Hypoxic preconditioning attenuates neuronal cell death by preventing MEK/ERK signaling pathway activation after transient global cerebral ischemia in adult rats

Molecular Neurobiology

Volumn 48, Issue 1, 2013, Pages 109-119

  Zhan, Lixuan ^a   Yan, Hongxin ^a   Zhou, Huarong ^a   Sun, Weiwen ^a   Hou, Qinghua ^a   Xu, En ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Cerebral ischemia; Hypoxic preconditioning; MEK ERK signaling pathway; Neuroprotection

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ASTROCYTE; BRAIN ISCHEMIA; BRAIN PERFUSION; BRAIN REGION; CONTROLLED STUDY; ENZYME ACTIVATION; GLIA CELL; HISTOLOGY; HYPOXIA; HYPOXIC PRECONDITIONING; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; ISCHEMIC PRECONDITIONING; MALE; NERVE CELL NECROSIS; NEUROFILAMENT; NEUROPROTECTION; NONHUMAN; PYRAMIDAL NERVE CELL; RAT; REVIEW; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84880920218     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-013-8436-4     Document Type: Review

References (40)

1. Kapinya KJ (2005) Ischemic tolerance in the brain. Acta Physiol Hung 92:67-92
2. Zhan L, Wang T, Li W, Xu ZC, Sun W, Xu E (2010) Activation of Akt/FoxO signaling pathway contributes to induction of neuroprotection against transient global ischemia by hypoxic preconditioning in adult rats. J Neurochem 114:897-908
3. Yano S, Morioka M, Fukunaga K, Kawano T, Hara T, Kai Y, Hamada J, Miyamoto E, Ushio Y (2001) Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus. J Cereb Blood Flow Metab 21:351-360
4. Kitano H, Young JM, Cheng J, Wang L, Hum PD, Murphy SJ (2007) Gender-specific response to isoflurane preconditioning in focal cerebral ischemia. J Cereb Blood Flow Metab 27:1377-1386
5. Lee SR, Lo EH (2003) Interactions between p38 mitogen-activated protein kinase and caspase-3 in cerebral endothelial cell death after hypoxia-reoxygenation. Stroke 34:2704-2709
6. Mebratu Y, Tesfaigzi Y (2009) How ERK1/2 activation controls cell proliferation and cell death: is subcellular localization the answer? Cell Cycle 8:1168-1175
7. Subramaniam S, Unsicker K (2010) ERK and cell death: ERK1/2 in neuronal death. FEBS J 277:22-29
8. Chong YH, Shin YJ, Lee EO, Kayed R, Glabe CG, Tenner AJ (2006) ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures. J Biol Chem 281:20315-20325
9. Zhuang S, Schnellmann RG (2006) A death-promoting role for extracellular signal-regulated kinase. J Pharmacol Exp Ther 319:991-997
10. Numakawa Y, Matsumoto T, Yokomaku D, Taguchi T, Niki E, Hatanaka H, Kunugi H, Numakawa T (2007) 17beta-estradiol protects cortical neurons against oxidative stress-induced cell death through reduction in the activity of mitogen-activated protein kinase and in the accumulation of intracellular calcium. Endocrinology 148:627-637
11. Satoh T, Nakatsuka D, Watanabe Y, Nagata I, Kikuchi H, Namura S (2000) Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. Neurosci Lett 288:163-166
12. Lu K, Liang CL, Liliang PC, Yang CH, Cho CL, Weng HC, Tsai YD, Wang KW, Chen HJ (2010) Inhibition of extracellular signal-regulated kinases 1/2 provides neuroprotection in spinal cord ischemia/reperfusion injury in rats: relationship with the nuclear factor-kappaB-regulated anti-apoptotic mechanisms. J Neurochem 114:237-246
13. Irving EA, Bamford M (2002) Role of mitogen- and stress-activated kinases in ischemic injury. J Cereb Blood Flow Metab 22:631-647
14. Maddahi A, Edvinsson L (2010) Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway. J Neuroinflammation 7:14
15. Pulsinelli WA, Brierley JB (1979) A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 10:267-272
16. Schmued LC, Stowers CC, Scallet AC, Xu (2005) Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons. Brain Res 1035:24-31
17. Wang Y, Zhan L, Zeng W, Li K, Sun W, Xu ZC, Xu E (2011) The effect of GABA on the hypoxia-induced increase of epilepsy susceptibility in neonate rat. Neurochem Res 36:2409-2416
