메뉴 건너뛰기




Volumn 1833, Issue 12, 2013, Pages 2639-2652

E3 ubiquitin ligase Fbw7 negatively regulates granulocytic differentiation by targeting G-CSFR for degradation

Author keywords

Fbw7; G CSFR; GSK3 ; Ubiquitin proteasome degradation

Indexed keywords

F BOX AND WD REPEAT DOMAIN CONTAINING 7 PROTEIN; F BOX PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; SMALL INTERFERING RNA; STAT3 PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

EID: 84881117483     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2013.06.018     Document Type: Article
Times cited : (31)

References (48)
  • 1
    • 0028000668 scopus 로고
    • Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization
    • Lieschke G.J., Grail D., Hodgson G., Metcalf D., Stanley E., Cheers C., Fowler K.J., Basu S., Zhan Y.F., Dunn A.R. Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood 1994, 84:1737-1746.
    • (1994) Blood , vol.84 , pp. 1737-1746
    • Lieschke, G.J.1    Grail, D.2    Hodgson, G.3    Metcalf, D.4    Stanley, E.5    Cheers, C.6    Fowler, K.J.7    Basu, S.8    Zhan, Y.F.9    Dunn, A.R.10
  • 2
    • 0029780711 scopus 로고    scopus 로고
    • Molecular analysis of the granulocyte colony-stimulating factor receptor
    • Avalos B.R. Molecular analysis of the granulocyte colony-stimulating factor receptor. Blood 1996, 88:761-777.
    • (1996) Blood , vol.88 , pp. 761-777
    • Avalos, B.R.1
  • 3
    • 0033555810 scopus 로고    scopus 로고
    • Deletion of a critical internalization domain in the G-CSFR in acute myelogenous leukemia preceded by severe congenital neutropenia
    • Hunter M.G., Avalos B.R. Deletion of a critical internalization domain in the G-CSFR in acute myelogenous leukemia preceded by severe congenital neutropenia. Blood 1999, 93:440-446.
    • (1999) Blood , vol.93 , pp. 440-446
    • Hunter, M.G.1    Avalos, B.R.2
  • 4
    • 32144453842 scopus 로고    scopus 로고
    • JAK/STAT signal transduction: regulators and implication in hematological malignancies
    • Valentino L., Pierre J. JAK/STAT signal transduction: regulators and implication in hematological malignancies. Biochem. Pharmacol. 2006, 71:713-721.
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 713-721
    • Valentino, L.1    Pierre, J.2
  • 5
    • 0034614626 scopus 로고    scopus 로고
    • Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation
    • Yu C.L., Jin Y.J., Burakoff S.J. Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation. J. Biol. Chem. 2000, 275:599-604.
    • (2000) J. Biol. Chem. , vol.275 , pp. 599-604
    • Yu, C.L.1    Jin, Y.J.2    Burakoff, S.J.3
  • 6
    • 6344266977 scopus 로고    scopus 로고
    • Loss of SHIP and CIS recruitment to the granulocyte colony-stimulating factor receptor contribute to hyperproliferative responses in severe congenital neutropenia/acute myelogenous leukemia
    • Hunter M.G., Jacob A., O'Donnell L C., Agler A., Druhan L.J., Coggeshall K.M., Avalos B.R. Loss of SHIP and CIS recruitment to the granulocyte colony-stimulating factor receptor contribute to hyperproliferative responses in severe congenital neutropenia/acute myelogenous leukemia. J. Immunol. 2004, 173:5036-5045.
    • (2004) J. Immunol. , vol.173 , pp. 5036-5045
    • Hunter, M.G.1    Jacob, A.2    O'Donnell, L.C.3    Agler, A.4    Druhan, L.J.5    Coggeshall, K.M.6    Avalos, B.R.7
  • 8
    • 34047123668 scopus 로고    scopus 로고
    • Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling
    • Erkeland S.J., Aarts L.H., Irandoust M., Roovers O., Klomp A., Valkhof M., Gits J., Eyckerman S., Tavernier J., Touw I.P. Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling. Oncogene 2007, 26:1985-1994.
