-
1
-
-
37449028923
-
Morphological and cytochemical determination of cell death by apoptosis
-
Taatjes DJ, Sobel BE, &, Budd RC, (2008) Morphological and cytochemical determination of cell death by apoptosis. Histochem Cell Biol Rev 129, 33-43.
-
(2008)
Histochem Cell Biol Rev
, vol.129
, pp. 33-43
-
-
Taatjes, D.J.1
Sobel, B.E.2
Budd, R.C.3
-
2
-
-
54249096028
-
Caspases in apoptosis and beyond
-
Li J, &, Yuan J, (2008) Caspases in apoptosis and beyond. Oncogene Rev 27, 6194-6206.
-
(2008)
Oncogene Rev
, vol.27
, pp. 6194-6206
-
-
Li, J.1
Yuan, J.2
-
3
-
-
33746892660
-
Identification of PP1alpha as a caspase-9 regulator in IL-2 deprivation-induced apoptosis
-
Dessauge F, Cayla X, Albar JP, Fleischer A, Ghadiri A, Duhamel M, &, Rebollo A, (2006) Identification of PP1alpha as a caspase-9 regulator in IL-2 deprivation-induced apoptosis. J Immunol 177, 2441-2451.
-
(2006)
J Immunol
, vol.177
, pp. 2441-2451
-
-
Dessauge, F.1
Cayla, X.2
Albar, J.P.3
Fleischer, A.4
Ghadiri, A.5
Duhamel, M.6
Rebollo, A.7
-
4
-
-
1242276248
-
P38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils
-
Alvarado-Kristensson M, Melander F, Leandersson K, Rönnstrand L, Wernstedt C, &, Andersson T, (2004) p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils. J Exp Med 199, 449-458.
-
(2004)
J Exp Med
, vol.199
, pp. 449-458
-
-
Alvarado-Kristensson, M.1
Melander, F.2
Leandersson, K.3
Rönnstrand, L.4
Wernstedt, C.5
Andersson, T.6
-
5
-
-
75349109122
-
Regulation of cell proliferation and survival: Convergence of protein kinases and caspases
-
Duncan JS, Turowec JP, Vilk G, Li SS, Gloor GB, &, Litchfield DW, (2010) Regulation of cell proliferation and survival: convergence of protein kinases and caspases. Biochim Biophys Acta Rev 1804, 505-510.
-
(2010)
Biochim Biophys Acta Rev
, vol.1804
, pp. 505-510
-
-
Duncan, J.S.1
Turowec, J.P.2
Vilk, G.3
Li, S.S.4
Gloor, G.B.5
Litchfield, D.W.6
-
6
-
-
50349089711
-
Phosphatases and regulation of cell death
-
Chiang CW, Yan L, &, Yang E, (2008) Phosphatases and regulation of cell death. Methods Enzymol 446, 237-257.
-
(2008)
Methods Enzymol
, vol.446
, pp. 237-257
-
-
Chiang, C.W.1
Yan, L.2
Yang, E.3
-
7
-
-
67749117934
-
Signal integration by JNK and p38 MAPK pathways in cancer development
-
Wagner EF, &, Nebreda AR, (2009) Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer Rev 9, 537-549.
-
(2009)
Nat Rev Cancer Rev
, vol.9
, pp. 537-549
-
-
Wagner, E.F.1
Nebreda, A.R.2
-
8
-
-
69449095860
-
Caspases and kinases in a death grip
-
Kurokawa M, &, Kornbluth S, (2009) Caspases and kinases in a death grip. Cell Rev 138, 838-854.
-
(2009)
Cell Rev
, vol.138
, pp. 838-854
-
-
Kurokawa, M.1
Kornbluth, S.2
-
9
-
-
0035976991
-
CAD/DFF40 nuclease is dispensable for high molecular weight DNA cleavage and stage i chromatin condensation in apoptosis
-
Samejima K, Tone S, &, Earnshaw WC, (2001) CAD/DFF40 nuclease is dispensable for high molecular weight DNA cleavage and stage I chromatin condensation in apoptosis. J Biol Chem 276, 45427-45432.
-
(2001)
J Biol Chem
, vol.276
, pp. 45427-45432
-
-
Samejima, K.1
Tone, S.2
Earnshaw, W.C.3
-
10
-
-
17644397571
-
Modulation of DNA fragmentation factor 40 nuclease activity by poly(ADP-ribose) polymerase-1
-
West JD, Ji C, &, Marnett LJ, (2005) Modulation of DNA fragmentation factor 40 nuclease activity by poly(ADP-ribose) polymerase-1. J Biol Chem 280, 15141-15147.
-
(2005)
J Biol Chem
, vol.280
, pp. 15141-15147
-
-
West, J.D.1
Ji, C.2
Marnett, L.J.3
-
11
-
-
47849120976
-
Serum starvation induces H2AX phosphorylation to regulate apoptosis via p38 MAPK pathway
-
Lu C, Shi Y, Wang Z, Song Z, Zhu M, Cai Q, &, Chen T, (2008) Serum starvation induces H2AX phosphorylation to regulate apoptosis via p38 MAPK pathway. FEBS Lett 582, 2703-2708.
-
(2008)
FEBS Lett
, vol.582
, pp. 2703-2708
-
-
Lu, C.1
Shi, Y.2
Wang, Z.3
Song, Z.4
Zhu, M.5
Cai, Q.6
Chen, T.7
-
12
-
-
0035811496
-
Endonuclease G is an apoptotic DNase when released from mitochondria
-
Li LY, Luo X, &, Wang X, (2001) Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412, 95-99.
-
(2001)
Nature
, vol.412
, pp. 95-99
-
-
Li, L.Y.1
Luo, X.2
Wang, X.3
-
13
-
-
0032724653
-
Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation
-
Wolf BB, Schuler M, Echeverri F, &, Green DR, (1999) Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation. J Biol Chem 274, 30651-30656.
-
(1999)
J Biol Chem
, vol.274
, pp. 30651-30656
-
-
Wolf, B.B.1
Schuler, M.2
Echeverri, F.3
Green, D.R.4
-
14
-
-
0034624061
-
Characterization of the rat DNA fragmentation factor 35/inhibitor of caspase-activated DNase (short form). The endogenous inhibitor of caspase-dependent DNA fragmentation in neuronal apoptosis
-
Chen D, Stetler RA, Cao G, Pei W, O'Horo C, Yin XM, &, Chen J, (2000) Characterization of the rat DNA fragmentation factor 35/inhibitor of caspase-activated DNase (short form). The endogenous inhibitor of caspase-dependent DNA fragmentation in neuronal apoptosis. J Biol Chem 275, 38508-38517.
-
(2000)
J Biol Chem
, vol.275
, pp. 38508-38517
-
-
Chen, D.1
Stetler, R.A.2
Cao, G.3
Pei, W.4
O'Horo, C.5
Yin, X.M.6
Chen, J.7
-
15
-
-
74549143794
-
Okadaic acid induces DNA fragmentation via caspase-3-dependent and caspase-3-independent pathways in Chinese hamster ovary (CHO)-K1 cells
-
Kitazumi I, Maseki Y, Nomura Y, Shimanuki A, Sugita Y, &, Tsukahara M, (2010) Okadaic acid induces DNA fragmentation via caspase-3-dependent and caspase-3-independent pathways in Chinese hamster ovary (CHO)-K1 cells. FEBS J 277, 404-412.
-
(2010)
FEBS J
, vol.277
, pp. 404-412
-
-
Kitazumi, I.1
Maseki, Y.2
Nomura, Y.3
Shimanuki, A.4
Sugita, Y.5
Tsukahara, M.6
-
16
-
-
58149230974
-
Multiple signal transduction pathways in okadaic acid induced apoptosis in HeLa cells
-
Jayaraj R, Gupta N, &, Rao PV, (2009) Multiple signal transduction pathways in okadaic acid induced apoptosis in HeLa cells. Toxicology 256, 118-127.
