Receptor interacting protein 3 suppresses vascular smooth muscle cell growth by inhibition of the phosphoinositide 3-kinase-Akt axis

Journal of Biological Chemistry

Volumn 285, Issue 13, 2010, Pages 9535-9544

  Li, Qian ^a   Li, Geng ^a   Lan, Xiaomei ^a   Zheng, Ming ^a   Chen, Kuang Hueih ^b   Cao, Chun Mei ^a   Xiao, Rui Ping ^a,b,c  

^a PEKING UNIVERSITY   (China)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AKT ACTIVATION; ANGIOTENSIN II; APOPTOSIS; BALLOON INJURY; CELL-CYCLE ARREST; CONSTITUTIVELY ACTIVES; GENE DELIVERY; GENE SILENCING; GROWTH ARREST; IN-VIVO; INACTIVE MUTANTS; KINASE ACTIVITY; MITOGENIC STIMULATION; NEOINTIMAL FORMATION; OVER-EXPRESSION; PHOSPHOINOSITIDE 3-KINASE; PLATELET-DERIVED GROWTH FACTORS; PRIMARY MECHANISM; PRO-APOPTOTIC EFFECTS; PROTEIN KINASE B; RECEPTOR-INTERACTING PROTEINS; SHARP CONTRAST; SIGNALING PATHWAYS; UP-REGULATION; VASCULAR SMOOTH MUSCLE CELLS; WILD TYPES;

ACTIVATION ANALYSIS; BIOACTIVITY; BLOOD SUBSTITUTES; CELL DEATH; CELL PROLIFERATION; GENE TRANSFER; GROWTH KINETICS; MUSCLE; PEPTIDES; PLATELETS; SIGNALING;

BLOOD VESSEL PROSTHESES;

ADENOVIRUS VECTOR; ANGIOTENSIN II; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; RECEPTOR INTERACTING PROTEIN 3; UNCLASSIFIED DRUG; WORTMANNIN; ENZYME INHIBITOR; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERY INTIMA PROLIFERATION; ARTICLE; CAROTID ARTERY INJURY; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME INHIBITION; GENE OVEREXPRESSION; GENE SILENCING; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR SMOOTH MUSCLE; VIRAL GENE DELIVERY SYSTEM; WILD TYPE; ANIMAL; BIOLOGICAL MODEL; CAROTID ARTERY; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; METABOLISM; MUTATION; WISTAR KYOTO RAT;

RATTUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CAROTID ARTERIES; CELL PROLIFERATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; MODELS, BIOLOGICAL; MUSCLE, SMOOTH, VASCULAR; MUTATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, INBRED WKY; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 77951228261     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.071332     Document Type: Article

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