메뉴 건너뛰기




Volumn 40, Issue 6, 2013, Pages 776-787

Microfluidics in radiopharmaceutical chemistry

Author keywords

Microfluidic; Molecular imaging; PET; Radiochemistry; Radiopharmaceutical; SPECT

Indexed keywords

CARBON 11; COPPER 64; FLUORINE 18; FLUORODEOXYGLUCOSE F 18; IODINE 125; IODINE 131; RADIOPHARMACEUTICAL AGENT; TECHNETIUM 99M;

EID: 84881025943     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2013.04.004     Document Type: Review
Times cited : (86)

References (86)
  • 1
    • 45849134118 scopus 로고    scopus 로고
    • Factors affecting the specific activity of [18F]fluoride from a [18O]water target. Nuklearmedizin
    • Fuchtner F., Preusche S., Mading P., Zessin J., Steinbach J. Factors affecting the specific activity of [18F]fluoride from a [18O]water target. Nuklearmedizin. Nucl Med 2008, 47:116-119.
    • (2008) Nucl Med , vol.47 , pp. 116-119
    • Fuchtner, F.1    Preusche, S.2    Mading, P.3    Zessin, J.4    Steinbach, J.5
  • 2
    • 33751345115 scopus 로고    scopus 로고
    • Microreactors as tools for synthetic chemists-the chemists' round-bottomed flask of the 21st century?
    • Geyer K., Codée J.D.C., Seeberger P.H. Microreactors as tools for synthetic chemists-the chemists' round-bottomed flask of the 21st century?. Chem- Eur J 2006, 12:8434-8442.
    • (2006) Chem- Eur J , vol.12 , pp. 8434-8442
    • Geyer, K.1    Codée, J.D.C.2    Seeberger, P.H.3
  • 3
    • 15944413181 scopus 로고    scopus 로고
    • The application of microreactors for small scale organic synthesis
    • Watts P., Haswell S.J. The application of microreactors for small scale organic synthesis. Chem Eng Technol 2005, 28:290-301.
    • (2005) Chem Eng Technol , vol.28 , pp. 290-301
    • Watts, P.1    Haswell, S.J.2
  • 4
    • 37649010665 scopus 로고    scopus 로고
    • Microfluidics for drug discovery and development: from target selection to product lifecycle management
    • Kang L., Chung B.G., Langer R., Khademhosseini A. Microfluidics for drug discovery and development: from target selection to product lifecycle management. Drug Discov Today 2008, 13:1-13.
    • (2008) Drug Discov Today , vol.13 , pp. 1-13
    • Kang, L.1    Chung, B.G.2    Langer, R.3    Khademhosseini, A.4
  • 5
    • 33845236565 scopus 로고    scopus 로고
    • Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles
    • Baumann M., Baxendale I.R., Ley S.V., Smith C.D., Tranmer G.K. Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles. Org Lett 2006, 8:5231-5234.
    • (2006) Org Lett , vol.8 , pp. 5231-5234
    • Baumann, M.1    Baxendale, I.R.2    Ley, S.V.3    Smith, C.D.4    Tranmer, G.K.5
  • 6
    • 70749084653 scopus 로고    scopus 로고
    • A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands
    • Petersen T.P., Ritzén A., Ulven T. A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands. Org Lett 2009, 11:5134-5137.
    • (2009) Org Lett , vol.11 , pp. 5134-5137
    • Petersen, T.P.1    Ritzén, A.2    Ulven, T.3
  • 7
    • 58149125469 scopus 로고    scopus 로고
    • An integrated microreactor for the multicomponent synthesis of α-aminonitriles1
    • Wiles C., Watts P. An integrated microreactor for the multicomponent synthesis of α-aminonitriles1. Org Process Res Dev 2008, 12:1001-1006.
    • (2008) Org Process Res Dev , vol.12 , pp. 1001-1006
    • Wiles, C.1    Watts, P.2
  • 8
    • 65649146430 scopus 로고    scopus 로고
    • Microreactors for radiopharmaceutical synthesis
    • Elizarov A.M. Microreactors for radiopharmaceutical synthesis. Lab Chip 2009, 9:1326-1333.
    • (2009) Lab Chip , vol.9 , pp. 1326-1333
    • Elizarov, A.M.1
  • 9
    • 66149157301 scopus 로고    scopus 로고
    • Radiolabelling with short-lived PET (positron emission tomography) isotopes using microfluidic reactors
    • Miller P.W. Radiolabelling with short-lived PET (positron emission tomography) isotopes using microfluidic reactors. J Chem Technol Biotechnol 2009, 84:309-315.