-
(2009)
Toxicology
, vol.256
, pp. 118-127
-
-
Jayaraj, R.1
Gupta, N.2
Rao, P.V.3
-
17
-
-
0031888955
-
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
-
Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, &, Nagata S, (1998) A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391, 43-50.
-
(1998)
Nature
, vol.391
, pp. 43-50
-
-
Enari, M.1
Sakahira, H.2
Yokoyama, H.3
Okawa, K.4
Iwamatsu, A.5
Nagata, S.6
-
18
-
-
40049091482
-
The major apoptotic endonuclease DFF40/CAD is a deoxyribose-specific and double-strand-specific enzyme
-
Hanus J, Kalinowska-Herok M, &, Widlak P, (2008) The major apoptotic endonuclease DFF40/CAD is a deoxyribose-specific and double-strand-specific enzyme. Apoptosis 13, 377-382.
-
(2008)
Apoptosis
, vol.13
, pp. 377-382
-
-
Hanus, J.1
Kalinowska-Herok, M.2
Widlak, P.3
-
19
-
-
0035930523
-
Action of recombinant human apoptotic endonuclease G on naked DNA and chromatin substrates
-
Widlak P, Li LY, Wang X, &, Garrard WT, (2001) Action of recombinant human apoptotic endonuclease G on naked DNA and chromatin substrates. J Biol Chem 276, 48404-48409.
-
(2001)
J Biol Chem
, vol.276
, pp. 48404-48409
-
-
Widlak, P.1
Li, L.Y.2
Wang, X.3
Garrard, W.T.4
-
20
-
-
33750719125
-
Unique features of the apoptotic endonuclease DFF40/CAD relative to micrococcal nuclease as a structural probe for chromatin
-
Widlak P, &, Garrard WT, (2006) Unique features of the apoptotic endonuclease DFF40/CAD relative to micrococcal nuclease as a structural probe for chromatin. Biochem Cell Biol Rev 84, 405-410.
-
(2006)
Biochem Cell Biol Rev
, vol.84
, pp. 405-410
-
-
Widlak, P.1
Garrard, W.T.2
-
21
-
-
0035400124
-
Caspase-activated DNase/DNA fragmentation factor 40 mediates apoptotic DNA fragmentation in transient cerebral ischemia and in neuronal cultures
-
Cao G, Pei W, Lan J, Stetler RA, Luo Y, Nagayama T, Graham SH, Yin XM, Simon RP, &, Chen J, (2001) Caspase-activated DNase/DNA fragmentation factor 40 mediates apoptotic DNA fragmentation in transient cerebral ischemia and in neuronal cultures. J Neurosci 21, 4678-4690.
-
(2001)
J Neurosci
, vol.21
, pp. 4678-4690
-
-
Cao, G.1
Pei, W.2
Lan, J.3
Stetler, R.A.4
Luo, Y.5
Nagayama, T.6
Graham, S.H.7
Yin, X.M.8
Simon, R.P.9
Chen, J.10
-
22
-
-
0033056950
-
Functional differences of two forms of the inhibitor of caspase-activated DNase, ICAD-L, and ICAD-S
-
Sakahira H, Enari M, &, Nagata S, (1999) Functional differences of two forms of the inhibitor of caspase-activated DNase, ICAD-L, and ICAD-S. J Biol Chem 274, 15740-15744.
-
(1999)
J Biol Chem
, vol.274
, pp. 15740-15744
-
-
Sakahira, H.1
Enari, M.2
Nagata, S.3
-
23
-
-
28844492992
-
Oligomerization state of the DNA fragmentation factor in normal and apoptotic cells
-
Lechardeur D, Dougaparsad S, Nemes C, &, Lukacs GL, (2005) Oligomerization state of the DNA fragmentation factor in normal and apoptotic cells. J Biol Chem 280, 40216-40225.
-
(2005)
J Biol Chem
, vol.280
, pp. 40216-40225
-
-
Lechardeur, D.1
Dougaparsad, S.2
Nemes, C.3
Lukacs, G.L.4
-
24
-
-
0034710247
-
Determinants of the nuclear localization of the heterodimeric DNA fragmentation factor (ICAD/CAD)
-
Lechardeur D, Drzymala L, Sharma M, Zylka D, Kinach R, Pacia J, Hicks C, Usmani N, Rommens JM, &, Lukacs GL, (2000) Determinants of the nuclear localization of the heterodimeric DNA fragmentation factor (ICAD/CAD). J Cell Biol 150, 321-334.
-
(2000)
J Cell Biol
, vol.150
, pp. 321-334
-
-
Lechardeur, D.1
Drzymala, L.2
Sharma, M.3
Zylka, D.4
Kinach, R.5
Pacia, J.6
Hicks, C.7
Usmani, N.8
Rommens, J.M.9
Lukacs, G.L.10
-
25
-
-
2442505378
-
Structural mechanism for inactivation and activation of CAD/DFF40 in the apoptotic pathway
-
Woo EJ, Kim YG, Kim MS, Han WD, Shin S, Robinson H, Park SY, &, Oh BH, (2004) Structural mechanism for inactivation and activation of CAD/DFF40 in the apoptotic pathway. Mol Cell 14, 531-539.
-
(2004)
Mol Cell
, vol.14
, pp. 531-539
-
-
Woo, E.J.1
Kim, Y.G.2
Kim, M.S.3
Han, W.D.4
Shin, S.5
Robinson, H.6
Park, S.Y.7
Oh, B.H.8
-
26
-
-
27444441304
-
The contribution of apoptosis-inducing factor, caspase-activated DNase, and inhibitor of caspase-activated DNase to the nuclear phenotype and DNA degradation during apoptosis
-
Yuste VJ, Sánchez-López I, Solé C, Moubarak RS, Bayascas JR, Dolcet X, Encinas M, Susin SA, &, Comella JX, (2005) The contribution of apoptosis-inducing factor, caspase-activated DNase, and inhibitor of caspase-activated DNase to the nuclear phenotype and DNA degradation during apoptosis. J Biol Chem 280, 35670-35683.
-
(2005)
J Biol Chem
, vol.280
, pp. 35670-35683
-
-
Yuste, V.J.1
Sánchez-López, I.2
Solé, C.3
Moubarak, R.S.4
Bayascas, J.R.5
Dolcet, X.6
Encinas, M.7
Susin, S.A.8
Comella, J.X.9
-
27
-
-
0033597882
-
Functional interaction of DFF35 and DFF45 with caspase-activated DNA fragmentation nuclease DFF40
-
Gu J, Dong RP, Zhang C, McLaughlin DF, Wu MX, &, Schlossman SF, (1999) Functional interaction of DFF35 and DFF45 with caspase-activated DNA fragmentation nuclease DFF40. J Biol Chem 274, 20759-20762.
-
(1999)
J Biol Chem
, vol.274
, pp. 20759-20762
-
-
Gu, J.1
Dong, R.P.2
Zhang, C.3
McLaughlin, D.F.4
Wu, M.X.5
Schlossman, S.F.6
-
28
-
-
0037100613
-
The effect of ICAD-S on the formation and intracellular distribution of a nucleolytically active caspase-activated DNase
-
Scholz SR, Korn C, Gimadutdinow O, Knoblauch M, Pingoud A, &, Meiss G, (2002) The effect of ICAD-S on the formation and intracellular distribution of a nucleolytically active caspase-activated DNase. Nucleic Acids Res 30, 3045-3051.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 3045-3051
-
-
Scholz, S.R.1
Korn, C.2
Gimadutdinow, O.3
Knoblauch, M.4
Pingoud, A.5
Meiss, G.6
-
29
-
-
0034653343
-
Differential localization of ICAD-L and ICAD-S in cells due to removal of a C-terminal NLS from ICAD-L by alternative splicing
-
Samejima K, &, Earnshaw WC, (2000) Differential localization of ICAD-L and ICAD-S in cells due to removal of a C-terminal NLS from ICAD-L by alternative splicing. Exp Cell Res 255, 314-320.