18. Endo H, Nito C, Kamada H, Nishi T, Chan PH (2006) Activation of the Akt/GSK3β signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats. J Cereb Blood Flow Metab 26:1479-1489
19. Chan SH, Wu CA, Wu KL, Ho YH, Chang AY, Chan JY (2009) Transcriptional upregulation of mitochondrial uncoupling protein 2 protects against oxidative stress-associated neurogenic hypertension. Circ Res 105:886-896
20. Zhan L, Li D, Liang D, Wu B, Zhu P, Wang Y, Sun W, Xu E (2012) Activation of Akt/FoxO and inactivation of MEK/ERK pathways contribute to induction of neuroprotection against transient global cerebral ischemia by delayed hypoxic postconditioning in adult rats. Neuropharmacology 63:873-882
21. Zhan L, Peng W, Sun W, Xu E (2011) Hypoxic preconditioning induces neuroprotection against transient global ischemia in adult rats via preserving the activity of Na+/K + -ATPase. Neurochem Int 59:65-72
22. Kim GS, Hong JS, Kim SW, Koh JM, An CS, Choi JY, Cheng SL (2003) Leptin induces apoptosis via ERK/cPLA2/cytochrome c pathway in human bone marrow stromal cells. J Biol Chem 278:21920-21929
23. Nowak G, Clifton GL, Godwin ML, Bakajsova D (2006) Activation of ERK1â?., 2 pathway mediates oxidant-induced decreases in mitochondrial function in renal cells. Am J Physiol Renal Physiol 291:F840-F855
24. Noshita N, Sugawara T, Hayashi T, Lewen A, Omar G, Chan PH (2002) Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice. J Neurosci 22:7923-7930
25. Sugawara T, Fujimura M, Noshita N, Kim GW, Saito A, Hayashi T, Narasimham P, Maier CM, Chan P (2004) Neuronal death/survival signaling pathways in cerebral ischemia. NeuroRx 1:17-25
26. Zhang F, Signore AP, Zhou Z, Wang S, Cao G, Chen J (2006) Erythropoietin protects CA1 neurons against global cerebral ischemia in rat: potential signaling mechanisms. J Neurosci Res 83:1241-1251
27. Zheng YQ, Liu JX, Wang JN, Xu L (2007) Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia. Brain Res 1138:86-94
28. Namura S, Iihara K, Takami S, Nagata I, Kikuchi H, Matsushita K, Moskowitz MA, Bonventre JV, Alessandrini A (2001) Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc Natl Acad Sci USA 98:11569-11574
29. Farrokhnia N, Ericsson A, Terént A, Lennmyr F (2008) MEK-inhibitor U0126 in hyperglycaemic focal ischaemic brain injury in the rat. Eur J Clin Invest 38:679-685
30. Allan LA, Morrice N, Brady S, Magee G, Pathak S, Clarke PR (2003) Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat Cell Biol 5:647-654
31. Kitazumi I, Tsukahara M (2011) Regulation of DNA fragmentation: the role of caspases and phosphorylation. FEBS J 278:427-441
32. Wang X, Wang H, Xu L, Rozanski J, Sugawara T, Chan PH, Trazskos JM, Feuerstein GZ (2003) Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J Pharmacol Exp Ther 304:172-178
33. Castro-Obregon S, Rao R, del Rio G, Chen S, Poksay K, Rabizadeh S, Vesce S, Zhang X, Swanson RA, Bredesen DE (2004) Alternative, nonapoptotic programmed cell death. J Biol Chem 279:17543-17553
34. Subramaniam S, Zirrgiebel U, von Bohlen Und Halbach O, Strelau J, Laliberté C, Kaplan DR, Unsicker K (2004) ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3. J Cell Biol 165:357-369
35. Lobner D, Liot G (2004) Role of MAPK/ERK neurotropin-4 potentiation of necrotic neuronal death. Neurochem Res 29:2303-2309
36. Wang ZQ, Wu DC, Huang FP, Yang GY (2004) Inhibition of MEK/ERK 1/2 pathway reduces pro-inflammatory cytokine interleukin-1 expression in focal cerebral ischemia. Brain Res 996:55-66
37. Zhang F, Wang S, Signore AP, Chen J (2007) Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia. Stroke 38:2329-2336
38. Franke TF, Kaplan DR, Cantley LC (1997) PI3K: downstream AKTion blocks apoptosis. Cell 88:435-437
39. Zimmermann S, Moelling K (1999) Phosphorylation and regulation of Raf by Akt (protein kinase B). Science 286:1741-1744
40. Mizukami Y, Kobayashi S, Uberall F, Hellbert K, Kobayashi N, Yoshida K (2000) Nuclear mitogen-activated protein kinase activation by protein kinase czeta during reoxygenation after ischemic hypoxia. J Biol Chem 275:19921-19927 Higher Education of China