Design and optimization of coin-shaped microreactor chips for PET radiopharmaceutical synthesis

Journal of Nuclear Medicine

Volumn 51, Issue 2, 2010, Pages 282-287

  Elizarov, Arkadij M ^a,b   Van Dam, R Michael ^b   Shin, Young Shik ^b   Kolb, Hartmuth C ^a   Padgett, Henry C ^a   Stout, David ^c   Shu, Jenny ^c   Huang, Jiang ^d   Daridon, Antoine ^d   Heath, James R ^c  

^a Siemens MI Biomarker Research   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d FLUIDIGM CORPORATION   (United States)

Author keywords

18F FDG; Instrumentation; Microfluidics; PET; Radiosynthesis

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ARTICLE; CHEMICAL REACTION; DEVICE; MICROFLUIDIC ANALYSIS; NUCLEAR REACTOR; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOMETRY;

ANIMALS; CHROMATOGRAPHY, ION EXCHANGE; ELASTOMERS; EQUIPMENT DESIGN; FLUORINE RADIOISOTOPES; FLUORODEOXYGLUCOSE F18; HUMANS; MICE; MICROFLUIDIC ANALYTICAL TECHNIQUES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RHABDOMYOSARCOMA;

EID: 75749115994     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.109.065946     Document Type: Article

References (33)

1. Czernin J, Phelps ME. Positron emission tomography scanning: current and future applications. Annu Rev Med. 2002;53:89-112.
2. Dresel S. PET in Oncology. Berlin, Germany: Springer GmbH; 2008.
3. Mishina M. Positron emission tomography for brain research. J Nippon Med Sch. 2008;75:68-76.
4. Knuuti J, Bengel FM. Positron emission tomography and molecular imaging. Heart. 2008;94:360-367.
5. Laverman P, Bleeker-Rovers CP, Corstens FHM, Boeman OC, Oyen WJG. Development of infection and inflammation targeting compounds. Curr Radiopharm. 2008;1:42-48.
6. Wang J, Maurer L. Positron emission tomography: applications in drug discovery and drug development. Curr Top Med Chem. 2005;5:1053-1075.
7. Boss DS, Olmos RV, Sinaasappel M, Beijnen JH, Schellens JHM. Application of PET/CT in the development of novel anticancer drugs. Oncologist. 2008;13:25-38.
8. Gupta N, Price PM, Aboagye EO. PET for in vivo pharmacokinetic and pharmacodynamic measurements. Eur J Cancer. 2002;38:2094-2107.
9. 18F]-fludeoxyglucose production. Eur J Nucl Med Mol Imaging. 2008;35:80-88.
10. 18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med. 1986;27:235-238.
11. 18F-FDG PET for preoperative staging in non-small cell lung cancer. Eur J Nucl Med Mol Imaging. 2008;35:236-245.
12. 18F]-FMAU). J Label Compd Radiopharm. 2002;45:583-590.
13. Grosu A-L, Souvatzoglou M, Röper B, et al. Hypoxia imaging with FAZA-PET and theoretical considerations with regard to dose painting for individualization of radiotherapy in patients with head and neck cancer. Int J Radiat Oncol Biol Phys. 2007;69:541-551.
14. 18F]FDG for PET investigation at IFIN-HH Bucharest. Proceedings of Application of Accelerators in Research and Industry: 20th International Conference. AIP Conf Proc. 2009;1: 496-499.
15. 18F]FMISO based upon a modified Explora FDG4 module. J Radioanal Nucl Chem. 2009;280:149-155.
16. Huebner A, Sharma S, Srisa-Art M, Hollfelder F, Edel JB, deMello AJ. Microdroplets: a sea of applications? Lab Chip. 2008;8:1244-1254.
17. Hashimoto M, Barany F, Soper SA. Polymerase chain reaction/ligase detection reaction/hybridization assays using flow-through microfluidic devices for the detection of low-abundant DNA point mutations. Biosens Bioelectron. 2006; 21:1915-1923.
18. Roberge DM, Ducry L, Bieler N, Cretton P, Zimmerman B. Microreactor technology: a revolution for the fine chemical and pharmaceutical industries? Chem Eng Technol. 2005;28:318-323.
19. Elizarov A. Microreactors for radiopharmaceutical synthesis. Lab Chip. 2009; 9:1326-1333.
20. 18F]FDG. Eur J Nucl Med Mol Imaging. 2009;36:653-658.
21. 18O]water [poster]. Paper presented at: Eleventh International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2007); October 7-11, 2007; Paris, France.
22. Liu J, Hansen C, Quake SR. Solving the "world-to-chip" interface problem with a microfluidic matrix. Anal Chem. 2003;75:4718-4723.
23. Lee C-C, Sui G, Elizarov A, et al. Tseng H-R. Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics. Science. 2005; 310:1793-1796.
24. Studer V, Hang G, Pandolfi A, Oritz M, Anderson WF, Quake SR. Scaling properties of a low-actuation pressure microfluidic valve. J Appl Phys. 2004; 95:393-398.
25. Duffy DC, McDonald JC, Schueller OJA, Whitesides GM. Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane). Anal Chem. 1998;70:4974-4984.
26. Loening AM, Gambhir S. AMIDE: a free software tool for multimodality medical image analysis. Mol Imaging. 2003;2:131-137.
27. Elizarov AM, Kolb H, Heath J, van Dam RM, inventors; Siemens Medical Solutions USA, Inc., assignee. Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography. International patent application PCT/US2006/038418. September 29, 2006; Pub No WO 2007/041486 A2. Siemens Medical Solutions USA, Inc.
28. Leng J, Lonetti B, Tabeling P. Microevaporators for kinetic exploration of phase diagrams. Phys Rev Lett. 2006;96:084503-1-084503-4.
29. Huang Y, Castrataro P, Lee C-C, Quake SR. Solvent resistant microfluidic DNA synthesizer. Lab Chip. 2007;7:24-26.
30. Stoyanov I, Tewes M, Koch M, Löhndorf M. Microfluidic devices with integrated active valves based on thermoplastic elastomers. Microelectron Eng. 2006;83:1681-1683.
31. Song S, Lee KY. Polymers for microfluidic chips. Macromol Res. 2006;14:121-128.
32. Cherry SR, Shao Y, Silverman RW, et al. MicroPET: a high resolution PET scanner for imaging small animals. IEEE Trans Nucl Sci. 1997;44:1161-1166.
33. 4 [brochure]. Available at: http://www.medical. siemens.com/siemens/en-US/gg-nm-FBAs/files/brochures/2007/ ExplorExpl4AutomatedRadiochemistry-MIND-12116493-1.pdf. Accessed December 14, 2009.