestine: Stem cells, signals and combinatorial control
    • Crosnier C, Stamataki D, Lewis J. Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat Rev Genet 2006; 7:349-59.
    • (2006) Nat Rev Genet , vol.7 , pp. 349-359
    • Crosnier, C.1    Stamataki, D.2    Lewis, J.3
  • 65
    • 69249212242 scopus 로고    scopus 로고
    • The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage
    • Fox DT, Spradling AC. The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage. Cell Stem Cell 2009; 5:290-7.
    • (2009) Cell Stem Cell , vol.5 , pp. 290-297
    • Fox, D.T.1    Spradling, A.C.2
  • 66
    • 69249211133 scopus 로고    scopus 로고
    • Stem cell in the adult Drosophila hindgut: Just a sleeping beauty
    • Xie T. Stem cell in the adult Drosophila hindgut: just a sleeping beauty. Cell Stem Cell 2009; 5:227-8.
    • (2009) Cell Stem Cell , vol.5 , pp. 227-228
    • Xie, T.1
  • 67
    • 33847168133 scopus 로고    scopus 로고
    • Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling
    • Ohlstein B, Spradling A. Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling. Science 2007; 315:988-92.
    • (2007) Science , vol.315 , pp. 988-992
    • Ohlstein, B.1    Spradling, A.2
  • 68
    • 54549104587 scopus 로고    scopus 로고
    • Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells
    • Lin G, Xu N, Xi R. Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells. Nature 2008; 455:1119-23.
    • (2008) Nature , vol.455 , pp. 1119-1123
    • Lin, G.1    Xu, N.2    Xi, R.3
  • 69
    • 67650388208 scopus 로고    scopus 로고
    • Pathogenic stimulation of intestinal stem cell response in Drosophila
    • Chatterjee M, Ip YT. Pathogenic stimulation of intestinal stem cell response in Drosophila. J Cell Physiol 2009; 220:664-71.
    • (2009) J Cell Physiol , vol.220 , pp. 664-671
    • Chatterjee, M.1    Ip, Y.T.2
  • 70
    • 70349617469 scopus 로고    scopus 로고
    • Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila
    • Buchon N, Broderick NA, Chakrabarti S, Lemaitre B. Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev 2009; 23:2333-44.
    • (2009) Genes Dev , vol.23 , pp. 2333-2344
    • Buchon, N.1    Broderick, N.A.2    Chakrabarti, S.3    Lemaitre, B.4
  • 71
    • 58049218983 scopus 로고    scopus 로고
    • Tissue damage-induced intestinal stem cell division in Drosophila
    • Amcheslavsky A, Jiang J, Ip YT. Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell 2009; 4:49-61.
    • (2009) Cell Stem Cell , vol.4 , pp. 49-61
    • Amcheslavsky, A.1    Jiang, J.2    Ip, Y.T.3
  • 72
    • 67549133157 scopus 로고    scopus 로고
    • Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut
    • Jiang H, Patel PH, Kohlmaier A, Grenley MO, McEwen DG, Edgar BA. Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 2009; 137:1343-55.
    • (2009) Cell , vol.137 , pp. 1343-1355
    • Jiang, H.1    Patel, P.H.2    Kohlmaier, A.3    Grenley, M.O.4    McEwen, D.G.5    Edgar, B.A.6
  • 73
    • 67650831470 scopus 로고    scopus 로고
    • Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection
    • Cronin SJ, Nehme NT, Limmer S, Liegeois S, Pospisilik JA, Schramek D et al. Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science 2009; 325:340-3.
    • (2009) Science , vol.325 , pp. 340-343
    • Cronin, S.J.1    Nehme, N.T.2    Limmer, S.3    Liegeois, S.4    Pospisilik, J.A.5    Schramek, D.6
  • 74
    • 52949093944 scopus 로고    scopus 로고
    • JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut
    • Biteau B, Hochmuth CE, Jasper H. JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. Cell Stem Cell 2008; 3:442-55.
    • (2008) Cell Stem Cell , vol.3 , pp. 442-455
    • Biteau, B.1    Hochmuth, C.E.2    Jasper, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.