2-D gel electrophoresis-based proteomic analysis reveals that ormeloxifen induces G0-G1 growth arrest and ERK-mediated apoptosis in chronic myeloid leukemia cells K562

Proteomics

Volumn 11, Issue 8, 2011, Pages 1517-1529

  Pal, Pooja ^a   Kanaujiya, Jitendra K ^a   Lochab, Savita ^a   Tripathi, Shashi B ^a   Bhatt, Madan L B ^b   Singh, Pradhyumna K ^c   Sanyal, Sabyasachi ^a   Trivedi, Arun K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b KING GEORGE'S MEDICAL UNIVERSITY   (India)

^c CSIR NATIONAL BOTANICAL RESEARCH INSTITUTE   (India)

Author keywords

Apoptosis; Cell biology; K562; Myeloid leukemia; Ormeloxifen

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CASPASE 3; CENTCHROMAN; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; PROTEIN P21;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL STRAIN K 562; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; GROWTH INHIBITION; HUMAN; HUMAN CELL; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEOMICS; TWO DIMENSIONAL GEL ELECTROPHORESIS; UPREGULATION;

APOPTOSIS; BENZOPYRANS; CASPASE 3; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA-BINDING PROTEINS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; G0 PHASE; G1 PHASE; HUMANS; IN SITU NICK-END LABELING; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MASS SPECTROMETRY; MITOCHONDRIA; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; PROTEOMICS; PROTO-ONCOGENE PROTEINS C-MYC;

EID: 79953701637     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.201000720     Document Type: Article

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