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Volumn 51, Issue 1, 2010, Pages 64-66

Fast production of highly concentrated reactive [18F] fluoride for aliphatic and aromatic nucleophilic radiolabelling

Author keywords

F 18; Fluoride; Nucleophilic substitution; Positron emission tomography; Radiofluorination; Radiopharmaceuticals; SPE

Indexed keywords

ALIPHATIC COMPOUND; ALKYL GROUP; AROMATIC COMPOUND; FLUORINE 18; NUCLEOPHILE; QUATERNARY AMMONIUM DERIVATIVE; RADIOPHARMACEUTICAL AGENT;

EID: 70849122728     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.10.085     Document Type: Article
Times cited : (39)

References (26)
  • 17
    • 70849125038 scopus 로고    scopus 로고
    • note
    • 10Br) was dissolved in 1 ml of ACN. The solution was added to 100 mg of N-vinyl lactame/divinylbenzene copolymer sorbent, a typical example is Waters Oasis™ HLB. The suspension was triturated until complete evaporation of the solvent.
  • 18
    • 70849134192 scopus 로고    scopus 로고
    • note
    • 3 in water and rinsed with 3 ml of water. When using a bicarbonate salt, the functionalised sorbent was used without conditioning.
  • 19
    • 70849087194 scopus 로고    scopus 로고
    • note
    • - was passed through the extraction cartridge (at 1 ml/min). The cartridge was dried for 4 min with a nitrogen flow (10 l/min, upstream pressure 3.25 bar). The radioactivity was eluted with 1 ml ACN (dried on molecular sieves, <100 ppm water).
  • 20
    • 70849113446 scopus 로고    scopus 로고
    • note
    • A Waters Sep-pak® QMA cartridge was eluted with a mixture of equal volumes of potassium carbonate in water (35 mg/1.5 ml) and Kryptofix K222 in ACN (110 mg/1.5 ml). A 500 μL aliquot was submitted to an azeotropic drying (95 °C, nitrogen flow, 5 min). The residue was dissolved in 1 ml of dry ACN (water <100 ppm) and the mixture was heated at 100 °C in capped reactor to simulate a labelling step. After cooling, the residual water concentration was estimated by Karl Fisher titration (541 ± 118 ppm, n = 3).
  • 22
    • 70849133363 scopus 로고    scopus 로고
    • note
    • 18F] incorporation. The yields were calculated from the chromatography results and the transferred percentages of activity.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.