Digestibility of transglutaminase cross-linked caseinate versus native caseinate in an in vitro multicompartmental model simulating young child and adult gastrointestinal conditions

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 31, 2013, Pages 7636-7644

  Havenaar, Robert ^a   De Jong, Aard ^a   Koenen, Marjorie E ^a   Van Bilsen, Jolanda ^a   Janssen, Armand M ^b   Labij, Erik ^b   Westerbeek, Hans J M ^b  

^a TNO   (Netherlands)

^b FrieslandCampina DMV ^*  (Netherlands)

Author keywords

adults and children; Cross linked caseinate; food matrix; in vitro digestion

Indexed keywords

ADULTS AND CHILDREN; CASEINATE; FOOD MATRIXES; GASTRIC CONDITIONS; GASTROINTESTINAL MODEL; GEL ELECTROPHORESIS; IN-VITRO DIGESTIONS; TRANSGLUTAMINASES;

ELECTROPHORESIS; NITROGEN; PEPTIDES;

BIOLOGICAL MATERIALS;

EID: 84881238066     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf402824u     Document Type: Article

References (53)

1. Zhu, Y.; Rinzema, A.; Tramper, J.; Bol, J. Microbial transglutaminase-A review of its production and application in food processing Appl. Microbiol. Biotechnol. 1995, 44, 277-282
2. De Jong, G. A. H.; Koppelman, S. J. Transglutaminase catalyzed reaction: impact on food applications J. Food Sci. 2002, 67, 2798-2806
3. Jaros, D.; Jacob, M.; Otto, C.; Rohm, H. Excessive cross-linking of caseins by microbial transglutaminase and its impact on physical properties of acidified milk gels Int. Dairy J. 2010, 20, 321-327
4. Jiang, S.-J.; Zhao, X.-H. Transglutaminase-induced cross-linking and glucosamine conjugation of casein and some functional properties of the modified product Int. Dairy J. 2011, 21, 198-205
5. Zhang, Y.-N.; Liu, N.; Zhao, X.-H. A study on the preparation and some functional properties of a cross-linked casein-gelatin composite by a microbial transglutaminase Int. J. Food Sci. Technol. 2011, 46, 2641-2647
6. Dinkci, N. The influence of transglutaminase treatment on functional properties of strained yoghurt J. Anim. Vet. Adv. 2012, 11, 2238-2246
7. Desá, E. M. F.; Bordignon-Luiz, M. T. The effect of transglutaminase on the properties of milk gels and processed cheese Int. J. Dairy Technol. 2010, 63, 243-251
8. Jiang, S.-J.; Zhao, X.-H. Cross-linking and glucosamine conjugation of casein by transglutaminase and the emulsifying property and digestibility in vitro of the modified product Int. J. Food Prop. 2012, 15, 1286-1299
9. Monogioudi, E.; Faccio, G.; Lille, M.; Poutanen, K.; Buchert, J.; Mattinen, M.-L. Effect of enzymatic cross-linking of ß-casein on proteolysis by pepsin Food Hydrocolloids 2011, 25, 71-81
10. Monogioudi, E. Enzymatic cross-linking of ß-casein and its impact on digestibility and allergenicity VTT Publi. 2010, 752, 1-92
11. Schulten, V.; Lauer, L.; Scheurer, S.; Thalhammer, T.; Bohle, B. A food matrix reduces digestion and absorption of food allergens in vivo Mol. Nutr. Food Res. 2011, 55, 1484-1491
12. Neu, J. Gastrointestinal maturation and implications for infant feeding Early Hum. Dev. 2007, 83, 767-775
13. Bowles, A.; Keane, J.; Ernest, T.; Clapham, D.; Tuleu, C. Specific aspects of gastro-intestinal transit in children for drug delivery design Int. J. Pharm. 2010, 395, 37-43
14. Kaye, J. Review of paediatric gastrointestinal physiology data relevant to oral drug delivery Int. J. Clin. Pharm. 2011, 33, 20-24
15. Moreno, F. J. Gastrointestinal digestion of food allergens: Effect on their allergenicity Biomed. Pharmacother. 2007, 61, 50-60
16. Wickham, M.; Faulks, R.; Mills, C. In vitro digestion methods for assessing the effect of food structure on allergen breakdown Mol. Nutr. Food Res. 2009, 53, 952-958
17. Minekus, M.; Marteau, P.; Havenaar, R.; Huis in 't Veld, J. H. J. A multi compartmental dynamic computer-controlled model simulating the stomach and small intestine ATLA 1995, 23, 197-209
18. Minekus, M. In Development and Validation of a Dynamic Model of the Gastrointestinal Tract. PhD Thesis, Utrecht University. Elinkwijk b.v.: Utrecht, Netherlands. 1998, (ISBN: 90-393-1666-x).
