Decreased ERK and JNK signaling contribute to gene overexpression in "senescent" CD4+CD28- T cells through epigenetic mechanisms

Journal of Leukocyte Biology

Volumn 87, Issue 1, 2010, Pages 137-145

  Chen, Yingxuan ^a   Gorelik, Gabriela J ^a   Strickland, Faith M ^a   Richardson, Bruce C ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

Autoimmunity; DNA methylation; Senescence

Indexed keywords

CD28 ANTIGEN; CD70 ANTIGEN; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; FAS LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; PERFORIN; STRESS ACTIVATED PROTEIN KINASE;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; ENZYME INHIBITION; EPIGENETICS; GENE OVEREXPRESSION; HEART INFARCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; UPREGULATION;

ADULT; AGED; ANTIGENS, CD28; ANTIGENS, CD70; ARTHRITIS, RHEUMATOID; CD4-POSITIVE T-LYMPHOCYTES; CELL AGING; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EPIGENESIS, GENETIC; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MIDDLE AGED; OSTEOARTHRITIS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS;

EID: 74949129499     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0809562     Document Type: Article

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