Synthesis of hypoxia imaging agent 1-(5-deoxy-5-fluoro-α-d-arabinofuranosyl)-2-nitroimidazole using microfluidic technology

Nuclear Medicine and Biology

Volumn 38, Issue 2, 2011, Pages 235-245

  Bouvet, Vincent R ^a   Wuest, Melinda ^a   Wiebe, Leonard I ^a   Wuest, Frank ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

18F FAZA; EMT 6 tumor bearing mice; Microfluidic technology

Indexed keywords

1 (2,3 DI O ACETYL 5 O TOSYL ALPHA DEXTRO ARABINOFURANOSYL) 2 NITROIMIDAZOLE; 1 (5 DEOXY 5 FLUORO ALPHA DEXTRO ARABINOFURANOSYL) 2 NITROIMIDAZOLE F 18; FLUORINE 18; RADIOPHARMACEUTICAL AGENT; TRACER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIAGNOSTIC IMAGING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; FEMALE; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXIA; ISOTOPE LABELING; MICROFLUIDICS; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROCESS OPTIMIZATION; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; RADIOCHEMISTRY; RADIOISOTOPE DECAY; REACTION TIME; TEMPERATURE SENSITIVITY; TUMOR MODEL;

ANIMALS; CELL HYPOXIA; CELL LINE, TUMOR; FEMALE; MICE; MICE, INBRED BALB C; MICROFLUIDIC ANALYTICAL TECHNIQUES; NEOPLASMS; NITROIMIDAZOLES; POSITRON-EMISSION TOMOGRAPHY; RADIOCHEMISTRY; RIBOSE;

EID: 79551682052     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2010.09.002     Document Type: Article

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