    • (2007) Oncogene , vol.26 , pp. 1985-1994
    • Erkeland, S.J.1    Aarts, L.H.2    Irandoust, M.3    Roovers, O.4    Klomp, A.5    Valkhof, M.6    Gits, J.7    Eyckerman, S.8    Tavernier, J.9    Touw, I.P.10
  • 10
    • 54849416137 scopus 로고    scopus 로고
    • G-CSFR ubiquitination critically regulates myeloid cell survival and proliferation
    • Ai J., Druhan L.J., Loveland M.J., Avalos B.R. G-CSFR ubiquitination critically regulates myeloid cell survival and proliferation. PLoS One 2008, 3:e3422.
    • (2008) PLoS One , vol.3
    • Ai, J.1    Druhan, L.J.2    Loveland, M.J.3    Avalos, B.R.4
  • 11
    • 0037462424 scopus 로고    scopus 로고
    • Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase
    • Orlicky S., Tang X., Willems A., Tyers M., Sicheri F. Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase. Cell 2003, 112:243-256.
    • (2003) Cell , vol.112 , pp. 243-256
    • Orlicky, S.1    Tang, X.2    Willems, A.3    Tyers, M.4    Sicheri, F.5
  • 14
    • 22244476115 scopus 로고    scopus 로고
    • The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase
    • Wei W., Jin J., Schlisio S., Harper J.W., Kaelin W.G. The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer cell 2005, 8:25-33.
    • (2005) Cancer cell , vol.8 , pp. 25-33
    • Wei, W.1    Jin, J.2    Schlisio, S.3    Harper, J.W.4    Kaelin, W.G.5
  • 16
    • 77955342148 scopus 로고    scopus 로고
    • The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation
    • Bengoechea-Alonso M.T., Ericsson J. The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:11817-11822.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 11817-11822
    • Bengoechea-Alonso, M.T.1    Ericsson, J.2
  • 17
    • 33646349442 scopus 로고    scopus 로고
    • Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226
    • Liu H.K., Perrier S., Lipina C., Finlay D., McLauchlan H., Hastie C.J., Hundal H.S., Sutherland C. Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226. BMC Mol. Biol. 2006, 7:14.
    • (2006) BMC Mol. Biol. , vol.7 , pp. 14
    • Liu, H.K.1    Perrier, S.2    Lipina, C.3    Finlay, D.4    McLauchlan, H.5    Hastie, C.J.6    Hundal, H.S.7    Sutherland, C.8
  • 18
    • 77953310667 scopus 로고    scopus 로고
    • The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs
    • Liu N., Li H., Li S., Shen M., Xiao N., Chen Y., Wang Y., Wang W., Wang R., Wang Q., Sun J., Wang P. The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. J. Biol. Chem. 2010, 285:18858-18867.
    • (2010) J. Biol. Chem. , vol.285 , pp. 18858-18867
    • Liu, N.1    Li, H.2    Li, S.3    Shen, M.4    Xiao, N.5    Chen, Y.6    Wang, Y.7    Wang, W.8    Wang, R.9    Wang, Q.10    Sun, J.11    Wang, P.12
  • 19
    • 77953158826 scopus 로고    scopus 로고
    • The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation
    • Zhao D., Zheng H.Q., Zhou Z., Chen C. The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation. Cancer Res. 2010, 70:4728-4738.
    • (2010) Cancer Res. , vol.70 , pp. 4728-4738
    • Zhao, D.1    Zheng, H.Q.2    Zhou, Z.3    Chen, C.4
  • 20
    • 23844530704 scopus 로고    scopus 로고
    • Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7)
    • Sundqvist A., Bengoechea-Alonso M.T., Ye X., Lukiyanchuk V., Jin J., Harper J.W., Ericsson J. Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). Cell Metab. 2005, 1:379-391.
    • (2005) Cell Metab. , vol.1 , pp. 379-391
    • Sundqvist, A.1    Bengoechea-Alonso, M.T.2    Ye, X.3    Lukiyanchuk, V.4    Jin, J.5    Harper, J.W.6    Ericsson, J.7
  • 22
    • 38349057556 scopus 로고    scopus 로고
    • SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis
    • Olson B.L., Hock M.B., Ekholm-Reed S., Wohlschlegel J.A., Dev K.K., Kralli A., Reed S.I. SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis. Genes Dev. 2008, 22:252-264.
