The PI3K/Akt/mTOR Pathway Is Implicated in the Premature Senescence of Primary Human Endothelial Cells Exposed to Chronic Radiation

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Yentrapalli, Ramesh ^a,b   Azimzadeh, Omid ^a   Sriharshan, Arundhathi ^a   Malinowsky, Katharina ^c   Merl, Juliane ^a   Wojcik, Andrzej ^b   Harms Ringdahl, Mats ^b   Atkinson, Michael J ^a,d   Becker, Karl Friedrich ^c   Haghdoost, Siamak ^b   Tapio, Soile ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b STOCKHOLM UNIVERSITY   (Sweden)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; INITIATION FACTOR 2; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P21; RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR;

ARTICLE; CELL AGING; CELL GROWTH; CELL STRUCTURE; CONTROLLED STUDY; DOSIMETRY; ELECTROSPRAY; ENDOTHELIUM CELL; ENZYME INACTIVATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LIQUID CHROMATOGRAPHY; MOLECULAR DYNAMICS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; RADIATION EXPOSURE; SENESCENCE; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; UPREGULATION;

CELL AGING; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEOMICS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TIME FACTORS; TOR SERINE-THREONINE KINASES;

EID: 84880986745     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070024     Document Type: Article

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