Proteomic identification of profilin1 as a corepressor of estrogen receptor alpha in MCF7 breast cancer cells

Proteomics

Volumn 13, Issue 14, 2013, Pages 2100-2112

  Kanaujiya, Jitendra Kumar ^a   Lochab, Savita ^a   Kapoor, Isha ^a   Pal, Pooja ^a   Datta, Dipak ^a   Bhatt, Madan L B ^b   Sanyal, Sabyasachi ^a   Behre, Gerhard ^c   Trivedi, Arun Kumar ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b Dr Ram Manohar Lohia Institute of Medical Sciences ^*  (India)

^c UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

Breast cancer; Cell biology; GST pull down; MCF7; Profilin1

Indexed keywords

ESTROGEN RECEPTOR ALPHA; PROFILIN; PROFILIN1; TAMOXIFEN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; TRANSCRIPTION INITIATION;

BREAST CANCER; CELL BIOLOGY; GST-PULL DOWN; MCF7; PROFILIN1;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BREAST NEOPLASMS; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMANS; MCF-7 CELLS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROFILINS; PROTEIN BINDING; PROTEOME; PROTEOMICS; TAMOXIFEN;

EID: 84880642274     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.201200534     Document Type: Article

References (50)

1. McDonnell, D. P., Norris, J. D., Connections and regulation of the human estrogen receptor. Science 2002, 296, 1642-1644.
2. Katzenellenbogen, B. S., Estrogen receptors: bioactivities and interactions with cell signaling pathways. Biol. Reprod. 1996, 54, 287-293.
3. Ariazi, E. A., Ariazi, J. L., Cordera, F., Jordan, V. C., Estrogen receptors as therapeutic targets in breast cancer. Curr. Top Med. Chem. 2006, 6, 181-202.
4. Ali, S., Coombes, R. C., Estrogen receptor alpha in human breast cancer: occurrence and significance. J. Mammary Gland Biol. Neoplasia 2000, 5, 271-281.
5. Nilsson, S., Makela, S., Treuter, E., Tujague, M. et al., Mechanisms of estrogen action. Physiol. Rev. 2001, 81, 1535-1565.
6. Kumar, V., Green, S., Stack, G., Berry, M. et al., Functional domains of the human estrogen receptor. Cell 1987, 51, 941-951.
7. Leo, C., Chen, J. D., The SRC family of nuclear receptor coactivators. Gene 2000, 245, 1-11.
8. Xu, L., Glass, C. K., Rosenfeld, M. G., Coactivator and corepressor complexes in nuclear receptor function. Curr. Opin. Genet. Dev. 1999, 9, 140-147.
9. Yuan, C. X., Ito, M., Fondell, J. D., Fu, Z. Y., Roeder, R. G., The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc. Natl. Acad. Sci. USA 1998, 95, 7939-7944.
10. Smith, C. L., Onate, S. A., Tsai, M. J., O'Malley, B. W., CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription. Proc. Natl. Acad. Sci. USA 1996, 93, 8884-8888.
11. Brann, D. W., Zhang, Q. G., Wang, R. M., Mahesh, V. B., Vadlamudi, R. K., PELP1-a novel estrogen receptor-interacting protein. Mol. Cell Endocrinol. 2008, 290, 2-7.
12. Jackson, T. A., Richer, J. K., Bain, D. L., Takimoto, G. S. et al., The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT. Mol. Endocrinol. 1997, 11, 693-705.
13. Horlein, A. J., Naar, A. M., Heinzel, T., Torchia, J. et al., Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 1995, 377, 397-404.
14. Wu, L., Wu, Y., Gathings, B., Wan, M. et al., Smad4 as a transcription corepressor for estrogen receptor alpha. J. Biol. Chem. 2003, 278, 15192-15200.
15. Meng, Q., Zhao, Z., Yan, M., Zhou, L. et al., ERR-10: a new repressor in transcriptional signaling activation of estrogen receptor-alpha. FEBS Lett. 2004, 576, 190-200.
16. Han, X., Guo, J., Deng, W., Zhang, C. et al., High-throughput cell-based screening reveals a role for ZNF131 as a repressor of ERalpha signaling. BMC Genomics 2008, 9, 476.
17. McEwan, I. J., Gene regulation through chromatin remodelling by members of the nuclear receptor superfamily. Biochem. Soc. Trans. 2000, 28, 369-373.
18. McKenna, N. J., Lanz, R. B., O'Malley, B. W., Nuclear receptor coregulators: cellular and molecular biology. Endocr. Rev. 1999, 20, 321-344.
19. Heery, D. M., Kalkhoven, E., Hoare, S., Parker, M. G., A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 1997, 387, 733-736.
20. Meng, X., Webb, P., Yang, Y. F., Shuen, M. et al., E1A and a nuclear receptor corepressor splice variant (N-CoRI) are thyroid hormone receptor coactivators that bind in the corepressor mode. Proc. Natl. Acad. Sci. USA 2005, 102, 6267-6272.
21. Perissi, V., Staszewski, L. M., McInerney, E. M., Kurokawa, R. et al., Molecular determinants of nuclear receptor-corepressor interaction. Genes Dev. 1999, 13, 3198-3208.
22. Osborne, C. K., Zhao, H., Fuqua, S. A., Selective estrogen receptor modulators: structure, function, and clinical use. J. Clin. Oncol. 2000, 18, 3172-3186.
23. Teran Davila, J., Teppa Garran, A. D., [Selective estrogen receptors modulators (SERMs): biochemistry, pharmacology, and clinical use in gynecology]. Ginecol. Obstet. Mex. 2005, 73, 424-435.