    • (2008) Genes Dev. , vol.22 , pp. 252-264
    • Olson, B.L.1    Hock, M.B.2    Ekholm-Reed, S.3    Wohlschlegel, J.A.4    Dev, K.K.5    Kralli, A.6    Reed, S.I.7
  • 23
    • 79953701637 scopus 로고    scopus 로고
    • 2-D gel electrophoresis-based proteomic analysis reveals that ormeloxifen induces G0-G1 growth arrest and ERK-mediated apoptosis in chronic myeloid leukemia cells K562
    • Pal P., Kanaujiya J.K., Lochab S., Tripathi S.B., Bhatt M.L., Singh P.K., Sanyal S., Trivedi A.K. 2-D gel electrophoresis-based proteomic analysis reveals that ormeloxifen induces G0-G1 growth arrest and ERK-mediated apoptosis in chronic myeloid leukemia cells K562. Proteomics 2011, 11:1517-1529.
    • (2011) Proteomics , vol.11 , pp. 1517-1529
    • Pal, P.1    Kanaujiya, J.K.2    Lochab, S.3    Tripathi, S.B.4    Bhatt, M.L.5    Singh, P.K.6    Sanyal, S.7    Trivedi, A.K.8
  • 24
    • 17144427278 scopus 로고    scopus 로고
    • Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors
    • Moucadel V., Constantinescu S.N. Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors. J. Biol. Chem. 2005, 280:13364-13373.
    • (2005) J. Biol. Chem. , vol.280 , pp. 13364-13373
    • Moucadel, V.1    Constantinescu, S.N.2
  • 25
    • 6944227551 scopus 로고    scopus 로고
    • A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size
    • Welcker M., Orian A., Grim J.E., Eisenman R.N., Clurman B.E. A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size. Curr. Biol. 2004, 14:1852-1857.
    • (2004) Curr. Biol. , vol.14 , pp. 1852-1857
    • Welcker, M.1    Orian, A.2    Grim, J.E.3    Eisenman, R.N.4    Clurman, B.E.5
  • 26
    • 37349094929 scopus 로고    scopus 로고
    • GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers
    • Kang T., Wei Y., Honaker Y., Yamaguchi H., Appella E., Hung M.C., Piwnica-Worms H. GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers. Cancer cell 2008, 13:36-47.
    • (2008) Cancer cell , vol.13 , pp. 36-47
    • Kang, T.1    Wei, Y.2    Honaker, Y.3    Yamaguchi, H.4    Appella, E.5    Hung, M.C.6    Piwnica-Worms, H.7
  • 27
    • 84880642274 scopus 로고    scopus 로고
    • Proteomic identification of Profilin1 as a co-repressor of estrogen receptor alpha in MCF7 breast cancer cells
    • (in press),
    • Kanaujiya J.K., Lochab S., Kapoor I., Pal P., Datta D., Bhatt M.L., Sanyal S., Behre G., Trivedi A.K. Proteomic identification of Profilin1 as a co-repressor of estrogen receptor alpha in MCF7 breast cancer cells. Proteomics 2013 Apr 10, (in press), http://dx.doi.org/10.1002/pmic.201200534.
    • (2013) Proteomics
    • Kanaujiya, J.K.1    Lochab, S.2    Kapoor, I.3    Pal, P.4    Datta, D.5    Bhatt, M.L.6    Sanyal, S.7    Behre, G.8    Trivedi, A.K.9
  • 28
    • 84876929095 scopus 로고    scopus 로고
    • E6AP, an E3 ubiquitin ligase negatively regulates granulopoiesis by targeting transcription factor C/EBPalpha for ubiquitin-mediated proteasome degradation
    • Pal P., Lochab S., Kanaujiya J.K., Kapoor I., Sanyal S., Behre G., Trivedi A.K. E6AP, an E3 ubiquitin ligase negatively regulates granulopoiesis by targeting transcription factor C/EBPalpha for ubiquitin-mediated proteasome degradation. Cell Death Dis. 2013, 4:e590.