-
(2000)
Exp Cell Res
, vol.255
, pp. 314-320
-
-
Samejima, K.1
Earnshaw, W.C.2
-
30
-
-
34249987162
-
Bioinformatic and image analyses of the cellular localization of the apoptotic proteins endonuclease G, AIF, and AMID during apoptosis in human cells
-
Vařecha M, Amrichová J, Zimmermann M, Ulman V, Lukášová E, &, Kozubek M, (2007) Bioinformatic and image analyses of the cellular localization of the apoptotic proteins endonuclease G, AIF, and AMID during apoptosis in human cells. Apoptosis 12, 1155-1171.
-
(2007)
Apoptosis
, vol.12
, pp. 1155-1171
-
-
Vařecha, M.1
Amrichová, J.2
Zimmermann, M.3
Ulman, V.4
Lukášová, E.5
Kozubek, M.6
-
31
-
-
12544251669
-
Mitochondrial release of pro-apoptotic proteins: Electrostatic interactions can hold cytochrome c but not Smac/DIABLO to mitochondrial membranes
-
Uren RT, Dewson G, Bonzon C, Lithgow T, Newmeyer DD, &, Kluck RM, (2005) Mitochondrial release of pro-apoptotic proteins: electrostatic interactions can hold cytochrome c but not Smac/DIABLO to mitochondrial membranes. J Biol Chem 280, 2266-2274.
-
(2005)
J Biol Chem
, vol.280
, pp. 2266-2274
-
-
Uren, R.T.1
Dewson, G.2
Bonzon, C.3
Lithgow, T.4
Newmeyer, D.D.5
Kluck, R.M.6
-
32
-
-
33749617086
-
Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury
-
Bajt ML, Cover C, Lemasters JJ, &, Jaeschke H, (2006) Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. Toxicol Sci 94, 217-225.
-
(2006)
Toxicol Sci
, vol.94
, pp. 217-225
-
-
Bajt, M.L.1
Cover, C.2
Lemasters, J.J.3
Jaeschke, H.4
-
33
-
-
23944462470
-
Regulation of the human apoptotic DNase/RNase endonuclease G: Involvement of Hsp70 and ATP
-
Kalinowska M, Garncarz W, Pietrowska M, Garrard WT, &, Widlak P, (2005) Regulation of the human apoptotic DNase/RNase endonuclease G: involvement of Hsp70 and ATP. Apoptosis 10, 821-830.
-
(2005)
Apoptosis
, vol.10
, pp. 821-830
-
-
Kalinowska, M.1
Garncarz, W.2
Pietrowska, M.3
Garrard, W.T.4
Widlak, P.5
-
34
-
-
0035844170
-
NADH oxidase activity of mitochondrial apoptosis-inducing factor
-
Miramar MD, Costantini P, Ravagnan L, Saraiva LM, Haouzi D, Brothers G, Penninger JM, Peleato ML, Kroemer G, &, Susin SA, (2001) NADH oxidase activity of mitochondrial apoptosis-inducing factor. J Biol Chem 276, 16391-16398.
-
(2001)
J Biol Chem
, vol.276
, pp. 16391-16398
-
-
Miramar, M.D.1
Costantini, P.2
Ravagnan, L.3
Saraiva, L.M.4
Haouzi, D.5
Brothers, G.6
Penninger, J.M.7
Peleato, M.L.8
Kroemer, G.9
Susin, S.A.10
-
35
-
-
0033521741
-
Molecular characterization of mitochondrial apoptosis-inducing factor
-
Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, et al. (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397, 441-446.
-
(1999)
Nature
, vol.397
, pp. 441-446
-
-
Susin, S.A.1
Lorenzo, H.K.2
Zamzami, N.3
Marzo, I.4
Snow, B.E.5
Brothers, G.M.6
Mangion, J.7
Jacotot, E.8
Costantini, P.9
Loeffler, M.10
-
36
-
-
77951975356
-
AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX
-
Artus C, Boujrad H, Bouharrour A, Brunelle MN, Hoos S, Yuste VJ, Lenormand P, Rousselle JC, Namane A, England P, et al. (2010) AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX. EMBO J 29, 1585-1599.
-
(2010)
EMBO J
, vol.29
, pp. 1585-1599
-
-
Artus, C.1
Boujrad, H.2
Bouharrour, A.3
Brunelle, M.N.4
Hoos, S.5
Yuste, V.J.6
Lenormand, P.7
Rousselle, J.C.8
Namane, A.9
England, P.10
-
37
-
-
8444220527
-
Molecular mechanisms of caspase regulation during apoptosis
-
Riedl SJ, &, Shi Y, (2004) Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol Rev 5, 897-907.
-
(2004)
Nat Rev Mol Cell Biol Rev
, vol.5
, pp. 897-907
-
-
Riedl, S.J.1
Shi, Y.2
-
38
-
-
34247345833
-
The apoptosome: Signalling platform of cell death
-
Riedl SJ, &, Salvesen GS, (2007) The apoptosome: signalling platform of cell death. Nat Rev Mol Cell Biol Rev 8, 405-413.
-
(2007)
Nat Rev Mol Cell Biol Rev
, vol.8
, pp. 405-413
-
-
Riedl, S.J.1
Salvesen, G.S.2
-
39
-
-
38049126036
-
Delineation of the caspase-9 signaling cascade
-
Guerrero AD, Chen M, &, Wang J, (2008) Delineation of the caspase-9 signaling cascade. Apoptosis 13, 177-186.
-
(2008)
Apoptosis
, vol.13
, pp. 177-186
-
-
Guerrero, A.D.1
Chen, M.2
Wang, J.3
-
40
-
-
0035831473
-
Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis
-
Slee EA, Adrain C, &, Martin SJ, (2001) Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem 276, 7320-7326.
-
(2001)
J Biol Chem
, vol.276
, pp. 7320-7326
-
-
Slee, E.A.1
Adrain, C.2
Martin, S.J.3
-
41
-
-
0041853690
-
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
-
Micheau O, &, Tschopp J, (2003) Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114, 181-190.
-
(2003)
Cell
, vol.114
, pp. 181-190
-
-
Micheau, O.1
Tschopp, J.2
-
42
-
-
62849093368
-
Death receptor signal transducers: Nodes of coordination in immune signaling networks
-
Wilson NS, Dixit V, &, Ashkenazi A, (2009) Death receptor signal transducers: nodes of coordination in immune signaling networks. Nat Immunol Rev 10, 348-355.
-
(2009)
Nat Immunol Rev
, vol.10
, pp. 348-355
-
-
Wilson, N.S.1
Dixit, V.2
Ashkenazi, A.3
-
43
-
-
2342471409
-
Toxic proteins released from mitochondria in cell death
-
Saelens X, Festjens N, Vande Walle L, van Gurp M, van Loo G, &, Vandenabeele P, (2004) Toxic proteins released from mitochondria in cell death. Oncogene Rev 23, 2861-2874.