19. Nabil, S.; Gauthier, S. F.; Drouin, R.; Poubelle, P. E.; Pouliot, Y. In vitro digestion of proteins and growth factors in a bovine whey protein extract as determined using a computer-controlled dynamic gastrointestinal system (TIM-1) Food Dig. 2011, 2, 13-22
20. Minekus, M.; Jelier, M.; Xiao, J.-Z.; Kondo, S.; Iwatsuki, K.; Kokubo, S.; Bos, M.; Dunnewind, B.; Havenaar, R. Effect of partially hydrolyzed guar gum (PHGG) on the bioaccessibility of fat and cholesterol Biosci., Biotechnol., Biochem. 2005, 69, 932-938
21. Gervais, R.; Gagnon, F.; Kheadr, E. E.; Van Calsteren, R.-M.; Farnworth, E. R.; Fliss, I.; Chouinard, P. Y. Bioaccessibility of fatty acids from conjugated linoleic acid-enriched milk and milk emulsions studied in a dynamic in vitro gastrointestinal model Int. Dairy J. 2009, 19, 574-581
22. ArkbaÌŠge, K.; Verwei, M.; Havenaar, R.; Witthöft, C. Bioaccessibility of folic acid and (6S)-5-methyltetrahydrofolate decreases after addition of folate-binding protein to yogurt as studied in a dynamic in vitro gastrointestinal model J. Nutr. 2003, 133, 3678-3683
23. Verwei, M.; Freidig, A. P.; Havenaar, R.; Groten, J. P. Predicted serum folate concentrations based on in vitro studies and kinetic modeling are consistent with measured folate concentrations in humans J. Nutr. 2006, 136, 3074-3078
24. Deat, E.; Blanquet-Diot, S.; Jarrige, J.-F.; Denis, S.; Beyssac, E.; Alric, M. Combining the dynamic TNO-gastrointestinal tract system with a Caco-2 cell culture model: Application to the assessment of lycopene and r-tocopherol bioavailability from a whole food J. Agric. Food Chem. 2009, 57, 11314-11320 (Correction of Fig. 4: JAFC p 11314).
25. Richelle, M.; Sanchez, B.; Tavazzi, I.; Lambelet, P.; Bortlik, K.; Williamson, G. Lycopene isomerisation takes place within enterocytes during absorption in human subjects Br. J. Nutr. 2010, 103, 1800-1807
26. Salovaara, S.; Larsson Alminger, M.; Eklund-Jonsson, C.; Andlid, T.; Sandberg, A.-S. Prolonged transit time through the stomach and small intestine improves iron dialyzability and uptake in vitro J. Agric. Food Chem. 2003, 51, 5131-5136
27. Eklund-Jonsson, C.; Sandberg, A.-S.; Hulthen, L.; Larsson-Alminger, M. Tempé fermentation of whole grain barley increased human iron absorption and in vitro iron availability Open Nutr. J. 2008, 2, 42-47
28. Mateo Anson, N.; Havenaar, R.; Bast, A.; Haenen, G. R. M. M. Antioxidant and anti-inflammatory capacity of bioaccessible compounds from wheat fractions after gastrointestinal digestion J. Cereal Sci. 2010, 51, 110-114
29. Hemery, Y. M.; Mateo Anson, N.; Havenaar, R.; Haenen, G. R. M. M.; Noort, M. W. J.; Rouau, X. Dry-fractionation of wheat bran increases the bioaccessibility of phenolic acids in breads made from processed bran fractions Food Res. Int. 2010, 43, 1429-1438
30. Chen, L.; Hebrard, G.; Beyssac, E.; Denis, S.; Subirade, M. In Vitro study of the release properties of soy-zein protein microspheres with a dynamic artificial digestive system J. Agric. Food Chem. 2010, 58, 9861-9867
31. Mitea, C.; Havenaar, R.; Drijfhout, J. W.; Edens, L.; Dekking, L.; Koning, F. Efficient degradation of gluten by prolyl endoprotease in gastrointestinal model: Implications for coeliac disease Gut 2008, 57, 25-32
32. Schaafsma, G. The Protein Digestibility-Corrected Amino Acid Score (PDCAAS). A concept for describing protein quality in foods and food ingredients: A critical review J. AOAC Int. 2005, 88, 988-994
33. Lankhorst, C.; Tran, Q.; Havenaar, R.; Hendriks, W.; van der Poel, A. The effect of extrusion on the nutritional value of canine diets as assessed by in vitro indicators Anim. Feed Sci. Technol. 2007, 138, 285-297
34. Bradford, M. M. A rapid and sensitive method for quantization of microgram quantities of protein utilizing the principle of protein-dye-binding Anal. Biochem. 1976, 72, 248-254
35. Exl, B.-M.; Fritsché, R. Cow's milk protein allergy and possible means for its prevention Nutrition 2001, 17, 642-651