24. Jordan, V. C., The strategic use of antiestrogens to control the development and growth of breast cancer. Cancer 1992, 70, 977-982.
25. Shang, Y., Brown, M., Molecular determinants for the tissue specificity of SERMs. Science 2002, 295, 2465-2468.
26. Carlsson, L., Nystrom, L. E., Sundkvist, I., Markey, F., Lindberg, U., Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells. J. Mol. Biol. 1977, 115, 465-483.
27. Kullmann, J. A., Neumeyer, A., Gurniak, C. B., Friauf, E. et al., Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons. EMBO Rep. 13, 75-82.
28. Kang, F., Purich, D. L., Southwick, F. S., Profilin promotes barbed-end actin filament assembly without lowering the critical concentration. J. Biol. Chem. 1999, 274, 36963-36972.
29. Reinhard, M., Giehl, K., Abel, K., Haffner, C. et al., The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins. Embo. J. 1995, 14, 1583-1589.
30. Miki, H., Suetsugu, S., Takenawa, T., WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. Embo. J. 1998, 17, 6932-6941.
31. Mammoto, A., Sasaki, T., Asakura, T., Hotta, I. et al., Interactions of drebrin and gephyrin with profilin. Biochem. Biophys. Res. Commun. 1998, 243, 86-89.
32. Watanabe, N., Madaule, P., Reid, T., Ishizaki, T. et al., p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. Embo. J. 1997, 16, 3044-3056.
33. Sato, A., Khadka, D. K., Liu, W., Bharti, R. et al., Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation. Development 2006, 133, 4219-4231.
34. Zou, L., Jaramillo, M., Whaley, D., Wells, A. et al., Profilin-1 is a negative regulator of mammary carcinoma aggressiveness. Br. J. Cancer 2007, 97, 1361-1371.
35. Zou, L., Ding, Z., Roy, P., Profilin-1 overexpression inhibits proliferation of MDA-MB-231 breast cancer cells partly through p27kip1 upregulation. J. Cell Physiol. 2010, 223, 623-629.
36. Zoidakis, J., Makridakis, M., Zerefos, P. G., Bitsika, V. et al., Profilin 1 is a potential biomarker for bladder cancer aggressiveness. Mol. Cell Proteomics 11, M111 009449.
37. Yao, W., Yu, X., Fang, Z., Yin, P. et al., Profilin1 facilitates staurosporine-triggered apoptosis by stabilizing the integrin beta1-actin complex in breast cancer cells. J. Cell Mol. Med. 2012, 16, 824-835.
38. Pal, P., Lochab, S., Kanaujiya, J., Sanyal, S., Trivedi, A. K., Ectopic expression of hC/EBPs in breast tumor cells induces apoptosis. Mol. Cell Biochem. 2010, 337, 111-118.
39. Lochab, S., Pal, P., Kanaujiya, J. K., Tripathi, S. B. et al., Proteomic identification of E6AP as a molecular target of tamoxifen in MCF7 cells. Proteomics 2012, 12, 1363-1377.
40. Bae, Y. H., Ding, Z., Das, T., Wells, A. et al., Profilin1 regulates PI(3, 4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells. Proc. Natl. Acad. Sci. USA 107, 21547-21552.
41. Trivedi, A. K., Bararia, D., Christopeit, M., Peerzada, A. A. et al., Proteomic identification of C/EBP-DBD multiprotein complex: JNK1 activates stem cell regulator C/EBPalpha by inhibiting its ubiquitination. Oncogene 2007, 26, 1789-1801.
42. Pal, P., Kanaujiya, J. K., Lochab, S., Tripathi, S. B. et al., 2-D gel electrophoresis-based proteomic analysis reveals that ormeloxifen induces G0-G1 growth arrest and ERK-mediated apoptosis in chronic myeloid leukemia cells K562. Proteomics 2011, 11, 1517-1529.
43. Stanford, J. L., Szklo, M., Brinton, L. A., Estrogen receptors and breast cancer. Epidemiol. Rev. 1986, 8, 42-59.
44. Zheng, A., Kallio, A., Harkonen, P., Tamoxifen-induced rapid death of MCF7 breast cancer cells is mediated via extracellularly signal-regulated kinase signaling and can be abrogated by estrogen. Endocrinology 2007, 148, 2764-2777.
45. Paige, L. A., Christensen, D. J., Gron, H., Norris, J. D. et al., Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. Proc. Natl. Acad. Sci. USA 1999, 96, 3999-4004.
46. Leo, C., Li, H., Chen, J. D., Differential mechanisms of nuclear receptor regulation by receptor-associated coactivator 3. J. Biol. Chem. 2000, 275, 5976-5982.
47. Miyajima, D., Hayata, T., Suzuki, T., Hemmi, H. et al., Profilin1 regulates sternum development and endochondral bone formation. J. Biol. Chem. 2012, 28, 33545-33553.
48. Das, T., Bae, Y. H., Wells, A., Roy, P., Profilin-1 overexpression upregulates PTEN and suppresses AKT activation in breast cancer cells. J. Cell Physiol. 2009, 218, 436-443.
49. Bararia, D., Trivedi, A. K., Zada, A. A., Greif, P. A. et al., Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha. Leukemia 2008, 22, 800-807.
50. Miyajima, D., Hayata, T., Suzuki, T., Hemmi, H. et al., Profilin1 regulates sternum development and endochondral bone formation. J. Biol. Chem. 2012, 287, 33545-33553.