-
(2004)
Oncogene Rev
, vol.23
, pp. 2861-2874
-
-
Saelens, X.1
Festjens, N.2
Vande Walle, L.3
Van Gurp, M.4
Van Loo, G.5
Vandenabeele, P.6
-
44
-
-
0037058964
-
Structure and zymogen activation of caspases
-
Donepudi M, &, Grütter MG, (2002) Structure and zymogen activation of caspases. Biophys Chem Rev 101-102, 145-153.
-
(2002)
Biophys Chem Rev
, vol.101-102
, pp. 145-153
-
-
Donepudi, M.1
Grütter, M.G.2
-
45
-
-
0042347713
-
Structure-based thermodynamic analysis of caspases reveals key residues for dimerization and activity
-
Piana S, Sulpizi M, &, Rothlisberger U, (2003) Structure-based thermodynamic analysis of caspases reveals key residues for dimerization and activity. Biochemistry 42, 8720-8728.
-
(2003)
Biochemistry
, vol.42
, pp. 8720-8728
-
-
Piana, S.1
Sulpizi, M.2
Rothlisberger, U.3
-
46
-
-
0037291871
-
A unified model for apical caspase activation
-
Boatright KM, Renatus M, Scott FL, Sperandio S, Shin H, Pedersen IM, Ricci JE, Edris WA, Sutherlin DP, Green DR, et al. (2003) A unified model for apical caspase activation. Mol Cell 11, 529-541.
-
(2003)
Mol Cell
, vol.11
, pp. 529-541
-
-
Boatright, K.M.1
Renatus, M.2
Scott, F.L.3
Sperandio, S.4
Shin, H.5
Pedersen, I.M.6
Ricci, J.E.7
Edris, W.A.8
Sutherlin, D.P.9
Green, D.R.10
-
47
-
-
67650455882
-
The Apaf-1 procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
-
Malladi S, Challa-Malladi M, Fearnhead HO, &, Bratton SB, (2009) The Apaf-1 procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. EMBO J 28, 1916-1925.
-
(2009)
EMBO J
, vol.28
, pp. 1916-1925
-
-
Malladi, S.1
Challa-Malladi, M.2
Fearnhead, H.O.3
Bratton, S.B.4
-
48
-
-
34347209876
-
Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9
-
Denault JB, Eckelman BP, Shin H, Pop C, &, Salvesen GS, (2007) Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. Biochem J 405, 11-19.
-
(2007)
Biochem J
, vol.405
, pp. 11-19
-
-
Denault, J.B.1
Eckelman, B.P.2
Shin, H.3
Pop, C.4
Salvesen, G.S.5
-
49
-
-
0141893341
-
Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions
-
Egger L, Schneider J, Rhême C, Tapernoux M, Häcki J, &, Borner C, (2003) Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions. Cell Death Differ 10, 1188-1203.
-
(2003)
Cell Death Differ
, vol.10
, pp. 1188-1203
-
-
Egger, L.1
Schneider, J.2
Rhême, C.3
Tapernoux, M.4
Häcki, J.5
Borner, C.6
-
50
-
-
50549089426
-
Interaction with XIAP prevents full caspase-3/-7 activation in proliferating human T lymphocytes
-
Paulsen M, Ussat S, Jakob M, Scherer G, Lepenies I, Schütze S, Kabelitz D, &, Adam-Klages S, (2008) Interaction with XIAP prevents full caspase-3/-7 activation in proliferating human T lymphocytes. Eur J Immunol 38, 1979-1987.
-
(2008)
Eur J Immunol
, vol.38
, pp. 1979-1987
-
-
Paulsen, M.1
Ussat, S.2
Jakob, M.3
Scherer, G.4
Lepenies, I.5
Schütze, S.6
Kabelitz, D.7
Adam-Klages, S.8
-
51
-
-
34347401025
-
Apoptosis of human neutrophils induced by protein phosphatase 1/2A inhibition is caspase-independent and serine protease-dependent
-
Park HY, Song MG, Lee JS, Kim JW, Jin JO, Park JI, Chang YC, &, Kwak JY, (2007) Apoptosis of human neutrophils induced by protein phosphatase 1/2A inhibition is caspase-independent and serine protease-dependent. J Cell Physiol 212, 450-462.
-
(2007)
J Cell Physiol
, vol.212
, pp. 450-462
-
-
Park, H.Y.1
Song, M.G.2
Lee, J.S.3
Kim, J.W.4
Jin, J.O.5
Park, J.I.6
Chang, Y.C.7
Kwak, J.Y.8
-
52
-
-
0032582539
-
Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis
-
Tang D, &, Kidd VJ, (1998) Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis. J Biol Chem 273, 28549-28552.
-
(1998)
J Biol Chem
, vol.273
, pp. 28549-28552
-
-
Tang, D.1
Kidd, V.J.2
-
53
-
-
0031889132
-
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
-
Sakahira H, Enari M, &, Nagata S, (1998) Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391, 96-99.
-
(1998)
Nature
, vol.391
, pp. 96-99
-
-
Sakahira, H.1
Enari, M.2
Nagata, S.3
-
54
-
-
74049114207
-
Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes
-
Agarwal A, Mahfouz RZ, Sharma RK, Sarkar O, Mangrola D, &, Mathur PP, (2009) Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes. Reprod Biol Endocrinol Rev 7, 143-162.
-
(2009)
Reprod Biol Endocrinol Rev
, vol.7
, pp. 143-162
-
-
Agarwal, A.1
Mahfouz, R.Z.2
Sharma, R.K.3
Sarkar, O.4
Mangrola, D.5
Mathur, P.P.6
-
55
-
-
0033214624
-
Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7
-
Germain M, Affer EB, D'Amours D, Dixit VM, Salvesen GS, &, Poirier GG, (1999) Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J Biol Chem 274, 28379-28384.
-
(1999)
J Biol Chem
, vol.274
, pp. 28379-28384
-
-
Germain, M.1
Affer, E.B.2
D'Amours, D.3
Dixit, V.M.4
Salvesen, G.S.5
Poirier, G.G.6
-
56
-
-
51349139607
-
Executioner caspase-3 and caspase-7 are functionally distinct proteases
-
Walsh JG, Cullen SP, Sheridan C, Lüthi AU, Gerner C, &, Martin SJ, (2008) Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proc Natl Acad Sci USA 105, 12815-12819.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 12815-12819
-
-
Walsh, J.G.1
Cullen, S.P.2
Sheridan, C.3
Lüthi, A.U.4
Gerner, C.5
Martin, S.J.6
-
57
-
-
68349127233
-
The riddle of mitochondrial caspase-3 from liver
-
Milisav I, Nipič D, &, Šuput D, (2009) The riddle of mitochondrial caspase-3 from liver. Apoptosis 14, 1070-1075.
-
(2009)
Apoptosis
, vol.14
, pp. 1070-1075
-
-
Milisav, I.1
Nipič, D.2
Šuput, D.3
-
58
-
-
0036848165
-
Caspases are not localized in mitochondria during life or death
-
van Loo G, Saelens X, Matthijssens F, Schotte P, Beyaert R, Declercq W, &, Vandenabeele P, (2002) Caspases are not localized in mitochondria during life or death. Cell Death Differ 9, 1207-1211.
-
(2002)
Cell Death Differ
, vol.9
, pp. 1207-1211
-
-
Van Loo, G.1
Saelens, X.2
Matthijssens, F.3
Schotte, P.4
Beyaert, R.5
Declercq, W.6
Vandenabeele, P.7
-
59
-
-
12544256390
-
Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s)
-
Kamada S, Kikkawa U, Tsujumoto Y, &, Hunter T, (2005) Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s). J Biol Chem 280, 857-860.