    • (2009) J Chem Technol Biotechnol , vol.84 , pp. 309-315
    • Miller, P.W.1
  • 10
    • 39049185012 scopus 로고    scopus 로고
    • Micro-reactors for PET tracer labeling
    • Lu S.Y., Pike V.W. Micro-reactors for PET tracer labeling. PET Chem 2007, 271-287.
    • (2007) PET Chem , pp. 271-287
    • Lu, S.Y.1    Pike, V.W.2
  • 11
    • 34249688345 scopus 로고    scopus 로고
    • Positron emission tomography (PET) and microfluidic devices: a breakthrough on the microscale?
    • Audrain H. Positron emission tomography (PET) and microfluidic devices: a breakthrough on the microscale?. Angew Chem Int Ed 2007, 46:1772-1775.
    • (2007) Angew Chem Int Ed , vol.46 , pp. 1772-1775
    • Audrain, H.1
  • 12
    • 33745556552 scopus 로고    scopus 로고
    • Pivotal role of nanotechnologies and biotechnologies for molecular imaging and therapy
    • Lucignani G. Pivotal role of nanotechnologies and biotechnologies for molecular imaging and therapy. Eur J Nucl Med Mol Imaging 2006, 33:849-851.
    • (2006) Eur J Nucl Med Mol Imaging , vol.33 , pp. 849-851
    • Lucignani, G.1
  • 13
    • 77954342330 scopus 로고    scopus 로고
    • Application of microfluidics to the ultra-rapid preparation of fluorine-18 labelled compounds
    • Miller P.W., deMello A.J., Gee A.D. Application of microfluidics to the ultra-rapid preparation of fluorine-18 labelled compounds. Curr Radiopharm 2010, 3:254-262.
    • (2010) Curr Radiopharm , vol.3 , pp. 254-262
    • Miller, P.W.1    deMello, A.J.2    Gee, A.D.3
  • 15
    • 84880767316 scopus 로고    scopus 로고
    • Microfluidic-assisted radiochemistry and PET probe synthesis
    • Shen K.-F.C. Microfluidic-assisted radiochemistry and PET probe synthesis. MI Gateway 2011, 1-5.
    • (2011) MI Gateway , pp. 1-5
    • Shen, K.-F.C.1
  • 16
    • 42549137976 scopus 로고    scopus 로고
    • Fabrication approaches for generating complex micro- and nanopatterns on polymeric surfaces
    • del Campo A., Arzt E. Fabrication approaches for generating complex micro- and nanopatterns on polymeric surfaces. Chem Rev 2008, 108:911-945.
    • (2008) Chem Rev , vol.108 , pp. 911-945
    • del Campo, A.1    Arzt, E.2
  • 18
    • 78149407066 scopus 로고    scopus 로고
    • Review of atomic MEMS: driving technologies and challenges
    • Dong H., Fang J., Zhou B., Qin J., Wan S. Review of atomic MEMS: driving technologies and challenges. Microsyst Technol 2010, 16:1683-1689.
    • (2010) Microsyst Technol , vol.16 , pp. 1683-1689
    • Dong, H.1    Fang, J.2    Zhou, B.3    Qin, J.4    Wan, S.5
  • 19
    • 26944440933 scopus 로고    scopus 로고
    • Controlled microfluidic interfaces
    • Atencia J., Beebe D.J. Controlled microfluidic interfaces. Nature 2005, 437:648-655.
    • (2005) Nature , vol.437 , pp. 648-655
    • Atencia, J.1    Beebe, D.J.2
  • 20
    • 33846201265 scopus 로고    scopus 로고
    • Multiphase microfluidics: from flow characteristics to chemical and materials synthesis
    • Gunther A., Jensen K.F. Multiphase microfluidics: from flow characteristics to chemical and materials synthesis. Lab Chip 2006, 6:1487-1503.
    • (2006) Lab Chip , vol.6 , pp. 1487-1503
    • Gunther, A.1    Jensen, K.F.2
  • 22
    • 84855963036 scopus 로고    scopus 로고
    • Radioactivity resistance evaluation of polymeric materials for application in radiopharmaceutical production at microscale
    • Zacheo A., Arima V., Pascali G., Salvadori P.A., Zizzari A., Perrone E., et al. Radioactivity resistance evaluation of polymeric materials for application in radiopharmaceutical production at microscale. Microfluid Nanofluid 2011, 11:35-44.
    • (2011) Microfluid Nanofluid , vol.11 , pp. 35-44
    • Zacheo, A.1    Arima, V.2    Pascali, G.3    Salvadori, P.A.4    Zizzari, A.5    Perrone, E.6
  • 23
    • 29144528086 scopus 로고    scopus 로고
    • Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics
    • Lee C.-C., Sui G., Elizarov A., Shu C.J., Shin Y.-S., Dooley A.N., et al. Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics. Science 2005, 310:1793-1796.