    • (2013) Cell Death Dis. , vol.4
    • Pal, P.1    Lochab, S.2    Kanaujiya, J.K.3    Kapoor, I.4    Sanyal, S.5    Behre, G.6    Trivedi, A.K.7
  • 29
    • 33947250778 scopus 로고    scopus 로고
    • Proteomic identification of C/EBP-DBD multiprotein complex: JNK1 activates stem cell regulator C/EBPalpha by inhibiting its ubiquitination
    • Trivedi A.K., Bararia D., Christopeit M., Peerzada A.A., Singh S.M., Kieser A., Hiddemann W., Behre H.M., Behre G. Proteomic identification of C/EBP-DBD multiprotein complex: JNK1 activates stem cell regulator C/EBPalpha by inhibiting its ubiquitination. Oncogene 2007, 26:1789-1801.
    • (2007) Oncogene , vol.26 , pp. 1789-1801
    • Trivedi, A.K.1    Bararia, D.2    Christopeit, M.3    Peerzada, A.A.4    Singh, S.M.5    Kieser, A.6    Hiddemann, W.7    Behre, H.M.8    Behre, G.9
  • 31
    • 34047249627 scopus 로고    scopus 로고
    • Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases
    • Hao B., Oehlmann S., Sowa M.E., Harper J.W., Pavletich N.P. Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases. Mol. Cell 2007, 26:131-143.
    • (2007) Mol. Cell , vol.26 , pp. 131-143
    • Hao, B.1    Oehlmann, S.2    Sowa, M.E.3    Harper, J.W.4    Pavletich, N.P.5
  • 32
    • 51749095471 scopus 로고    scopus 로고
    • FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression
    • Mao J.H., Kim I.J., Wu D., Climent J., Kang H.C., DelRosario R., Balmain A. FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science 2008, 321:1499-1502.
    • (2008) Science , vol.321 , pp. 1499-1502
    • Mao, J.H.1    Kim, I.J.2    Wu, D.3    Climent, J.4    Kang, H.C.5    DelRosario, R.6    Balmain, A.7
  • 34
    • 0345059082 scopus 로고    scopus 로고
    • The murine myeloid cell line 32Dcl3 as a model system for studying neutrophil functions
    • Guchhait P., Tosi M.F., Smith C.W., Chakaraborty A. The murine myeloid cell line 32Dcl3 as a model system for studying neutrophil functions. J. Immunol. Methods 2003, 283:195-204.
    • (2003) J. Immunol. Methods , vol.283 , pp. 195-204
    • Guchhait, P.1    Tosi, M.F.2    Smith, C.W.3    Chakaraborty, A.4
  • 35
    • 0037438380 scopus 로고    scopus 로고
    • The effects of Bcr-Abl on C/EBP transcription-factor regulation and neutrophilic differentiation are reversed by the Abl kinase inhibitor imatinib mesylate
    • Schuster C., Forster K., Dierks H., Elsasser A., Behre G., Simon N., Danhauser-Riedl S., Hallek M., Warmuth M. The effects of Bcr-Abl on C/EBP transcription-factor regulation and neutrophilic differentiation are reversed by the Abl kinase inhibitor imatinib mesylate. Blood 2003, 101:655-663.
    • (2003) Blood , vol.101 , pp. 655-663
    • Schuster, C.1    Forster, K.2    Dierks, H.3    Elsasser, A.4    Behre, G.5    Simon, N.6    Danhauser-Riedl, S.7    Hallek, M.8    Warmuth, M.9
  • 36
    • 0032502719 scopus 로고    scopus 로고
    • Lactacystin, proteasome function, and cell fate
    • Fenteany G., Schreiber S.L. Lactacystin, proteasome function, and cell fate. J. Biol. Chem. 1998, 273:8545-8548.
    • (1998) J. Biol. Chem. , vol.273 , pp. 8545-8548
    • Fenteany, G.1    Schreiber, S.L.2
  • 39
    • 0042379932 scopus 로고    scopus 로고
    • Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes
    • Jope R.S. Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes. Trends Pharmacol. Sci. 2003, 24:441-443.