-
(2005)
J Biol Chem
, vol.280
, pp. 857-860
-
-
Kamada, S.1
Kikkawa, U.2
Tsujumoto, Y.3
Hunter, T.4
-
60
-
-
0042237031
-
Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization
-
Arnoult D, Gaume B, Karbowski M, Sharpe JC, Cecconi F, &, Youle RJ, (2003) Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. EMBO J 22, 4385-4399.
-
(2003)
EMBO J
, vol.22
, pp. 4385-4399
-
-
Arnoult, D.1
Gaume, B.2
Karbowski, M.3
Sharpe, J.C.4
Cecconi, F.5
Youle, R.J.6
-
61
-
-
0742324395
-
Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways
-
Suzuki Y, Takahashi-Niki K, Akagi T, Hashikawa T, &, Takahashi R, (2004) Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways. Cell Death Differ 11, 208-216.
-
(2004)
Cell Death Differ
, vol.11
, pp. 208-216
-
-
Suzuki, Y.1
Takahashi-Niki, K.2
Akagi, T.3
Hashikawa, T.4
Takahashi, R.5
-
62
-
-
42149134788
-
HtrA2 enhances the apoptotic functions of p73 on bax
-
Marabese M, Mazzoletti M, Vikhanskaya F, &, Broggini M, (2008) HtrA2 enhances the apoptotic functions of p73 on bax. Cell Death Differ 15, 849-858.
-
(2008)
Cell Death Differ
, vol.15
, pp. 849-858
-
-
Marabese, M.1
Mazzoletti, M.2
Vikhanskaya, F.3
Broggini, M.4
-
63
-
-
0037016686
-
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
-
Verhagen AM, Silke J, Ekert PG, Pakusch M, Kaufmann H, Connolly LM, Day CL, Tikoo A, Burke R, Wrobel C, et al. (2002) HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J Biol Chem 277, 445-454.
-
(2002)
J Biol Chem
, vol.277
, pp. 445-454
-
-
Verhagen, A.M.1
Silke, J.2
Ekert, P.G.3
Pakusch, M.4
Kaufmann, H.5
Connolly, L.M.6
Day, C.L.7
Tikoo, A.8
Burke, R.9
Wrobel, C.10
-
64
-
-
4344624526
-
Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils
-
Blink E, Maianski NA, Alnemri ES, Zervos AS, Roos D, &, Kuijpers TW, (2004) Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils. Cell Death Differ 11, 937-939.
-
(2004)
Cell Death Differ
, vol.11
, pp. 937-939
-
-
Blink, E.1
Maianski, N.A.2
Alnemri, E.S.3
Zervos, A.S.4
Roos, D.5
Kuijpers, T.W.6
-
65
-
-
56549091431
-
The complexity of mitogen-activated protein kinases (MAPKs) made simple
-
Krishna M, &, Narang H, (2008) The complexity of mitogen-activated protein kinases (MAPKs) made simple. Cell Mol Life Sci Rev 65, 3525-3544.
-
(2008)
Cell Mol Life Sci Rev
, vol.65
, pp. 3525-3544
-
-
Krishna, M.1
Narang, H.2
-
66
-
-
41549160315
-
Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
-
Junttila MR, Li SP, &, Westermarck J, (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J Rev 22, 954-965.
-
(2008)
FASEB J Rev
, vol.22
, pp. 954-965
-
-
Junttila, M.R.1
Li, S.P.2
Westermarck, J.3
-
67
-
-
2342562556
-
Mitogen-activated protein kinases in apoptosis regulation
-
Wada T, &, Penninger JM, (2004) Mitogen-activated protein kinases in apoptosis regulation. Oncogene Rev 23, 2838-2849.
-
(2004)
Oncogene Rev
, vol.23
, pp. 2838-2849
-
-
Wada, T.1
Penninger, J.M.2
-
68
-
-
24744454380
-
Protein phosphatase 2A regulates apoptosis in intestinal epithelial cells
-
Ray RM, Bhattacharya S, &, Johnson LR, (2005) Protein phosphatase 2A regulates apoptosis in intestinal epithelial cells. J Biol Chem 280, 31091-31100.
-
(2005)
J Biol Chem
, vol.280
, pp. 31091-31100
-
-
Ray, R.M.1
Bhattacharya, S.2
Johnson, L.R.3
-
69
-
-
72449171663
-
ERK-1 MAP kinase prevents TNF-induced apoptosis through Bad phosphorylation and inhibition of Bax translocation in HeLa Cells
-
Pucci B, Indelicato M, Paradisi V, Reali V, Pellegrini L, Aventaggiato M, Karpinich NO, Fini M, Russo MA, Farber JL, et al. (2009) ERK-1 MAP kinase prevents TNF-induced apoptosis through Bad phosphorylation and inhibition of Bax translocation in HeLa Cells. J Cell Biochem 108, 1166-1174.
-
(2009)
J Cell Biochem
, vol.108
, pp. 1166-1174
-
-
Pucci, B.1
Indelicato, M.2
Paradisi, V.3
Reali, V.4
Pellegrini, L.5
Aventaggiato, M.6
Karpinich, N.O.7
Fini, M.8
Russo, M.A.9
Farber, J.L.10
-
70
-
-
29044443481
-
P38 MAPK regulates phosphorylation of Bad via PP2A-dependent suppression of the MEK1/2-ERK1/2 survival pathway in TNF-α induced endothelial apoptosis
-
Grethe S, &, Pörn-Ares MI, (2006) p38 MAPK regulates phosphorylation of Bad via PP2A-dependent suppression of the MEK1/2-ERK1/2 survival pathway in TNF-α induced endothelial apoptosis. Cell Signal 18, 531-540.
-
(2006)
Cell Signal
, vol.18
, pp. 531-540
-
-
Grethe, S.1
Pörn-Ares, M.I.2
-
72
-
-
58049186804
-
Protein phosphatase 2A regulatory subunits and cancer
-
Eichhorn PJ, Creyghton MP, &, Bernards R, (2009) Protein phosphatase 2A regulatory subunits and cancer. Biochim Biophys Acta Rev 1795, 1-15.
-
(2009)
Biochim Biophys Acta Rev
, vol.1795
, pp. 1-15
-
-
Eichhorn, P.J.1
Creyghton, M.P.2
Bernards, R.3
-
73
-
-
68249106060
-
BH3-only proteins in apoptosis and beyond: An overview
-
Lomonosova E, &, Chinnadurai G, (2009) BH3-only proteins in apoptosis and beyond: an overview. Oncogene Rev 27, S2-S19.
-
(2009)
Oncogene Rev
, vol.27
-
-
Lomonosova, E.1
Chinnadurai, G.2
-
74
-
-
33846106906
-
Larger than life: Mitochondria and the Bcl-2 family
-
Skommer J, Wlodkowic D, &, Deptala A, (2007) Larger than life: mitochondria and the Bcl-2 family. Leuk Res Rev 31, 277-286.
-
(2007)
Leuk Res Rev
, vol.31
, pp. 277-286
-
-
Skommer, J.1
Wlodkowic, D.2
Deptala, A.3
-
75
-
-
1442310957
-
Structural biology of the Bcl-2 family of proteins
-
Petros AM, Olejniczak ET, &, Fesik SW, (2004) Structural biology of the Bcl-2 family of proteins. Biochim Biophys Acta Rev 1644, 83-94.
-
(2004)
Biochim Biophys Acta Rev
, vol.1644
, pp. 83-94
-
-
Petros, A.M.1
Olejniczak, E.T.2
Fesik, S.W.3
-
76
-
-
70350025502
-
Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis
-
Dewson G, &, Kluck RM, (2009) Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis. J Cell Sci Rev 122, 2801-2808.