    • (2005) Science , vol.310 , pp. 1793-1796
    • Lee, C.-C.1    Sui, G.2    Elizarov, A.3    Shu, C.J.4    Shin, Y.-S.5    Dooley, A.N.6
  • 24
    • 75749115994 scopus 로고    scopus 로고
    • Design and optimization of coin-shaped microreactor chips for PET radiopharmaceutical synthesis
    • Elizarov A.M., van Dam R.M., Shin Y.S., Kolb H.C., Padgett H.C., Stout D., et al. Design and optimization of coin-shaped microreactor chips for PET radiopharmaceutical synthesis. J Nucl Med 2010, 51:282-287.
    • (2010) J Nucl Med , vol.51 , pp. 282-287
    • Elizarov, A.M.1    van Dam, R.M.2    Shin, Y.S.3    Kolb, H.C.4    Padgett, H.C.5    Stout, D.6
  • 25
    • 1542375006 scopus 로고    scopus 로고
    • Solvent-resistant photocurable "Liquid Teflon" for microfluidic device fabrication
    • Rolland J.P., Van Dam R.M., Schorzman D.A., Quake S.R., DeSimone J.M. Solvent-resistant photocurable "Liquid Teflon" for microfluidic device fabrication. J Am Chem Soc 2004, 126:2322-2323.
    • (2004) J Am Chem Soc , vol.126 , pp. 2322-2323
    • Rolland, J.P.1    Van Dam, R.M.2    Schorzman, D.A.3    Quake, S.R.4    DeSimone, J.M.5
  • 26
    • 79952784368 scopus 로고    scopus 로고
    • Batch-mode microfluidic radiosynthesis of N-succinimidyl-4-[18F]fluorobenzoate for protein labelling
    • Bejot R., Elizarov A.M., Ball E., Zhang J., Miraghaie R., Kolb H.C., et al. Batch-mode microfluidic radiosynthesis of N-succinimidyl-4-[18F]fluorobenzoate for protein labelling. J Label Compd Radiopharm 2011, 54:117-122.
    • (2011) J Label Compd Radiopharm , vol.54 , pp. 117-122
    • Bejot, R.1    Elizarov, A.M.2    Ball, E.3    Zhang, J.4    Miraghaie, R.5    Kolb, H.C.6
  • 28
    • 84864509669 scopus 로고    scopus 로고
    • Microfluidic single vessel production of hypoxia tracer 1H-1-(3-[(18)F]-fluoro-2-hydroxy-propyl)-2-nitro-imidazole ([(18)F]-FMISO)
    • Yokell D.L., Leece A.K., Lebedev A., Miraghaie R., Ball C.E., Zhang J., et al. Microfluidic single vessel production of hypoxia tracer 1H-1-(3-[(18)F]-fluoro-2-hydroxy-propyl)-2-nitro-imidazole ([(18)F]-FMISO). Appl Radiat Isot 2012, 70:2313-2316.
    • (2012) Appl Radiat Isot , vol.70 , pp. 2313-2316
    • Yokell, D.L.1    Leece, A.K.2    Lebedev, A.3    Miraghaie, R.4    Ball, C.E.5    Zhang, J.6
  • 31
    • 78649519916 scopus 로고    scopus 로고
    • Microfluidic labeling of biomolecules with radiometals for use in nuclear medicine
    • Wheeler T.D., Zeng D., Desai A.V., Onal B., Reichert D.E., Kenis P.J.A. Microfluidic labeling of biomolecules with radiometals for use in nuclear medicine. Lab Chip 2010, 10:3387-3396.
    • (2010) Lab Chip , vol.10 , pp. 3387-3396
    • Wheeler, T.D.1    Zeng, D.2    Desai, A.V.3    Onal, B.4    Reichert, D.E.5    Kenis, P.J.A.6
  • 33
    • 10644235590 scopus 로고    scopus 로고
    • Syntheses of 11C- and 18F-labeled carboxylic esters within a hydrodynamically-driven micro-reactor
    • Lu S.-Y., Watts P., Chin F.T., Hong J., Musachio J.L., Briard E., et al. Syntheses of 11C- and 18F-labeled carboxylic esters within a hydrodynamically-driven micro-reactor. Lab Chip 2004, 4:523-525.
    • (2004) Lab Chip , vol.4 , pp. 523-525
    • Lu, S.-Y.1    Watts, P.2    Chin, F.T.3    Hong, J.4    Musachio, J.L.5    Briard, E.6
  • 37
    • 84881025158 scopus 로고    scopus 로고
    • http://www.scintomics.com/en/production/-mu-icr/index.html.