36. Ma, H.; Forssell, P.; Kylli, P.; Lampi, A.-M.; Buchert, J.; Boer, H.; Partanen, R. Transglutaminase catalyzed cross-linking of sodium caseinate improves oxidative stability of flaxseed oil emulsion J. Agric. Food Chem. 2012, 60, 6223-6229
37. Roos, N.; Lorenzen, P. C.; Sick, H.; Schrezenmeir, J.; Schlimme, E. Cross-linking by transglutaminase changes neither the in vitro proteolysis nor the in vivo digestibility of caseinate Kiel. Milchwirtsch. Forschungsber. 2003, 55, 261-276
38. Juvonen, K. R.; Lille, M. E.; Laaksonen, D. E.; Mykkänen, L. K.; Herzig, K.-H.; Poutanen, K. S.; Karhunen, L. J. Crosslinking with transglutaminase does not change metabolic effects of sodium caseinate in model beverage in healthy young individuals Nutr. J. 2012, 11 (35) 1-12
39. Bönisch, M. P.; Heidebach, T. C.; Kulozik, U. Influence of transglutaminase protein cross-linking on rennet coagulation of casein Food Hydrocolloids 2008, 22, 288-297
40. Jovanovic, S.; Barac, M.; Macej, O.; Vucic, T.; Lacnjevac, C. 2007. SDS-PAGE analysis of soluble proteins in reconstituted milk exposed to different heat treatments. Sensor 2007, 7) 371-383.
41. Pardo, M. F.; Natalucci, C. L. Electrophoretic analysis (Tricine-SDS-PAGE) of bovine caseins. Acta Farm Bonaerense 2002, 21, 57-60
42. Stanic, D.; Monogioudi, E.; Dilek, E.; Radosavljevic, J.; Atanaskovic-Markovic, M.; Vuckovic, O.; Raija, L.; Mattinen, M.; Buchert, J.; Cirkovic Velickovic, T. Digestibility and allergenicity assessment of enzymatically cross-linked β-casein Mol. Nutr. Food Res. 2010, 54, 1273-1284
43. Chatterton, D.; Rasmussen, J.; Heegaard, C.; Sørensen, E.; Petersen, T. In vitro digestion of novel milk protein ingredients for use in infant formulas: research on biological functions Trends Food Sci. Technol. 2004, 15, 373-383
44. Mandalari, G.; Adel-Patient, K.; Barkholt, V.; Baro, C.; Bennett, L.; Bublin, M.; Gaier, S.; Graser, G.; Ladics, G.; Mierzejewska, D.; Vassilopoulou, E.; Vissers, Y.; Zuidmeer, L.; Rigby, N.; Salt, L.; Defernez, M.; Mulholland, F.; Mackie, A.; Wickham, M.; Mills, C. In vitro digestibility of β-casein and β-lactoglobulin under simulated human gastric and duodenal conditions: a multi-laboratory evaluation Regul. Toxicol. Pharmacol. 2009, 55, 372-381
45. Hellwig, M.; Löbner, J.; Schneider, A.; Schwarzenbolz, U.; Henle, T. Release of protein-bound N-ε-(γ-glutamyl)-lysine during simulated gastrointestinal digestion Czech J. Food Sci. 2009, 27, S153-S155
46. Seguro, K.; Kumazawa, Y.; Ohtsuka, T.; Ide, H.; Nio, N.; Motoki, M.; Kubota, K. E-(y-Glutamyl)lysine: Hydrolysis by y-glutamyltransferase of different origins, when free or protein bound J. Agric. Food Chem. 1995, 43, 1977-1981
47. Astwood, J. D.; Leach, J. N.; Fuchs, R. L. Stability of food allergens to digestion in vitro Nat. Biotechnol. 1996, 14, 1269-1273
48. FAO/WHO. Evaluation of Allergenicity of Genetically Modified Foods. Report of a Joint FAO/WHO Expert Consultation on Allergenicity of Foods Derived from Biotechnology; Food and Agricultural Organization/World Health Organization: Rome, Italy, 2001.
49. Codex Alimentarius. Guideline for the Conduct of Food Safety Assessment of Foods Derived from Recombinant-DNA Plants. CAC/GL 45-2003. In Food and Agriculture Organization, Joint FAO/WHO Food Standards Program; Codex Alimentarius Commission: Rome, Italy, 2003.
50. European Food Safety Authority. Scientific Opinion on the assessment of allergenicity of GM plants and microorganisms and derived food and feed. EFSA J. 2010, 8, 1700
51. Chehade, M.; Mayer, L. Oral tolerance and its relation to food hypersensitivities. J. Allergy Clin. Immunol. 2005, 115, 3-12; quiz 13.
52. Eiwegger, T.; Rigby, N.; Mondoulet, L.; Bernard, H.; Krauth, M. T.; Boehm, A.; Dehlink, E.; Valent, P.; Wal, J. M.; Mills, E. N.; Szepfalusi, Z. Gastro-duodenal digestion products of the major peanut allergen Ara h1 retain an allergenic potential Clin. Exp. Allergy 2006, 36, 1281-1288
53. Rosendal, A.; Barkholt, V. Detection of potentially allergenic material in 12 hydrolyzed milk formulas J. Dairy Sci. 2000, 83, 2200-2210