A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development

Cell Reports

Volumn 3, Issue 1, 2013, Pages 200-210

  Lin, Juan ^a   Li, Hanjie ^a   Yang, Min ^b   Ren, Junming ^a   Huang, Zhe ^a   Han, Felicia ^a   Huang, Jian ^c   Ma, Jianhui ^a   Zhang, Duanwu ^a   Zhang, Zhirong ^a   Wu, Jianfeng ^a   Huang, Deli ^a   Qiao, Muzhen ^a   Jin, Guanghui ^a   Wu, Qiao ^a   Huang, Yinghui ^d   Du, Jie ^b   Han, Jiahuai ^a  

^a XIAMEN UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

^d JILIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; CASPASE; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN KINASE; RECEPTOR INTERACTING PROTEIN 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL DEATH; CONTROLLED STUDY; DISEASE COURSE; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE DELETION; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DEPLETION; PROTEIN EXPRESSION;

ANIMALS; APOLIPOPROTEINS E; APOPTOSIS; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; BODY WEIGHT; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CASPASE 8; CASPASE INHIBITORS; CELL SHAPE; CHOLESTEROL; COLLAGEN; CYTOKINES; ELASTIN; FEMALE; INFLAMMATION; LIPOPROTEINS, LDL; MACROPHAGES; MICE; MICRODISSECTION; NECROSIS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RECEPTORS, LDL; RNA, MESSENGER; UP-REGULATION;

MUS;

EID: 84873152891     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2012.12.012     Document Type: Article

References (28)

1. Bao L.P., Li Y.K., Deng S.X., Landry D., Tabas I. Sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent macrophages. J. Biol. Chem. 2006, 281:33635-33649.
2. Barish G.D., Atkins A.R., Downes M., Olson P., Chong L.W., Nelson M., Zou Y., Hwang H., Kang H., Curtiss L., et al. PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis. Proc. Natl. Acad. Sci. USA 2008, 105:4271-4276.
3. Bauriedel G., Schluckebier S., Hutter R., Welsch U., Kandolf R., Lüderitz B., Prescott M.F. Apoptosis in restenosis versus stable-angina atherosclerosis: implications for the pathogenesis of restenosis. Arterioscler. Thromb. Vasc. Biol. 1998, 18:1132-1139.
4. Cho Y.S., Challa S., Moquin D., Genga R., Ray T.D., Guildford M., Chan F.K. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 2009, 137:1112-1123.
5. Crisby M., Kallin B., Thyberg J., Zhivotovsky B., Orrenius S., Kostulas V., Nilsson J. Cell death in human atherosclerotic plaques involves both oncosis and apoptosis. Atherosclerosis 1997, 130:17-27.
6. Cybulsky M.I., Gimbrone M.A. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 1991, 251:788-791.
7. Feng B., Yao P.M., Li Y., Devlin C.M., Zhang D., Harding H.P., Sweeney M., Rong J.X., Kuriakose G., Fisher E.A., et al. The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat. Cell Biol. 2003, 5:781-792.
8. Han J., Zhong C.Q., Zhang D.W. Programmed necrosis: backup to and competitor with apoptosis in the immune system. Nat. Immunol. 2011, 12:1143-1149.
9. He S., Wang L., Miao L., Wang T., Du F., Zhao L., Wang X. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 2009, 137:1100-1111.
10. Hegyi L., Skepper J.N., Cary N.R.B., Mitchinson M.J. Foam cell apoptosis and the development of the lipid core of human atherosclerosis. J. Pathol. 1996, 180:423-429.
11. Kaiser W.J., Upton J.W., Long A.B., Livingston-Rosanoff D., Daley-Bauer L.P., Hakem R., Caspary T., Mocarski E.S. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 2011, 471:368-372.
12. Kono H., Rock K.L. How dying cells alert the immune system to danger. Nat. Rev. Immunol. 2008, 8:279-289.
13. Lee C.H., Chawla A., Urbiztondo N., Liao D., Boisvert W.A., Evans R.M., Curtiss L.K. Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science 2003, 302:453-457.
14. Libby P. Inflammation in atherosclerosis. Nature 2002, 420:868-874.
15. Moore K.J., Tabas I. Macrophages in the pathogenesis of atherosclerosis. Cell 2011, 145:341-355.
16. Newton K., Sun X., Dixit V.M. Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol. Cell. Biol. 2004, 24:1464-1469.
17. Oberst A., Dillon C.P., Weinlich R., McCormick L.L., Fitzgerald P., Pop C., Hakem R., Salvesen G.S., Green D.R. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 2011, 471:363-367.
18. Osuga J., Ishibashi S., Oka T., Yagyu H., Tozawa R., Fujimoto A., Shionoiri F., Yahagi N., Kraemer F.B., Tsutsumi O., Yamada N. Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity. Proc. Natl. Acad. Sci. USA 2000, 97:787-792.
19. Seimon T.A., Wang Y., Han S., Senokuchi T., Schrijvers D.M., Kuriakose G., Tall A.R., Tabas I.A. Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice. J. Clin. Invest. 2009, 119:886-898.
20. Sekiya M., Osuga J., Nagashima S., Ohshiro T., Igarashi M., Okazaki H., Takahashi M., Tazoe F., Wada T., Ohta K., et al. Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis. Cell Metab. 2009, 10:219-228.
21. Sun L., Wang H., Wang Z., He S., Chen S., Liao D., Wang L., Yan J., Liu W., Lei X., Wang X. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012, 148:213-227.
22. Tabas I. Macrophage death and defective inflammation resolution in atherosclerosis. Nat. Rev. Immunol. 2010, 10:36-46.
23. Tabas I., Marathe S., Keesler G.A., Beatini N., Shiratori Y. Evidence that the initial up-regulation of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response that prevents cholesterol-induced cellular necrosis. Proposed role of an eventual failure of this response in foam cell necrosis in advanced atherosclerosis. J. Biol. Chem. 1996, 271:22773-22781.
24. Thorp E., Li G., Seimon T.A., Kuriakose G., Ron D., Tabas I. Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. Cell Metab. 2009, 9:474-481.
25. Trichonas G., Murakami Y., Thanos A., Morizane Y., Kayama M., Debouck C.M., Hisatomi T., Miller J.W., Vavvas D.G. Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis. Proc. Natl. Acad. Sci. USA 2010, 107:21695-21700.
26. Tupin E., Nicoletti A., Elhage R., Rudling M., Ljunggren H.G., Hansson G.K., Berne G.P. CD1d-dependent activation of NKT cells aggravates atherosclerosis. J. Exp. Med. 2004, 199:417-422.
27. Welz P.S., Wullaert A., Vlantis K., Kondylis V., Fernandez-Majada V., Ermolaeva M., Kirsch P., Sterner-Kock A., van Loo G., Pasparakis M. FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature 2011.
28. Zhang D.W., Shao J., Lin J., Zhang N., Lu B.J., Lin S.C., Dong M.Q., Han J. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009, 325:332-336.