  • 38
    • 77649270738 scopus 로고    scopus 로고
    • Synthesis of [18F]fallypride in a micro-reactor: rapid optimization and multiple-production in small doses for micro-PET studies
    • Lu S., Giamis A.M., Pike V.W. Synthesis of [18F]fallypride in a micro-reactor: rapid optimization and multiple-production in small doses for micro-PET studies. Curr Radiopharm 2009, 2:49-55.
    • (2009) Curr Radiopharm , vol.2 , pp. 49-55
    • Lu, S.1    Giamis, A.M.2    Pike, V.W.3
  • 39
    • 84862806803 scopus 로고    scopus 로고
    • Microfluidic technology: an economical and versatile approach for the synthesis of O-(2-[18F]fluoroethyl)-l-tyrosine ([18F]FET)
    • Bouvet V., Wuest M., Tam P.-H., Wang M., Wuest F. Microfluidic technology: an economical and versatile approach for the synthesis of O-(2-[18F]fluoroethyl)-l-tyrosine ([18F]FET). Bioorg Med Chem Lett 2012, 22:2291-2295.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 2291-2295
    • Bouvet, V.1    Wuest, M.2    Tam, P.-H.3    Wang, M.4    Wuest, F.5
  • 40
    • 79954425261 scopus 로고    scopus 로고
    • Microfluidic preparation of [18F]FEatSUPPY and [18F]FEatSUPPY:2-comparison with conventional radiosyntheses
    • Ungersboeck J., Philippe C., Mien L.K., Haeusler D., Shanab K., Lanzenberger R., et al. Microfluidic preparation of [18F]FEatSUPPY and [18F]FEatSUPPY:2-comparison with conventional radiosyntheses. Nucl Med Biol 2011, 38:427-434.
    • (2011) Nucl Med Biol , vol.38 , pp. 427-434
    • Ungersboeck, J.1    Philippe, C.2    Mien, L.K.3    Haeusler, D.4    Shanab, K.5    Lanzenberger, R.6
  • 41
    • 61449112099 scopus 로고    scopus 로고
    • Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET
    • Briard E., Zoghbi S.S., Siméon F.G., Imaizumi M., Gourley J.P., Shetty H.U., et al. Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET. J Med Chem 2009, 52:688-699.
    • (2009) J Med Chem , vol.52 , pp. 688-699
    • Briard, E.1    Zoghbi, S.S.2    Siméon, F.G.3    Imaizumi, M.4    Gourley, J.P.5    Shetty, H.U.6
  • 42
    • 80052730913 scopus 로고    scopus 로고
    • Syntheses of mGluR5 PET radioligands through the radiofluorination of diaryliodonium tosylates
    • Telu S., Chun J.H., Simeon F.G., Lu S., Pike V.W. Syntheses of mGluR5 PET radioligands through the radiofluorination of diaryliodonium tosylates. Org Biomol Chem 2011, 9:6629-6638.
    • (2011) Org Biomol Chem , vol.9 , pp. 6629-6638
    • Telu, S.1    Chun, J.H.2    Simeon, F.G.3    Lu, S.4    Pike, V.W.5
  • 44
    • 77953809373 scopus 로고    scopus 로고
    • Microfluidic approach for fast labeling optimization and dose-on-demand implementation
    • Pascali G., Mazzone G., Saccomanni G., Manera C., Salvadori P.A. Microfluidic approach for fast labeling optimization and dose-on-demand implementation. Nucl Med Biol 2010, 37:547-555.
    • (2010) Nucl Med Biol , vol.37 , pp. 547-555
    • Pascali, G.1    Mazzone, G.2    Saccomanni, G.3    Manera, C.4    Salvadori, P.A.5
  • 45
    • 79959639639 scopus 로고    scopus 로고
    • Dose-on-demand of diverse 18F-fluorocholine derivatives through a two-step microfluidic approach
    • Pascali G., Nannavecchia G., Pitzianti S., Salvadori P.A. Dose-on-demand of diverse 18F-fluorocholine derivatives through a two-step microfluidic approach. Nucl Med Biol 2011, 38:637-644.
    • (2011) Nucl Med Biol , vol.38 , pp. 637-644
    • Pascali, G.1    Nannavecchia, G.2    Pitzianti, S.3    Salvadori, P.A.4
  • 46
    • 79551682052 scopus 로고    scopus 로고
    • Synthesis of hypoxia imaging agent 1-(5-deoxy-5-fluoro-α-d-arabinofuranosyl)-2-nitroimidazole using microfluidic technology
    • Bouvet V.R., Wuest M., Wiebe L.I., Wuest F. Synthesis of hypoxia imaging agent 1-(5-deoxy-5-fluoro-α-d-arabinofuranosyl)-2-nitroimidazole using microfluidic technology. Nucl Med Biol 2011, 38:235-245.