    • (2003) Trends Pharmacol. Sci. , vol.24 , pp. 441-443
    • Jope, R.S.1
  • 40
    • 0035102228 scopus 로고    scopus 로고
    • STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation
    • McLemore M.L., Grewal S., Liu F., Archambault A., Poursine-Laurent J., Haug J., Link D.C. STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation. Immunity 2001, 14:193-204.
    • (2001) Immunity , vol.14 , pp. 193-204
    • McLemore, M.L.1    Grewal, S.2    Liu, F.3    Archambault, A.4    Poursine-Laurent, J.5    Haug, J.6    Link, D.C.7
  • 41
    • 0033591347 scopus 로고    scopus 로고
    • Multiple signals mediate proliferation, differentiation, and survival from the granulocyte colony-stimulating factor receptor in myeloid 32D cells
    • Ward A.C., Smith L., de Koning J.P., van Aesch Y., Touw I.P. Multiple signals mediate proliferation, differentiation, and survival from the granulocyte colony-stimulating factor receptor in myeloid 32D cells. J. Biol. Chem. 1999, 274:14956-14962.
    • (1999) J. Biol. Chem. , vol.274 , pp. 14956-14962
    • Ward, A.C.1    Smith, L.2    de Koning, J.P.3    van Aesch, Y.4    Touw, I.P.5
  • 42
    • 0031825333 scopus 로고    scopus 로고
    • Stat3 and G-CSF-induced myeloid differentiation
    • Chakraborty A., Tweardy D.J. Stat3 and G-CSF-induced myeloid differentiation. Leuk. Lymphoma 1998, 30:433-442.
    • (1998) Leuk. Lymphoma , vol.30 , pp. 433-442
    • Chakraborty, A.1    Tweardy, D.J.2
  • 43
    • 0023182058 scopus 로고
    • Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line
    • Valtieri M., Tweardy D.J., Caracciolo D., Johnson K., Mavilio F., Altmann S., Santoli D., Rovera G. Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line. J. Immunol. 1987, 138:3829-3835.
    • (1987) J. Immunol. , vol.138 , pp. 3829-3835
    • Valtieri, M.1    Tweardy, D.J.2    Caracciolo, D.3    Johnson, K.4    Mavilio, F.5    Altmann, S.6    Santoli, D.7    Rovera, G.8
  • 44
    • 33846266628 scopus 로고    scopus 로고
    • Fbw7 isoform interaction contributes to cyclin E proteolysis
    • Zhang W., Koepp D.M. Fbw7 isoform interaction contributes to cyclin E proteolysis. Mol. Cancer Res. 2006, 4:935-943.
    • (2006) Mol. Cancer Res. , vol.4 , pp. 935-943
    • Zhang, W.1    Koepp, D.M.2
  • 45
    • 0029129034 scopus 로고
    • Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia
    • Dong F., Brynes R.K., Tidow N., Welte K., Lowenberg B., Touw I.P. Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. N. Engl. J. Med. 1995, 333:487-493.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 487-493
    • Dong, F.1    Brynes, R.K.2    Tidow, N.3    Welte, K.4    Lowenberg, B.5    Touw, I.P.6
  • 47
    • 0347695988 scopus 로고    scopus 로고
    • Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization
    • Gregory M.A., Qi Y., Hann S.R. Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization. J. Biol. Chem. 2003, 278:51606-51612.
    • (2003) J. Biol. Chem. , vol.278 , pp. 51606-51612
    • Gregory, M.A.1    Qi, Y.2    Hann, S.R.3
  • 48
    • 0038784346 scopus 로고    scopus 로고
    • Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cells
    • Hermans M.H., van de Geijn G.J., Antonissen C., Gits J., van Leeuwen D., Ward A.C., Touw I.P. Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cells. Blood 2003, 101:2584-2590.
    • (2003) Blood , vol.101 , pp. 2584-2590
    • Hermans, M.H.1    van de Geijn, G.J.2    Antonissen, C.3    Gits, J.4    van Leeuwen, D.5    Ward, A.C.6    Touw, I.P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.