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note
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10Br) was dissolved in 1 ml of ACN. The solution was added to 100 mg of N-vinyl lactame/divinylbenzene copolymer sorbent, a typical example is Waters Oasis™ HLB. The suspension was triturated until complete evaporation of the solvent.
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18
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70849134192
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note
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3 in water and rinsed with 3 ml of water. When using a bicarbonate salt, the functionalised sorbent was used without conditioning.
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19
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70849087194
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note
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- was passed through the extraction cartridge (at 1 ml/min). The cartridge was dried for 4 min with a nitrogen flow (10 l/min, upstream pressure 3.25 bar). The radioactivity was eluted with 1 ml ACN (dried on molecular sieves, <100 ppm water).
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-
-
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20
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70849113446
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note
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A Waters Sep-pak® QMA cartridge was eluted with a mixture of equal volumes of potassium carbonate in water (35 mg/1.5 ml) and Kryptofix K222 in ACN (110 mg/1.5 ml). A 500 μL aliquot was submitted to an azeotropic drying (95 °C, nitrogen flow, 5 min). The residue was dissolved in 1 ml of dry ACN (water <100 ppm) and the mixture was heated at 100 °C in capped reactor to simulate a labelling step. After cooling, the residual water concentration was estimated by Karl Fisher titration (541 ± 118 ppm, n = 3).
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22
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70849133363
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note
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18F] incorporation. The yields were calculated from the chromatography results and the transferred percentages of activity.
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