    • (2011) Nucl Med Biol , vol.38 , pp. 235-245
    • Bouvet, V.R.1    Wuest, M.2    Wiebe, L.I.3    Wuest, F.4
  • 47
    • 77952551337 scopus 로고    scopus 로고
    • Improved synthesis of 2'-deoxy-2'-[18F]-fluoro-1-β-d-arabinofuranosyl-5-iodouracil ([18F]-FIAU)
    • Anderson H., Pillarsetty N., Cantorias M., Lewis J.S. Improved synthesis of 2'-deoxy-2'-[18F]-fluoro-1-β-d-arabinofuranosyl-5-iodouracil ([18F]-FIAU). Nucl Med Biol 2010, 37:439-442.
    • (2010) Nucl Med Biol , vol.37 , pp. 439-442
    • Anderson, H.1    Pillarsetty, N.2    Cantorias, M.3    Lewis, J.S.4
  • 49
    • 84866362479 scopus 로고    scopus 로고
    • [18F]FEatSNAP-a new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): microfluidic and vessel-based approaches
    • Philippe C., Ungersboeck J., Schirmer E., Zdravkovic M., Nics L., Zeilinger M., et al. [18F]FEatSNAP-a new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): microfluidic and vessel-based approaches. Bioorg Med Chem 2012, 20:5936-5940.
    • (2012) Bioorg Med Chem , vol.20 , pp. 5936-5940
    • Philippe, C.1    Ungersboeck, J.2    Schirmer, E.3    Zdravkovic, M.4    Nics, L.5    Zeilinger, M.6
  • 50
    • 77952537955 scopus 로고    scopus 로고
    • Fast and high-yield microreactor syntheses of ortho-substituted [18F]fluoroarenes from reactions of [18F]fluoride ion with diaryliodonium salts
    • Chun J.-H., Lu S., Lee Y.-S., Pike V.W. Fast and high-yield microreactor syntheses of ortho-substituted [18F]fluoroarenes from reactions of [18F]fluoride ion with diaryliodonium salts. J Org Chem 2010, 75:3332-3338.
    • (2010) J Org Chem , vol.75 , pp. 3332-3338
    • Chun, J.-H.1    Lu, S.2    Lee, Y.-S.3    Pike, V.W.4
  • 51
    • 84866257014 scopus 로고    scopus 로고
    • Selective syntheses of no-carrier-added 2- and 3-[18F]fluorohalopyridines through the radiofluorination of halopyridinyl(4[prime or minute]-methoxyphenyl)iodonium tosylates
    • Chun J.-H., Pike V.W. Selective syntheses of no-carrier-added 2- and 3-[18F]fluorohalopyridines through the radiofluorination of halopyridinyl(4[prime or minute]-methoxyphenyl)iodonium tosylates. Chem Commun 2012, 48:9921-9923.
    • (2012) Chem Commun , vol.48 , pp. 9921-9923
    • Chun, J.-H.1    Pike, V.W.2
  • 52
    • 84865046494 scopus 로고    scopus 로고
    • Single-step radiosynthesis of "18F-labeled click synthons" from azide-functionalized diaryliodonium salts
    • Chun J.-H., Pike V.W. Single-step radiosynthesis of "18F-labeled click synthons" from azide-functionalized diaryliodonium salts. Eur J Org Chem 2012, 2012:4541-4547.
    • (2012) Eur J Org Chem , vol.2012 , pp. 4541-4547
    • Chun, J.-H.1    Pike, V.W.2
  • 54
    • 84870175161 scopus 로고    scopus 로고
    • Radiofluorination and reductive amination using a microfluidic device
    • Dahl K., Schou M., Halldin C. Radiofluorination and reductive amination using a microfluidic device. J Label Compd Radiopharm 2012, 55:455-459.
    • (2012) J Label Compd Radiopharm , vol.55 , pp. 455-459
    • Dahl, K.1    Schou, M.2    Halldin, C.3
  • 55
    • 0020736560 scopus 로고
    • Radiofluorination with xenon difluoride: a new high yield synthesis of [18F]2-fluoro-2-deoxy-d-glucose
    • Sood S., Firnau G., Garnett E.S. Radiofluorination with xenon difluoride: a new high yield synthesis of [18F]2-fluoro-2-deoxy-d-glucose. Int J Appl Radiat Isot 1983, 34:743-745.