-
(2009)
J Cell Sci Rev
, vol.122
, pp. 2801-2808
-
-
Dewson, G.1
Kluck, R.M.2
-
77
-
-
22944479314
-
JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3
-
Sunayama J, Tsuruta F, Masuyama N, &, Gotoh Y, (2005) JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3. J Cell Biol 170, 295-304.
-
(2005)
J Cell Biol
, vol.170
, pp. 295-304
-
-
Sunayama, J.1
Tsuruta, F.2
Masuyama, N.3
Gotoh, Y.4
-
78
-
-
62949138866
-
Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis
-
Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y, &, Brenner DA, (2009) Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Gastroenterology 136, 1423-1434.
-
(2009)
Gastroenterology
, vol.136
, pp. 1423-1434
-
-
Kodama, Y.1
Taura, K.2
Miura, K.3
Schnabl, B.4
Osawa, Y.5
Brenner, D.A.6
-
79
-
-
34547092443
-
Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1
-
Kobayashi S, Lee SH, Meng XW, Mott JL, Bronk SF, Werneburg NW, Craig RW, Kaufmann SH, &, Gores GJ, (2007) Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1. J Biol Chem 282, 18407-18417.
-
(2007)
J Biol Chem
, vol.282
, pp. 18407-18417
-
-
Kobayashi, S.1
Lee, S.H.2
Meng, X.W.3
Mott, J.L.4
Bronk, S.F.5
Werneburg, N.W.6
Craig, R.W.7
Kaufmann, S.H.8
Gores, G.J.9
-
80
-
-
33644855216
-
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
-
Maurer U, Charvet C, Wagman AS, Dejardin E, &, Green DR, (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell 21, 749-760.
-
(2006)
Mol Cell
, vol.21
, pp. 749-760
-
-
Maurer, U.1
Charvet, C.2
Wagman, A.S.3
Dejardin, E.4
Green, D.R.5
-
81
-
-
58149090998
-
Identification of the major phosphorylation site in Bcl-xL induced by microtubule inhibitors and analysis of its functional significance
-
Upreti M, Galitovskaya EN, Chu R, Tackett AJ, Terrano DT, Granell S, &, Chambers TC, (2008) Identification of the major phosphorylation site in Bcl-xL induced by microtubule inhibitors and analysis of its functional significance. J Biol Chem 283, 35517-35525.
-
(2008)
J Biol Chem
, vol.283
, pp. 35517-35525
-
-
Upreti, M.1
Galitovskaya, E.N.2
Chu, R.3
Tackett, A.J.4
Terrano, D.T.5
Granell, S.6
Chambers, T.C.7
-
82
-
-
0347089015
-
Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions
-
Deng X, Gao F, Flagg T, &, May WS Jr, (2004) Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions. Proc Natl Acad Sci USA 101, 153-158.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 153-158
-
-
Deng, X.1
Gao, F.2
Flagg, T.3
May, Jr.W.S.4
-
83
-
-
2442681877
-
Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils
-
Gardai SJ, Hildeman DA, Frankel SK, Whitlock BB, Frasch SC, Borregaard N, Marrack P, Bratton DL, &, Henson PM, (2004) Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem 279, 21085-21095.
-
(2004)
J Biol Chem
, vol.279
, pp. 21085-21095
-
-
Gardai, S.J.1
Hildeman, D.A.2
Frankel, S.K.3
Whitlock, B.B.4
Frasch, S.C.5
Borregaard, N.6
Marrack, P.7
Bratton, D.L.8
Henson, P.M.9
-
84
-
-
33745812349
-
Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation
-
Xin M, &, Deng X, (2006) Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation. J Biol Chem 281, 18859-18867.
-
(2006)
J Biol Chem
, vol.281
, pp. 18859-18867
-
-
Xin, M.1
Deng, X.2
-
85
-
-
20944438745
-
Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel
-
Dejean LM, Martinez-Caballero S, Guo L, Hughes C, Teijido O, Ducret T, Ichas F, Korsmeyer SJ, Antonsson B, Jonas EA, et al. (2005) Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. Mol Biol Cell 16, 2424-2432.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 2424-2432
-
-
Dejean, L.M.1
Martinez-Caballero, S.2
Guo, L.3
Hughes, C.4
Teijido, O.5
Ducret, T.6
Ichas, F.7
Korsmeyer, S.J.8
Antonsson, B.9
Jonas, E.A.10
-
86
-
-
0043193866
-
Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis
-
Chiang CW, Kanies C, Kim KW, Fang WB, Parkhurst C, Xie M, Henry T, &, Yang E, (2003) Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Mol Cell Biol 23, 6350-6362.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 6350-6362
-
-
Chiang, C.W.1
Kanies, C.2
Kim, K.W.3
Fang, W.B.4
Parkhurst, C.5
Xie, M.6
Henry, T.7
Yang, E.8
-
87
-
-
2442429306
-
JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins
-
Tsuruta F, Sunayama J, Mori Y, Hattori S, Shimizu S, Tsujimoto Y, Yoshioka K, Masuyama N, &, Gotoh Y, (2004) JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J 23, 1889-1899.
-
(2004)
EMBO J
, vol.23
, pp. 1889-1899
-
-
Tsuruta, F.1
Sunayama, J.2
Mori, Y.3
Hattori, S.4
Shimizu, S.5
Tsujimoto, Y.6
Yoshioka, K.7
Masuyama, N.8
Gotoh, Y.9
-
88
-
-
70349956567
-
Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation
-
Allan LA, &, Clarke PR, (2009) Apoptosis and autophagy: regulation of caspase-9 by phosphorylation. FEBS J Rev 276, 6063-6073.
-
(2009)
FEBS J Rev
, vol.276
, pp. 6063-6073
-
-
Allan, L.A.1
Clarke, P.R.2
-
89
-
-
42949174816
-
The docking interaction of caspase-9 with ERK2 provides a mechanism for the selective inhibitory phosphorylation of caspase-9 at threonine 125
-
Martin MC, Allan LA, Mancini EJ, &, Clarke PR, (2008) The docking interaction of caspase-9 with ERK2 provides a mechanism for the selective inhibitory phosphorylation of caspase-9 at threonine 125. J Biol Chem 283, 3854-3865.
-
(2008)
J Biol Chem
, vol.283
, pp. 3854-3865
-
-
Martin, M.C.1
Allan, L.A.2
Mancini, E.J.3
Clarke, P.R.4
-
90
-
-
41949117115
-
Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8
-
Jia SH, Parodo J, Kapus A, Rotstein OD, &, Marshall JC, (2008) Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8. J Biol Chem 283, 5402-5413.
-
(2008)
J Biol Chem
, vol.283
, pp. 5402-5413
-
-
Jia, S.H.1
Parodo, J.2
Kapus, A.3
Rotstein, O.D.4
Marshall, J.C.5
-
91
-
-
33646542701
-
Src kinase phosphorylates caspase-8 on Tyr380: A novel mechanism of apoptosis suppression
-
Cursi S, Rufini A, Stagni V, Condò I, Matafora V, Bachi A, Bonifazi AP, Coppola L, Superti-Furga G, Testi R, et al. (2006) Src kinase phosphorylates caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. EMBO J 25, 1895-1905.
-
(2006)
EMBO J
, vol.25
, pp. 1895-1905
-
-
Cursi, S.1
Rufini, A.2
Stagni, V.3
Condò, I.4
Matafora, V.5
Bachi, A.6
Bonifazi, A.P.7
Coppola, L.8
Superti-Furga, G.9
Testi, R.10
-
92
-
-
70450224676
-
H2AX: Functional roles and potential applications
-
Dickey JS, Redon CE, Nakamura AJ, Baird BJ, Sedelnikova OA, &, Bonner WM, (2009) H2AX: functional roles and potential applications. Chromosoma Rev 118, 683-692.
