E6AP, an E3 ubiquitin ligase negatively regulates granulopoiesis by targeting transcription factor C/EBPα for ubiquitin-mediated proteasome degradation

Cell Death and Disease

Volumn 4, Issue 4, 2013, Pages

  Pal, P ^a   Lochab, S ^a   Kanaujiya, J K ^a   Kapoor, I ^a   Sanyal, S ^a   Behre, G ^b   Trivedi, A K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

C EBP ; Differentiation; E6AP; Myeloid leukemia; Ubiquitination

Indexed keywords

ALANINE; AMINO ACID; CCAAT ENHANCER BINDING PROTEIN ALPHA; E6 ASSOCIATED PROTEIN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; PROTEASOME; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ISOPROTEIN; SMALL INTERFERING RNA; UBE3A PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE; ESTROGEN RECEPTOR;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; BONE MARROW CELL; CATALYSIS; CELL DIFFERENTIATION; CLONE; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; ENZYME DEGRADATION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; GIEMSA STAIN; GRANULOCYTE; GRANULOPOIESIS; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY EPITHELIUM; MODULATION; MOUSE; MUTANT; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; TRANSACTIVATION; WESTERN BLOTTING; WILD TYPE; CELL STRAIN HEK293; CELL STRAIN K 562; CELL STRAIN U937; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; PATHOLOGY; PROTEIN BINDING; RNA INTERFERENCE; TRANSCRIPTION INITIATION; ANIMAL CELL; LEUKEMIA CELL; MOLECULAR INTERACTION; PROTEIN TARGETING; UBIQUITINATION;

CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL DIFFERENTIATION; ESTRADIOL; GRANULOCYTES; HEK293 CELLS; HUMANS; K562 CELLS; LEUKEMIA, MYELOID, ACUTE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN ISOFORMS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSCRIPTIONAL ACTIVATION; U937 CELLS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 84876929095     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.120     Document Type: Article

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