    • (1983) Int J Appl Radiat Isot , vol.34 , pp. 743-745
    • Sood, S.1    Firnau, G.2    Garnett, E.S.3
  • 57
    • 37049113699 scopus 로고
    • Synthesis of [18F]XeF2, a novel agent for the preparation of 18F-radiopharmaceuticals
    • Schrobilgen G., Firnau G., Chirakal R., Garnett E.S. Synthesis of [18F]XeF2, a novel agent for the preparation of 18F-radiopharmaceuticals. J Chem Soc Chem Commun 1981, 198-199.
    • (1981) J Chem Soc Chem Commun , pp. 198-199
    • Schrobilgen, G.1    Firnau, G.2    Chirakal, R.3    Garnett, E.S.4
  • 58
    • 0035961590 scopus 로고    scopus 로고
    • Xenon difluoride exchanges fluoride under mild conditions: a simple preparation of [18F]xenon difluoride for PET and mechanistic studies
    • Constantinou M., Aigbirhio F.I., Smith R.G., Ramsden C.A., Pike V.W. Xenon difluoride exchanges fluoride under mild conditions: a simple preparation of [18F]xenon difluoride for PET and mechanistic studies. J Am Chem Soc 2001, 123:1780-1781.
    • (2001) J Am Chem Soc , vol.123 , pp. 1780-1781
    • Constantinou, M.1    Aigbirhio, F.I.2    Smith, R.G.3    Ramsden, C.A.4    Pike, V.W.5
  • 59
    • 0037202141 scopus 로고    scopus 로고
    • On the preparation of fluorine-18 labelled XeF2 and chemical exchange between fluoride ion and XeF2
    • Vasdev N., Pointner B.E., Chirakal R., Schrobilgen G.J. On the preparation of fluorine-18 labelled XeF2 and chemical exchange between fluoride ion and XeF2. J Am Chem Soc 2002, 124:12863-12868.
    • (2002) J Am Chem Soc , vol.124 , pp. 12863-12868
    • Vasdev, N.1    Pointner, B.E.2    Chirakal, R.3    Schrobilgen, G.J.4
  • 60
    • 77956912822 scopus 로고    scopus 로고
    • Synthesis of [18F]xenon difluoride as a radiolabeling reagent from [18F]fluoride ion in a micro-reactor and at production scale
    • Lu S., Pike V.W. Synthesis of [18F]xenon difluoride as a radiolabeling reagent from [18F]fluoride ion in a micro-reactor and at production scale. J Fluorine Chem 2010, 131:1032-1038.
    • (2010) J Fluorine Chem , vol.131 , pp. 1032-1038
    • Lu, S.1    Pike, V.W.2
  • 63
    • 73349105250 scopus 로고    scopus 로고
    • A microfluidic approach to the rapid screening of palladium-catalysed aminocarbonylation reactions
    • Miller P.W., Jennings L.E., deMello A.J., Gee A.D., Long N.J., Vilar R. A microfluidic approach to the rapid screening of palladium-catalysed aminocarbonylation reactions. Adv Synthesis Catalysis 2009, 351:3260-3268.
    • (2009) Adv Synthesis Catalysis , vol.351 , pp. 3260-3268
    • Miller, P.W.1    Jennings, L.E.2    deMello, A.J.3    Gee, A.D.4    Long, N.J.5    Vilar, R.6
  • 64
    • 79954440288 scopus 로고    scopus 로고
    • Microfluidic reactions using [11C]carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer
    • Kealey S., Plisson C., Collier T.L., Long N.J., Husbands S.M., Martarello L., et al. Microfluidic reactions using [11C]carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer. Org Biomol Chem 2011, 9:3313-3319.
    • (2011) Org Biomol Chem , vol.9 , pp. 3313-3319
    • Kealey, S.1    Plisson, C.2    Collier, T.L.3    Long, N.J.4    Husbands, S.M.5    Martarello, L.6
  • 66
    • 84856348786 scopus 로고    scopus 로고
    • Preparation of technetium-99m bifunctional chelate complexes using a microfluidic reactor: a comparative study with conventional and microwave labeling methods
    • Simms R.W., Causey P.W., Weaver D.M., Sundararajan C., Stephenson K.A., Valliant J.F. Preparation of technetium-99m bifunctional chelate complexes using a microfluidic reactor: a comparative study with conventional and microwave labeling methods. J Label Compd Radiopharm 2012, 55:18-22.