-
(2009)
Chromosoma Rev
, vol.118
, pp. 683-692
-
-
Dickey, J.S.1
Redon, C.E.2
Nakamura, A.J.3
Baird, B.J.4
Sedelnikova, O.A.5
Bonner, W.M.6
-
93
-
-
63849187827
-
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
-
Cook PJ, Ju BG, Telese F, Wang X, Glass CK, &, Rosenfeld MG, (2009) Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature 458, 591-596.
-
(2009)
Nature
, vol.458
, pp. 591-596
-
-
Cook, P.J.1
Ju, B.G.2
Telese, F.3
Wang, X.4
Glass, C.K.5
Rosenfeld, M.G.6
-
94
-
-
67649313760
-
The apoptotic ring: A novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases
-
Solier S, &, Pommier Y, (2009) The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases. Cell Cycle 8, 1853-1859.
-
(2009)
Cell Cycle
, vol.8
, pp. 1853-1859
-
-
Solier, S.1
Pommier, Y.2
-
95
-
-
33745487368
-
Cell apoptosis: Requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3
-
Lu C, Zhu F, Cho YY, Tang F, Zykova T, Ma WY, Bode AM, &, Dong Z, (2006) Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. Mol Cell 23, 121-132.
-
(2006)
Mol Cell
, vol.23
, pp. 121-132
-
-
Lu, C.1
Zhu, F.2
Cho, Y.Y.3
Tang, F.4
Zykova, T.5
Ma, W.Y.6
Bode, A.M.7
Dong, Z.8
-
96
-
-
0343280013
-
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
-
Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, &, Bonner WM, (2000) A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 10, 886-895.
-
(2000)
Curr Biol
, vol.10
, pp. 886-895
-
-
Paull, T.T.1
Rogakou, E.P.2
Yamazaki, V.3
Kirchgessner, C.U.4
Gellert, M.5
Bonner, W.M.6
-
97
-
-
18344377030
-
The p53 pathway: Positive and negative feedback loops
-
Harris SL, &, Levine AJ, (2005) The p53 pathway: positive and negative feedback loops. Oncogene Rev 24, 2899-2908.
-
(2005)
Oncogene Rev
, vol.24
, pp. 2899-2908
-
-
Harris, S.L.1
Levine, A.J.2
-
98
-
-
55949083781
-
Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage
-
Cai X, &, Liu X, (2008) Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage. Proc Natl Acad Sci USA 105, 16958-16963.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 16958-16963
-
-
Cai, X.1
Liu, X.2
-
99
-
-
77950520346
-
HSP72 depletion suppresses γh2AX activation by genotoxic stresses via p53/p21 signaling
-
Gabai VL, Sherman MY, &, Yaglom JA, (2010) HSP72 depletion suppresses γH2AX activation by genotoxic stresses via p53/p21 signaling. Oncogene 29, 1952-1962.
-
(2010)
Oncogene
, vol.29
, pp. 1952-1962
-
-
Gabai, V.L.1
Sherman, M.Y.2
Yaglom, J.A.3
-
100
-
-
34247613558
-
Activation of PKCδ and p38δ MAPK during okadaic acid dependent keratinocyte apoptosis
-
Kraft CA, Efimova T, &, Eckert RL, (2007) Activation of PKCδ and p38δ MAPK during okadaic acid dependent keratinocyte apoptosis. Arch Dermatol Res 299, 71-83.
-
(2007)
Arch Dermatol Res
, vol.299
, pp. 71-83
-
-
Kraft, C.A.1
Efimova, T.2
Eckert, R.L.3
-
101
-
-
42949110704
-
Bcl-xL prevents staurosporine-induced hepatocyte apoptosis by restoring protein kinase B/mitogen-activated protein kinase activity and mitochondria integrity
-
Wang Y, Zhang B, Peng X, Perpetua M, &, Harbrecht BG, (2008) Bcl-xL prevents staurosporine-induced hepatocyte apoptosis by restoring protein kinase B/mitogen-activated protein kinase activity and mitochondria integrity. J Cell Physiol 215, 676-683.
-
(2008)
J Cell Physiol
, vol.215
, pp. 676-683
-
-
Wang, Y.1
Zhang, B.2
Peng, X.3
Perpetua, M.4
Harbrecht, B.G.5
-
102
-
-
56849104094
-
Marine toxins and the cytoskeleton: Okadaic acid and dinophysistoxins
-
Vale C, &, Botana LM, (2008) Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins. FEBS J Rev 275, 6060-6066.
-
(2008)
FEBS J Rev
, vol.275
, pp. 6060-6066
-
-
Vale, C.1
Botana, L.M.2
-
103
-
-
0030720062
-
Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A
-
Walsh AH, Cheng A, &, Honkanen RE, (1997) Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A. FEBS Lett 416, 230-234.
-
(1997)
FEBS Lett
, vol.416
, pp. 230-234
-
-
Walsh, A.H.1
Cheng, A.2
Honkanen, R.E.3
-
104
-
-
33845367029
-
Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase
-
Boudreau RT, Conrad DM, &, Hoskin DW, (2007) Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase. Cell Signal 19, 139-151.
-
(2007)
Cell Signal
, vol.19
, pp. 139-151
-
-
Boudreau, R.T.1
Conrad, D.M.2
Hoskin, D.W.3
-
105
-
-
77953318704
-
L in a PP2A-dependent manner during oxidative stress and promotes retinal pigment epithelial cell survival
-
L in a PP2A-dependent manner during oxidative stress and promotes retinal pigment epithelial cell survival. J Biol Chem 285, 18301-18308.
-
(2010)
J Biol Chem
, vol.285
, pp. 18301-18308
-
-
Antony, R.1
Lukiw, W.J.2
Bazan, N.G.3
-
106
-
-
3142683869
-
MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol
-
Domina AM, Vrana JA, Gregory MA, Hann SR, &, Craig RW, (2004) MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. Oncogene 23, 5301-5315.
-
(2004)
Oncogene
, vol.23
, pp. 5301-5315
-
-
Domina, A.M.1
Vrana, J.A.2
Gregory, M.A.3
Hann, S.R.4
Craig, R.W.5
-
107
-
-
0842278331
-
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
-
Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, &, Green DR, (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303, 1010-1014.
-
(2004)
Science
, vol.303
, pp. 1010-1014
-
-
Chipuk, J.E.1
Kuwana, T.2
Bouchier-Hayes, L.3
Droin, N.M.4
Newmeyer, D.D.5
Schuler, M.6
Green, D.R.7
-
108
-
-
33646889064
-
Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities
-
Li DC, Liu JP, Schmid PC, Schlosser R, Feng H, Liu WB, Yan Q, Gong L, Sun SM, Deng M, et al. (2006) Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities. Oncogene 25, 3006-3022.
-
(2006)
Oncogene
, vol.25
, pp. 3006-3022
-
-
Li, D.C.1
Liu, J.P.2
Schmid, P.C.3
Schlosser, R.4
Feng, H.5
Liu, W.B.6
Yan, Q.7
Gong, L.8
Sun, S.M.9
Deng, M.10
-
109
-
-
2942594540
-
Protein phosphatase 1, but not protein phosphatase 2A, dephosphorylates DNA-damaging stress-induced phospho-serine 15 of p53
-
Haneda M, Kojima E, Nishikimi A, Hasegawa T, Nakashima I, &, Isobe K, (2004) Protein phosphatase 1, but not protein phosphatase 2A, dephosphorylates DNA-damaging stress-induced phospho-serine 15 of p53. FEBS Lett 567, 171-174.
