Sirolimus accelerates senescence of endothelial progenitor cells through telomerase inactivation

Atherosclerosis

Volumn 189, Issue 2, 2006, Pages 288-296

  Imanishi, Toshio ^a   Kobayashi, Katsunobu ^a   Kuki, Shintaro ^a   Takahashi, Chizu ^a   Akasaka, Takashi ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Endothelial progenitor cells; Senescence; Sirolimus; Telomerase activity

Indexed keywords

BETA GALACTOSIDASE; BROXURIDINE; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 12; MATRIGEL; RAPAMYCIN; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; CELL AGING; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; COLONY FORMATION; COLONY FORMING UNIT; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG ELUTING STENT; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; HUMAN; HUMAN CELL; IMMUNOASSAY; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MONONUCLEAR CELL; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENESCENCE; STATISTICAL SIGNIFICANCE; STEM CELL; UPREGULATION; VOLUNTEER;

BLOTTING, WESTERN; CELL AGING; CELL DIVISION; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P27; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKOCYTES, MONONUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SIROLIMUS; STEM CELLS; TACROLIMUS BINDING PROTEIN 1A; TELOMERASE;

EID: 33750366826     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2005.12.031     Document Type: Article

References (34)

1. Babapulle M.N., Joseph L., Belisle P., Brophy J.M., and Eisenberg M.J. Lancet 364 (2004) 583-591
2. McFadden E.P., Stabile E., Regar E., et al. Late thrombosis in drug-eluting stents after discontinuation of antiplatelet therapy. Lancet 364 (2004) 1519-1521
3. Ong A.T.L., McFadden E.P., Regar E., et al. Late angiographic stent thrombosis (LAST) events with drug-eluting stents. J Am Coll Cardiol 45 (2005) 2088-2092
4. Asahara T., Murohara T., Sullivan M., et al. Isolation of putative progenitor cells for angiogenesis. Science 275 (1997) 964-967
5. Shi Q., Rafii S., Wu M.H., et al. Evidence for circulating bone marrow-derived endothelial cells. Blood 92 (1998) 362-367
6. Kalka C., Masuda H., Takahashi T., et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci USA 97 (2000) 3422-3427
7. Imanishi T., McBride J., Ho Q., et al. Expression of cellular FLICE-inhibitory protein in human coronary arteries and in a rat vascular injury model. Am J Pathol 156 (2000) 125-137
8. Dimri G.P., Lee X., Basile G., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vitro. Proc Natl Acad Sci USA 92 (1995) 9363-9367
9. Imanishi T., Hano T., and Nishio I. Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity. J Hypertens 23 (2005) 1699-1706
10. Breitschopf K., Zeiher A.M., and Dimmeler S. Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism. FEBS Lett 493 (2001) 21-25
11. Virmani R., Guagliumi G., Farb A., et al. Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious. Circulation 109 (2004) 701-705
12. Gualiumi G., Virmani R., Musumeci G., et al. Drug-eluting versus bare metal coronary stents: long-term human pathology: findings from different coronary arteries in the same patient. Ital Heart J 4 (2003) 713-720
13. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 340 (1999) 115-126
14. Schachinger V., Britten M.B., and Zeiher A.M. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 101 (2000) 1899-1906
15. Suwaidi J.A., Hamasaki S., Higano S.T., Nishimura R.A., and Holmes Jr. L.A. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 101 (2000) 948-954
16. Halcox J.P.J., Schenke W.H., Zalos G., et al. Prognostic value of coronary vascular endothelial dysfunction. Circulation 106 (2002) 653-658
17. Gokce N., Keaney Jr. J.F., Hunter L.M., et al. Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function: a prospective study. Circulation 105 (2002) 1567-1572
18. Walter D., Rittig K., Bahlmann F., et al. Statin therapy accelerates reendotheliazation: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells. Circulation 105 (2002) 3017-3024
19. Griese D., Ehsan A., Melo L., et al. Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts:implications for cell-based vascular therapy. Circulation 108 (2003) 2710-2715
20. Hill J.M., Zalos G., Halcox J.P., et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 348 (2003) 593-600
21. Greider C.W., and Blackburn E.H. Identification of a specific telomere terminal transferase activity in tetrahymena extracts. Cell 43 (1985) 405-413
22. Greider C.W., and Blackburn E.H. A telomeric sequence in the RNA of tetrahymena telomerase required for telomere repeat synthesis. Nature 337 (1989) 331-337
23. Crow J.P., and Beckman J.S. The importance of superoxide in nitric oxide-dependent toxicity: evidence for peroxynitrite-mediated injury. Adv Exp Med Biol 387 (1996) 147-161
24. Bodnar A.G., Ouellette M., Frolkis M., et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279 (1998) 349-352
25. Broccoli D., Young J.W., and de Lange T. Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci USA 92 (1995) 9082-9086
26. Hiyama K., Hirai Y., Kyoizumi S., et al. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol 155 (1995) 3711-3715
27. Morrison S.J., Prowse K.R., Ho P., and Weissman I.L. Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity 5 (1996) 207-216
28. Feng J., Funk W.D., Wang S.S., et al. The RNA component of human telomerase. Science 269 (1995) 1236-1241
29. Nakamura T.M., Morin G.B., Chapman K.B., et al. Telomerase catalytic subunit homologs from diffusion yeast and human. Science 277 (1997) 955-959
30. Greider C.W. Telomerase activity, cell proliferation, and cancer. Proc Natl Acad Sci USA 95 (1998) 90-92
31. Murasawa S., Llevadot J., Silver M., et al. Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells. Circulation 106 (2002) 1133-1139
32. kip1 down-regulates telomerase activity and human telomerase reverse transcriptase expression in human cervical cancer. FEBS Lett 579 (2005) 1027-1033
33. Edelberg J.M., Tang L., Hattori K., Lyden D., and Rafii S. Young adult bone marrow-derived endothelial progenitor cells restore aging-impaired cardiac angiogenic function. Circ Res 90 (2002) e89-e93
34. Heiss C., Keymel S., Niesler U., et al. Impaired progenitor cell activity in age-related endothelial dysfunction. J Am Coll Cardiol 45 (2005) 1441-1448