    • (2012) J Label Compd Radiopharm , vol.55 , pp. 18-22
    • Simms, R.W.1    Causey, P.W.2    Weaver, D.M.3    Sundararajan, C.4    Stephenson, K.A.5    Valliant, J.F.6
  • 67
    • 84867873817 scopus 로고    scopus 로고
    • 18F-Labeled phosphopeptide-cell-penetrating peptide dimers with enhanced cell uptake properties in human cancer cells
    • Richter S., Bouvet V., Wuest M., Bergmann R., Steinbach J., Pietzsch J., et al. 18F-Labeled phosphopeptide-cell-penetrating peptide dimers with enhanced cell uptake properties in human cancer cells. Nucl Med Biol 2012, 39:1202-1212.
    • (2012) Nucl Med Biol , vol.39 , pp. 1202-1212
    • Richter, S.1    Bouvet, V.2    Wuest, M.3    Bergmann, R.4    Steinbach, J.5    Pietzsch, J.6
  • 69
    • 79959537070 scopus 로고    scopus 로고
    • On-chip pre-concentration and complexation of [18F]fluoride ions via regenerable anion exchange particles for radiochemical synthesis of Positron Emission Tomography tracers
    • De Leonardis F., Pascali G., Salvadori P.A., Watts P., Pamme N. On-chip pre-concentration and complexation of [18F]fluoride ions via regenerable anion exchange particles for radiochemical synthesis of Positron Emission Tomography tracers. J Chromatogr A 2011, 1218:4714-4719.
    • (2011) J Chromatogr A , vol.1218 , pp. 4714-4719
    • De Leonardis, F.1    Pascali, G.2    Salvadori, P.A.3    Watts, P.4    Pamme, N.5
  • 70
    • 84881025513 scopus 로고    scopus 로고
    • ROC: radiochemistry on chip, EU FP7 project
    • ROC: radiochemistry on chip, EU FP7 project; http://www.roc-project.eu/site/.
  • 71
    • 70849122728 scopus 로고    scopus 로고
    • Fast production of highly concentrated reactive [18F] fluoride for aliphatic and aromatic nucleophilic radiolabelling
    • Aerts J., Voccia S., Lemaire C., Giacomelli F., Goblet D., Thonon D., et al. Fast production of highly concentrated reactive [18F] fluoride for aliphatic and aromatic nucleophilic radiolabelling. Tetrahedron Lett 2010, 51:64-66.
    • (2010) Tetrahedron Lett , vol.51 , pp. 64-66
    • Aerts, J.1    Voccia, S.2    Lemaire, C.3    Giacomelli, F.4    Goblet, D.5    Thonon, D.6
  • 73
    • 84857158062 scopus 로고    scopus 로고
    • Cryptate mediated nucleophilic 18F-fluorination without azeotropic drying. Nuklearmedizin
    • Wessmann S.H., Henriksen G., Wester H. Cryptate mediated nucleophilic 18F-fluorination without azeotropic drying. Nuklearmedizin. Nucl Med 2012, 51:1-8.
    • (2012) Nucl Med , vol.51 , pp. 1-8
    • Wessmann, S.H.1    Henriksen, G.2    Wester, H.3
  • 74
  • 75
    • 84881023750 scopus 로고    scopus 로고
    • Positron source, method of preparing the same and automated system for supplying the same
    • Fujiwara I, Ito Y, Iwata R, Hyodo T, Yano Y, Goto A, et al. Positron source, method of preparing the same and automated system for supplying the same. 1999.
    • (1999)
    • Fujiwara, I.1    Ito, Y.2    Iwata, R.3    Hyodo, T.4    Yano, Y.5    Goto, A.6
  • 76
    • 33746337952 scopus 로고    scopus 로고
    • No-carrier-added nucleophilic 18F-labelling in an electrochemical cell exemplified by the routine production of [18F]altanserin
    • Hamacher K., Coenen H.H. No-carrier-added nucleophilic 18F-labelling in an electrochemical cell exemplified by the routine production of [18F]altanserin. Appl Radiat Isot 2006, 64:989-994.
    • (2006) Appl Radiat Isot , vol.64 , pp. 989-994
    • Hamacher, K.1    Coenen, H.H.2
  • 77
    • 0036152642 scopus 로고    scopus 로고
    • Electrochemical cell for separation of [18F]fluoride from irradiated 18O-water and subsequent no carrier added nucleophilic fluorination
    • Hamacher K., Hirschfelder T., Coenen H.H. Electrochemical cell for separation of [18F]fluoride from irradiated 18O-water and subsequent no carrier added nucleophilic fluorination. Appl Radiat Isot 2002, 56:519-523.