-
(2004)
FEBS Lett
, vol.567
, pp. 171-174
-
-
Haneda, M.1
Kojima, E.2
Nishikimi, A.3
Hasegawa, T.4
Nakashima, I.5
Isobe, K.6
-
110
-
-
0942301178
-
Phosphorylation of p53 at serine 37 is important for transcriptional activity and regulation in response to DNA damage
-
Dohoney KM, Guillerm C, Whiteford C, Elbi C, Lambert PF, Hager GL, &, Brady JN, (2004) Phosphorylation of p53 at serine 37 is important for transcriptional activity and regulation in response to DNA damage. Oncogene 23, 49-57.
-
(2004)
Oncogene
, vol.23
, pp. 49-57
-
-
Dohoney, K.M.1
Guillerm, C.2
Whiteford, C.3
Elbi, C.4
Lambert, P.F.5
Hager, G.L.6
Brady, J.N.7
-
111
-
-
42949170340
-
Protein phosphatase-2A is a target of epigallocatechin-3-gallate and modulates p53-Bak apoptotic pathway
-
Qin J, Chen HG, Yan Q, Deng M, Liu J, Doerge S, Ma W, Dong Z, &, Li DW, (2008) Protein phosphatase-2A is a target of epigallocatechin-3-gallate and modulates p53-Bak apoptotic pathway. Cancer Res 68, 4150-4162.
-
(2008)
Cancer Res
, vol.68
, pp. 4150-4162
-
-
Qin, J.1
Chen, H.G.2
Yan, Q.3
Deng, M.4
Liu, J.5
Doerge, S.6
Ma, W.7
Dong, Z.8
Li, D.W.9
-
112
-
-
58149505583
-
PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53
-
Mi J, Bolesta E, Brautigan DL, &, Larner JM, (2009) PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53. Mol Cancer Ther 8, 135-140.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 135-140
-
-
Mi, J.1
Bolesta, E.2
Brautigan, D.L.3
Larner, J.M.4
-
113
-
-
28444483130
-
γ-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair
-
Chowdhury D, Keogh MC, Ishii H, Peterson CL, Buratowski S, &, Lieberman J, (2005) γ-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell 20, 801-809.
-
(2005)
Mol Cell
, vol.20
, pp. 801-809
-
-
Chowdhury, D.1
Keogh, M.C.2
Ishii, H.3
Peterson, C.L.4
Buratowski, S.5
Lieberman, J.6
-
114
-
-
33845291508
-
Negative regulation of Akt activity by p38α MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1
-
Zuluaga S, Alvarez-Barrientos A, Gutiérrez-Uzquiza A, Benito M, Nebreda AR, &, Porras A, (2007) Negative regulation of Akt activity by p38α MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1. Cell Signal 19, 62-74.
-
(2007)
Cell Signal
, vol.19
, pp. 62-74
-
-
Zuluaga, S.1
Alvarez-Barrientos, A.2
Gutiérrez-Uzquiza, A.3
Benito, M.4
Nebreda, A.R.5
Porras, A.6
-
115
-
-
58849089256
-
Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding
-
Deng X, Gao F, &, May WS, (2009) Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding. Blood 113, 422-428.
-
(2009)
Blood
, vol.113
, pp. 422-428
-
-
Deng, X.1
Gao, F.2
May, W.S.3
-
116
-
-
44649115720
-
The cytotoxicity and genotoxicity of okadaic acid are cell-line dependent
-
Souid-Mensi G, Moukha S, Mobio TA, Maaroufi K, &, Creppy EE, (2008) The cytotoxicity and genotoxicity of okadaic acid are cell-line dependent. Toxicon 51, 1338-1344.
-
(2008)
Toxicon
, vol.51
, pp. 1338-1344
-
-
Souid-Mensi, G.1
Moukha, S.2
Mobio, T.A.3
Maaroufi, K.4
Creppy, E.E.5
-
117
-
-
0030924806
-
Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin
-
Hemmings BA, Favre B, &, Turowski P, (1997) Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin. J Biol Chem 272, 13856-13863.
-
(1997)
J Biol Chem
, vol.272
, pp. 13856-13863
-
-
Hemmings, B.A.1
Favre, B.2
Turowski, P.3
-
118
-
-
4644317330
-
Inhibitors of protein phosphatases 1 and 2A differentially prevent intrinsic and extrinsic apoptosis pathways
-
Chatfield K, &, Eastman A, (2004) Inhibitors of protein phosphatases 1 and 2A differentially prevent intrinsic and extrinsic apoptosis pathways. Biochem Biophys Res Commun 323, 1313-1320.
-
(2004)
Biochem Biophys Res Commun
, vol.323
, pp. 1313-1320
-
-
Chatfield, K.1
Eastman, A.2
-
119
-
-
14044268205
-
Protein phosphatase 2A regulates apoptosis in neutrophils by dephosphorylating both p38 MAPK and its substrate caspase 3
-
Alvarado-Kristensson M, &, Andersson T, (2005) Protein phosphatase 2A regulates apoptosis in neutrophils by dephosphorylating both p38 MAPK and its substrate caspase 3. J Biol Chem 280, 6238-6244.
-
(2005)
J Biol Chem
, vol.280
, pp. 6238-6244
-
-
Alvarado-Kristensson, M.1
Andersson, T.2
-
120
-
-
68649102538
-
P38MAPK regulates caspase-3 by binding to caspase-3 in nucleus of human hepatoma Bel-7402 cells during anti-Fas antibody- and actinomycin D-induced apoptosis
-
Wang Y, Sun L, Xia C, Ye L, &, Wang B, (2009) P38MAPK regulates caspase-3 by binding to caspase-3 in nucleus of human hepatoma Bel-7402 cells during anti-Fas antibody- and actinomycin D-induced apoptosis. Biomed Pharmacother 63, 343-350.
-
(2009)
Biomed Pharmacother
, vol.63
, pp. 343-350
-
-
Wang, Y.1
Sun, L.2
Xia, C.3
Ye, L.4
Wang, B.5
-
121
-
-
59649092928
-
Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death
-
Roy SS, Madesh M, Davies E, Antonsson B, Danial N, &, Hajnóczky G, (2009) Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death. Mol Cell 33, 377-388.
-
(2009)
Mol Cell
, vol.33
, pp. 377-388
-
-
Roy, S.S.1
Madesh, M.2
Davies, E.3
Antonsson, B.4
Danial, N.5
Hajnóczky, G.6
-
122
-
-
33746379603
-
JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells
-
Kim BJ, Ryu SW, &, Song BJ, (2006) JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J Biol Chem 281, 21256-21265.
-
(2006)
J Biol Chem
, vol.281
, pp. 21256-21265
-
-
Kim, B.J.1
Ryu, S.W.2
Song, B.J.3
-
123
-
-
77649246037
-
Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis
-
Geng Y, Walls KC, Ghosh AP, Akhtar RS, Klocke BJ, &, Roth KA, (2010) Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription- independent neural precursor cell apoptosis. J Histochem Cytochem 58, 265-275.
-
(2010)
J Histochem Cytochem
, vol.58
, pp. 265-275
-
-
Geng, Y.1
Walls, K.C.2
Ghosh, A.P.3
Akhtar, R.S.4
Klocke, B.J.5
Roth, K.A.6
-
124
-
-
53649092150
-
Expression of Arl2 is associated with p53 localization and chemosensitivity in a breast cancer cell line
-
Béghin A, Matera EL, Brunet-Manquat S, &, Dumontet C, (2008) Expression of Arl2 is associated with p53 localization and chemosensitivity in a breast cancer cell line. Cell Cycle 7, 3074-3082.
-
(2008)
Cell Cycle
, vol.7
, pp. 3074-3082
-
-
Béghin, A.1
Matera, E.L.2
Brunet-Manquat, S.3
Dumontet, C.4
|