Reactivity of electrochemically concentrated anhydrous [ 18F]fluoride for microfluidic radiosynthesis of 18F-labeled compounds

Applied Radiation and Isotopes

Volumn 70, Issue 1, 2012, Pages 193-199

  Wong, Rebecca ^a   Iwata, Ren ^a   Saiki, Hidekazu ^b   Furumoto, Shozo ^a,c   Ishikawa, Yoichi ^a   Ozeki, Eiichi ^b  

^a TOHOKU UNIVERSITY   (Japan)

^b SHIMADZU CORPORATION   (Japan)

^c TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

18F fluoride; F 18; Microfluidics; PET probe; Radiosynthesis

Indexed keywords

[ 18F]FLUORIDE; APROTIC SOLVENTS; F-18; HIGH TEMPERATURE; MICROFLUIDIC REACTIONS; OPTIMIZED CONDITIONS; PET PROBE; PRECURSOR CONCENTRATION; RADIOCHEMICAL YIELD; RADIOSYNTHESIS; REACTION SOLVENTS;

BROMINE COMPOUNDS; FLUORINE; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

MICROFLUIDICS;

1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL F 18; FLUMAZENIL F18; FLUORINE 18; FLUORODEOXYGLUCOSE F 18; FLUOROMETHYL BROMIDE F 18; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONCENTRATION PROCESS; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROCHEMICAL ANALYSIS; EQUIPMENT DESIGN; FLUORINATION; ISOTOPE LABELING; MICROFLUIDIC ANALYSIS; NUCLEOPHILICITY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; REACTION OPTIMIZATION; REACTION TIME; SOLVENT EFFECT; TEMPERATURE SENSITIVITY;

ELECTROCHEMISTRY; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; MICROFLUIDIC ANALYTICAL TECHNIQUES; WATER;

EID: 80955135557     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2011.09.022     Document Type: Article

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