    • (2002) Appl Radiat Isot , vol.56 , pp. 519-523
    • Hamacher, K.1    Hirschfelder, T.2    Coenen, H.H.3
  • 78
    • 79952196844 scopus 로고    scopus 로고
    • Electrochemical concentration of no-carrier-added [18F]fluoride from [18O]water in a disposable microfluidic cell for radiosynthesis of 18F-labeled radiopharmaceuticals
    • Saiki H., Iwata R., Nakanishi H., Wong R., Ishikawa Y., Furumoto S., et al. Electrochemical concentration of no-carrier-added [18F]fluoride from [18O]water in a disposable microfluidic cell for radiosynthesis of 18F-labeled radiopharmaceuticals. Appl Radiat Isot 2010, 68:1703-1708.
    • (2010) Appl Radiat Isot , vol.68 , pp. 1703-1708
    • Saiki, H.1    Iwata, R.2    Nakanishi, H.3    Wong, R.4    Ishikawa, Y.5    Furumoto, S.6
  • 79
    • 80955135557 scopus 로고    scopus 로고
    • Reactivity of electrochemically concentrated anhydrous [18F]fluoride for microfluidic radiosynthesis of 18F-labeled compounds
    • Wong R., Iwata R., Saiki H., Furumoto S., Ishikawa Y., Ozeki E. Reactivity of electrochemically concentrated anhydrous [18F]fluoride for microfluidic radiosynthesis of 18F-labeled compounds. Appl Radiat Isot 2012, 70:193-199.
    • (2012) Appl Radiat Isot , vol.70 , pp. 193-199
    • Wong, R.1    Iwata, R.2    Saiki, H.3    Furumoto, S.4    Ishikawa, Y.5    Ozeki, E.6
  • 80
    • 84871058196 scopus 로고    scopus 로고
    • Nitrogen supported solvent evaporation using continuous-flow microfluidics
    • Cvetkovic B.Z., Lade O., Marra L., Arima V., Rinaldi R., Dittrich P.S. Nitrogen supported solvent evaporation using continuous-flow microfluidics. RSC Adv 2012, 2:11117-11122.
    • (2012) RSC Adv , vol.2 , pp. 11117-11122
    • Cvetkovic, B.Z.1    Lade, O.2    Marra, L.3    Arima, V.4    Rinaldi, R.5    Dittrich, P.S.6
  • 81
    • 33751254091 scopus 로고    scopus 로고
    • Reactions in droplets in microfluidic channels
    • Song H., Chen D.L., Ismagilov R.F. Reactions in droplets in microfluidic channels. Angew Chem Int Ed 2006, 45:7336-7356.
    • (2006) Angew Chem Int Ed , vol.45 , pp. 7336-7356
    • Song, H.1    Chen, D.L.2    Ismagilov, R.F.3
  • 82
    • 84863012589 scopus 로고    scopus 로고
    • Micro-chemical synthesis of molecular probes on an electronic microfluidic device
    • Keng P.Y., Chen S., Ding H., Sadeghi S., Shah G.J., Dooraghi A., et al. Micro-chemical synthesis of molecular probes on an electronic microfluidic device. Proc Natl Acad Sci 2012, 109:690-695.
    • (2012) Proc Natl Acad Sci , vol.109 , pp. 690-695
    • Keng, P.Y.1    Chen, S.2    Ding, H.3    Sadeghi, S.4    Shah, G.J.5    Dooraghi, A.6
  • 83
    • 79955011730 scopus 로고    scopus 로고
    • Microfluidic-based 18F-labeling of biomolecules for immuno-positron emission tomography
    • Liu K., Lepin E.J., Wang M.W., Guo F., Lin W.Y., Chen Y.C., et al. Microfluidic-based 18F-labeling of biomolecules for immuno-positron emission tomography. Mol Imaging 2011, 10(168-76):1-7.
    • (2011) Mol Imaging , vol.10 , Issue.168-176 , pp. 1-7
    • Liu, K.1    Lepin, E.J.2    Wang, M.W.3    Guo, F.4    Lin, W.Y.5    Chen, Y.C.6
  • 84
    • 84881023284 scopus 로고    scopus 로고
    • http://advancedbiomarkers.com.
  • 85
    • 84881024033 scopus 로고    scopus 로고
    • http://qc1.com.
  • 86
    • 84870191667 scopus 로고    scopus 로고
    • Batch-reactor microfluidic device: first human use of a microfluidically produced PET radiotracer
    • Lebedev A., Miraghaie R., Kotta K., Ball C.E., Zhang J., Buchsbaum M.S., et al. Batch-reactor microfluidic device: first human use of a microfluidically produced PET radiotracer. Lab Chip 2013, 13:136-145.
    • (2013) Lab Chip , vol.13 , pp. 136-145
    • Lebedev, A.1    Miraghaie, R.2    Kotta, K.3    Ball, C.E.4    Zhang, J.5    Buchsbaum, M.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.