An integrated microreactor for the multicomponent synthesis of α-aminonitriles

Organic Process Research and Development

Volumn 12, Issue 5, 2008, Pages 1001-1006

  Wiles, Charlotte ^a   Watts, Paul ^a  

^a UNIVERSITY OF HULL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 58149125469     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op800025p     Document Type: Article

References (14)

1. Presented in part at the 234th American Chemical Society National Meeting, Bostaon, MA, 2007. Wiles, C. Abstr. Pap. Am. Chem. 2007, ORGAN 105
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5. (a) For recent reviews of the technology, see: Fukuyama, T.; Rahman, M. T.; Sato, M.; Ryu, I. Synlett 2008, 2, 51.
6. (b) Wiles, C.; Watts. P. Eur. J. Org. Chem. 2008, http://dx.doi.org/10.1002/ejoc.200701041.
7. (c) Wiles, C.; Watts, P. Chem. Commun. 2007, 443.
8. (d) Mason, B. P.; Price, K. E.; Steinbacher, J. L.; Bogdan, A. R.; McQuade, D. T. Chem. Rev. 2007, 107, 2300.
9. (e) Geyer, K.; Codee, J. D. C.; Seeberger, P. H. Chem. Eur. J. 2006, 12, 8434.
10. Caution! All experiments should be performed within a fumecupboard in order to avoid inhalation of HCN, which may be liberated upon hydrolysis of trimethylsilylcyanide (TMSCN) should the reaction not go to completion.
11. -1, 50-100 mesh) is commercially available from Sigma-Aldrich.
12. El-Ahl, S. A. Synth. Commun. 2003, 33, 989.
13. (a) Azizi, N.; Saidi, R. M. Synth. Commun. 2004, 34, 1207.
14. (b) Ranu, R. C.; Gey, S. S.; Hajra, A. Tetrahedron 2002, 58, 2529.